SUBJECT: INORGANIC BIOCHEMISTRY OF THE METALLIC ELEMENTS COD. 12973
(BIOCHEMISTRY DEGREE)
Teacher in charge of the subject: Hermas R. Jiménez García
OBJECTIVES:
The didactic aims centre on introducing the student in the complex and interesting world of the inorganic biochemistry. After analyzing the concepts of electronic structure and biocoordination together with the aspects of structural characterization, there is claimed that the student knows the functions recovered in the organisms by the most important metalloproteins and the aspects physicist-chemist who regulate them. That understands the different mechanisms of performance of proteins and enzymes relating them to the structural characteristics.
SYLLABUS:
Introduction. Basic principles in the biological selection of the elements. Biocoordination. Electronic structure and stereochemistry of the metallic ions in Biology. Effect chelate and macrocyclical. Structural characterization of the metalloproteins. Captation, transport and storage of metallic ions. Transport and storage of the dioxygen. Properties of the dioxygen of biological interest. Study of Hemoglobin and Myoglobin. Model systems. Alternative transport of the dioxygen in low systems. Reactions of the dioxygen and derivatives catalyzed for metalloenzymes. Activation of the dioxygen. Toxicity of the dioxygen and mechanisms of defense opposite to the toxicity of some by-products of the dioxygen. Metalloproteins of electronic transference. Proteins iron-sulphur. Blue copper proteins: compared study of the Plastocyanin and Azurin. Cytochromes. Electronic transference to great distance in the metalloproteins. Biological fixation of the dinitrogen and reactions of transference of atom of oxygen. Nitrogenases and oxotransferases of molybdenum. Union and activation of the substratum by mean of enzymes non-redox. Carbonic Anhydrase, Carboxypeptidase and Alcohol dehydrogenase. Other metallic elements in Biological Systems. Inorganic biochemistry in Medicine. Ureases and hydrogenases of nickel. Reactions catalyzed for enzymes of manganese. The magnesium and the calcium in the biological systems.
BIBLIOGRAPHY:
1. M. Vallet, J. Faus, E. García-España y J. Moratal, "Introducción a la Química Bioinorgánica", Síntesis, Madrid, 2003.
2. J. S. Casas, V. Moreno, A. Sánchez, J. L. Sánchez y J. Sordo, "Química Bioinorgánica", Síntesis, Madrid, 2002.
3. J. A. Cowan, "Inorganic Biochemistry: An Introduction", Wiley-VCH, New York, 1997.
4. W. Kaim y B. Schwederski, "Bioinorganic Chemistry: Inorganic Elements in the Chemistry of Life. An Introduction and Guide", Wiley, Chichester, 1996.
5. S. J. Lippard y J. M. Berg, "Principles of Bioinorganic Chemistry", W. H. Freeman & Co., Mill Valley, California, 1994.
EDUCATIONAL METHOD:
The development of the subject is constructed in three meetings theories a week. In the classes the students will correct in the blackboard the proposed exercises. At the same time it will be possible realize the presentation of an individual work of theory. In any case they will give themselves instructions during the course.
SYSTEM OF EVALUATION:
Final examination. Content: Totality of the given matter.
Type of examination: writing, questions, short questions and you ask to developing. Also there will be valued works related to the content of the subject.
Minimal note to pass: 5.