Química Orgánica Computacional - ComputChem

Jorge Escorihuela

Dr. Jorge Escorihuela obtained his Bachelor in Chemistry from Universitat Jaume I (UJI) in 2003 and developed his doctoral thesis with a predoctoral fellowship (FPI) under the program University-CSIC. In this period, he studied the synthesis of chiral catalysts derived from natural amino acids and their application in catalytic enantioselective reactions, such as the addition of diethylzinc to aldehydes, in homogeneous as well as in heterogeneous phase. Dr. Escorihuela received the extraordinary doctorate award (2008/2009). After completing the PhD studies, he continued his research in the group of Prof. Luis with a continuity grant from UJI. During this period, he studied peptidomimetic ligands in molecular recognition and its applications in supramolecular chemistry . After this period, his research activity continued in the group of Prof. Angel Maquieira (Universitat Politècnica de València, UPV) during almost 4 years and was focused on the design of biosensors in silicon-based materials and the development of DNA microarrays. In Sept 2014 and until Dec 2016, Dr. Escorihuela worked as a post-doctoral researcher at Wageningen University and Research (WUR) in The Netherlands) under the supervision of Prof. Han Zuilhof, where he developed his research on surface modification and in the study of click-type reactions on solid supports. The postdoctoral work at WUR can be considered of high impact the field of surface modification as it has led to 7 scientific publications (highligting 2 papers published in Angew. Chem. Inte. Ed. and 1 J. Am. Chem. Soc.). Later, in 2017 till Jan 2019, he rejoined the UPV, with a research contract in the development and evaluation of new polymer membranes reinforced with nanofibers for application in fuel cells at the group of Prof. Vicente Compañ. From 2017 till September 2019, he hold a position as Profesor Asociado at the Organic Chemistry Department at Universitat de Valencia. In Sept 2019, he started as Assistant Professor at the same department. In this new position, he has continued studying polymer membranes for fuel cell applications and the catalytic applications of 1,7-enynes with several publications along the last years. He has also a research line based on the use of computational chemistry methods applied to organic chemistry reactions. In the last works, the use of DFT methodologies has helped to understand supramolecular interactions, to rationalize the origin of the experimental regio- and diastereoselectivities in the addition of propargylic magnesium reagents to fluorinated aromatic sulfinyl imines) and to study the mechanism of the Pauson-Khand reaction. In 2023, he became Associate Professor and has his own research group ComputChem.

RESEARCH INTERESTS

 

CLICK CHEMISTRY

The concept of "click chemistry" defines certain organic reactions, similar to those carried out by living organisms. A click reaction must be wide-ranging with very high degrees of conversion and selectivity, generating the minimum number of by-products. If they occur, they should be easily separable, without recourse to chromatographic separations, and should ideally be produced under sustainable conditions (preferably in water).

Within strain-promoted chemistry, it's worth noting three reactions that have been extensively researched and utilized in the past 20 years, both experimentally and computationally. These reactions are: (1) Strain-Promoted Azide-Alkyne Cycloaddition (SPAAC), (2) Inverse Electron Demand Diels-Alder (IEDDA), and (3) Strain-Promoted Oxidation-Controlled Cyclooctyne-1,2-Quinone Cycloaddition (SPOCQ).

 

COMPUTATIONAL CHEMISTRY

Computacional chemistry is a branch of chemistry that uses computer simulations to assist in solving complex chemical problems. It employs theoretical chemistry methods embedded in computer programs to calculate the structures, interactions, and properties of molecules. The significant increase in computing power, coupled with the development of software and quantum chemistry methods, allows for accurate calculations of energy profiles for complex molecular systems. However, there isn't always a clear understanding of the sources of errors and inherent limitations in these techniques, nor their quality control. Various computational methods exist in computational chemistry, such as those based on molecular mechanics and those based on quantum chemistry, including ab initio methods, semiempirical methods, and density functional theory (DFT).

 

FLUORINE CHEMISTRY

The introduction of fluorine-containing groups into organic molecules can significantly alter the chemical, physical, and biological properties of the original compound. As a result, organofluorine compounds are gaining growing interest across medicinal, pharmaceutical, agricultural, and materials science fields.

 

PHOTOCATALYSIS

Photocatalysis is a process that uses light energy, usually from the sun or UV lamps, to activate a substance called a photocatalyst, which then accelerates a chemical reaction.

