Research
I
earned my bachelor degree in Sport Sciences on 1998. Since
then I´ ve been working on my doctoral thesis in the
Department of Physiology in the University of Valencia in
Jose Viña´s laboratory. I got the European PhD in 2004
with a thesis entitled Role of Free Radicals in Exhaustive
Physical Exercise. Effect of antioxidant
administration.
My
research interest is focused in physical exercise and
oxidative stress (see specific lines of work section).
During these years in the department of Physiology I have
had the opportunity of visiting different laboratories. In
2001 I visited, for 3 months, Kelvin Davies´ lab in the
University of Southern California (Los Angeles). Professor
Davies´ pioneering work in 1982 first showed that there is
a free radical production in skeletal muscle after exercise.
In his department I was trained in different molecular
biology techniques. In 2002 and 2003 I spent 6 months
working in Li Li Ji´s laboratory in the University of
Wisconsin-Madison. Professor Ji first observed that exercise
increases the activity of antioxidant enzymes. During this
period of time we studied the NF- kB Signaling Pathway in
Rat Skeletal Muscle after an acute bout of physical exercise
(Ji et al. 2004). Since 2004 I have spent 9 months in Prof.
Jackson´s department in the University of Liverpool.
Malcolm Jackson is a major expert in muscle physiology and
oxidants in the UK. We studied the effect of allopurinol
administration in the production of free radicals in
gastrocnemius during muscle contraction using the
microdialysis technique.
I
really like doing sports maybe that´s why I enjoy doing
research in this topic. Swimming is my favourite.
Selected
Publications
Gomez-Cabrera
MC, Domenech E, Viña J. Moderate
exercise is an antioxidant: upregulation of antioxidant
genes by training. Free
Radic Biol Med. 2008 Jan 15;44(2):126-31.
Gomez-Cabrera
MC, Domenech E, Romagnoli M, Arduini A, Borras C, Pallardo
FV, Sastre J, Viña J. Oral
administration of vitamin C decreases muscle mitochondrial
biogenesis and hampers training-induced adaptations in
endurance performance. Am
J Clin Nutr. 2008 Jan;87(1):142-9.
Ji
LL, Gomez-Cabrera MC, Vina J. Role
of nuclear factor kappaB and mitogen-activated protein
kinase signaling in exercise-induced antioxidant enzyme
adaptation. Appl
Physiol Nutr Metab. 2007 Oct;32(5):930-5.
Viña
J, Gomez-Cabrera MC, Borras C. Fostering
antioxidant defences: up-regulation of antioxidant genes or
antioxidant supplementation?. Br
J Nutr. 2007 Oct;98 Suppl 1:S36-40.
Gomez-Cabrera
MC, Zaragoza R, Pallardo FV, Viña JR.
SIRT1
regulation of insulin-signalling pathways in liver, white
adipose tissue and pancreas during fasting or calorie
restriction. Trends
Endocrinol Metab. 2007 Apr;18(3):91-2
Gomez-Cabrera
MC, Martínez A, Santangelo G, Pallardó FV, Sastre J, Viña
J. Oxidative
stress in marathon runners: interest of antioxidant
supplementation. Br
J Nutr. 2006 Aug;96 Suppl 1:S31-3.
Ji
LL, Gomez-Cabrera MC, Vina J. Exercise
and hormesis: activation of cellular antioxidant signaling
pathway. Ann
N Y Acad Sci. 2006 May;1067:425-35.
Vina
J, Borras C, Gomez-Cabrera MC, Orr WC.
Part
of the series: from dietary antioxidants to regulators in
cellular signalling and gene expression. Role of reactive
oxygen species and (phyto)oestrogens in the modulation of
adaptive response to stress. Free
Radic Res. 2006 Feb;40(2):111-9.
1.-
Beneficial
effects of physical exercise to prevent and
eventually treat
age-associated sarcopenia.
Specific
lines of work:
Determination
of the mitochondriogenic and myogenic pathways.
Cell
signalling related to the role of reactive oxygen species in
myogenesis.
Beneficial
or adverse effects of antioxidant vitamins on the
above-mentioned pathway
2.- Beneficial effects
of exercise in the prevention against pollutant toxicity
Specific
lines of work:
The
effect of exercise on the up-regulation of detoxication
enzymes.
Effect
of exercise in the prevention of death by paraquat.
3.- The exercise
antioxidant paradox.
Specific
lines of work:
Exercise
as an important factor to up-regulate antioxidant enzymes:
exercise is an antioxidant.
Adverse
effects of antioxidants taken orally on the beneficial
effects of exercise in terms of promoting antioxidant
enzymes.
Determination
of the cell-signalling pathways by which exercise promotes
antioxidant enzyme up-regulation.
4.- Effect of xanthine
oxidase knocked-down animals on oxidative stress parameters.
The
rationale of this last point being that we have found that
xanthine oxidase is involved in the generation of reactive
oxygen species which act as signals to promote adaptation
associated with exercise.
5.-
- Effects of training on the
antioxidant capacity and the mitochondrial content in PGC-1α
knock-out mice.
Specific
lines of work
Similar
to those described for point 1
Download CV
with complete list of publications
|
