Prof. Dr. José Luis Ríos Cañavate
PhD, Full Professor (Catedrático de Universidad)
Departament de Farmacologia, Facultat de Farmàcia, Universitat de València.
Avda. Vicent Andrés Estellés s/n. 46100 Burjassot (Valencia). Spain
Phone: +34 963544973 /Fax: +34 963544498
Email: Jose.L.Rios@uv.es and riosjl@uv.es
Web: http://www.uv.es/riosjl/
Research interest
Antimicrobial activity
Anti-inflammatory activity
Medicinal plants
Natural products
Most cited articles
20. RÍOS JL, RECIO MC, VILLAR A. Screening methods for natural products with antimicrobial activity: a review of the literature. J Ethnopharmacol 23: 127-149 (1988)
33. MORA A, PAYÁ M, RÍOS JL, ALCARAZ MJ. Structure activity relationships of polymethoxyflavones and other flavonoids as inhibitors of non-enzymic lipid peroxidation. Biochem Pharmacol 40: 793-797 (1990)
38. MARTÍNEZ LA, RÍOS JL, PAYÁ M, ALCARAZ MJ. Inhibition of non-enzymic lipid peroxidation by benzylisoquinoline alkaloids. Free Rad Biol Med 12: 287-292 (1992)
55. RECIO MC, GINER RM, MÁÑEZ S, RÍOS JL. Structural requirements for the anti-inflammatory activity of natural triterpenoids. Planta Med 61: 182-185 (1995)
58. RÍOS JL, RECIO MC, GINER RM, MÁÑEZ S. An updated review of saffron (Crocus sativus L.) and their active constituents. Phytother Res 10: 189-193 (1996)
65. RÍOS JL, WATERMAN PG. A review on the pharmacology and toxicology of Astragalus". Phytother Res 11: 411-418 (1997)
86. SCHINELLA GR, TOURNIER HA, PRIETO JM, MORDUJOVICH P, RÍOS JL. Antioxidant activity of anti-inflammatory plant extracts. Life Sci 70: 1023-1033 (2002)
110. RÍOS JL, RECIO MC. Medicinal plants and antimicrobial activity. J Ethnopharmacol 100: 80-84 (2005)
Articles last five years (2008-2013)
131. PRIETO JM, RECIO MC, GINER RM, SCHINELLA G, MÁÑEZ S, RÍOS JL. In vitro and in vivo effects of Ranunculus peltatus subsp. baudotii methanol extract on models of eicosanoid production and contact dermatitis. Phytother Res 22 (3) 297-302 (2008)
132. SCHINELLA G, AQUILA S, DADE M, GINER RM, RECIO MC, SPEGAZZINI E, BUSCHIAZZO P, TOURNIER H, RÍOS JL. Anti-inflammatory and apoptotic activities of pomolic acid isolated from Cecropia pachystachya. Planta Med 74 (3) 215-220 (2008)
133. BORGI W, RECIO MC, RÍOS JL, CHOUCHANE N. Anti-inflammatory and analgesic activities of flavonoid and saponin fractions from Zizyphus lotus (L.) Lam. S Afr J Bot 74 (2) 320-324 (2008)
134. OLMOS A, GINER RM, RECIO MC, GIL-BENSO R, RÍOS JL, MÁÑEZ S. Interaction of dicaffeoylquinic derivatives with peroxynitrite and other reactive nitrogen species. Arch Biochem Biophys 475 (1) 66-71 (2008)
135. ESCANDELL JM, KALER P, RECIO MC, SASAZUKI T, SHIRASAWA S, AUGENLICHT L, RÍOS JL, KLAMPFER L. Activated kRas protects colon cancer cells from cucurbitacin-induced apoptosis: The role of p53 and p21. Biochem Pharmacol 76 (2) 198-207 (2008)
136. VONAPARTI A, KARIOTI A, RECIO MC, MÁÑEZ S, RÍOS JL, SKALTSA E, GINER RM. Effect of terpenoids from Salvia willeana in delayed-type hypersensitivity, human lymphocyte proliferation and cytokine production. Nat Prod Comm 3 (12) 1953-1958 (2008)
137. AQUILA S, GINER RM, RECIO MC, SPEGAZZINI ED, RÍOS JL. Anti-inflammatory activity of flavonoids from Cayaponia tayuya roots. J Ethnopharmacol 121 (2) 333-337 (2009)
138. AQUILA S, ROJANO B, RECIO MC, GINER RM, SCHINELLA GR, DEBENEDETTI SL, RÍOS JL. Anti-inflammatory activity of berenjenol and related compounds. Planta Med 75 (1) 18-23 (2009)
139. RÍOS JL, RECIO MC, ESCANDELL JM, ANDÚJAR I. Inhibition of transcription factors by plant-derived compounds and their implications in inflammation and cancer. Curr Pharm Design 15 (11) 1212-1237 (2009)