Publicaciones

PUBLICATIONS

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95. “Repurposing HFC-125 to tetrafluoroethylene: A step toward a more sustainable fluoropolymer feedstock strategy”

Hiroto Iwasaki, Naoyuki Hoshiya, Yosuke Kishikawa, Jorge Escorihuela, Norio Shibata 

 iScience 2025, 28, 6, 112580 

https://doi.org/10.1016/j.isci.2025.112580 

94. “Evaluation of Pyrones in Bioorthogonal Reactions: Correlation between Structure, Reactivity, and Bioorthogonality”

Wei Huang, Kangqiao Wen, Paul F. Muschitiello, Jorge Escorihuela, Scott T. Laughlin 

 J. Org. Chem. 2025, 90, 8, 2848–2859 

https://doi.org/10.1021/acs.joc.4c02336 

93. “An Electrochemical Route to Novel N-benzoyl-1,2,3-triazoles and Protein Binding Studies of Selected Triazole Derivatives” 

Manas Bandyopadhyay, Upasi Goswami, Shubhankar Ghorai, Swastik Pathak, Debabani Ganguly, Jorge Escorihuela, Jhuma Ganguly, Mrinal K. Bera

Asian J. Org. Chem. 2025, 14, 1, e202400415

https://doi.org/10.1002/ajoc.202400415

92. “Electrochemical Dual Trifluoromethylation/Cyclization of 2-Aryl-N-Acryloyl Indoles Enabling Assembly of Indole[2,1-a]isoquinolines”

Haibo Mei, Yucheng Zhang, Jiang Liu, Jorge Escorihuela, Loránd Kiss, Jianlin Han

Advanced Synthesis & Catalysis 2025, 367, 3, e202401225

https://doi.org/10.1002/adsc.202401225

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91. “Mechanistic Studies on the Gold-Catalyzed Intramolecular Hydroalkylation of Ynamides to Indenes”

Julien Annibaletto, Clément Jacob, Pierre Thilmany, Anaïs Loison, Jorge Escorihuela, Gwilherm Evano

ACS Omega 2024, 9, 52, 51690–51700

https://doi.org/10.1021/acsomega.4c09973

90. “Unveiling the reactivity of 2H-(thio)pyran-2-(thi)ones in cycloaddition reactions with strained alkynes through density functional theory studies”

Wei Huang, Kangqiao Wen, Scott T. Laughlin, Jorge Escorihuela

Org. Biomol. Chem., 2024,22, 8285-8292

https://doi.org/10.1039/D4OB01263A

89. “A silylboronate-mediated strategy for cross-coupling of alkyl fluorides with aryl alkanes: mechanistic insights and scope expansion”

Jun Zhou, Zhengyu Zhao, Tatsuki Kiyono, Ayaka Matsuno, Jorge Escorihuela, Norio Shibata 

Publication: Chem. Sci. 2024,15, 17418-17424

https://doi.org/10.1039/D4SC04357J

88. “Halo-perfluoroalkoxylation of gem-difluoroalkenes with short-lived alkali metal perfluoroalkoxides in triglyme”

Koki Kawai, Yoshimitsu Kato, Taichi Araki, Sota Ikawa, Mai Usui, Naoyuki Hoshiya, Yosuke Kishikawa, Jorge Escorihuela, Norio Shibata

Publication: Chem. Sci, 2024,15, 9574-9581

87. “Selective Hydro and Deuterodechlorination of Trichloroacetamide under Controlled Electrochemical Conditions to Prepare Mono-, Di-, and Deuterochloroacetamides”

Manas Bandyopadhyay, Biman Bera, Swastik Pathak, Dipendu Bhunia, Sayan Bhadra, Snehangshu Patra, Manish Pal Chowdhury, Jorge Escorihuela, Mrinal K. Bera

Publication: Adv. Synth. Catal. 2024, 366 (12), 2696–2704

https://doi.org/10.1002/adsc.202400372

86. “Electrochemical Multicomponent Cascade Radical Process Enabling Synthesis of Iodomethyl Spiropyrrolidinyl-Oxindoles”

Jingrui He, Haibo Mei, Jorge Escorihuela, Jianlin Han

Chin. J. Chem. 2024, 42 (15), 1691–1698

https://doi.org/10.1002/cjoc.202400127

85. “Pyranthiones/Pyrones: “Click and Release” Donors for Subcellular Hydrogen Sulfide Delivery and Labeling”

Wei Huang, Nipuni Gunawardhana, Yunlei Zhang, Jorge Escorihuela, Scott T. Laughlin

Chem. Eur. J. 2024, 30 (7), e202303465

https://doi.org/10.1002/chem.202303465

84. “Transition-Metal-Free Approach for Z-Vinyl Fluorides by Hydrofluorination of Alkynes bearing SF4 and SF5 Groups”

Yusuke Murata, Kenshiro Hada, Trapti Aggarwal, Jorge Escorihuela, Norio Shibata

Angew. Chem. Int. Ed. 2024, 63 (10), e202318086

https://doi.org/10.1002/anie.202318086

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83. “An Atom-Economic Method for 1,2,3-Triazole Derivatives via Oxidative [3 + 2] Cycloaddition Harnessing the Power of Electrochemical Oxidation and Click Chemistry”

Manas Bandyopadhyay,Sayan Bhadra, Swastik Pathak, Anila M. Menon,, Deepak Chopra, Snehangshu Patra, Jorge Escorihuela, Souradeep De, Debabani Ganguly, Suman Bhadra, Mrinal K. Bera Publication: 

