Probability that human cutaneous neoplastic lesions will progress to invasive carcinoma.The likelihood of AKs in patients with fewer than 5 or more than 20 lesions progressing to cSCC is shown

From keratinocyte to cancer: the pathogenesis and modeling of cutaneous squamous cell carcinoma. ladimir Ratushny, Michael D. Gober, Ryan Hick, Todd W. Ridky and John T. Seykora J Clin Invest. 2012;122(2):464–472