Title: Counteracting COVID19 progression by the use of therapeutic interfering particles
Research groups: Virus Experimental Evolution, Evolutionary Systems Virology and Molecular Epidemiology
Defective interfering particles (DIP) are degenerate forms of viral genomes that are non-replicative but remain infectious by complementation with the wildtype (WT) virus. DIPs play a significant role in modulating the outcome of infection and immune responses, and can be artificially selected to strengthen their interfering activity and suppress replication of the full virus (therapeutic interfering particles, or TIPs). We propose to produce DIPs during SARS-CoV-2 replication in cell culture, purify them, test their antiviral effects, and characterize them molecularly. The outcome of the project will be a SARS-CoV-2 specific set of TIPs that could be used right away to treat COVID19.
Ref. PIE 202020E153
Santiago F. Elena
- Rafael Sanjuán
- Fernándo González
CSIC
Universitat de València