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Endocytosis: Counting endocytic events and estimation of their durations from TIRFM image sequences using temporal Boolean models

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Endocytosis is a process by which cells carry traffic from the extracellular space into various intracellular compartments. Visualization of fluorescently-tagged clathrin proteins (mediators of endocytosis) allows us to image endocytosis in real-time. When imaging the plasma membrane, areas of fluorescence generated by different endocytic processes overlap, forming random clumps. We model a sequence of segmented clathrin spots as a realization of a temporal Boolean model. We obtain the estimates of the intensity (mean number of events per unit area and unit time) and the density function of the durations.

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Software

Temporal Random Sets. A Matlab toolbox for simulation and estimation

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© María Elena Díaz, Universitat de Valencia email elena.diaz@uv.es Mod: 15 enero 2021 12:40  documentacion wiki traza de la pagina Editar