The monoclonal antibody resistance frequency was determined from many small cultures undergoing one cell infection cycle or less was and the mutation rate to the phenotype using the null-class method was m = 1.2 ´ 10^-5 s/r (1). T_s = 6 from references therein, thus m_s/n/r = 3 ´ 1.2 ´ 10^-5 / 6 = 6.0 ´ 10^-6.

1. Furió, V., A. Moya, and R. Sanjuan. 2005. The cost of replication fidelity in an RNA virus. Proc. Natl. Acad. Sci. USA 102:10233-10237.