The Hammerhead ribozyme.... the last ribolution

Aug, 2010

Posted by M. de la Peña
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Hammerhead ribozymes and self-cleaving RNAs in general are everywhere... from bacterial to animal genomes

De la Peña and García-Robles (2010) Ubiquitous presence of the hammerhead ribozyme motif along the tree of life, RNA 16:1943. (doi:10.1261/rna.2130310)

 

Ultraconserved ribozymes in Amniotes

Jul, 2010

Posted by  M. de la Peña
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One of the most simple ribozymes has been found now among the most complex organisms... from reptils to humans

humanhammerhead
De la Peña and García-Robles (2010) Intronic hammerhead ribozymes are ultraconserved in the human genome, EMBO Rep. 11(10): 711-716 (doi:10.1038/embor.2010.100)

 

A swiss-RNife: Y-RNAs with remote interactions

Aug, 2009

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Y-RNAs (three-helical junctions) stabilized by remote tertiary contacts are widespread in nature and involved in different biological roles; rRNAs, RNPs, SRP, ribozymes, riboswitches...


Eukaryotic capping

Nov, 2007

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Lectures from large DNA-viruses