Fitxa persona

PATRICIA CASINO FERRANDO

PDI-Titular d'Universitat
Bioquimica i Biologia Molecular, Facultat de Ciencies Biologiques

patricia.casino@uv.es
http://www.uv.es/cafepa

Knowledge area: BIOCHEMISTRY AND MOLECULAR BIOLOGY
Department: Biochemistry and Molecular Biology

Facultad de Biológicas edif. A Departamento Bioquímica y Biología molecular 1º piso
(9635) 43444

Subjects taught and teaching methods

36456 - Bioquímica - Double Degree in Physics and Chemistry
36456 - Bioquímica - Degree in Chemistry
33159 - Trab.Fin Grado Bioquím.Cienc.Biomèd. - Degree in Biochemistry and Biomedical Sciences
36456 - Bioquímica - Double Degree in Chemistry and Chemical Engineering
46495 - Análisis Celular y Molecular de la Señal - Master's Degree in Molecular Approaches in Health Sciences
33199 - Tecnología de Proteínas - Grau en Biotecnologia
33179 - Inmunología: Métodos Inmunológicos - Grau en Biotecnologia

Academic training

Journal Publications

Casino, P; Morais, S.; Puchades, R.; Maquieira A (2001) Evaluation of enzyme-linked immunoassays for the determination of chlororacetanilides in water and soil. Environmental Science and Technology. ISSN: 1520-5851
Hur O; Niks D; Casino P; Dunn MF (2002) Proton transfers in the beta-reaction catalyzed by tryptophan synthase. Biochemistry. ISSN: 0006-2960
Morais, S.; Casino, P.; Marin, M. Luisa; Puchades, R.; Maquieira A (2002) Assessment of enzyme-liked immunosorbent assay for the determination of 2,4,5-TP in water and soil. Analytical and Bioanalytical Chemistry. ISSN: 1618-2642
Casino P.; Fernández-Alvarez A.; Alfonso C.; Rivas G.; Marina A (2007) Identification of a novel two component system in Thermotoga maritima. Complex stoichiometry and crystallization. Biochimica et Biophysica Acta. ISSN: 0006-3002
Ngo H, Harris R, Kimmich N, Casino P, Niks D, Blumenstein L, Barends TR, Kulik V, Weyand M, Schlichting I, Dunn MF. (2007) Synthesis and Characterization of Allosteric Probes of Substrate Channeling in the Tryptophan Synthase Bienzyme Complex. Biochemistry. ISSN: 0006-2960
Casino P, Niks D, Ngo H, Pan P, Brzovic P, Blumenstein L, Barends TR, Schlichting I, Dunn MF. (2007) Allosteric Regulation of Tryptophan Synthase Channeling: The Internal Aldimine Probed by trans-3-Indole-3'-acrylate Binding. Biochemistry. ISSN: 0006-2960
Casino P, Rubio V, Marina A. (2009) Structural Insight into Partner Specificity and Phosphoryl Transfer in Two-Component Signal Transduction. Cell. ISSN: 0092-8674
Casino P, Rubio V, Marina A. (2010) The mechanism of signal transduction by two-component systems. Current Opinion in Structural Biology. ISSN: 0959-440X
Podgornaia AI*, Casino P*, Marina A, Laub MT (2013) Structural basis of a rationally rewired protein-protein interface critical to bacterial signaling. Structure. ISSN: 0969-2126
Casino P, Miguel-Romero L, Marina A (2014) Visualizing autophosphorylation in histidine kinases. Nature Communications. ISSN: 2041-1723
Miguel-Romero*, Casino P*, Landete JM, Monedero V, Zúñiga M, Marina A (2017) The malate sensing two-component system MaeKR is a non-canonical class of sensory complex for C4-dicarboxylates. Scientific Reports. ISSN: 2045-2322
Casino P; Miguel-Romero L; Huesa J; García P; García-Del Portillo F; Marina A. (2017) Conformational dynamism for DNA interaction in the Salmonella RcsB response regulator. Nucleic Acids Research. ISSN: 0305-1048
Lorena E Rosaleny; Salvador Cardona-Serra; Luis Escalera-Moreno; José J Baldoví; Violetta Gołȩbiewska; Karolina Wlazło; Patricia Casino; Helena Prima-Garcia; Alejandro Gaita-Ariño; Eugenio Coronado (2018) Peptides as Versatile Platforms for Quantum Computing. Journal Of Physical Chemistry Letters, 9(16), pp. 4522 - 4526 . ISSN: 1948-7185
Casino, P.; Gozalbo-Rovira, R.; Rodríguez-Díaz, J.; Banerjee S.; Boutaud A.; Rubio, V.; Hudson, B. G.; Saus, J.; Cervera, J.; Marina, A. (2018) Structures of collagen IV globular domains: insight into associated pathologies, folding and network assembly. Iucrj, 5(6), pp. 765 - 779 . ISSN: 2052-2525
