University of Valencia, Faculty of Chemistry, Physical Chemistry Department Avda. Dr. Moliner, 50 C.P. 46100 Burjassot Valencia Research Group SIGMO Signal & Modelling The structure of a protein-protein interaction, its affinity and thermodynamic characteristics depict a 'frozen' state of a complex. This  picture ignores the kinetic nature of complex formation and dissociation, which are of major biological and biophysical interest. The  research focus should be on the kinetic pathway of protein-protein complexation, the nature of the encounter complex, transition state  and intermediate along the reaction, and the effects of mutation, viscosity, pH and salt on association. So Arthur Kornberg (1918-2007)  was visionary when he said:  "With occasional gestures in the direction of biology, chemistry  departments still retain the classical separations into discrete divisions of  organic, physical, and inorganic-analytical chemistry. Perhaps the  departments can now ignore the analysis and synthesis of proteins and  nucleic acids because these procedures have become straightforward  enough to be machine-programmed and operated. But the structure-  function relationship of these macromolecules is another matter".  Hence, the research group focus is on technological applications of biological  interactions through molecular systems that once understood can lead to new  mimetic-based technologies and devices for diagnostics. The group has  interdisciplinary interest and some expertise that goes from nanoscience to  biotechnology.   The study of the protein-protein interactions constitues a  powerful tool able to allow ultrasensitive label free  detection of clinically important targets and binding affinity.  Within these studies biofunctionalized transducer surfaces  (in microarray platform or not) can be generated using  specific surface chemistries and binding moieties to target  specific clinically important proteins associated with  diseases and pathological disorders. The main purpose of  this subject is to continue to develop the concept and  explore its functionality for clinical important markers  aiming devices to be clinically tested.