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The Symbiosis (Evolutionary Genetics) group of the Institute for Integrative Systems Biology (I2Sysbio) is devoted to the study of animal and human microbiome from an evolutionary and systems biology perspective. We are also interested in the study of endosymbiosis and natural minimal cells.

Research lines

  • Evolution of animal symbiosis
  • Human and animal microbiome
  • Synthetic biology and minimal cells

Funding

RNA communication across kingdoms: new mechanisms and strategies in pathogen control (COST- CA20110). exRNA-PATH

Funding: COST action, European Science Foundation.

Period: 2021-2025.

Temperature and antibiotics stress: effects on phage-bacteria interactions in the gut microbiota of Blattella germanica (CIPROM/2021/042). TEANS-PB

Funding agencies: Generalitat Valenciana. Conselleria de Sanitat Universal i Salut Pública.

Period: 2022-2025.

Host-symbiont communication and its utility in biological pest and pathogen control (PID2021-128201NB-I00). SYMB-CONTROL

Funding: Proyectos Generación de Conocimiento, MICIN-FEDER-AEI

Period: 01/09/2022 - 31/05/2026

Trasplante de microbioma fecal en cirrosis. Ensayos aleatorizados dobles ciegos y controlados con placebo en pacientes con cirrosis compensada y descompensada (ICI22/00018). LIVERGUT

Funding agencies: Instituto de Salud Carlos III.

Period: 2023-2026.

Tecnología de cribado genotípico de alto rendimiento de genoma y microbioma para la detección temprana, diagnóstico y seguimiento de la fragilidad (PLEC2022-009352). FRAILTECH

Funding agencies: Ministerio de Ciencia e Innovación.

Period: 2023-2025.

Caracterización multiómica del carcinoma escamoso de cabeza y cuello mediante biopsia gasesosa y líquida: aplicación diagnóstica, pronóstica y de seguimiento (PMP22/00004). HN-OMICS

Funding agencies: Instituto de Salud Carlos III.

Period: 2023-2025.

Implementación de un algoritmo predictivo multiescala, mediante la integración de tecnologías -ómicas humanas y microbianas, para la detección temprana, diagnóstico y seguimiento de la sarcopenia (PMPTA23/00001)

Funding agencies: Instituto de Salud Carlos III-CDTI.

Period: 2024-2025.

Lifelong changes in the human gut and vaginal microbiomes: focus on nutrition, metabolism, and virome / Cambios a lo largo de la vida en los microbiomas vaginal e intestinal humanos: enfoque sobre nutrición, metabolismo y viroma (PID2023-149958NB-I00)

Funding agencies: Ministerio de Ciencia, Innovación y Universidades.

Period: 2024-2027.

Selected recent publications

  • Dinleyici, M; Pérez-Brocal, V; Arslanoglu, S; Aydemir, O; Sevuk Ozumut, S; Tekin, N; Vandenplas, Y; Moya, A; and Cagri Dinleyici, E. 2024. Composition of microbiota in transient and mature human milk: Significant changes in large for gestational age group. Nutrients 16:208. [URL]
  • Domínguez-Santos, R; Baixeras, J; Moya, A; Latore, A; Gil, R; and García-Ferris, C. 2024. Gut microbiota is not essential for survival and development in Blattella germanica, but affects uric acid storage. Life 14:153. [URL]
  • Falgueras-Cano, J; Falgueras-Cano, J.A; and Moya, A. 2024. The influence of stochastic fluctuations on population dynamics: an in-silico approach. Ecological Modelling 490:110668. [URL]
  • Falgueras-Cano, J; Falgueras-Cano, J.A; and Moya, A. 2024. ECA, a Python tool to study the evolution of life. Software Impacts 20:100633. [URL]
  • García-Gamboa, R; Senés-Guerrero, C; Díaz-Torres, O; Gradilla-Hernández, M.S; Moya, A; Pérez-Brocal, V; García-González, A; and González-Ávila, M. 2024. Associations between bacterial and fungal communities in the human gut microbiota and their implications for nutritional status and body weight. Scientific Reports 14:5703. [URL]
  • Soria-Villalba, A; Pesantes, N; Jímenez-Hernández, N; Pons, J; Moya, A; and Pérez-Brocal, V. 2024. Comparison of experimental methodologies based on bulk-metagenome and virus-like particle enrichment: pros and cons for representativeness and reproducibility in the study of the fecal human virome. Microorganisms 12:162. [URL]