Miguel-Romero L; Mideros-Mora C; Marina A; Casino P (2019) Structural and Functional Characterization of Autophosphorylation in Bacterial Histidine Kinases. Methods in Molecular Biology, 2077, pp. 121 - 140 . ISSN: 1064-3745
Mideros-Mora C; Miguel-Romero L; Felipe-Ruiz A; Casino P; Marina A (2020) Revisiting the pH-gated conformational switch on the activities of HisKA-family histidine kinases. Nature Communications, 11, p. 769 . ISSN: 2041-1723
Núñez-Ramírez R; Huesa J; Bel Y; Ferré J; Casino P; Arias-Palomo E. (2020) Molecular architecture and activation of the insecticidal protein Vip3Aa from Bacillus thuringiensis. Nature Communications, 11(3974), pp. 1 - 9 . ISSN: 2041-1723
Huesa J; Giner-Lamia J; Pucciarelli MG; Paredes-Martínez P; Garcia-del Portillo F; Marina A; Casino P (2021) Structure-based analyses of Salmonella RcsB variants unravel new features of the Rcs regulon. Nucleic Acids. Nucleic Acids Research. ISSN: 0305-1048
Isidoro Olmeda; Patricia Casino; Robert E. Collins; Ramón Sendra; Sara Callejón; Juanjo Huesa; Alexei S. Soares; Sergi Ferrer; Isabel Pardo (2021) Structural analysis and biochemical properties of laccase enzymes from two Pediococcus species. Microbial Biotechnology, 14(3), pp. 1026 - 1043 . ISSN: 1751-7915
Lázaro-Berenguer, M; Paredes-Martínez, F; Bel, Y; Núñez-Ramírez, R; Arias-Palomo, E, Casino, P; Ferré, J. (2022) Structural and functional role of Domain I for the insecticidal activity of the Vip3Aa protein from Bacillus thuringiensis . Microbial Biotechnology, 15(10), pp. 2607 - 2618 . ISSN: 1751-7907
Sena-Torralba A; Gabaldón-Atienza J; Cubells-Gómez A; Casino P: Maquieira Á; Morais S. (2022) Lateral Flow Microimmunoassay (LFµIA) for the Reliable Quantification of Allergen Traces in Food Consumables. Biosensors (Basel). ISSN: 2079-6374
Quintero-Campos P; Segovia-de Los Santos P; Ibáñez-Echevarria E; Hernández-Fernández de Rojas D; Casino P; Lassabe G; González-Sapienza G; Maquieira Á, Morais S. (2022) An ultra-sensitive homologous chemiluminescence immunoassay to tackle penicillin allergy. Analytica Chimica Acta. ISSN: 0003-2670
Leticia Rodríguez; Marcos Peñalver; Patricia Casino; Francisco García-Del Portillo (2023) Evolutionary analysis and structure modelling of the Rcs-repressor IgaA unveil a functional role of two cytoplasmic small β-barrel (SBB) domains. Heliyon. ISSN: 2405-8440
Isidoro Olmeda; Francisco Paredes-Martínez; Ramón Sendra; Patricia Casino; Isabel Pardo; Sergi Ferrer (2024) Biochemical and structural characterization of novel psycrophilic laccase (multicopper oxidase) discovered from Oenococcus oeni 229 (ENOLAB 4002). International Journal Of Molecular Sciences, 25, p. 8521 . ISSN: 1661-6596
Paredes-Martínez F; Eixerés L; Zamora-Caballero S; Casino P (2024) Structural and functional insights underlying recognition of histidine phosphotransfer protein in fungal phosphorelay systems. Communications Biology, 7(814), pp. 1 - 15 . ISSN: 2399-3642
Raquel Gascó; Ramón Sendra; Isidoro Olmeda; Francisco Paredes-Martínez; Sergi Ferrer; Isabel Pardo; Patricia Casino (2026) Laccases from lactic acid bacteria show cuprous oxidase activity and capture Cu(II) and Ag(I) ions. Protein Science, 35(1), pp. 1 - 17 . ISSN: 0961-8368
Navarro-Lleó N; Ramírez-Cárdenas J; Paredes-Martínez F; Serna S; Gozalbo-Rovira R; Muñoz-García JC; Reichardt NC; Casino P; Angulo J; Rodríguez-Díaz J; Buesa J (2025) Interaction of the VP8* protein of a bovine rotavirus C with the H type-2 antigen and its precursor N-acetyl-lactosamine. International Journal of Biological Macromolecules, 10(149621), pp. 1 - 12 . ISSN: 0141-8130
Valerio Di Domenico; Jorick Franceus; Leonardo Mastrella; Emma De Beul; Adrià Alcaide-Jiménez; Francisco Paredes-Martínez; Juan Carlos Villegas-Ruiz; Elena Holden; Alejandro Delgado Rey; Cecilia D'Angelo; Javier O Cifuente; Weston B Struwe; Ricardo M Biondi; Alberto Marina; Sean R Connell; Justin L P Benesch; Patricia Casino; Christophe Colleoni; Tom Desmet; Marcelo E Guerin (2026) Structural basis for phosphorylation and allosteric regulation of bacterial glycogen phosphorylase by histidine phosphocarrier protein. Nature Communications. ISSN: 2041-1723

