Docencia               Investigación               Colaboración

Dr. Carlos Hermenegildo

Nombre Completo

>> Carlos Hermenegildo Caudevilla

 

Cargos

>> Catedrático por la Universidad de Valencia

>> Coordinador de la U.C.I.M.

>> Director Científico del grupo L.In.C.E.

 

Líneas de Investigación

>> Diferencias de género en el área cardiovascular.

>> Efectos vasculares de las hormonas sexuales.

>> Identificación de nuevas rutas de señalización

 reguladas hormonalmente en el endotelio.

Publicaciones

Mobilization of endothelial progenitor cells in acute cardiovascular events in the PROCELL study: Time-course after acute myocardial infarction and stroke.
Regueiro A, Cuadrado-Godia E, Bueno-Betí C, Diaz-Ricart M, Oliveras A, Novella S, Gené GG, Jung C, Subirana I, Ortiz-Pérez JT, Roqué M, Freixa X, Núñez J, Escolar G, Marrugat J, Hermenegildo C, Valverde MA, Roquer J, Sanchis J, Heras M.
J Mol Cell Cardiol. 2015 Mar;80:146-55. doi: 10.1016/j.yjmcc.2015.01.005.

Combined Sub-Optimal Doses of Rosuvastatin and Bexarotene Impair Angiotensin II-Induced Arterial Mononuclear Cell Adhesion Through Inhibition of Nox5 Signaling Pathways and Increased RXR/PPARα and RXR/PPARγ Interactions.
Escudero P, Martinez de Marañón A, Collado A, Gonzalez-Navarro H, Hermenegildo C, Peiró C, Piqueras L, Sanz MJ
Antioxid Redox Signal. 2015 Apr 10;22(11):901-20. doi: 10.1089/ars.2014.5969

Frailty and other geriatric conditions for risk stratification of older patients with acute coronary syndrome.
Sanchís J, Bonanad C, Ruiz V, Fernández J, García-Blas S, Mainar L, Ventura S, Rodríguez-Borja E, Chorro FJ, Hermenegildo C, Bertomeu-Gonzalez V, Núñez E, Núñez J.
Am Heart J. 2014 Nov;168(5):784-91. doi: 10.1016/j.ahj.2014.07.022.

Diminished neurogenic femoral artery vasoconstrictor response in a Zucker obese rat model: differential regulation of NOS and COX derivatives.
Martínez AC, Hernández M, Novella S, Martínez MP, Pagán RM, Hermenegildo C, García-Sacristán A, Prieto D, Benedito S.
PLoS One. 2014 Sep 12;9(9):e106372. doi: 10.1371/journal.pone.0106372.

Changes in sex ratio from fertilization to birth in assisted-reproductive-treatment cycles.
Tarín JJ, García-Pérez MA, Hermenegildo C, Cano A.
Reprod Biol Endocrinol. 2014 Jun 23;12:56. doi: 10.1186/1477-7827-12-56

Recovering the enthusiasm for novel strategies to threat sepsis.
Garcia-Gimenez JL, Novella S, Carbonell N, Garcia-Simon M, Blanquer J, Hermenegildo C, Pallardo FV.
J Blood. 2014 Apr 25. (e-letter)

Gene expression profile induced by ovariectomy in bone marrow of mice: a functional approach to identify new candidate genes associated to osteoporosis risk in women.
Pineda B, Serna E, Laguna-Fernández A, Noguera I, Panach L, Hermenegildo C, Tarín JJ, Cano A, García-Pérez MA.
Bone. 2014 Aug;65:33-41. doi: 10.1016/j.bone.2014.05.001.

An affordable method to obtain cultured endothelial cells from peripheral blood.
Bueno-Betí C, Novella S, Lázaro-Franco M, Pérez-Cremades D, Heras M, Sanchís J, Hermenegildo C
J Cell Mol Med. 2013 Oct 1. doi: 10.1111/jcmm.12133.

Dynamics of serum-induced endothelial cell apoptosis in patients with myocardial infarction.
Forteza MJ, Novella S, Trapero I, Hermenegildo C, Ruiz-Sauri A, Chaustre F, Bonanad C, Oltra R, Palacios L, O Connor JE, Chorro FJ, Bodi V.
Eur J Clin Invest. 2013 Oct 10. doi: 10.1111/eci.12189.

