Free Radicals & Rare diseases

The main topic of Professor Pallardó and his group relies on the implication of oxidative stress in rare diseases. The group is included within the area of genomic instability and predisposition to cancer in the framework of the CIBERER (Spanish acronym for Center for Biomedical Research on Rare Diseases) a network of research centers hosted by the Spanish Ministry of Science and Innovation. Our research focuses on two distinct pathologies:

- Fanconi Anaemia 
- Down's syndrome

Recently, their investigations are expanding into other diseases such as Friedreich's ataxia and Kindler Syndrome in collaboration with different CIBERER groups.

CIBERER scientific projects.

Cell cycle regulation in Down's syndrome. Implications of oxidative stress (project #733.1)

Coenzime Q as mitochondrial homeostasis sensor (projet #729.1).

Oxidative profile and cell proliferation in fibroblasts from patients with Fanconi anemia subjected to hypoxia (project #733.2).

CIBERER. Centro de Investigación Biomédica en Red de Enfermedades Raras.

CIBERER is one of the seven consortia created by the Instituto de Salud Carlos III (ISCIII) in 2006 to promote research excellence in the field of biomedicine and health sciences. The main mission of CIBERER is support the study of rare diseases in different areas such as genetic, molecular, biochemistry and cellular fields to understand the causes and pathogenic mechanisms that induce these diseases and develop new diagnostic and therapeutic strategies.