Research
Juan
Sastre was born in Valencia, Spain, in 1963. He graduated in
Pharmacy at the University of Valencia, and obtained his PhD
in 1987 doing a doctoral thesis on oxidative stress and
aging of the liver supervised by Prof. José Viña and Dr.
Federico V. Pallardó. After staying in the Human Nutrition
Research Center on Aging at Tufts University (Boston, USA),
King's College London, and Unité INSERM 99 at the Hôpital
Henri Mondor (France), he returned to the Department of
Physiology of the University of Valencia to work as
Assistant Professor. He has acquired teaching experience in
Human Physiology from 1987 to date and also in Human
Pathophysiology from 1998 to date.
Juan
Sastre is currently Associate Professor (“Profesor
Titular”, Permanent Position) at the University of
Valencia and his research work focuses on the role of
oxidative stress and MAP kinases in gastroenterology,
particularly in experimental acute pancreatitis, biliary
liver cirrhosis and alcoholic liver disease. He has
published more than 70 papers on oxidative stress,
glutathione, mitochondria, apoptosis, aging and experimental
gastroenterology. He has obtained different awards for
research work: “Harwood
Young Investigator Award” for free radical research 1998,
given by the Society for Free Radical Research (European
Region); and “García Blanco” medal given to young
researchers in Biomedicine by the School of Medicine of
Valencia (Spain).
Selected
Publications
Serviddio
G, Pereda J, Pallardo FV, Carretero J, Borras C, Cutrin J,
Vendemiale G, Poli G, Vina J, Sastre J. Ursodeoxycholic
acid protects against secondary biliary cirrhosis in rats by
preventing mitochondrial oxidative stress.
Hepatology. 2004 Mar;39(3):711-20.
Minana
JB, Gomez-Cambronero L, Lloret A, Pallardo FV, Del Olmo J,
Escudero A, Rodrigo JM, Pelliin A, Vina JR, Vina J, Sastre
J. Mitochondrial
oxidative stress and CD95 ligand: a dual mechanism for
hepatocyte apoptosis in chronic alcoholism.
Hepatology. 2002 May;35(5):1205-14.
Sandoval
J, Rodriguez JL, Tur G, Serviddio G, Pereda J, Boukaba A,
Sastre J, Torres L, Franco L, Lopez-Rodas G. RNAPol-ChIP: a
novel application of chromatin immunoprecipitation to the
analysis of real-time gene transcription. Nucleic Acids Res.
2004 Jun 24;32(11):e88. Print 2004 Jun.
Pereda
J, Sabater L, Cassinello N, Gomez-Cambronero L, Closa D,
Folch-Puy E, Aparisi L, Calvete J, Cerda M, Lledo S, Vina J,
Sastre J. Effect of simultaneous inhibition of
TNF-alpha
production and xanthine oxidase in experimental acute
pancreatitis: the role of mitogen activated protein kinases.
Ann Surg. 2004 Jul;240(1):108-16.
Borras
C, Esteve JM, Vina JR, Sastre J, Vina J, Pallardo FV.
Glutathione regulates telomerase activity in 3T3
fibroblasts. J Biol Chem. 2004 Aug 13;279(33):34332-5. Epub
2004 Jun 07.
Granell
S, Pereda J, Gomez-Cambronero L, Cassinello N, Sabater L,
Closa D, Sastre J. Circulating
TNF-alpha and its soluble
receptors during experimental acute pancreatitis.
Cytokine.
2004 Feb 21;25(4):187-91.
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