Aging-related endothelial dysfunction in the aorta from female senescence-accelerated mice is associated with decreased nitric oxide synthase expression.
Novella S, Dantas AP, Segarra G, Vidal-Gómez X, Mompeón A, Garabito M, Hermenegildo C, Medina P.
Exp Gerontol. 2013 Nov;48(11):1329-37. doi: 10.1016/j.exger.2013.08.003.

Endocrinology and physiology of pseudocyesis.
Tarín JJ, Hermenegildo C, García-Pérez MA, Cano A.
Reprod Biol Endocrinol. 2013 May 14;11:39. doi: 10.1186/1477-7827-11-39.

Complete blockade of the vasorelaxant effects of angiotensin-(1-7) and bradykinin in murine microvessels by antagonists of the receptor Mas.
Peiró C, Vallejo S, Gembardt F, Palacios E, Novella S, Azcutia V, Rodríguez-Mañas L, Hermenegildo C, Sánchez-Ferrer CF, Walther T.
J Physiol. 2013 May 1;591(Pt 9):2275-85. doi: 10.1113/jphysiol.2013.251413.

Unpredicted ovulations and conceptions during early pregnancy: an explanatory mechanism of human superfetation.
Tarín JJ, García-Pérez MA, Hermenegildo C, Cano A.
Reprod Fertil Dev. 2013;25(7):1012-9. doi: 10.1071/RD12238.

Estradiol, acting through estrogen receptor alpha, restores dimethylarginine dimethylaminohydrolase activity and nitric oxide production in oxLDL-treated human arterial endothelial cells.
Novella S, Laguna-Fernández A, Lázaro-Franco M, Sobrino A, Bueno-Betí C, Tarín JJ, Monsalve E, Sanchís J, Hermenegildo C
Mol Cell Endocrinol. 2013 Jan 5;365(1):11-6. doi: 10.1016/j.mce.2012.08.020.

Vascular Aging in Women: is Estrogen the Fountain of Youth?
Novella S, Dantas AP, Segarra G, Medina P, Hermenegildo C.
Front Physiol. 2012;3:165.

Effects of estrogen on vascular inflammation: a matter of timing.
Novella S, Heras M, Hermenegildo C, Dantas AP.
Arterioscler Thromb Vasc Biol. 2012 Aug;32(8):2035-42.

Endometrial response to concurrent treatment with vaginal progesterone and transdermal estradiol.
Fernández-Murga L, Hermenegildo C, Tarín JJ, García-Pérez MA, Cano A.
Climacteric. 2012 Feb 9.

Endothelial and neural factors functionally involved in the modulation of noradrenergic vasoconstriction in healthy pig internal mammary artery.
Pagán RM, Martínez AC, Hernández M, Martínez MP, García-Sacristán A, Correa C, Novella S, Hermenegildo C, Prieto D, Benedito S.
Biochem Pharmacol. 2012 Apr 1;83(7):882-92.

Aging enhances contraction to thromboxane A(2) in aorta from female senescence-accelerated mice.
Novella S, Dantas AP, Segarra G, Novensa L, Heras M, Hermenegildo C, Medina P.
Age (Dordr). 2011 Nov 19.

Effects of administration of hormone therapy or raloxifene on the immune system and on biochemical markers of bone remodeling.
Pineda B, Hermenegildo C, Tarín JJ, Cano A, García-Pérez MÁ.
Menopause. 2012 Mar;19(3):319-27.

Aging negatively affects estrogens-mediated effects on nitric oxide bioavailability by shifting ERα/ERβ balance in female mice.
Novensà L, Novella S, Medina P, Segarra G, Castillo N, Heras M, Hermenegildo C, Dantas AP.
PLoS One. 2011;6(9):e25335.

Trans- but not cis-resveratrol impairs angiotensin-II-mediated vascular inflammation through inhibition of NF-κB activation and peroxisome proliferator-activated receptor-gamma upregulation.
Rius C, Abu-Taha M, Hermenegildo C, Piqueras L, Cerda-Nicolas JM, Issekutz AC, Estañ L, Cortijo J, Morcillo EJ, Orallo F, Sanz MJ.
J Immunol. 2010 Sep 15;185(6):3718-27.