140. AQUILA S, WENG ZY, ZENG YQ, SUN HD, RÍOS JL. Inhibition of NF-kB activation and iNOS induction by ent-kaurane diterpenoids in LPS-stimulated RAW 264.7 murine macrophages. J Nat Prod 72 (7) 1269-1272 (2009)
141. ESCANDELL JM, RECIO MC, GINER RM, MÁÑEZ S, CERDÁ-NICOLÁS M, MERFORT I, RÍOS JL. Inhibition of delayed-type hypersensitivity by cucurbitacin R through the curving of lymphocyte proliferation and cytokine expression by means of NF-AT translocation to the nucleus. J Pharmacol Exp Ther 332 (2) 352-363 (2010)
142. RIOS JL. Effects of triterpenes on the immune system. J Ethnopharmacol 128 (1) 1-14 (2010)
143. ANDÚJAR I, RECIO MC, BACELLI T, GINER RM, RÍOS JL. Shikonin reduces oedema induced by phorbol ester by interfering with IkB degradation thus inhibiting translocation of NF-kB to the nucleus. Br J Pharmacol 160 (2) 376-388 (2010)
144. ESCANDELL JM, RECIO MC, MÁÑEZ S, GINER RM, RÍOS JL. Bcl-2 is a negative regulator of interleukin-1b secretion in pharmacological-induced apoptosis. Br J Pharmacol 160 (7) 1844-1856 (2010)
145. SCHINELLA G, MOSCA S, CIENFUEGOS E, PASAMAR MA, MUGUERZA B, RAMÓN D, RÍOS JL. Antioxidant properties of polyphenol-rich cocoa products industrially processed. Food Res Int 43 (6) 1614-1623 (2010)
146. RIOS JL. Chemical constituents and pharmacological properties of Poria cocos. Planta Med 77 (7) 681-691 (2011)
147. GINER E, EL-ALAMI M, MÁÑEZ S, RECIO MC, RÍOS JL, GINER RM. Phenolic substances from Phagnalon rupestre protect against 2,4,6-trinitrochlorobenzene-induced contact dermatitis. J Nat Prod 74 (5) 1079-1084 (2011)
148. ANDÚJAR I, RECIO MC, GINER RM, CIENFUEGOS-JOVELLANOS E, LAGHI S, MUGUERZA B, RÍOS JL. Inhibition of ulcerative colitis in mice after oral administration of a polyphenol-enriched cocoa extract is mediated by the inhibition of STAT1 and STAT3 phosphorylation in colon cells. J Agric Food Chem 59 (12) 6474-6483 (2011)
149. GINER E, ANDÚJAR I, RECIO MC, RÍOS JL, CERDÁ-NICOLÁS, GINER RM. Oleuropein ameriorates acute colitis in mice. J Agric Food Chem 59 (24) 12885-12892 (2011)
150. AMIRA S, DADE M, SCHINELLA G, RÍOS JL. Anti-inflammatory, anti-oxidant, and apoptotic activities of four plant species used in folk medicine in the Mediterranean basin. Pak J Pharm Sci 25 (1) 65-72 (2012)
151. RÍOS JL, ANDÚJAR I, ESCANDELL JM, GINER RM, RECIO MC. Cucurbitacins as inducers of cell death and a rich source of potential anticancer compounds. Curr Pharm Des 18 (12) 1663-1676 (2012)
152. RECIO MC, ANDÚJAR I, RÍOS JL. Anti-inflammatory agents from plants: Progress and potential. Curr Med Chem 19 (14) 2088-2103 (2012)
153. RAMELLA NA, SCHINELLA GR, FERREIRA ST, PRIETO ED, VELA ME, RÍOS JL, TRICERRI MA, RIMOLDI OJ. Human apolipoprotein A-I natural variants: molecular mechanisms underlying amyloidogenic propensity. PLOS ONE 7 (8) e43755 (2012)
154. ANDÚJAR I, RECIO MC, GINER RM, RÍOS JL. Cocoa polyphenols and their potential benefits for human health. Oxid Med Cell Longev Article ID 906252, 23 pp. (2012)
155. RÍOS JL, ANDÚJAR I, RECIO MC, GINER RM. Lanostanids from fungi: a group of potential anticancer compounds. J Nat Prod 75 (11) 2016-2044 (2012)
156. ANDÚJAR I, RÍOS JL, GINER RM, CERDÁ-NICOLÁS M, RECIO MC. Beneficial effect of shikonin on experimental colitis induced by dextran sulfate sodium in Balb/C mice. Evid Based Complement Alternat Med Article ID 271606, 15 pp. (2012)
157. LOPERA YE, FANTINELLI J, GONZÁLEZ-ARBELÁEZ LF, ROJANO B, RÍOS JL, SCHINELLA G, MOSCA S. Anti-oxidant activity and cardioprotective effect of a non-alcoholic extract of Vaccinium meridionale Swartz during ischemia-reperfusion in rats. Evid Based Complement Alternat Med Article ID 516727, 10 pp. (2013)
