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| There are numerous disorders that can mimic vasculitis clinically. When
cutaneous vasculitis is suspected, the first step in management should be to confirm the diagnosis by skin biopsy. Geographic areas of purpura with necrosis and ulceration can be due to antiphospholipid antibody syndrome, recognized histologically by noninflammatory small vessel thrombi (left-sided panels) or small vessel neutrophilic vasculitis, identified histologically by the findings of vessel wall fibrin deposits, perivascular nuclear debris, and disruption of the vessel wall by the neutrophilic infiltrate (right-sided panels).
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