Docencia               Investigación               Colaboración

Dra. Susana Novella

Nombre Completo

>> Susana Novella del Campo

 

Cargos

>> Profesora Ayudante Doctor de la Universidad de Valencia

>> Responsable de laboratorio de grupo L.In.C.E.

 

Líneas de Investigación

>> Células Endoteliales Progenitoras (EPCs)

>> Interacción de las hormonas sexuales con factores

     proaterogénicos.

>> Reactividad Vascular en modelo murino.

Publicaciones

Mobilization of endothelial progenitor cells in acute cardiovascular events in the PROCELL study: Time-course after acute myocardial infarction and stroke.
Regueiro A, Cuadrado-Godia E, Bueno-Betí C, Diaz-Ricart M, Oliveras A, Novella S, Gené GG, Jung C, Subirana I, Ortiz-Pérez JT, Roqué M, Freixa X, Núñez J, Escolar G, Marrugat J, Hermenegildo C, Valverde MA, Roquer J, Sanchis J, Heras M.
J Mol Cell Cardiol. 2015 Mar;80:146-55. doi: 10.1016/j.yjmcc.2015.01.005. Epub 2015 Jan 22.

Diminished neurogenic femoral artery vasoconstrictor response in a Zucker obese rat model: differential regulation of NOS and COX derivatives.
Martínez AC, Hernández M, Novella S, Martínez MP, Pagán RM, Hermenegildo C, García-Sacristán A, Prieto D, Benedito S
PLoS One. 2014 Sep 12;9(9):e106372. doi: 10.1371/journal.pone.0106372.

Recovering the enthusiasm for novel strategies to threat sepsis.
Garcia-Gimenez JL, Novella S, Carbonell N, Garcia-Simon M, Blanquer J, Hermenegildo C, Pallardo FV.
Blood. 2014 Apr 25. e-letter

An affordable method to obtain cultured endothelial cells from peripheral blood.
Bueno-Betí C, Novella S, Lázaro-Franco M, Pérez-Cremades D, Heras M, Sanchís J, Hermenegildo C.
J Cell Mol Med. 2013 Oct 1. doi: 10.1111/jcmm.12133.

Dynamics of serum-induced endothelial cell apoptosis in patients with myocardial infarction.
Forteza MJ, Novella S, Trapero I, Hermenegildo C, Ruiz-Sauri A, Chaustre F, Bonanad C, Oltra R, Palacios L, O Connor JE, Chorro FJ, Bodi V.
Eur J Clin Invest. 2013 Oct 10. doi: 10.1111/eci.12189.

Aging-related endothelial dysfunction in the aorta from female senescence-accelerated mice is associated with decreased nitric oxide synthase expression.
Novella S, Dantas AP, Segarra G, Vidal-Gómez X, Mompeón A, Garabito M, Hermenegildo C, Medina P.
Exp Gerontol. 2013 Nov;48(11):1329-37. doi: 10.1016/j.exger.2013.08.003.

Complete blockade of the vasorelaxant effects of angiotensin-(1-7) and bradykinin in murine microvessels by antagonists of the receptor Mas.
Peiró C, Vallejo S, Gembardt F, Palacios E, Novella S, Azcutia V, Rodríguez-Mañas L, Hermenegildo C, Sánchez-Ferrer CF, Walther T.
J Physiol. 2013 May 1;591(Pt 9):2275-85. doi: 10.1113/jphysiol.2013.251413.

Estradiol, acting through estrogen receptor alpha, restores dimethylarginine dimethylaminohydrolase activity and nitric oxide production in oxLDL-treated human arterial endothelial cells.
Novella S, Laguna-Fernández A, Lázaro-Franco M, Sobrino A, Bueno-Betí C, Tarín JJ, Monsalve E, Sanchís J, Hermenegildo C.
Mol Cell Endocrinol. 2013 Jan 5;365(1):11-6. doi: 10.1016/j.mce.2012.08.020.