158. ANDÚJAR I, MARTÍ A, RÍOS JL, RECIO MC. Could shikonin, a drug used in traditional Chinese medicine, be effective in ulcerative colitis?. Actual Farmacol Ter 11 (1) 56-59 (2013)
159. ANDÚJAR I, RECIO MC, GINER RM, RÍOS JL. Traditional Chinese medicine remedy to jury: the pharmacological basis for the use of shikonin as an ancancer therapy. Curr Med Chem In press (2013)
160. ANDÚJAR I, RÍOS JL, GINER RM, RECIO MC. Shikonin promotes intestinal wound healing in vitro via induction of TGF-β release in IEC-18 cells. Eur J Pharm Sci In press (2013)
Selected books and book chapters
8. RÍOS JL, MÁÑEZ S, GINER RM, RECIO MC. “Pharmacological activity of aporphinoids”. In: The Alkaloids (GA Cordell, ed.), Academic Press, San Diego, 2000, pp. 57-117 (ISBN 0-12-469553-1)
9. RÍOS JL, RECIO MC, MÁÑEZ S, GINER RM. “Natural triterpenoids as anti-inflammatory agents”. In: Studies in Natural Products Chemistry: Bioactive Natural Products. Vol. 22. Part C (Atta-Ur-Rahman, ed.), Elsevier Science Publishers, Amsterdam, 2000, pp. 93-143 (ISBN 0-44-450588-1)
10. GINER-LARZA EM, MÁÑEZ S, RECIO MC, GINER RM, RÍOS JL. “A review on the pharmacology of lanostanes and related tetracyclic triterpenes”. In: Research Advances in Phytochemistry (RM Mohan, ed.), Global Research Net Work, Tivandrum (India), 2000, pp. 65-82 (ISBN 81-87736-03-8)
11. RÍOS JL, GINER RM, PRIETO JM. “New finding on the bioactivity of lignans”. In: Studies in Natural Products Chemistry: Bioactive Natural Products Vol. 26. Part G (Atta-Ur-Rahman, ed.), Elsevier Science Publishers, Amsterdam, 2002, pp. 183-292 (ISBN 0-444-51004-4)
24. RÍOS JL, ESCANDELL JM, RECIO MC. “New insight on the bioactivity of cucurbitacins”. In: Studies in Natural Products Chemistry: Bioactive Natural Products Vol. 32. Part L (Atta-Ur-Rahman, ed.), Elsevier Science Publishers, Amsterdam, 2005, pp. 429-469 (ISBN 0-444-52171-2)
27. RÍOS JL, RECIO MC. “Natural product as modulators of apoptosis and their role in the inflammation”. In: Studies in Natural Products Chemistry: Bioactive Natural Products Vol. 33. Part M (Atta-Ur-Rahman, ed.), Elsevier Science Publishers: Amsterdam, 2006, pp. 141-192 (ISBN 978-0-444-52717-2)
48. RÍOS JL, SENDRA RA. “Bioactivity of Medicinal Plants: Progress and Perspectives”. In: Novel Therapeutic Agents from Plants: Progress and Future Perspectives (M Rai, C Carpinella, eds.), Science Publisher: Enfield (New Hampshire, USA), 2008, pp. 265-299 (ISBN 978-1-57808-546-0).
49. RÍOS JL. “Mechanisms of action of anti-inflammatory phytochemicals”. In: The Encyclopedia of Herbal Medicine in Clinical Practice (Watson R, Preedy V, eds.), CABI Publishing, Oxon (GB), 2008, pp. 524-534 (ISBN 978-1-84593-413-2).
51. RÍOS JL. “Testing of herbal products used to treat infections”. In: Evaluation of Herbal Medicinal Products (PJ Houghton, PK Mukherjee, eds.), Pharmaceutical Press, London (GB), 2009, pp. 133-148 (ISBN 978-0-85369-751-0)
52. RÍOS JL. Fitoterapia. PUV: Valencia, 2009, pp. 1-291 (ISBN 978-84-370-7598-3).
53. RÍOS JL. “Ethnomedicinal Plants: Progress and the Future of Drug Development”. In: Current Advances in Ethnomedicinal Plants (M Rai, D Acharya, JL Ríos, eds.), Science Publisher: Enfield (New Hampshire, USA), 2011, pp. 1-24 (ISBN 978-1-57808-696-2)
54. ACHARYA D, RÍOS JL, RAI M. Naturally occurring biocides in food industry. In: Natural Antimicrobials in Food Safety and Quality (M Rai, M Chikindas eds.), CAB International: CABI Publishing, Oxon (GB), 2011, pp. 1-9 (ISBN 978-1845937690)
55. HARDAS D, RÍOS JL, RAI M. Revitalization of knowledge of herbs: a way forward to discovery of new drugs. In: Medicinal Plants. Biodiversity and Drugs (M Rai, GA Cordell, JL Martínez, M Marinoff, L Rastrelli, eds.), CRC Press, Boca Raton, 2012, pag. 68-83 (ISBN 978-1578087938)