Gathering of aging and estrogen withdrawal in vascular dysfunction of senescent accelerated mice.
Novella S, Dantas AP, Segarra G, Novensà L, Bueno C, Heras M, Hermenegildo C, Medina P.
Exp Gerontol. 2010 Nov;45(11):868-74.

Estradiol induces endothelial cell migration and proliferation through estrogen receptor-enhanced RhoA/ROCK pathway.
Oviedo PJ, Sobrino A, Laguna-Fernandez A, Novella S, Tarín JJ, García-Pérez MA, Sanchís J, Cano A, Hermenegildo C.
Mol Cell Endocrinol. 2011 Mar 30;335(2):96-103.

Gene-gene interaction between CD40 and CD40L reduces bone mineral density and increases osteoporosis risk in women.
Pineda B, Tarín JJ, Hermenegildo C, Laporta P, Cano A, García-Pérez MÁ.
Osteoporos Int. 2011 May;22(5):1451-8.

Progestogens reduce thromboxane production by cultured human endothelial cells.
Oviedo PJ, Sobrino A, Novella S, Rius C, Laguna-Fernandez A, García-Pérez MA, Tarín JJ, Cano A, Hermenegildo C.
Climacteric. 2011 Feb;14(1):41-8.

Common polymorphisms rather than rare genetic variants of the Runx2 gene are associated with femoral neck BMD in Spanish women.
Pineda B, Hermenegildo C, Laporta P, Tarín JJ, Cano A, García-Pérez MÁ.
J Bone Miner Metab. 2010 Nov;28(6):696-705.

Estradiol selectively stimulates endothelial prostacyclin production through estrogen receptor-{alpha}.
Sobrino A, Oviedo PJ, Novella S, Laguna-Fernandez A, Bueno C, García-Pérez MA, Tarín JJ, Cano A, Hermenegildo C.
J Mol Endocrinol. 2010 Apr;44(4):237-46.

Estradiol stimulates vasodilatory and metabolic pathways in cultured human endothelial cells.
Sobrino A, Mata M, Laguna-Fernandez A, Novella S, Oviedo PJ, García-Pérez MA, Tarín JJ, Cano A, Hermenegildo C.
PLoS One. 2009 Dec 14;4(12):e8242.

Menopause and ovariectomy cause a low grade of systemic inflammation that may be prevented by chronic treatment with low doses of estrogen or losartan.
Abu-Taha M, Rius C, Hermenegildo C, Noguera I, Cerda-Nicolas JM, Issekutz AC, Jose PJ, Cortijo J, Morcillo EJ, Sanz MJ.
J Immunol. 2009 Jul 15;183(2):1393-402.

No effect of Cimicifuga racemosa extract on serum interleukin-6 levels and prostacyclin production by human endothelial cells.
Pineda B, García-Pérez MA, Vázquez F, Juliá MD, Tarín JJ, Hermenegildo C, Cano A.
Eur J Obstet Gynecol Reprod Biol. 2009 May;144(1):93-4.

Alleles and haplotypes of the estrogen receptor alpha gene are associated with an increased risk of spontaneous abortion.
Pineda B, Hermenegildo C, Tarín JJ, Laporta P, Cano A, García-Pérez MA.
Fertil Steril. 2010 Apr;93(6):1809-15.

Long-term effects of delayed fatherhood in mice on postnatal development and behavioral traits of offspring.
García-Palomares S, Pertusa JF, Miñarro J, García-Pérez MA, Hermenegildo C, Rausell F, Cano A, Tarín JJ.
Biol Reprod. 2009 Feb;80(2):337-42.

Delayed fatherhood in mice decreases reproductive fitness and longevity of offspring.
García-Palomares S, Navarro S, Pertusa JF, Hermenegildo C, García-Pérez MA, Rausell F, Cano A, Tarín JJ.
Biol Reprod. 2009 Feb;80(2):343-9.

Therapeutic dosages of oral or transdermal estradiol did not modify sCD40L levels in postmenopausal women.
Oviedo PJ, Hermenegildo C, Sobrino A, Tarín JJ, Cano A.
Gynecol Endocrinol. 2008 Jun;24(6):354-7.

Are the serum levels of sCD40L modified by raloxifene in postmenopausal women?
Oviedo PJ, Hermenegildo C, Novella S, Tarín JJ, Cano A.
Eur J Obstet Gynecol Reprod Biol. 2008 Oct;140(2):296-7.

