Next Monday 12th February 12:30am at Seminars Room I2SysBio, Dr. Jaume BertranPetit (Institut de Biologia Evolutiva-UPF-CSIC, and IEC, Barcelona) will give a Seminar on "Natural selection in functional pathways: an approach to evolutionary systems biology".
DARWIN’S DAY SEMINAR(i): NATURAL SELECTION IN FUNCTIONAL PATHWAYS
Co-organized with the Institute for Integrative Systems Biology (I2SysBio)
With support from Societat Catalana de Biologia (SCB-IEC)
WHO?: Dr. JAUME BERTRANPETIT (Institut de Biologia Evolutiva-UPF-CSIC, and IEC, Barcelona)
WHAT?: Natural selection in functional pathways: an approach to evolutionary systems biology
WHEN?: Monday 12/2/2018 – 12:30 h
WHERE?: Seminars Room I2SysBio
ABSTRACT:
Evolutionary analysis at the molecular level provides new tools to biology by considering the action of natural selection in genes on their functional setting of molecular pathways of their gene products. Gene products function in molecular networks, as such, the position within the network may determine the strength of selection applied to the gene. It is possible to interrogate how selection is distributed across the molecular networks. This analysis may be applied to the pathway level (with a low number of interacting units but a very detailed molecular knowledge), the entire metabolome, or even the whole interactome. We present here all these cases in order to relate selection to the specificity of reactions and their function. This analysis opens the scope of understanding how natural selection works within the biomolecular complexity of life
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