|
Frecuencia de mutaciones en las vías de señalización kinasa de los diferentes tipos de melanoma |
||||
| cutáneo | Acral | Mucosa | Uveal | |
| BRAF | 40-60 | 15-20 | 3-5 | <1 |
| NRAS | 15-25 | 10-15 | 5-15 | <1 |
| c-KIT (mutación) | <2 (CSD: 2-17) | 10-20 | 15-20 | <1 |
| c-KIT (amplificación) | 0-7 (CSD:6) | 25-30 | 25-30 | <1 |
| GNαQ | <1 (CSD:5) | <1 | <1 | 45-50 |
| CSD: daño solar crónico | ||||
Distribution of activating mutations in different melanoma
subtypes
Genetic classification with distribution of tumour types according to the
activating gene mutation. Mutations with a frequency of more than 5% are
shown. Frequencies are as reported for cutaneous,23 acral,32 mucosal,35
conjunctival,36 and uveal37−40 melanoma. BRAF=B-Raf proto-oncogene
serine/threonine kinase.