Isopropanolic Cimicifuga racemosa is favorable on bone markers but neutral on an osteoblastic cell line.
García-Pérez MA, Pineda B, Hermenegildo C, Tarín JJ, Cano A.
Fertil Steril. 2009 Apr;91(4 Suppl):1347-50.

Transdermal estradiol reduces F2alpha-isoprostane levels in postmenopausal women.
Hermenegildo C, Oviedo PJ, Laguna A, García-Pérez MA, Tarín JJ, Cano A.
Menopause. 2008 Jul-Aug;15(4 Pt 1):714-7.

A C >T polymorphism located at position -1 of the Kozak sequence of CD40 gene is associated with low bone mass in Spanish postmenopausal women..
Pineda B, Laporta P, Hermenegildo C, Cano A, García-Pérez MA.
Osteoporos Int. 2008 Aug;19(8):1147-52.

Comparative effects of 17beta-estradiol, raloxifene and genistein on bone 3D microarchitecture and volumetric bone mineral density in the ovariectomized mice.
Cano A, Dapía S, Noguera I, Pineda B, Hermenegildo C, del Val R, Caeiro JR, García-Pérez MA.
Osteoporos Int. 2008 Jun;19(6):793-800.

Selective estrogen receptor modulators and risk for coronary heart disease.
Cano A, Hermenegildo C, Oviedo P, Tarín JJ.
Climacteric. 2007 Apr;10(2):97-111. Review.

Raloxifene increases proliferation of human endothelial cells in association with increased gene expression of cyclins A and B1.
Oviedo PJ, Hermenegildo C, Tarín JJ, Cano A.
Fertil Steril. 2007 Aug;88(2):326-32.

Beneficial effects of dithiothreitol on relative levels of glutathione S-transferase activity and thiols in oocytes, and cell number, DNA fragmentation and allocation at the blastocyst stage in the mouse.
Rausell F, Pertusa JF, Gómez-Piquer V, Hermenegildo C, García-Pérez MA, Cano A, Tarín JJ.
Mol Reprod Dev. 2007 Jul;74(7):860-9.

Estrogen receptor agonists and immune system in ovariectomized mice.
García-Pérez MA, Del Val R, Noguera I, Hermenegildo C, Pineda B, Martinez-Romero A, Cano A.
Int J Immunopathol Pharmacol. 2006 Oct-Dec;19(4):807-19.

The risk for cardiovascular disease in women: from estrogens to selective estrogen receptor modulators.
Cano A, Hermenegildo C, Oviedo P, Tarín JJ.
Front Biosci. 2007 Jan 1;12:49-68. Review.

Estradiol counteracts oxidized LDL-induced asymmetric dimethylarginine production by cultured human endothelial cells.
Monsalve E, Oviedo PJ, García-Pérez MA, Tarín JJ, Cano A, Hermenegildo C.
Cardiovasc Res. 2007 Jan 1;73(1):66-72.

Comparative effects of estradiol, raloxifene, and genistein on the uterus of ovariectomized mice.
García-Pérez MA, Noguera R, del Val R, Noguera I, Hermenegildo C, Cano A.
Fertil Steril. 2006 Oct;86(4):1003-5.

Alterations in the phenotype and function of immune cells in ovariectomy-induced osteopenic mice.
García-Pérez MA, Noguera I, Hermenegildo C, Martínez-Romero A, Tarín JJ, Cano A.
Hum Reprod. 2006 Apr;21(4):880-7.

Cyclooxygenases regulation by estradiol on endothelium.
Hermenegildo C, Oviedo PJ, Cano A.
Curr Pharm Des. 2006;12(2):205-15. Review.

Therapeutic dosages of raloxifene do not modify myeloperoxidase and F2alpha-isoprostane levels in postmenopausal women.
Oviedo PJ, Hermenegildo C, Tarín JJ, Cano A.
Fertil Steril. 2005 Dec;84(6):1789-92.

Effects of phytoestrogens genistein and daidzein on prostacyclin production by human endothelial cells.
Hermenegildo C, Oviedo PJ, García-Pérez MA, Tarín JJ, Cano A.
J Pharmacol Exp Ther. 2005 Nov;315(2):722-8.