Vascular Aging in Women: is Estrogen the Fountain of Youth?
Novella S, Dantas AP, Segarra G, Medina P, Hermenegildo C.
Front Physiol. 2012;3:165. Epub 2012 Jun 6.

Effects of estrogen on vascular inflammation: a matter of timing.
Novella S, Heras M, Hermenegildo C, Dantas AP.
Arterioscler Thromb Vasc Biol. 2012 Aug;32(8):2035-42.

Endothelial and neural factors functionally involved in the modulation of noradrenergic vasoconstriction in healthy pig internal mammary artery.
Pagán RM, Martínez AC, Hernández M, Martínez MP, García-Sacristán A, Correa C, Novella S, Hermenegildo C, Prieto D, Benedito S.
Biochem Pharmacol. 2012 Apr 1;83(7):882-92.

Aging enhances contraction to thromboxane A(2) in aorta from female senescence-accelerated mice.
Novella S, Dantas AP, Segarra G, Novensa L, Heras M, Hermenegildo C, Medina P.
Age (Dordr). 2011 Nov 19.

Aging negatively affects estrogens-mediated effects on nitric oxide bioavailability by shifting ERα/ERβ balance in female mice.
Novensà L, Novella S, Medina P, Segarra G, Castillo N, Heras M,Hermenegildo C, Dantas AP.
PLoS One. 2011;6(9):e25335.

Gathering of aging and estrogen withdrawal in vascular dysfunction of senescent accelerated mice.
Novella S, Dantas AP, Segarra G, Novensà L, Bueno C, Heras M, Hermenegildo C, Medina P.
Exp Gerontol. 2010 Nov;45(11):868-74.

Estradiol induces endothelial cell migration and proliferation through estrogen receptor-enhanced RhoA/ROCK pathway.
Oviedo PJ, Sobrino A, Laguna-Fernandez A, Novella S, Tarín JJ, García-Pérez MA, Sanchís J, Cano A, Hermenegildo C.
Mol Cell Endocrinol. 2011 Mar 30;335(2):96-103.

Progestogens reduce thromboxane production by cultured human endothelial cells.
Sobrino A, Oviedo PJ, Novella S, Rius C, Laguna-Fernandez A, García-Pérez MA, Tarín JJ, Cano A, Hermenegildo C.
Climacteric. 2011 Feb;14(1):41-8.

Estradiol selectively stimulates endothelial prostacyclin production through estrogen receptor-{alpha}.
Sobrino A, Oviedo PJ, Novella S, Laguna-Fernandez A, Bueno C, García-Pérez MA, Tarín JJ, Cano A, Hermenegildo C.
J Mol Endocrinol. 2010 Apr;44(4):237-46.

Estradiol stimulates vasodilatory and metabolic pathways in cultured human endothelial cells.
Sobrino A, Mata M, Laguna-Fernandez A, Novella S, Oviedo PJ, García-Pérez MA, Tarín JJ, Cano A, Hermenegildo C.
PLoS One. 2009 Dec 14;4(12):e8242.

Are the serum levels of sCD40L modified by raloxifene in postmenopausal women?
Oviedo PJ, Hermenegildo C, Novella S, Tarín JJ, Cano A.
Eur J Obstet Gynecol Reprod Biol. 2008 Oct;140(2):296-7.

Plasma levels and vascular effects of vasopressin in patients undergoing coronary artery bypass grafting.
Novella S, Martínez AC, Pagán RM, Hernández M, García-Sacristán A, González-Pinto A, González-Santos JM, Benedito S.
Eur J Cardiothorac Surg. 2007 Jul;32(1):69-76.

Aspirin and COX-2 inhibitor nimesulide potentiate adrenergic contractions of human gastroepiploic artery.
Aldasoro M, Mauricio MD, Serna E, Cortina B, Medina P, Segarra G, Novella S, Vila JM.
Am J Hypertens. 2007 May;20(5):514-9.

