The aim of this study was to evaluate the effects of a basketball-specific neuromuscular warm-up (the Basket-Up approach) on physical performance (jumping, agility, and sprinting) in comparison to a standard warm-up. Twenty-two highly trained youth basketball players (age: 15.68 ± 1.17 years) participated in this study. In a randomized crossover design, players performed two different warm-up protocols on separate days: the Basket-Up program (which includes mobility, core stability, eccentric strength, and specific jumping exercises) and a club standard warm-up. Physical performance was assessed using the countermovement jump (CMJ), the V-cut agility test, and 10 m and 20 m sprint tests. The results showed that the Basket-Up program led to significant improvements in CMJ height (p < 0.01) and 10 m and 20 m sprint times (p < 0.05) compared to the standard warm-up. No significant differences were found in the V-cut agility test between the two protocols. In conclusion, the Basket-Up approach is an effective and specific tool for optimizing immediate neuromuscular performance in basketball players, outperforming traditional warm-up routines. These findings suggest that implementing targeted, sport-specific neuromuscular exercises during the warm-up can enhance key physical attributes required in basketball.