Area de investigación
Fisiología, fisiopatología y farmacología de la circulación cerebral.
Proyecto en curso
Influencia de
estrógenos endógenos y fitoestrógenos sobre el estrés oxidativo y la
inflamación inducidos por la isquemia cerebral en ratas de ambos sexos
(PI030323).
Tesis doctorales dirigidas
Papel del calcio en la vasoconstricción cerebral experimental, por Dª Cristina
Alvarez Lozano. Universidad de Valencia, 1992.
Efectos de la endotelina-1 y péptidos relacionados sobre el lecho cerebrovascular
de la cabra, por Dª María Dolores Barberá Ortíz. Universidad de Valencia, 1995.
Dadores de óxido nítrico: efectos cerebrovasculares y utilidad en la isquemia
cerebral experimental, por Dª Marta Ortí Morales. Universidad de Valencia,
1998.
Efectos
vasoactivos de 17-β-estradiol y fitoestrógenos en arterias cerebrales, por
Dª María Consuelo Burguete López. Universidad de Valencia, 2005.
Publicaciones
Torregrosa G, Terrasa JC, Salom JB, Miranda FJ, Campos V, Alborch E. P 1-purinoceptors in the
cerebrovascular bed of the goat in vivo. Eur. J. Pharmacol. 1988;
149:17-24.
Miranda FJ, Torregrosa G, Salom JB, Campos V, Alabadí JA, Alborch E. Inhibitory effect of GABA on cerebrovascular
sympathetic neurotransmission. Brain
Res. 1989; 492:45-52.
Salom JB,
Torregrosa G, Miranda FJ, Alabadí JA, Alvarez C, Alborch E. Effects of Ca2+ entry
blockers on CaCl2-, KCl- and noradrenaline-induced contractions of
goat cerebral arteries. Eur. J. Pharmacol. 1990; 177:1-8.
Salom JB, Campos V, Perales A, Torregrosa G, Miranda FJ, Alabadí JA, Alborch E.
Effects of calcium entry blockers on
KCl- and 5-hydroxytryptamine-induced contractions of human umbilical arteries. Arch. int.
Pharmacodyn. Ther. 1990; 304:219-231.
Torregrosa G, Miranda FJ, Salom JB, Alabadí JA, Alvarez C, Alborch E. Heterogeneity of P2-purinoceptors
in brain circulation. J. Cereb. Blood
Flow Metab. 1990;
10:572-579.
Torregrosa G, Salom JB, Miranda FJ, Alabadí JA, Alvarez C, Alborch E. Adenosine A2 receptors
mediate cerebral vasodilation in the conscious goat. Blood Vessels 1990; 27:24-27.
Salom JB, Torregrosa G, Miranda FJ, Alabadí JA, Alvarez C, Alborch E. Effects of endothelin-1 in the
cerebrovascular bed of the goat. Eur. J. Pharmacol. 1991; 192:39-45.
Miranda FJ, Torregrosa G, Salom JB, Alabadí JA, Alvarez C, Alborch E. Modulatory action of acetylcholine
on cerebrovascular sympathetic neurotransmission. Gen. Pharmac. 1991;
22:1115-1120.
Salom JB, Torregrosa G, Miranda FJ, Alabadí JA, Alvarez C, Alborch E. Ca2+ entry blockers
inhibit prostaglandin F2alpha -induced cerebrovascular contractile
responses in goats. Eur. J. Pharmacol. 1991; 203:33-39.
Perales AJ, Torregrosa G, Salom JB, Miranda FJ, Alabadí JA, Monleón J, Alborch
E. In vivo and in vitro effects of
magnesium sulfate in the cerebrovascular bed of the goat. Am. J. Obst. Gynecol. 1991;
165:1534-1538.
Miranda FJ, Torregrosa G, Salom JB, Alabadí JA, Alvarez C, Alborch E. Direct and neuromodulatory effects
of histamine on isolated goat cerebral arteries. J. Auton. Pharmacol. 1992;
12:25-36.
Salom JB, Torregrosa G, Miranda FJ, Alabadí JA, Alborch E. Comparison of the contractile
effects of endothelin-1 and sarafotoxin S6b in goat isolated cerebral arteries. Br. J. Pharmacol. 1992;
106:95-100.