J. Org. Chem. 2023, 88 (22), 15772–15782   

https://doi.org/10.1021/acs.joc.3c01836 

Yumei Zhu, Jorge Escorihuela, Haiying Wang, Andrew C.-H. Sue, Han Zuilhof  

82. “Tunable Supramolecular Ag+-Host Interactions in Pillar[n]arene[m]quinones and Ensuing Specific Binding to 1-Alkynes”

Publication: Molecules 2023, 28 (20), 7009 

https://www.mdpi.com/1420-3049/28/20/7009

81. “Cascade Detrifluoroacetylation, C−S Bond Cleavage and SN2’ Reaction of α,α-Difluorinated gem-Diols with MBH Esters”

Xinyu Yao, Ziyi Li, Haibo Mei, Jorge Escorihuela, Vadim Soloshonok, Jianlin Han

J. Org. Chem. 2023, 88 (18), 13057-13066

https://pubs.acs.org/doi/abs/10.1021/acs.joc.3c01220

80. “Regio- and Z-Selective Alkyne Hydroamination and Hydrophenoxylation using Tetrafluoro-λ6-Sulfanyl Alkynes under Superbasic, Naked Anion Conditions”

Trapti Aggarwal, Kenshiro Hada, Yusuke Murata, Yuji Sumii, Kazuhiro Tanagawa, Kiyoteru Niina, Soichiro Mori, Jorge Escorihuela, Norio Shibata

Angew. Chem. Int. Ed. 2023, 62 (33), e202307090 

https://onlinelibrary.wiley.com/doi/abs/10.1002/anie.20230709020

79. “Anti-Markovnikov Intermolecular Hydroamination of Alkenes and Alkynes: A Mechanistic View”

Jorge Escorihuela, Agustí Lledós, Gregori Ujaque

Chem. Rev. 2023, 123 (15), 9139-9203

https://pubs.acs.org/doi/10.1021/acs.chemrev.2c00482

78. “A Cu-Promoted reaction of β-keto trifluoromethyl amines enabling stereoselective synthesis of trifluoromethylated aziridines”

Nana Wang, Youlong Du, Haibo Mei, Jorge Escorihuela, Jianlin Han

Org. Biomol. Chem. 2023, 21 (24), 4988-4992

https://pubs.rsc.org/en/content/articlelanding/2023/ob/d3ob00714f

77. “High Rates of Quinone-Alkyne Cycloaddition Reactions are Dictated by Entropic Factors”

Johannes A. M. Damen, Jorge Escorihuela, Han Zuilhof, Floris van Delft, Bauke Albada

Chem. Eur. J. 2023, 29 (39), e202300231

https://chemistry-europe.onlinelibrary.wiley.com/doi/full/10.1002/chem.202300231

76. “A computational study of 1,3-dipolar cycloadditions of nitrile oxides with dienes”

Loránd Kiss, Jorge Escorihuela

Tetrahedron 2023, 139, 133435  

https://www.sciencedirect.com/science/article/pii/S0040402023002260

75. “Fluorinated Imines in Tandem and Cycloaddition Reactions”

Jorge Escorihuela, Santos Fustero

Chem. Rec. 2023, 23 (9), e202200262

https://onlinelibrary.wiley.com/doi/full/10.1002/tcr.2022002620

74. “Evolution and Future of Hetero- and Hydro-Trifluoromethylations of Unsaturated C−C Bonds”

Shintaro Kawamura, Pablo Barrio, Santos Fustero, Jorge Escorihuela, Jianlin Han, Vadim A. Soloshonok, Mikiko Sodeoka

Adv. Synth. Catal. 2023, 365 (4), 398-462

https://onlinelibrary.wiley.com/doi/abs/10.1002/adsc.202201268

73. "A Density Functional Theory Study on the Cobalt-Mediated Intramolecular Pauson–Khand Reaction of Enynes Containing a Vinyl Fluoride Moiety"

Jorge Escorihuela 

Synthesis 2023, DOI: 10.1055/s-0042-1751392.

72. "A de novo Stereocontrolled Synthetic Approach to a Functionalized Indolizidine Core"

Melinda Nonn, Jorge Escorihuela and Lorand Kiss

Synlett 2023, DOI: 10.1055/s-0042-1751388

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71. "Hydrogen Production from Methanol–Water Solution and Pure Water Electrolysis Using Nanocomposite Perfluorinated Sulfocationic Membranes Modified by Polyaniline"

Carlos Sanchez, Francisco J. Espinos, Arturo Barjola, Jorge Escorihuela and Vicente Compañ

Polymers 2022, 14, 4500.

70. "Electric Conductivity Study of Porous Polyvinyl Alcohol/Graphene/Clay Aerogels: Effect of Compression"

Vicente Compañ, Andreu Andrio, Jorge Escorihuela, Josua Velasco, Alejandro Porras-Vazquez, and Jose Gamez-Perez

ACS Omega 2022, 7, 37954−37963.  

 69. "Computational Study on the Co-Mediated Intramolecular Pauson−Khand Reaction of Fluorinated and Chiral N‑Tethered 1,7- Enynes"

Jorge Escorihuela and Lawrence M. Wolf

Organometallics 2022, 41, 2525−2534. 

