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Biography

Amparo Latorre

Evolutionary Genetics Group

Institute for Integrative Systems Biology (I2SysBio)

Universitat de València –CSIC

Position

Full Professor of Genetics, University of Valencia (Spain)

Institute for Integrative Systems Biology (I2SysBio) University of Valencia - CSIC

Former Director of the Cavanilles Institute for Biodiversity and Evolutionary Biology (ICBiBE), from 2010 to 2013

Education

· 1986 Ph.D. Genetics, University of Valencia

· 1978 Degree in Biological Science, University of Valencia

Major research interests

· System biology of the interactions between eukaryotes (human and insects) and their symbionts. Particularly focus on the study of human gut microbiota and is impact in several diseases, and in the dialogue among endosymbionts, gut microbiota and the hosts in cockroaches.

Selected recent publications

Rosas, T.; García-Ferris, C.; Domínguez, R.; LLop.; Latorre, A* and Moya, A. (2018). Rifampicin treatment of Blattella germanica evidence a fecal transmission route of their gut microbiota. FEMS Microbial Ecology. DOI: 10.1093/femsec/fiy002.

Ponce-de-Leon, M.; Tamarit, D.; Calle-Espinosa, J.; Mori, M.; Latorre, A.; Montero, F. and Peretó, J. (2017). Determinism and contingency shape metabolic complementation in an endsoymbiotic consortium. Frontiers in Microbiology 8:2290. DOI: 10.1038/fmicb. 2017.02290 eCollection.

Gil, R.; Vargas-Chavez, C.; López-Madrigal, S.; Santos-García, D.; Latorre, A. and A. Moya. (2017). Tremblaya phenacola PPER: an evolutionary beta-gammaproteobacterium collage. The ISME Journal. doi: 10.1038/ismej.2017.144.

Gutiérrez-Preciado, A.; Vargas-Chávez, C.; Reyes-Prieto, M.; Ordoñez, O.F; Santos-García, D.; Rosas-Pérez, T.; Valdivia-Anistro, J.; Rebollar, E.A.; Saralegui, A.; Moya, A.; Merino, E.; Farías, M.E.; Latorre, A*.; Souza, V*. 2017. The genomic sequence of Exiguobacterium chiriqhucha str. N139 reveals a species that thrives in cold waters and extreme environmental conditions. PeerJ. DOI 10.7717/peerj.3162.

Martí, J.M.; Martínez-Martínez, D.; Rubio, T.; Gracia, C.; Peña, M.; Latorre, A.; Moya, A.; Garay, C.P. (2017). Health and disease imprinted in the time variability of the human microbiome. mSystems. doi.org/ 10.1128/mSystems.00144-16.

Manzano-Marín, A.; Szabo, G.; Simon, J.C.; Horn, M and Latorre, A. (2017). Happens in the best of subfamilies: establishment and repeated replacements of co-obligate secondary endosumbiontss within Lachninae aphids. Environmental MIcrobiology. doi: 10.1111/1462-2920.13633.

Latorre, A and Manzano-Marín, A. (2016). Dissecting genome reduction and trait loss in insect endosymbionts. Annals of the New York Academy of Sciences. DOI: 10.1111/nyas.13222.

Manzano-Marín, A and Latorre, A. (2016). Snapshots of a shrinking partner: genome reduction in Serratia symbiotica. Scietific Reports. DOI: 10.1038/srep32590.

Vilanova, C.; Baiixeras, J.; Latorre, A* and Porcar, M*. (2016). The generalist inside the specialist: gut bacterial communities of two insect species feeding on toxic plants are dominated by Enterococcus sp. Frontiers in Microbiology. DOI: 10.3389/fmicb.2016.01005

Serrano-Villar, S.; Rojo, D.; Martínez-Martínez, M.; Deusch, S.; Vázquez-Castellanos, J.F. Sainz, T.; Vera, M.; Moreno, S.; Estrada, V.; Gosalbes, M.J.; Latorre, A.; Margolles, A.; Seifert, J.; Barbas, C.; Moya, A. and Ferrer, M. (2016). HIV infection results in metabolic alterations in the gut microbiota different from those induced by other diseases. Scientifc Reports. DOI: 10.1038/srep26192.

