Research
I
attained my bachelor degree in Pharmacy in 2000. Since then
I have been working on my doctoral thesis in the Department
of Physiology at the University of Valencia, first in José
Estrela's lab and then, since 2002, in José Viña´s
laboratory. My work is funded by a government grant and is
mainly focused on the longevity manipulation of the
Drosophila Melangaster fly by using different natural
compounds such as phytoestrogens. Another of my research
interests is the role of oestrogens in preventing oxidative
stress associated with the ageing process. During this time
I have been trained in different molecular biology
techniques: gene and protein expression and determination of
the protein activities.
During
my PhD student period, I did a pre-doctoral stay in Dallas (EEUU)
at SMU University with Dr. Bill Orr working in Drosophila
and in Düsseldorf (Germany) at University of Düsseldorf
working with Dr. Klotz and Dr. Sies.
My
research interests are focused in longevity, nutrironal
modifications of longevity genes and oxidative stress.
Selected
Publications
Viña J,
Sastre J, Pallardó FV, Gambini J, Borrás C. Modulation
of longevity-associated genes by estrogens or phytoestrogens.
Biol Chem. 2008 Mar;389(3):273-7. Review.
Vallés
SL, Borrás C, Gambini J, Furriol J, Ortega A, Sastre J,
Pallardó FV, Viña J. Oestradiol
or genistein rescues neurons from amyloid beta-induced cell
death by inhibiting activation of p38. Aging Cell.
2008 Jan;7(1):112-8.
Borras C,
Gambini J, Vina J. Mitochondrial
oxidant generation is involved in determining why females
live longer than males. Front Biosci. 2007 Jan
1;12:1008-13. Review.
Viña J,
Sastre J, Pallardó FV, Gambini J, Borrás C. Role
of mitochondrial oxidative stress to explain the different
longevity between genders: protective effect of estrogens.
Free Radic Res. 2006 Dec;40(12):1359-65. Review.
Borrás
C, Gambini J, Gómez-Cabrera MC, Sastre J, Pallardó FV,
Mann GE, Viña J. Genistein, a soy
isoflavone, up-regulates expression of antioxidant genes:
involvement of estrogen receptors, ERK1/2, and NFkappaB.
FASEB J. 2006 Oct;20(12):2136-8.
Viña J,
Borrás C, Gambini J, Sastre J, Pallardó FV. Why
females live longer than males: control of longevity by sex
hormones. Sci Aging Knowledge Environ. 2005 Jun
8;2005(23):pe17. Review.
Borrás
C, Gambini J, Gómez-Cabrera MC, Sastre J, Pallardó FV,
Mann GE, Viña J. 17beta-oestradiol
up-regulates longevity-related, antioxidant enzyme
expression via the ERK1 and ERK2[MAPK]/NFkappaB cascade.
Aging Cell. 2005 Jun;4(3):113-8.
Viña J,
Borrás C, Gambini J, Sastre J, Pallardó FV. Why
females live longer than males? Importance of the
upregulation of longevity-associated genes by oestrogenic
compounds. FEBS Lett. 2005 May 9;579(12):2541-5.
Review.
Ortega
AL, Carretero J, Obrador E, Gambini J, Asensi M, Rodilla V,
Estrela JM. Tumor cytotoxicity by
endothelial cells. Impairment of the mitochondrial system
for glutathione uptake in mouse B16 melanoma cells that
survive after in vitro interaction with the hepatic
sinusoidal endothelium. J Biol Chem. 2003 Apr
18;278(16):13888-97.
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