68. "Computational insights into the inverse electron demand Diels–Alder reaction of norbornenes with1,2,4,5-tetrazines: norbornene substituents’ effects on the reaction rate"

Pablo García-Aznar and Jorge Escorihuela

Org. Biomol. Chem., 2022, 20, 6400–6412. 

67. "Asymmetric Michael Addition in Synthesis of b-Substituted GABA Derivatives"

Jianlin Han, Jorge Escorihuela, Santos Fustero, Aitor Landa, Vadim A. Soloshonok and Alexander Sorochinsky

Molecules 2022, 27, 3797. 

66. "Intramolecular rhodium-catalysed [2 + 2 + 2] cycloaddition of linear chiral N-bridged triynes: straightforward access to fused tetrahydroisoquinoline core"

Alberto Llobat, Jorge Escorihuela, Carmen Ramírez de Arellano, Santos Fustero and Mercedes Medio-Simón

Org. Biomol. Chem., 2022, 20, 2433–2445.  

65. "Distribution of Relaxation Times: Debye Length Distribution vsElectrode Polarization by a Cole−Cole Relaxation Model"

Vicente Compañ, Ricardo Diaz-Calleja,  Joaquín Diaz-Boils and Jorge Escorihuela

Journal of The Electrochemical Society, 2022 169 013506. 

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64. "Recent Advances on the Halo- and Cyano-Trifluoromethylation of Alkenes and Alkynes"

Bo Fu, Jorge Escorihuela, Jianlin Han, Santos Fustero, Pablo Barrio, Mikiko Sodeoka, Shintaro Kawamura, Alexander Sorochinsky  and Vadim A. Soloshonok

Molecules 2021, 26, 7221.  

63. "Asymmetric Methods for Carbon-Fluorine Bond Formation"

Attila M. Remete, Melinda Nonn, Jorge Escorihuela, Santos Fustero, and Loránd Kiss

Eur. J. Org. Chem 2021, 5946–5974. 

https://chemistry-europe.onlinelibrary.wiley.com/doi/10.1002/ejoc.202101094 

62. "On the Stability and Formation of Pillar[n]arenes: a DFT Study"

Han Zuilhof, Andrew C.-H. Sue, and Jor.ge Escorihuela

J. Org. Chem 2021, 86, 14956−14963.

https://pubs.rsc.org/en/content/articlelanding/2021/ra/d1ra05364g

61. "Proton Exchange Membrane Fuel Cells (PEMFCs): Advances and Challenges"

Miriam M. Tellez-Cruz, Jorge Escorihuela, Omar Solorza-Feria and Vicente Compañ

Polymers 2021, 13, 3064.

https://www.mdpi.com/2073-4360/13/18/3064

60. "Unveiling anion-induced folding in tripodal imidazolium receptors by ion-mobility mass spectrometry"

 Cristian Vicent,  Adriana Valls,  Jorge Escorihuela,  Belen Altava  and Santiago Luis

 Chemical Communications 2021, 57, 8616–8619.

  https://pubs.rsc.org/en/content/articlelanding/2021/cc/d1cc02818a

 59. "Diffusivity and free anion concentration of ionic liquid composite polybenzimidazole membranes"

 Arturo Barjola, Jorge Escorihuela,  Abel Garcia-Bernabé, Oscar Sahuquillo, Enrique Gimenez and Vicente Compan

 RSC Advances 2021, 11, 26379–26390.

 https://pubs.rsc.org/en/content/articlelanding/2021/ra/d1ra05364g

58. "Diastereoselectivity of the Addition of Propargylic Magnesium Reagents to Fluorinated Aromatic Sulfinyl Imines"

 Alberto Llobat, Jorge Escorihuela, Santos Fustero, and Mercedes Medio-Simón

 Organic Letters. 2021, 23, 3691−3695.

 https://pubs.acs.org/doi/full/10.1021/acs.orglett.1c01076

57. "Structural and Electrochemical Analysis of CIGS: Cr Crystalline Nanopowders and Thin Films Deposited onto ITO Substrates"

Suzan Saber, Bernabé Marí, Andreu Andrio, Jorge Escorihuela, Nagwa Khattab, Ali Eid, Amany El Nahrawy, Mohamed Abo Aly, Vicente Compañ

 Nanomaterials 2021, 11, 10936.

 https://www.mdpi.com/2079-4991/11/5/1093

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56. "Cycloaddition of Strained Cyclic Alkenes and Ortho-Quinones: A Distortion/Interaction Analysis"

 Jorge Escorihuela, Wilhelmus J. E. Looijen, Xiao Wang, Adelia J. A. Aquino, Hans Lischka, Han Zuilhof

 J. Org. Chem. 2020, 85, 13557−13566.

  https://pubs.acs.org/doi/10.1021/acs.joc.0c01674

55. " Acylsemicarbazide Moieties with Dynamic Reversibility and Multiple Hydrogen Bonding for Transparent, High Modulus, and Malleable Polymers"

 Daihua Fu, Wuli Pu, Jorge Escorihuela, Xiaorong Wang, Zhanhua Wang, Siyao Chen, Shaojie Sun, Shuo Wang, Han Zuilhof, Hesheng Xia.

