High risk basal cell carcinomas Size >2 cm diameter Location in high risk anatomical areas (centrofacial, periocular, “H zone,” and embryological fusion zones of face) Poorly defined edges Morphoeic, infiltrative, or aggressive histological subtypes Perineural or perivascular invasion Recurrent or previously incompletely excised basal cell carcinoma Host factors (immunosuppression, especially if organ transplant recipient)

Facial basal cell carcinoma BMJ 2012; 345 d