Raloxifene promotes prostacyclin release in human endothelial cells through a mechanism that involves cyclooxygenase-1 and -2.
Oviedo PJ, Hermenegildo C, Tarín JJ, Cano A.
Fertil Steril. 2005 Jun;83(6):1822-9.

Progestogens stimulate prostacyclin production by human endothelial cells.
Hermenegildo C, Oviedo PJ, García-Martínez MC, García-Pérez MA, Tarín JJ, Cano A.
Hum Reprod. 2005 Jun;20(6):1554-61.

Delayed motherhood decreases life expectancy of mouse offspring.
Tarín JJ, Gómez-Piquer V, Rausell F, Navarro S, Hermenegildo C, Cano A.
Biol Reprod. 2005 Jun;72(6):1336-43.

Association of female aging with decreased parthenogenetic activation, raised MPF, and MAPKs activities and reduced levels of glutathione S-transferases activity and thiols in mouse oocytes.
Tarín JJ, Gómez-Piquer V, Pertusa JF, Hermenegildo C, Cano A.
Mol Reprod Dev. 2004 Dec;69(4):402-10.

Drug targeting of estrogen receptor signaling in the cardiovascular system: preclinical and clinical studies.
Sanz-González SM, Cano A, Valverde MA, Hermenegildo C, Andrés V.
Curr Med Chem Cardiovasc Hematol Agents. 2004 Apr;2(2):107-22. Review.

Effect of delayed breeding on the reproductive performance of female mice.
Tarín JJ, Gómez-Piquer V, Rausell F, Hermenegildo C, Cano A.
Reprod Fertil Dev. 2004;16(3):373-8.

Raloxifene increases the capacity of serum to promote prostacyclin release in human endothelial cells: implication of COX-1 and COX-2.
Oviedo PJ, Hermenegildo C, Cano A.
Menopause. 2004 Jul-Aug;11(4):430-7.

The effect of hormone replacement therapy on Ca2+ mobilization and P-selectin (CD62P) expression in platelets examined under flow cytometry.
García-Martínez MC, Labiós M, Hermenegildo C, Tarín JJ, O'Connor E, Cano A.
Blood Coagul Fibrinolysis. 2004 Jan;15(1):1-8.

Long-term effects of delayed motherhood in mice on postnatal development and behavioural traits of offspring.
Tarín JJ, Gómez-Piquer V, Manzanedo C, Miñarro J, Hermenegildo C, Cano A.
Hum Reprod. 2003 Aug;18(8):1580-7.

Phytoestrogens increase the capacity of serum to stimulate prostacyclin release in human endothelial cells.
García-Martínez MC, Hermenegildo C, Tarín JJ, Cano A.
Acta Obstet Gynecol Scand. 2003 Aug;82(8):705-10.

Estrogens inhibit angiotensin II-induced leukocyte-endothelial cell interactions in vivo via rapid endothelial nitric oxide synthase and cyclooxygenase activation.
Alvarez A, Hermenegildo C, Issekutz AC, Esplugues JV, Sanz MJ.
Circ Res. 2002 Dec 13;91(12):1142-50.

Plasma concentration of asymmetric dimethylarginine, an endogenous inhibitor of nitric oxide synthase, is elevated in hyperthyroid patients.
Hermenegildo C, Medina P, Peiró M, Segarra G, Vila JM, Ortega J, Lluch S.
J Clin Endocrinol Metab. 2002 Dec;87(12):5636-40.

Inhibition of low-density lipoprotein oxidation by the pure antiestrogens ICI 182780 and EM-652 (SCH 57068).
Hermenegildo C, García-Martínez MC, Tarín JJ, Cano A.
Menopause. 2002 Nov-Dec;9(6):430-5.

Estradiol reduces F2alpha-isoprostane production in cultured human endothelial cells.
Hermenegildo C, García-Martínez MC, Tarín JJ, Cano A.
Am J Physiol Heart Circ Physiol. 2002 Dec;283(6):H2644-9.

Predictive variables of in vitro fertilization and pre-implantation embryo development in the mouse.
Tarín JJ, Gómez-Piquer V, Pérez-Albalá S, Hermenegildo C, Cano A.
Mol Reprod Dev. 2002 Sep;63(1):38-46.

