Our major aim now is identifying longevity-related genes, finding ways of upregulating these genes by physiological, nutritional, and pharmacological intervention and determining how to promote healthy ageing.
Isolation and characterisation of extracellular vesicles (EVs) in different helminth parasites. Identification of molecules present in EVs. Analysis for the usefulness of EVs in helminthiasis control and other diseases (diagnosis, vaccination and treatment).
Molecular and genetic basis of neurocognitive alterations in patients with SMI, in order to develop biomarkers, diagnostic assessment tools and therapeutic interventions helping to improve the functional prognosis, the autonomy and the life quality of these people.
Immortalisation of monocytes and hepatocytes from patients with severe AATD (ZZ). Cell cultures derived from nasal ciliated epithelium by using the Air-Liquid technique (ALI).
Comprehend the unexpected associations between apparently different diseases, like cancer and certain diseases of the central nervous system.
Epidemiological (life cycle, transmission, population dynamic) and ecological (influence of biotic and abiotic factors) analysis of human and animal parasites (especially rodents). Analysis of behaviour and response of parasites after natural disasters.
Study of the evolution of complete genomes and the genes present in them, with special emphasis on bacteria and viruses.
The main research lines are: i) Evolution of symbiosis ii) Synthetic biology iii) Genetic study of aphids
Our major aim was originally to test whether free radicals associated with exercise could lead to damage in muscle and to protect these muscles by various interventions such as training and nutrition.
We use viruses as model organisms in the laboratory to study evolutionary processes on an experimental basis.
Epidemiological study of food-transmitted human parasites (protozoa and helminths). Study of the influence of intrinsic and extrinsic factor on parasitism. Morphological and molecular diagnosis and identification of parasite species. Anisakiasis study.
Prevention of fragility signs in populations at risk by assessing human functions (functional and neurocognitive assessment) and by incorporating nutritional medicine studies on Omega 3.
Genome editing and repair by using the CRISPR/Cas9 system and non-viral gene therapy techniques of the Z mutation of the SERPINA1 gene that encodes for the alpha-1 antitrypsin gene in monocytes and hepatocytes of patients with alpha-1 antitrypsin deficiency.
Creation of Geographic Information Systems with the use of satellite images and thematic maps (climate, surface, parasitological parameters, etc.) for the modelling of epidemiology and the transmission of human / animal parasites, as well as the influence of climate change on them.
Networking on the burden of disease.
RRDs are very complex and are associated with alterations in multiple metabolic pathways. An important aspect for the RRD diagnosis, prognosis and treatment is to identify the aberrant changes that may occur in these metabolic pathways and to elucidate their connection with the disease. In this regard, we will use high performance trials such as microarrays and mass sequencing for the analysis of biological samples from patients with alpha-1 antitrypsin deficiency and primary ciliary dyskinesia syndrome in order to identify possible metabolic pathways involved in the development of these diseases, and with the aim, in turn, of identifying new diagnostic and prognostic biomarkers (including treatment response) and of identifying new therapeutic targets.
Diagnosis and epidemiological study of human ectoparasite arthropods (mosquitoes, myiasis, lice, bedbugs, etc.). Pest control and vectors on an individual level. Analysis of vector-transmitted parasitic diseases and influence of climate change on them.
This line of research focuses on the study of the epidemiology of rotavirus and norovirus through the application of molecular techniques (RT-PCR, qPCR, cDNA sequencing, etc.) and the detection of new variants of viral genotypes.
Use of genetic and genomic information of pathogenic microorganisms (bacteria and viruses) to study their spread in human populations and in their natural reservoirs, complementing the tasks of epidemiological care and control.
There's an analysis for the parasites-food intolerance relationship and the prevalence, transmission routes and risk factors of suffering from intestinal parasitosis, the correlation between parasitosis and the reception of breastfeeding, as well as the parasites-child development relationship.
The aim of this line of research is to study the pathogenic mechanisms and the immune response of infections by the two main enteric viruses (rotavirus and norovirus).
To determine the intercellular mechanisms of toxicity of amyloid beta, its interaction with mitochondrial metabolism and its consequences in cell signalling. Our idea is that Alzheimer’s and Tau toxicities are related and that free radicals play a major signalling role in this process.
Study by means of Flow Cytometry techniques of REDOX biology in patients with Alpha-1 Antitrypsin Deficiency and Primary Ciliary Dyskinesia Syndrome.
The aim of this line of research is to study the interactions that occur between enteric viruses and the host without excluding the interactions that occur between enteric viruses and the intestinal microbiota or the interaction between the intestinal microbiota and the host.
Study of molecular interactions between helminth parasites and their hosts. Tools destined to the control of said parasitosis (proteins and recombinant peptides along with polyclonal antibodies) stem from identified molecules.
Epidemiological study of teniasis / cisticercosis, with special reference to the third new parasitic tapeworm: Taenia asiatica. Ultrastructural studies of infective forms. Secretomics analysis of cisticercosis' infective forms (eggs) of the three human Taenia species.
Using various experimental approaches, we aim to identify and characterise mechanisms in the generation of RNA virus diversity, and to obtain quantitative estimates of mutation rates in RNA viruses.