Manzano-Marín, A.; Simon, J.C. and Latorre, A. (2016). Reinventing the wheel and making it round again: Evolutionary convergence in Buchnera-Serratia symbiotic consortia between the distantly related Lachninae aphids Tuberolachnus salignus and Cinara cedri. Genome Biology and Evolution. DOI: 10.1093/gbe/evw085.

Lloréns-Rico, V.; Cano, J.; Kamminga, T.;Gil, R.; Latorre, A.; Chen, W.H.; Bork, P.; Glass, J.I.; Serrano, L.; and Lluch-Senar, M. (2016). Bacterial antisense RNAs are mainly the product of transcriptional noise. Sciencie Advance. DOI: 10.1126/sciadv.1501363.

Gosalbes, M.J.; Vázquez-Castellanos, J.F.; Angebault, C.; Woerther, P.L.; Ruppé, E.; Ferrús, M.L.; Latorre, A.; Andremont, A. and Moya, A. (2016). Carriage of enterobacteria producing extended spectrum beta-lactamases and composition of the gut microbiota in an Amerindian community. Antimicrobial Agents and Chemotherapy. DOI:10.1128/AAC.01528-15.

Pérez-Cobas, A.E.; Moya, A.; Gosalbes, M.J. and Latorre, A. (2015). Colonization resistance of the gut microbiota against Clostridium difficile. Antibiotics. DOI:10.3390/antibiotics40x000x.

Manzano-Marín, A.; Oceguera-Figueroa, A.; Latorre, A.; Jiménez-Gacría, L.F. and Moya, A. (2015). Solving a bloody mess: B-vitamin independent metabolic convergence among gammaproteobacterial obligate endosymbionts from blood-feeding arthropods and the leech Haementeria officinalis. Genome Biology and Evolution. DOI: 10.1093/gbe/evv188.

Campos, M.; Llorens, C.; Sempere, J.M.: Futami, R.; Rodriguez, I.; Carrasco, P.; Capilla, R.; Latorre, A.; Coque, T.M.; Moya, A. and Baquero, F. (2015). A membrane computing simulator of trans-hierarchical antibiotic resistance evolution dynamics in nested ecological compartments (ARES). Biology direct. DOI: 10.1186/s13062-015-0070-9.

López-Madrigal, S.; Latorre, A.; Moya, A. and Gil, R. (2015). The link between independent acquisition of intracellular gamma-endosymbionts and concerted evolution in Tremblaya princeps. Frontiers in Microbiology. DOI: 10.1039/fmicrob.2015.00642.

Klein, A.; Schrader, L.; Gil, R.; Manzano-Marín, A.; Flórez, L.; Wheeler, D.; Werren, J.H.; Latorre, A.; Heinze, H.; Kaltenpoth, M.; Moya, A.; and Oettler, J. (2015). A novel intracellular mutualistic bacterium in the invasive ant Cardiocondyla obscurior. The ISME Journal. DOI: 10.1038/ismej.2015.119.

Pérez-Cobas, A.E.; Maiques, E.; Angelova, A.; Carrasco, P.; Moya, A.; and Latorre, A. (2015). Diet shapes the gut microbiota of the omnivorous cockroach Blatella germanica. FEMS Microbialogy Ecology. DOI: 10.1093/femsec/fiv022.

Rollat-Farnier, P.A.; Santos-Garcia, D.; Qiong, R.; Sagot, M.F.; Silva, F.J.; Henri, H.; Zchori-Fein, E.; Latorre, A.; Moya, A.; Barbe, V; Liu, S.S.; Wang, X.W.; Vavre, F. and Mouton, L (2015). Two host clades, two bacterial arsenals: evolution through gene losses in facultative endosymbionts. Genome Biology and Evolution. DOI: 10.1093/gbe/evv030.