Stage of the estrous cycle at the time of pregnant mare's serum gonadotropin injection affects pre-implantation embryo development in vitro in the mouse.
Tarín JJ, Pérez-Albalá S, Gómez-Piquer V, Hermenegildo C, Cano A.
Mol Reprod Dev. 2002 Jul;62(3):312-9.

Transdermal estradiol reduces plasma myeloperoxidase levels without affecting the LDL resistance to oxidation or the LDL particle size.
Hermenegildo C, García-Martínez MC, Valldecabres C, Tarín JJ, Cano A.
Menopause. 2002 Mar-Apr;9(2):102-9.

The effect of oral hormone replacement therapy on lipoprotein profile, resistance of LDL to oxidation and LDL particle size.
Hermenegildo C, García-Martínez MC, Tarín JJ, Llácer A, Cano A.
Maturitas. 2001 May 30;38(3):287-95..

The endometrial effects of SERMs.
Cano A, Hermenegildo C.
Hum Reprod Update. 2000 May-Jun;6(3):244-54. Review.

Pure anti-oestrogens.
Hermenegildo C, Cano A.
Hum Reprod Update. 2000 May-Jun;6(3):237-43. Review.

Modulation of the oestrogen receptor: a process with distinct susceptible steps.
Cano A, Hermenegildo C.
Hum Reprod Update. 2000 May-Jun;6(3):207-11. Review.

Differential effects of acute and chronic hyperammonemia on signal transduction pathways associated to NMDA receptors.
Monfort P, Montoliu C, Hermenegildo C, Muñoz M, Felipo V.
Neurochem Int. 2000 Aug-Sep;37(2-3):249-53. Review.

Activation of N-methyl-D-aspartate receptors in rat brain in vivo following acute ammonia intoxication: characterization by in vivo brain microdialysis.
Hermenegildo C, Monfort P, Felipo V.
Hepatology. 2000 Mar;31(3):709-15.

Long-term effects of postovulatory aging of mouse oocytes on offspring: a two-generational study.
Tarín JJ, Pérez-Albalá S, Aguilar A, Miñarro J, Hermenegildo C, Cano A.
Biol Reprod. 1999 Nov;61(5):1347-55.

Chronic exposure to aluminium impairs the glutamate-nitric oxide-cyclic GMP pathway in the rat in vivo.
Hermenegildo C, Sáez R, Minoia C, Manzo L, Felipo V.
Neurochem Int. 1999 Mar;34(3):245-53.

Chronic hyperammonemia impairs the glutamate-nitric oxide-cyclic GMP pathway in cerebellar neurons in culture and in the rat in vivo.
Hermenegildo C, Montoliu C, Llansola M, Muñoz MD, Gaztelu JM, Miñana MD, Felipo V.
Eur J Neurosci. 1998 Oct;10(10):3201-9.

Neurotoxicity of ammonia and glutamate: molecular mechanisms and prevention.
Felipo V, Hermenegildo C, Montoliu C, Llansola M, Miñana MD.
Neurotoxicology. 1998 Aug-Oct;19(4-5):675-81.

Carbachol-induced hydrolysis of phospholipids in hippocampal slices may be mediated in part by subsequent activation of metabotropic glutamate receptors.
Llansola M, Hermenegildo C, Miñana MD, Felipo V.
Neurochem Res. 1998 Jun;23(6):913-8.

Chronic exposure to aluminum impairs neuronal glutamate-nitric oxide-cyclic GMP pathway.
Cucarella C, Montoliu C, Hermenegildo C, Sáez R, Manzo L, Miñana MD, Felipo V.
J Neurochem. 1998 Apr;70(4):1609-14.

Nitroarginine, an inhibitor of nitric oxide synthase, prevents changes in superoxide radical and antioxidant enzymes induced by ammonia intoxication.
Kosenko E, Kaminsky Y, Lopata O, Muravyov N, Kaminsky A, Hermenegildo C, Felipo V.
Metab Brain Dis. 1998 Mar;13(1):29-41.

Superoxide production and antioxidant enzymes in ammonia intoxication in rats.
Kosenko E, Kaminsky Y, Kaminsky A, Valencia M, Lee L, Hermenegildo C, Felipo V.
Free Radic Res. 1997 Dec;27(6):637-44.

