A drug resistance frequency f = 4.0 ´ 10-5 was obtained and it was determined that T = Ts
=12, but c and the fitness effects of
the mutations were unknown
(1). Using Equation 6, max[ms/n/c]
= 3 ´ 4.0 ´ 10-5 / 12 = 1.0 ´ 10-5.
1. Heinz, B. A., R. R. Rueckert, D. A. Shepard, F. J. Dutko,
M. A. McKinlay, M. Fancher,
M. G. Rossmann, J. Badger, and T. J. Smith. 1989.
Genetic and molecular analyses of spontaneous mutants of human rhinovirus 14
that are resistant to an antiviral compound. J Virol. 63:2476-2485.