 Macromolecules 2020, 53, 7914−7924.

  https://pubs.acs.org/doi/10.1021/acs.macromol.0c01667

54. "Recent Progress in the Development of Composite Membranes Based on Polybenzimidazole for High Temperature Proton Exchange Membrane (PEM) Fuel Cell Applications"

 Jorge Escorihuela, Jessica Olvera-Mancilla, Larissa Alexandrova, Luis Felipe del Castillo, Vicente Compañ

  Polymers 2020, 12, 1861.

  https://www.mdpi.com/2073-4360/12/9/1861

53. " Effect of metallacarborane salt H[COSANE] doping on the performance properties of polybenzimidazole membranes for high temperature PEMFCs"

 Jessica Olvera-Mancilla, Jorge Escorihuela, Larissa Alexandrova, Andreu Andrio, Abel García-Bernabé, Luis Felipe del Castillo, Vicente Compañ

 Soft Matter 2020, 16, 7624–7635.

  https://pubs.rsc.org/en/content/articlelanding/2020/sm/d0sm00743a

52. "Pauson–Khand reaction of fluorinated compounds"

 Jorge Escorihuela, Daniel M. Sedgwick, Alberto Llobat, Mercedes Medio-Simón, Pablo Barrio, Santos Fustero

 Beilstein J. Org. Chem. 2020, 16, 1662–1682

51. " A Deep Insight into Different Acidic Additives as Doping Agents for Enhancing Proton Conductivity on Polybenzimidazole Membranes "

 Jorge Escorihuela, Abel García-Bernabé, Vicente Compañ

 Polymers 2020, 12, 1374..

50. " Influence of the anion on diffusivity and mobility of ionic liquids composite polybenzimidazol membranes"

 Vicente Compañ, Jorge Escorihuela, Jessica Olvera, Abel García-Bernabé, Andreu Andrio

 Electrochimica Acta 2020, 354, 136666.

49. "The Ruthenium-Catalyzed Domino Cross Enyne Metathesis/Ring-Closing Metathesis in the Synthesis of Enantioenriched Nitrogen-Containing Heterocycles"

 Alberto Llobat, Jorge Escorihuela, Daniel M. Sedgwick, Miriam Rodenes, Raquel Román, Vadim A. Soloshonok, Jianlin Han, Mercedes Medio-Simón, Santos Fustero

 Eur. J. Org. Chem 2020, 4193–4207.

48. "Asymmetric Synthesis of Fluorinated Monoterpenic Alkaloid Derivatives from Chiral Fluoroalkyl Aldimines via the Pauson-Khand Reaction"

 Alberto Llobat, Daniel M. Sedgwick, Albert Cabré, Raquel Román, Natalia Mateu, Jorge Escorihuela, Mercedes Medio Simón, Vadim Soloshonok, Jianlin Han, Antoni Riera, Santos Fustero

 Adv. Synth. Catal. 2020, 362, 1378–1384.

************************************2019************************************

47. "Proton Conductivity through Polybenzimidazole Composite Membranes Containing Silica Nanofiber Mats"

 Jorge Escorihuela, Abel García-Bernabé, Álvaro Montero, Andreu Andrio, Óscar Sahuquillo, Enrique Giménez, Vicente Compañ.

 Polymers 2019, 11, 1182.

46. "Dynamic covalent urea bonds and their potential for self-healing polymer materials"

 Zhanhua Wang, Satesh Gangarapu, Jorge Escorihuela, Guoxia Fei, Han Zuilhof, Hesheng Xia

 J. Mater. Chem A 2019, 7, 15933–15943.

45. "Supramolecularly assisted synthesis of chiral tripodal imidazolium compounds"

 Adriana Valls, Belén Altava, M. Isabel Burguete, Jorge Escorihuela, Vicente Martí-Centelles, Santiago V. Luis

 Org. Chem. Front. 2019, 6, 1214–1225.

44. "Proton Conductivity of Composite Polyelectrolyte Membranes with Metal-Organic Frameworks for Fuel Cell Applications"

 Jorge Escorihuela, Riccardo Narducci, Vicente Compañ, Ferdinando Constantino

 Adv. Mater. Interfaces 2019, 6, 1801146.

43. "Ionic Liquid Composite Polybenzimidazol Membranes for High Temperature PEMFC Applications"

 Jorge Escorihuela, Abel García-Bernabé, Álvaro Montero, Óscar Sahuquillo, Enrique Giménez, Vicente Compañ.

 Polymers 2019, 11, 732.