Modulation of glutamine synthesis in cultured astrocytes by nitric oxide.
Miñana MD, Kosenko E, Marcaida G, Hermenegildo C, Montoliu C, Grisolía S, Felipo V.
Cell Mol Neurobiol. 1997 Aug;17(4):433-45.

Glutamate and muscarinic receptors in the molecular mechanisms of acute ammonia toxicity and of its prevention.
Miñana MD, Llansola M, Hermenegildo C, Cucarella C, Montoliu C, Kosenko E, Grisolía S, Felipo V.
Adv Exp Med Biol. 1997;420:45-56. Review.

NMDA receptor antagonists prevent acute ammonia toxicity in mice.
Hermenegildo C, Marcaida G, Montoliu C, Grisolía S, Miñana MD, Felipo V.
Neurochem Res. 1996 Oct;21(10):1237-44.

Carnitine and choline derivatives containing a trimethylamine group prevent ammonia toxicity in mice and glutamate toxicity in primary cultures of neurons.
Miñana MD, Hermenegildo C, Llsansola M, Montoliu C, Grisolía S, Felipo V.
J Pharmacol Exp Ther. 1996 Oct;279(1):194-9.

Decreased glutathione peroxidase activity in sciatic nerve of alloxan-induced diabetic mice and its correlation with blood glucose levels.
Hermenegildo C, Raya A, Romá J, Romero FJ.
Neurochem Res. 1993 Aug;18(8):893-6.

Alterations in the antioxidant defense of peripheral nervous tissue following acute ethanol administration.
Raya A, Romá J, Hermenegildo C, Romero FJ.
Biochem Soc Trans. 1993 May;21(2):92S.

Sustained recovery of Na(+)-K(+)-ATPase activity in sciatic nerve of diabetic mice by administration of H7 or calphostin C, inhibitors of PKC.
Hermenegildo C, Felipo V, Miñana MD, Romero FJ, Grisolía S.
Diabetes. 1993 Feb;42(2):257-62.

Prevention of the acute neurotoxic effects of phenytoin on rat peripheral nerve by H7, an inhibitor of protein kinase C.
Raya A, Gallego J, Hermenegildo C, Puertas FJ, Romero FJ, Felipo V, Miñana MD, Grisolía S, Romá J.
Toxicology. 1992 Nov 15;75(3):249-56.

Inhibition of protein kinase C restores Na+,K(+)-ATPase activity in sciatic nerve of diabetic mice.
Hermenegildo C, Felipo V, Miñana MD, Grisolía S.
J Neurochem. 1992 Apr;58(4):1246-9.

Acute ammonia toxicity is mediated by the NMDA type of glutamate receptors.
Marcaida G, Felipo V, Hermenegildo C, Miñana MD, Grisolía S.
FEBS Lett. 1992 Jan 13;296(1):67-8.

Some glutathione-related enzymatic activities in skeletal muscle and myocardium of the rat. Adaptations to endurance training.
Monsalve E, Hermenegildo C, Nies E, Puertas FJ, Almar MM, Collado PS, Gonzalez J, Romero FJ.
Biochem Soc Trans. 1991 Apr;19(2):240S.

Oxygen toxicity in the nervous tissue: comparison of the antioxidant defense of rat brain and sciatic nerve.
Romero FJ, Monsalve E, Hermenegildo C, Puertas FJ, Higueras V, Nies E, Segura-Aguilar J, Romá J.
Neurochem Res. 1991 Feb;16(2):157-61..

The activity of glutathione S-transferase in hepatopancreas of Procambarus clarkii: seasonal variations and the influence of environmental pollutants.
Nies E, Almar MM, Hermenegildo C, Monsalve E, Romero FJ.
Comp Biochem Physiol C. 1991;100(1-2):65-6.

Some aspects of cardiac antioxidant defence: Ebselen (PZ 51) treatment increases glutathione peroxidase activity in the rat heart.
Hermenegildo C, Nies E, Monsalve E, Puertas FJ, Higueras V, Romero FJ.
Biochem Soc Trans. 1990 Dec;18(6):1193-4.

Antioxidant and glutathione-related enzymatic activities in rat sciatic nerve.
Romero FJ, Segura-Aguilar J, Monsalve E, Hermenegildo C, Nies E, Puertas FJ, Romá J.
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