Alborch E, Salom JB, Perales AJ, Torregrosa G, Miranda FJ, Alabadí JA, Jover T.
Comparison of the anticonstrictor
action of dihydropyridines (nimodipine and nicardipine) and Mg2+ in
isolated human cerebral arteries. Eur. J. Pharmacol. 1992; 229:83-89.
Miranda FJ, Torregrosa G, Salom JB, Alabadí JA, Jover T, Barberá MD,
Alborch E. Endothelial modulation of
5-hydroxytryptamine-induced contraction in goat cerebral arteries. Gen. Pharmac. 1993; 24:649-653.
Salom JB, Torregrosa G, Barberá MD, Jover T, Alborch E. Endothelin receptors mediating
contraction in goat cerebral arteries. Br. J. Pharmacol. 1993;
109:826-830.
Alabadí JA, Salom JB, Torregrosa G, Miranda FJ, Jover T, Alborch E. Changes in the cerebrovascular
effects of endothelin-1 and nicardipine after experimental subarachnoid
hemorrhage. Neurosurgery 1993; 33:707-715.
Torregrosa G, Perales AJ, Salom JB, Miranda FJ, Barberá MD, Alborch E. Different effects of Mg2+
on endothelin-1- and 5-hydroxytryptamine-elicited responses in the cerebrovascular
bed of the goat. J. Cardiovasc. Pharmacol. 1994; 23:1004-1010.
Torregrosa G, Salom JB, Jover T, Miranda FJ, Alborch E. Evidence of a direct constrictor
action of MK-801 and its modulation by the endothelium in cerebral arteries. J. Vasc. Res. 1994; 31:221-229.
Alabadí JA, Torregrosa G, Salom JB, Miranda FJ, Barberá MD, Mayordomo F,
Alborch E. Changes in the adrenergic mechanisms
of cerebral arteries after subarachnoid hemorrhage in goats. Neurosurgery 1994; 34:1027-1034.
Miranda FJ, Torregrosa G, Salom JB, Alabadí JA, Jover T, Barberá MD, Alborch E.
Characterization of
5-hydroxytryptamine receptors in goat cerebral arteries. Gen. Pharmac. 1995; 26:1267-1272.
Salom JB, Torregrosa G, Alborch E. Endothelins and the cerebral
circulation. Cerebrovasc. Brain Metab. Rev. 1995;
7:131-52.
Alborch E, Salom JB, Torregrosa G. Calcium channels in cerebral
arteries. Pharmacol. Ther. 1995; 68:1-34.
Salom JB, Torregrosa G, Barberá MD, Jover T, Ortí M, Alborch E. Effects of cocaine on human and goat
isolated cerebral arteries. Drug Alcohol Depen. 1996; 42:65-71.
Miranda FJ, Alabadí JA, Torregrosa G, Salom JB, Jover T, Barberá MD, Alborch E.
Modulatory role of endothelial and
non-endothelial nitric oxide on 5-hydroxytryptamine-induced contraction in
cerebral arteries after subarachnoid hemorrhage. Neurosurgery 1996; 39:998-1004.
Alabadí JA, Torregrosa G, Miranda FJ, Salom JB, Centeno JM, Alborch E. Impairment of the modulatory role of
nitric oxide on the endothelin-1-elicited contraction of cerebral arteries: a
pathogenetic factor in cerebral vasospasm after subarachnoid hemorrhage? Neurosurgery 1997; 41:245-253.
Perales A, Torregrosa G, Salom JB, Barberá MD, Jover T, Alborch E. Effects of magnesium sulphate on the
noradrenaline-induced cerebral vasoconstrictor and pressor responses in the
goat. Br. J. Obstet. Gynaecol. 1997; 104:898-903.
Torregrosa G, Barberá MD, Centeno JM, Ortí M, Salom JB, Jover T, Alborch E. Characterization of the cortical
laser-Doppler flow and hippocampal degenerative patterns after global cerebral
ischemia in the goat. Plügers Arch. – Eur. J. Physiol. 1998; 435:662-669.