Role of Ca2+-activated K+ channels on adrenergic responses of human saphenous vein.
Mauricio MD, Serna E, Cortina B, Novella S, Segarra G, Aldasoro M, Martínez-León JB, Vila JM.
Fertil Steril. 2007 Aug;88(2):326-32.

A validated PCR-based method to detect Listeria monocytogenes using raw milk as a food model--towards an international standard.
D'Agostino M, Wagner M, Vazquez-Boland JA, Kuchta T, Karpiskova R, Hoorfar J, Novella S, Scortti M, Ellison J, Murray A, Fernandes I, Kuhn M, Pazlarova J, Heuvelink A, Cook N.
J Food Prot. 2004 Aug;67(8):1646-55.

Negative control of Listeria monocytogenes virulence genes by a diffusible autorepressor.
Ermolaeva S, Novella S, Vega Y, Ripio MT, Scortti M, Vázquez-Boland JA.
Mol Microbiol. 2004 Apr;52(2):601-11.

Susceptibility of Listeria monocytogenes to antimicrobial peptides.
López-Solanilla E, González-Zorn B, Novella S, Vázquez-Boland JA, Rodríguez-Palenzuela P.
FEMS Microbiol Lett. 2003 Sep 12;226(1):101-5.

A simple method for the differentiation of Listeria monocytogenes based on induction of lecithinase activity by charcoal.
Ermolaeva S, Karpova T, Novella S, Wagner M, Scortti M, Tartakovskii I, Vazquez-Boland JA.
Int J Food Microbiol. 2003 Jan 26;82(1):87-94.

Comparative genomics of Listeria species.
Glaser P, Frangeul L, Buchrieser C, Rusniok C, Amend A, Baquero F, Berche P, Bloecker H, Brandt P, Chakraborty T, Charbit A, Chetouani F, Couvé E, de Daruvar A, Dehoux P, Domann E, Domínguez-Bernal G, Duchaud E, Durant L, Dussurget O, Entian KD, Fsihi H, García-del Portillo F, Garrido P, Gautier L, Goebel W, Gómez-López N, Hain T, Hauf J, Jackson D, Jones LM, Kaerst U, Kreft J, Kuhn M, Kunst F, Kurapkat G, Madueno E, Maitournam A, Vicente JM, Ng E, Nedjari H, Nordsiek G, Novella S, de Pablos B, Pérez-Diaz JC, Purcell R, Remmel B, Rose M, Schlueter T, Simoes N, Tierrez A, Vázquez-Boland JA, Voss H, Wehland J, Cossart P.
Science. 2001 Oct 26;294(5543):849-52.

SmcL, a novel membrane-damaging virulence factor in Listeria.
González-Zorn B, Domínguez-Bernal G, Suárez M, Ripio MT, Vega Y, Novella S, Rodríguez A, Chico I, Tierrez A, Vázquez-Boland JA.
Int J Med Microbiol. 2000 Oct;290(4-5):369-74.

The smcL gene of Listeria ivanovii encodes a sphingomyelinase C that mediates bacterial escape from the phagocytic vacuole.
González-Zorn B, Domínguez-Bernal G, Suárez M, Ripio MT, Vega Y, Novella S, Vázquez-Boland JA.
Mol Microbiol. 1999 Aug;33(3):510-23.

Functional similarities between the Listeria monocytogenes virulence regulator PrfA and cyclic AMP receptor protein: the PrfA* (Gly145Ser) mutation increases binding affinity for target DNA.
Vega Y, Dickneite C, Ripio MT, Böckmann R, González-Zorn B, Novella S, Domínguez-Bernal G, Goebel W, Vázquez-Boland JA.
J Bacteriol. 1998 Dec;180(24):6655-60.

Histamine receptors in isolated bovine oviductal arteries.
Martínez AC, Novella S, Raposo R, Recio P, Labadía A, Costa G, Garcia-Sacristán A, Benedito S.
Eur J Pharmacol. 1997 May 20;326(2-3):163-73.

® Laboratorio de Investigación en Células Endoteliales (L.In.C.E.) 2013