Rao, Q.; Rollat-Farnier, PA.; Zhu, D-T.; Santos-Garcia, D.; Silva, FJ.; Moya, A.; Latorre, A.; Klein, CC.; Vavre, F.; Sagot, MF.; Liu, SS.; Mouton, L.; and Wang, XW. (2015). Genome reduction and potential metabolic complementation of the dual endosymbionts in the whitefly Bemisia tabaci. BMC Genomics DOI. org/10.1186/s12864-015-1379-6.

Santos-Garcia, D.; Vargas-Chavez, C.; Moya, A.; Latorre, A. and Silva, F. J. (2015). Genome evolution in the primary endosymbiont of whiteflies sheds light on their divergence. Genome Biology and Evolution. DOI:10.1093/gbe/evv038.

Martínez-Cano, D.J.; Reyes-Prietos, M.; Martínez- Romero, E.; Partida-Martínez, L.P.; Latorre, A.; Moya, A. and Delaye, L. (2015). Evolution of small prokaryotic genomes. Frontiers in Microbiology. DOI:10.3389/fmicb.2014.00742.

Vázquez-Castellanos, J.F.; Serano-Villar, S.; Latorre, A.; Artacho A.Ferrús, M-L-; Madrid, N.; Vallejo, A.; Sainz, T.; Martínez-Botas, J.; Ferrando-Martínez, S.; Vera, M.; Dronda, F.; Leal, M.; Del Romero, J.; Moreno, S.; Estrada, V.; Gosalbes, M.J. and Moya, A. (2015). Altered metabolism of gut microbiota contributes to chronic immune activation in HIV-infected individuals. Mucosal Immunology. DOI:10.1038/mi.2014.107.

Santos-Garcia, D.; Silva, F.J; Moya, A. and Latorre, A. (2014). No exception to the rule: Candidatus Portiera aleyrodidarum cell wall revisited. FEMS Microbiology letters. DOI: 10.1111/1574-6968.12595

Carrasco, P.; Pérez-Cobas, A.E.; van de Pol, C.; Baixeras, J.; Moya, A.; and Latorre, A. (2014). Succession of the gut microbiota in the cockroach Blatella germanica. International Microbiology. DOI:10.2436/20.1501.01.212.

Santos-García, D.; Latorre, A.; Moya, A.; Gibbs, G.; Hartung, V.; Dettner, K.; Kuechler, S.M. and Silva, F.J. (2014). Small but powerful, the primary endosymbiont of moss bugs, Candidatus Evansia muelleri, holds a reduced genome with large biosynthetic capabilities. Genome Biology and Evolution. DOI:10.1093/gbe/evu149.

López-Madrigal, S.; Beltrà, A.; Resurrección, S.; Soto, A.; Latorre, A.; Moya, A.; and Gil, R. (2014). Molecular evidence for ongoing complementarity and horizontal gene transfer in endosymbiotic systems of mealybugs. Frontiers in Microbiology. DOI: 10.3389/fmicb.2014.00449.

Manzano-Marín, A. and Latorre, A. (2014). Settling down: The genome of Serratia symbiotica from the aphid Cinara tujafilina zooms in on the process of accommodation to a cooperative intracellular life. Genome Biology and Evolution. DOI: 10.1093/gbe/evu133.

Patiño-Navarrete, R.; Piulars, D.; Bellés, X.; Moya, A.; Latorre, A* and Peretó, J.* (2014). The cockroach Blattella germanica obtains nitrogen from uric acid through a metabolic pathway shared with its bacterial endosymbiont. Biology Letters. DOI: 10.1098/rsbl.2014.0407.

Pérez-Cobas, A.E.; Artacho, A.; Ott, S.J.; Moya, A.; Gosalbes, M.J* and Latorre, A.* (2014). Structural and functional changes in the gut microbiota associated to Clostridium difficile infection. Frontiers in Microbiology. DOI: 10.3389/fmicb.2014.00335.