42. "New structural insights into the role of TROVE2 complexes in the on-set and pathogenesis of systemic lupus erythematosus determined by a combination of QCM-D and DPI"

 A. Juste-Dolz, N. M. do Nascimento, I. Monzó, E. Grau-García, J. A. Román-Ivorra, J. L. Lopez-Paz, J. Escorihuela, R. Puchades, S. Morais, D. Gimenez-Romero, Á. Maquieira.

 Anal. Bioanal. Chem. 2019, 411, 4709–4720.

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41. "Enhanced Conductivity of Composite Membranes Based on Sulfonated Poly(Ether Ether Ketone) (SPEEK) with Zeolitic Imidazolate Frameworks (ZIFs) "

 Arturo Barjola, Jorge Escorihuela, Andreu Andrio, Enrique Giménez, Vicente Compañ.

 Nanomaterials 2018, 8, 1042.

40. "Phosphoric Acid Doped Polybenzimidazole (PBI)/Zeolitic Imidazolate Framework Composite Membranes with Significantly Enhanced Proton Conductivity under Low Humidity Conditions "

 Jorge Escorihuela, Oscar Sahuquillo, Abel García-Bernabé, Enrique Giménez, Vicente Compañ.

 Nanomaterials 2018, 8, 775.

39. "Strain-promoted cycloaddition of cyclopropenes with o–quinones: a rapid click reaction"

 D. Gahtory, R. Sen, A. R. Kuzmyn, J. Escorihuela, H. Zuilhof

 Angew. Chem. Int. Ed. 2018, 57, 10118–10122.

38.  "Experimental Study of the Oriented Immobilization of Antibodies on Photonic Sensing Structures by Using Protein A as an Intermediate Layer"

 R. Caroselli, J. García Castelló, J. Escorihuela, M. J. Bañuls, Á. Maquieira, J. García-Rupérez

 Sensors 2018, 18, 1012.

37. "Structural and dielectric properties of Cobaltacarborane Composite Polybenzimidazole Membranes as solid polymer electrolytes at high temperature"

 I. Fuentes, A. Andrio, A. García-Bernabé, J. Escorihuela, C. Viñas, F. Teixidor, V. Compañ

 Phys. Chem. Chem. Phys. 2018, 20, 10173−10184.

36. "Kinetics of the Strain-Promoted Oxidation-Controlled Cycloalkyne-1,2-Quinone Cycloaddition (SPOCQ): Experimental and Theoretical Studies"

 J. Escorihuela, A. Das, J. Looijen, F. van Delft, A. Aquino, H. Lischka, H. Zuilhof

 J. Org. Chem. 2018, 83, 244-252.

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35. "Approach Matters: The Kinetics of Interfacial Inverse-Electron Demand Diels–Alder Reactions"

 R. Sen, D. Gahtory, J. Escorihuela, J. Firet, S. P. Pujari, H. Zuilhof

 Chem. Eur. J. 2017, 23, 13015–13022.

34. "Proton conducting electrospun sulfonated polyether ether ketone graphene oxide composite membranes"

 J. L. Reyes-Rodriguez, J. Escorihuela, A. García-Bernabé, E. Giménez, O. Solorza-Feria, V. Compañ

 RSC Adv. 2017, 7, 53481-53491.

33. "Rapid surface functionalization of hydrogen-terminated silicon by alkyl silanols"

 Jorge Escorihuela, Han Zuilhof

 J. Am. Chem. Soc. 2017, 139, 5870−5876.

32. "Organic monolayers by B(C6F5)3-Catalyzed Siloxanation of Oxidized Silicon Surfaces"

 J. Escorihuela, S. P. Pujari, H. Zuilhof

 Langmuir 2017, 33, 2185–2193.

31. "Rapid and complete surface modification with strain-promoted oxidation-controlled cyclooctyne–1,2-quinone cycloaddition (SPOCQ)"

 Rickdeb Sen, Jorge Escorihuela, Floris L. van Delft, Han Zuilhof

 Angew. Chem. Int. Ed. 2017, 56, 3299–3303.

30. "Improved performance of DNA microarray multiplex hybridization using probes anchored at several points by Thiol-Ene or Thiol-Yne click chemistry"

 M. J. Bañuls, P. Jiménez-Meneses, A. Meyer, J. J. Vasseur, F. Morvan, J. Escorihuela, R. Puchades, A. Maquieira

 Bioconjugate Chem. 2017, 28, 496–506.

************************************2016************************************ 

29. "Mechanistic implications of the enantioselective addition of alkylzinc reagents to aldehydes catalysed by nickel complexes with a-amino amide ligands"

 Jorge Escorihuela, M. Isabel Burguete, Gregori Ujaque, Agustí Lledós, Santiago V. Luis

 Org. Biomol. Chem. 2016, 14, 11125–11136.

28. "Characterization of the Laccase-mediated Oligomerization of 4-Hydroxybenzoic Acid"

 S. Slagman, J. Escorihuela, H. Zuilhof, M. C. R. Franssen

 RSC Adv. 2016, 6, 99367–9937.

