• Consuelo Borrás

    Consuelo Borrás

  • Lecturer in Physiology (Faculty of Medicine, University of Valencia) I studied Pharmacy at the University of Valencia, where I graduated in 1999. In 2003 I obtained my European PhD degree in the Department of Physiology (Faculty of Medicine, University of Valencia) with a thesis entitled “Importance of oxidative stress on the different longevity between males and females”. The main finding was the role of oestrogens against oxidative stress, and therefore in the extension of longevity (Free Radic Biol Med. 2003; 34(5):546-52). During my PhD student period, I did a pre-doctoral stay in London at The Centre for Cardiovascular Biology and Medicine in King’s College, London, where I studied with an expert in cardiovascular research and cell signalling, Prof Giovanni E. Mann, the effect of soya administration in antioxidant enzyme levels in aorta and liver from rats (FASEB J. 2005; 19(12):1755-7). I also studied how glutathione is able to modulate telomerase activity, to modify cell cycle related protein expression, and to alter the normal rhythm of cell proliferation (J Biol Chem. 2004; 279(33):34332-59. Continuing on with this topic, I went to the Centro Nacional de Investigaciones Oncológicas in Madrid, and did a post-doctoral stay with a specialist in telomerase and telomeres, María A. Blasco. I was also interested to study new genes related to longevity and we published, in collaboration with Dr Manuel Serrano’s and Dr Maria Blasco’s groups, that p53 and telomerase can extend longevity in mice (Nature. 2007; 448(7151):375-9; Cell. 2008; 135(4):609-22). In 2005, I moved back to Valencia and took up the position of lecturer at the Catholic University of Valencia, and in 2008 I came back to the University of Valencia as an assistant professor. In 2011, I attained a position as a lecturer in the Department of Physiology of the Faculty of Medicine (University of Valencia). At present, I am interested in the factors that confer extreme longevity to centenarians, and we have already found that they are exceptionally well-regulated at the mRNA level by microRNAs (Sci Rep. 2012; 2:961). My second interest is the study of stem cells as a useful tool for regenerating aged tissues.

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