Vilanova, C.; Marín, M.; Baixeras, J.; Latorre, A. and Porcar, M. (2014). Selecting Microbial Strains from Pine Tree Resin: Biotechnological Applications from a Terpene World. PLoS ONE 9(6): e100740. DOI:10.1371/journal.pone.0100740.

Santos-Garcia, D.; Rollat-Farnier; P.A.; Beitia, F.; Zchori-Fein, E.; Vavre, F.; Mouton, L.; Moya, A.; Latorre, A*. and Silva, F.J*. (2014). The genome of Cardinium cBtQ1 provides insights into genome reduction, symbiont motility and its settlement in Bemisia tabaci. Genome Biology and Evolution. DOI:10.1093/gbe/evu077.

Oakeson, K.F.;Gil, R.; Clayton, A.L.; Dunn, D.M.; von Niederhausern, A.C.; Hamil, C.; Aoyagi, A.; Duval, B.; Baca, A.; Silva, F.J.; Vallier, A.; Jackson, D.G.; Latorre, A.; Weiss, R.B.; Heddi, A.; Moya, A. and Dale, C. (2014). Genome Degeneration and Adaptation in a Nascent Stage of Symbiosis. Genome Biology and Evolution. DOI:10.1093/gbe/evt210.

Reyes-Prieto, M., Latorre, A. and Moya, A. (2014). Scanty microbes, the “symbionelle” concept. Environmental Microbiology. DOI:10.1111/1462-2920.12220 .

Porcar, M., Latorre, A. and Moya, A. (2013). What symbionts teach us about modularity. Frontiers in Bioengineering and Biotechnology. DOI: 10.3389/fbioe.2013.00014.

D’Auria, G., Peris-Bondia, F., Dzunkova, M., Mira, A., Collado, M.C., Latorre, A. and Moya, A. (2013). Active and secreted IgA-coated bacterial fractions from the human gut reveal an under-represented microbiota core. Scientific Reports. DOI: 10.1083/srep03515.

Pérez-Brocal, V., García-López, R., Vázquez-Castellanos, J.F., Nos, P., Beltrám, P., Latorre, A. and Moya, A. (2013). Study of the viral and microbial communities associated with Chron’s disease: a metagenomic approach. Clinical and translational Gastroenterology. DOI:10.1038/ctg.2013.9.

Hernández, E., Bargiela, R., Suárez-Diez, M., Friedrichs, A., Pérez-Cobas, A.E.,Gosalbes, M.J., Knecht, H., Martínez-Martínez, M., Seifert, J.,von Vergen, M., Artacho, A., Ruiz, A., Campoy, C., Latorre, A., Ott, S.J., Moya, A., Suárez, A., Martins dos Santos, V.A.P. and Ferrer, M. (2013). Functional consequences of microbial shifts in the human gastrointestinal tract kinked to antibiotic treatment and obesity. Gut Microbes. DOI.org/10.4161/gmic.25321.

Durbán, A., Abellán, J.J., Jiménez-Hernández, N., Artacho, A., Garrigues, V., Ortíz, V., Ponce, J., Latorre, A*. and Moya, A*. (2013). Instability of the faecal microbiota in diarrhoea-predominant irritable bowel syndrome. FEMS Microbiology Ecology. DOIi: 10.1111/1574-6941.12184.

García-Garcerá, M., García-Etxebarría, K., Coscollá, M., Latorre, A. and Calafell, F. (2013). A new method for extracting skin microbes allows metagenomics analysis of whole-deep skin. PLoS ONE. DOI:10.1371/journal.pone.0074914.

López-Madrigal, S.; Balmand, S.; Latorre, A.; Heddi, A.; Moya, A. and Gil, R. (2013). How does Tremblaya princeps get essential proteins from its nested partner Moranella endobia in the mealybug Planoccocus citri. PLoS ONE. DOI:10.1371/journal.pone.0077307.