27.  "Use of Ambient Ionization High-Resolution Mass Spectrometry for the Kinetic Analysis of Organic Surface Reactions"

 Rickdeb Sen, Jorge Escorihuela, Maarten M. J. Smulders, Han Zuilhof

 Langmuir 2016, 32, 3412−3419.

************************************2015************************************ 

26. "Metal-Free Click Chemistry Reactions on Surfaces"

 Jorge Escorihuela, Antonius T. M. Marcelis, Han Zuilhof

 Adv. Mater. Interfaces 2015, 2, 1500135.

25. "Bis(imidazolium) salts derived from amino acids as receptors and transport agents for chloride anions"

 L. González-Mendoza, B. Altava, M. I. Burguete, J. Escorihuela, E. Hernando, S. V. Luis, R. Quesada, C. Vicent

 RSC Adv. 2015, 5, 34415–34423

24. "Application of optically active chiral bis-(imidazolium) salts as potential receptors of chiral dicarboxylate salts of biological relevance"

 Laura González-Mendoza, Jorge Escorihuela, Belén Altava, M. Isabel Burguete, Santiago V. Luis

 Org. Biomol. Chem. 2015, 13, 5450–5459.

23. "Dual stereocontrolled alkylation of aldehydes with polystyrene-supported nickel complexes derived from a-amino amides"

 Jorge Escorihuela, Belén Altava, M. Isabel Burguete, Santiago V. Luis

 RSC Adv. 2015, 5, 14653–14662.

22. "Dual-Polarization Interferometry: A Novel Technique To Light up the Nanomolecular World"

 J. Escorihuela, M. A. Gonzalez-Martínez, J. L. Lopez-Paz, R. Puchades, A. Maquieira, D. Gimenez-Romero

 Chem. Rev. 2015, 115, 265−294

************************************2014************************************ 

21. "Site-specific immobilization of DNA on silicon surfaces by using the thiol–yne reaction"

 Jorge Escorihuela, Maria José Bañuls, Rosa Puchades, Ángel Maquieira

 J. Mater. Chem. B 2014, 2, 8510–8517

20. "Chiral Room Temperature Ionic Liquids as Enantioselective Promoters for the Asymmetric Aldol Reaction"

 Laur aGonzález, Jorge Escorihuela, Belén Altava, M. Isabel Burguete, Santiago V. Luis

 Eur. J. Org. Chem. 2014, 5356–5363.

19. "Direct Covalent Attachment of DNA Microarrays by Rapid Thiol−Ene “Click” Chemistry"

 Jorge Escorihuela, Maria José Bañuls, Santiago Grijalvo, Ramón Eritja, Rosa Puchades, Ángel Maquieira

 Bioconjugate Chem. 2014, 25, 618−627.

18. "Direct and label-free monitoring oligonucleotide immobilization,non-specific binding and DNA biorecognition"

 J. L. López-Paz, M. Á. González-Martínez, J. Escorihuela, M. J. Bañuls, R. Puchades, Á. Maquieira

 Sensors and Actuators B 2014, 192, 221– 228.

************************************2013************************************ 

17. "Polymer-supported chiral a-amino amides for the asymmetric addition of diethylzinc to aldehydes: Transforming an inactive homogeneous system into an efficient catalyst"

 J. Escorihuela, L. González, B. Altava, M. I. Burguete, S. V. Luis

 Applied Catalysis A: General 2013, 462–463, 23–30.

16. "New advances in dual stereocontrol for asymmetric reactions"

 J. Escorihuela, M. I. Burguete, S. V. Luis

 Chem. Soc. Rev. 2013, 42, 5595-5617.

15. "C2 symmetrical nickel complexes derived from a-amino amides as efficient catalysts for the enantioselective addition of dialkylzinc reagents to aldehydes"

 J. Escorihuela, B. Altava, M. I. Burguete, S. V. Luis

 Tetrahedron 2013, 69, 551-558.

************************************2012************************************ 

14. "Real-time observation of antigen–antibody association using a low-cost biosensing system based on photonic bandgap structures"

 J. G. Castelló, V. Toccafondo, J. Escorihuela, M. J. Bañuls, A. Maquieira, and J. García-Rupérez

 Optics Letters 2012, 37, 3684–3686.

13. "Chemical silicon surface modification and bioreceptor attachment to develop competitive integrated photonic biosensors"

 J. Escorihuela, M. J. Bañuls, J. García Castelló, V. Toccafondo, J. García-Rupérez, R. Puchades, Á. Maquieira

 Anal. Bioanal. Chem. 2012, 404, 2831–2840.

12. "Development of Oligonucleotide Microarrays onto Si-Based Surfaces via Thioether Linkage Mediated by UV Irradiation"

 Jorge Escorihuela, Maria José Bañuls, Rosa Puchades, Angel Maquieira

 Bioconjugate Chem. 2012, 23, 2121−2128.

11. "Copper(II) complexes of bis(amino amide) ligands: effect of changes in the amino acid residue"

 I. Martí, A. Ferrer, J. Escorihuela, M. I. Burguete, S. V. Luis

 Dalton Trans. 2012, 41, 6764–6776."

