Mutaciones

We are part of a joint effort to better understand the effects of mutations in SARS-CoV-2 in real time. This grant aims at building a platform to deal with current and future threats.

Acronym

Mutaciones

Description

Title: PTI+: Mutation screening based on their potential biological relevance

Research groups: Viral Biology and Evolutionary Systems Virology

We are assessing the effects of different SARS-CoV-2 variants and mutations on evasion from antivirals and immune responses, as well as their effects on infectivity and stability. We are employing pseudotype systems as well as replication competent VSV encoding the SARS-CoV-2 spike protein.

Unión Europea - Next Generation EU Consejo Superior de Investigaciones Científicas (CSIC)

Developers of the project

Institut de Biologia Integrativa de Sistemes (I2SYSBIO)

i2sysbio.uv.es

iu.i2sysbio@uv.es

Non-UV principal researchers

Santiago Elena (CSIC, I2SysBio)

Iñaki Comas (IBV, CSIC)

Carmen Gil (CIB, CSIC)

David Rios (ICMAT, CSIC)

Alberto Marina (IBV, CSIC)

José Carazo (CNB, CSIC)

Start date

2021 January

End date

2022 December

Funding agencies:

European Commission – NextGenerationEU

“This contract/assignment is financed by the European Union Recovery Instrument, established by the Council Regulation (EU) 2020/2094 of 14 December 2020 establishing a European Union Recovery Instrument to support the recovery in the aftermath of the COVID-19 crisis, and regulated according to Regulation (EU) 2021/241 of the European Parliament and of the Council of 12 February 2021 establishing the Recovery and Resilience Facility”.

Partners:

Instituto de Biomedicina de Valencia

Centro de Investigaciones Biológicas

Instituto de Ciencias Matemáticas

Centro Nacional de Biotecnología