Reyes-Prieto, M., Oceguera-Figueroa, A., Snell, S., Negredo, A., Barba, E., Fernández, L., Moya, A. and Latorre, A. (2013). DNA barcodes reveal the presence of the introduced freshwater leech Helobdella europaea in Spain. Mitochondria DNA. DOI: 10.3109/19401736.2013.809426.

Pérez-Cobas, A.E., Artacho, A., Knecht, H., Ferrús, M.L., Friedrichs, A., Ott, S.J., Moya, A., Latorre, A* and Gosalbes, M.J*. (2013). Differential Effects of Antibiotic Therapy on the Structure and Function of Human Gut Microbiota. PLoS ONE. DOI:10.1371/journal.pone.0080201.

López-Madrigal, S., Latorre, A., Porcar, M., Moya, A. and Gil, R. (2013). Mealybugs nested endosymbionts: going into the “matryoshka” system in Planococcus citri in depth. BMC Microbiology. http://www.biomedcentral.com/1471-2180/13/74.

Patiño, R., Moya, A., Latorre, A*. and Peretó, J*. (2013). Comparative genomics of Blattabacterium cuenoti: the frozen legacy of an ancient endosymbiont genome. Genome Biology and Evolution. DOI:10.1093/gbe/evt011.

Pérez-Cobas, A.E., Gosalbes, M.J., Friedrichs, A., Knecht, H., Artacho, A., Eismann, K., Otto, W., Rojo, D., Bargiela, R., von Bergen, M., Neulinger, S.C., Däumer, C., Heinsen, F.A., Latorre, A., Barbas, C., Seifert, J., Martins dos Santos,V., Ott, S., Ferrer, M. and Moya, A. (2013). Gut microbiota disturbance during antibiotic therapy: a multi-omic approach. GUT. DOI: 10.1136/gutjnl-2012-303184.

 

People currently in the Evolutionary Genetics Lab

· Andres Moyá Simarro, Professor of Genetics

· Francisco J. Silva Moreno, Professor of Genetics

· Rosario Gil García, Associate Professor of Genetics

· David Martínez Torres, Associate Professor of Genetics

· Carlos García Ferris. Associate Professor of Biochemistry

· Miquel Barberá Solá, Postdoctoral researcher

· Carlos Vargas Predoctoral researcher

· Jesús Marín Miret, Predoctoral researcher

· Rebeca Domínguez, Postdoctoral researcher

· Nicolás Pérez Hidalgo, Postdoctoral researcher

· Jorge Mariano Collantes Alegre, Predoctoral researcher

· Bertha Mariana Reyes Prieto, Predoctoral researcher

· Joan Riera, Predoctoral researcher

· Pascual Asensi Belloch, Informatician

· Lucía Bori, Research Technician

 

Courses taught

  • Genetics (Degree in Biology)

  • Molecular Genetics (Degrees in Biology and Biochemistry)

  • Genetic Engineering (Degrees in Biology and Biochemistry)

  • Evolutionary Biology (Degree in Biochemistry and Biomedical Sciences)

  • Technical of Genetic Analysis (Degree in Biology)

  • Origin and Evolution of Genomic Complexity (Graduate programs in ‘Biodiversity and Evolutionary Biology’ and ‘Molecular and Evolutionary Genetics’)

  • Molecular techniques applied to the study of biodiversity (Graduate programs in ‘Biodiversity and Evolutionary Biology’ and ‘Molecular and Evolutionary Genetics’)

  • Molecular markers applied to the study of biodiversity (Graduate programs in ‘Biodiversity and Evolutionary Biology’ and ‘Molecular and Evolutionary Genetics’)

  • Comparative Genomics (Graduate programs in ‘Biodiversity and Evolutionary Biology’ and ‘Molecular and Evolutionary Genetics’)

  • Foundations of Gene Expression (Graduate Program in 'Research in Molecular and Cell Biology, and Genetics')