Salom JB, Barberá MD, Centeno JM, Ortí M, Torregrosa G, Alborch E. Relaxant effects of sodium
nitroprusside and NONOates in rabbit basilar artery. Pharmacology 1998; 57:79-87.
Salom JB, Barberá MD, Centeno JM, Ortí M, Torregrosa G, Alborch E. Comparative relaxant effects of the
NO donors sodium nitroprusside, DEA/NO and SPER/NO in rabbit carotid arteries. Gen. Pharmacol. 1999; 32: 75-79.
Salom JB, Barberá MD, Centeno JM, Ortí M, Torregrosa G, Alborch E. Relaxant effects of sodium
nitroprusside and NONOates in goat middle cerebral artery: delayed impairment
by global ischemia-reperfusion. Nitric Oxide 1999; 3:85-93.
Centeno JM, Ortí M, Salom JB, Sick TJ, Pérez-Pinzón MA. Nitric oxide is involved in anoxic
preconditioning neuroprotection in rat hippocampal slices. Brain Res. 1999; 836:62-69.
Torregrosa G, Barberá MD, Ortí M, Centeno JM, Salom JB, Alborch E. Cerebrovascular effects of
dotarizine, a piperazine derivative, in the goat. An in vivo
and in vitro complementary study. Arzneim.-Forsch./Drug Res. 1999; 49:668-672.
Salom JB, Centeno JM, Torregrosa G, Ortí M, Barberá MD, Alborch E.
Vasoconstriction to endothelin-1
in the goat middle cerebral artery after transient
global cerebral ischemia. J. Stroke Cerebrovasc. Dis. 2000;
9:16-21.
Salom JB, Ortí M, Centeno JM, Torregrosa G, Alborch E. Reduction of infarct size by the NO
donors sodium nitroprusside and spermine/NO after transient focal cerebral
ischemia in rats. Brain Res. 2000;
865:149-156.
Torregrosa G, Barberá MD, Ortí M, Centeno JM, Salom JB, Justicia C, Planas AM,
Alborch E. Temporospatial expression of HSP72
and c-JUN, and DNA fragmentation in goat hippocampus after global cerebral
ischemia. Hippocampus 2001; 11:146-156.
Salom JB, Burguete MC, Pérez-Asensio FJ, Torregrosa G, Alborch E. Relaxant effects of
17-beta-estradiol in cerebral arteries through Ca2+ entry
inhibition. J. Cereb. Blood Flow
Metab. 2001; 21:422-429.
Justicia C, Pérez-Asensio FJ, Burguete MC, Salom JB, Planas
AM. Administration of transforming
growth factor-alpha reduces infarct volume after transient focal cerebral
ischemia in the rat. J. Cereb. Blood Flow Metab. 2001; 21:1097-1104.
Salom JB, Burguete MC, Pérez-Asensio FJ, Centeno JM, Torregrosa G, Alborch E. Acute relaxant effects of
17-beta-estradiol through non-genomic mechanisms in rabbit carotid artery. Steroids 2002; 67:339-346.
Torregrosa G, Burguete MC, Pérez-Asensio FJ, Salom JB, Gil JV, Alborch E. Pharmacological profile of
phytoestrogens in cerebral vessels: in vitro study with rabbit basilar artery. Eur J Pharmacol 2003;
482:227-234.
Salom JB, Pérez-Asensio FJ, Burguete MC, Marín N, Pitarch C, Torregrosa G,
Romero FJ, Alborch E. Single-dose ebselen does not afford
sustained neuroprotection to rats subjected to severe focal cerebral isquemia. Eur J Pharmacol 2004; 495:55-62.
Perez-Asensio FJ, Hurtado O, Burguete MC, Moro MA, Salom JB, Lizasoain I,
Torregrosa G, Leza JC, Alborch E, Castillo J, Knowles RG, Lorenzo P. Inhibition of iNOS activity by 1400W
decreases glutamate release and
ameliorates stroke outcome after experimental ischemia. Neurobiol. Dis. 2005; 18:375-84.
Salom JB, Burguete MC, Pérez-Asensio FJ, Castelló-Ruiz
M, Torregrosa G, Alborch E. Relaxant
effect of sildenafil in the rabbit basilar artery. Vascul.
Pharmacol. 2006; 44:10-16.