10. "DNA microarrays on silicon surfaces through thiol-ene chemistry"

 Jorge Escorihuela, Maria José Banñuls, Rosa Puchades, Angel Maquieira

 Chem. Commun. 2012, 48, 2116–211.

************************************2010************************************

9. "A simple peptidomimetic that self-associates on the solid state to form a nanoporous architecture containing chiral pi-channels"

 Jorge Becerril, Michael Bolte, M. Isabel Burguete, Jorge Escorihuela, Francisco Galindo and Santiago V. Luis

 CrystEngComm, 2010, 12, 1722–1725.

8. "Coordination of Cu2+ Ions to C2 Symmetric Pseudopeptides Derived from Valine"

 S. Blasco, M. I. Burguete, M. P. Clares, E. García-España, J. Escorihuela, S. V. Luis

 Inorg. Chem. 2010, 49, 7841–7852.

7. "Chiral bis(amino amides) as chiral solvating agents for enantiomeric excess determination of a-hydroxy and arylpropionic acids"

 B. Altava, M. I. Burguete, N. Carbó, J. Escorihuela, S. V. Luis

 Tetrahedron: Asymmetry 2010, 21, 982–989.

************************************2009************************************

6. "Synthesis of new chiral imidazolium salts derived from amino acids: their evaluation in chiral molecular recognition"

 B. Altava, D. S. Barbosa, M. I. Burguete, J. Escorihuela, S. V. Luis

 Tetrahedron: Asymmetry 2009, 20, 999–1003.

************************************2008************************************ 

5. "Enantioselective nickel-catalyzed conjugate addition of dialkylzinc to chalcones using chiral a-amino amides"

 Jorge Escorihuela, M. Isabel Burguete, Santiago V. Luis,

 Tetrahedron Lett. 2008, 49, 6885–6888.

4. "New chiral tetraaza ligands for the efficient enantioselective addition of dialkylzinc to aromatic aldehydes"

 M. Isabel Burguete, Jorge Escorihuela, Santiago V. Luis, Agustí Lledos, Gregori Ujaque

 Tetrahedron 2008, 64, 9717–9724.

************************************2007************************************ 

3. "Efficient Chirality Switching in the Addition of Diethylzinc to Aldehydes in the Presence of Simple Chiral a-Amino Amides"

 M. Isabel Burguete, Manuel Collado, Jorge Escorihuela, Santiago V. Luis

Angew. Chem. Int. Ed. 2007, 46, 9002 –9005.

************************************2003************************************ 

2. "Nickel complexes from -amino amides as efficient catalysts for the enantioselective Et2Zn addition to benzaldehyde"

M. I. Burguete, M. Collado, J. Escorihuela, F. Galindo, E. García-Verdugo, S. V. Luis, M. J. Vicent

Tetrahedron Lett. 2003, 44, 6891–6894.

1. "Preparation and Optimization of Polymer-Supported and Amino Alcohol Based Enantioselective Reagents and Catalysts"

S. V. Luis, B. Altava, M. I. Burguete, M. Collado, J. Escorihuela, E. Garcia-Verdugo, M. J. Vicent, J. Martens

Ind. Eng. Chem. Res. 2003, 42, 5977–5982.

Projects

We participate in the following national and internationall research projects funded by different agencies:

 

PID2023-152131NB-I00 

Materiales fotoactivos elaborados para absorber en la región Vis-NIR.

Ministerio de Ciencia e Innovación.

PI: María González Béjar.

01/09/2024-31/08/2027.                                      224,933 €.

 

CIPROM/2022/57 

Selectively matching nanohybrids for light-driven applications. 

Generalitat Valenciana.

PI: Julia Pérez Prieto and Raquel Galián.

01/01/2023-31/12/2026.                                      596,000 € .

 

MFA/2022/051 

Nanomateriales fotoactivos con funcionalidades avanzadas (NanoPhotoFun)

Generalitat Valenciana.

PI: Julia Pérez Prieto and María González Béjar.

30/06/2022-29/06/2025.                                      209,703 €.

 

AMRAMR 101131231 

Advanced Multidisciplinary Research for Antimicrobial Resistance 

European Comission

Call MSCA Staff Exchanges 2022 (HORIZON-MSCA-2022-SE-01)

01/01/2024-31/12/2027.                                      276,000 €

Collaborations

We are deeply committed to highly interdisciplinary research in organic chemistry, and the success of our research is often enriched through scientific collaborations with outstanding research groups. We would therefore like to express our sincere gratitude to our collaborators for their valuable contributions:

• Prof. Norio Shibata, Nagoya Institute of Technology, Japan
• Dr. Jianlin Han, Jiangsu Co-Innovation Center of Efficient Processing and Utilization of Forest Resources, China
• Prof. Han Zuilhof, Wageningen University and Research, The Netherlands
• Dr. Scott T. Laughlin, Stony Book University, United states of America
• Prof. Mrinal Bera, Indian Institute of Engineering Science and Technology, India