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New research projects of the State Research Agency (AEI)

  • August 5th, 2020
I2SysBio

The State Research Agency (Agencia Estatal de Investigación AEI) has approved four new projects from our institute in the latest call for grants aimed at societal challenges. Over the next three years, I2SysBio research groups will be funded with a total of 892,000 euros. Two contracts will also be called for under the Research Staff Training (FPI) programme.

In the State Programme for Knowledge Generation, the projects led by Gustavo Gómez, Santiago F. Elena and Javier Buceta have received funding. Gómez, leader of the group Regulatory Networks Mediated by Non-Coding RNA, is the Principal Investigator of the project "Gene regulatory networks influenced by the environment involved in the control of the response to stress in melon (EGReNMel)". The main objective of EGReNMel is to understand how melon plants respond to stress by integrating processes that occur at three different regulatory levels: small RNAs, messenger RNAs and epigenetic marks. This knowledge can facilitate the development of global and innovative agricultural crop protection strategies.

The project entitled "Role of the host epicode in the evolution of viral populations" (EPICOVIR) has Santiago F. Elena, leader of the Evolutionary and Systems Virology research group, as Principal Investigator. A large-scale evolution experiment is proposed to test how virus populations evolve and interact in plants with compromised or improved epigenetic pathways, as well as to study the antiviral effect of epigenetic modifications in plants infected by Turnip Mosaic Virus (TuMV). Vicente Arnau, member of the Theory, Bioinformatics and Computation (TBC) group, also participates in the EPICOVIR project as a researcher.

The project led by Javier Buceta, Senior Scientist of the CSIC who has just joined our institute with his group TheSimBioSys, has also been selected by the AEI. The project "Mechanobiology of Escherichia coli filamentation and epithelial remodelling" aims to understand the mechanical signalling pathways during the filamentation of E. coli bacteria. It will also study the coupling between the tissue signalling pattern in cell interleaving events (in space and time).

Finally, within the state programme of R+D+i projects "Challenges-Collaboration" aimed at promoting the collaboration of research groups with companies, the project entitled "Development of EOSAL for its application to different types of genetic studies by means of mass sequencing in clinical and research settings" will be developed. This research, led by Vicente Arnau (TBC) and Felipe Javier Chaves de Seqplexing, aims to develop kits for different EOSAL (Easy One-Step Amplification and Labelling) applications using NGS (New Generation Sequencing) and their validation, for example, for the detection of somatic and germline mutations, mutations in RNA and DNA simultaneously, or mutations in a very low proportion and their application to cancer immunotherapy. Likewise, they will develop bioinformatic applications for the design of the kits.

See all the current projects of our institute.