Projects

Thesis, minor thesis and research reports

Clara Fos Vivó, (2015). ESTUDIO DE LA HISTIDINA QUINASA QseC, UN SENSOR ADRENÉRGICO BACTERIANO. (Master Thesis). .
Francisco Paredes Martínez, (2017). ESTUDIO MOLECULAR Y FUNCIONAL DE HISTIDINAS QUINASAS HÍBRIDAS DE CHAETOMIUM TERMOPHILUM. (Master Thesis). .
Laura Miguel Romero, (2017). ESTUDIO ESTRUCTURAL Y FUNCIONAL DEL MECANISMO DE TRANSDUCCIÓN DE SEÑAL POR SISTEMAS DE DOS COMPONENTES CANÓNICOS Y ATÍPICOS. (Doctoral Thesis). .
Miriam Hammou, (2018). ESTUDIO MOLECULAR Y FUNCIONAL DE HISTIDINA QUINASA HÍBRIDA DE CHAETOMIUM TERMOPHILUM. (Final Degree work). .
Cristina Mideros Mora, (2021). Bases moleculares de la especificidad en el mecanismo de transducción de señal en los sistemas de dos componentes bacterianos. (Doctoral Thesis). .
Jordi Jornet Plaza, (2020). Aproximación funcional y estructural para el estudio del sistema de dos componentes PmrB/PmrA de Salmonella enterica serovar Typhimurium, principal regulador de las modificaciones en la capa de lipopolisacárido. (Final Degree work). .
Eric Aguilera, (2022). Bases moleculares de la interacción entre el factor transcripcional RcsB y el DNA. (Final Degree work). .
Lluís Eixerés, (2022). Bases moleculares de los sistemas de fosfotransferencia en Candida albicans. (Master Thesis). .
Daniel Calvo, (2022). Aproximación al estudio de las bases moleculares del sistema Rcs. (Master Thesis). .
Gascó Raquel, (2023). APROXIMACIÓN FUNCIONAL PARA INHIBIR LA DIMERIZACIÓN DE FACTORES TRANSCRIPCIONALES BACTERIANOS IMPLICADOS EN VIRULENCIA. (Final Degree work). .
Daniel Martí Montón, (2024). Estudio funcional y estructural del reconocimiento de señales mediado por regiones sensoras de receptores bacterianos. (Final Degree work). .
Raquel Gascó Perea, (2024). Estudio funcional y estructural de factores transcripcionales implicados en virulencia de Salmonella para desarrollar aplicaciones biomédicas. (Master Thesis). .
Daniel Martí Montón, (2025). CARACTERIZACIÓN FUNCIONAL Y ESTRUCTURAL DE LA TRANSDUCCIÓN DE SEÑAL MEDIADA POR HISTIDINA QUINASAS HÍBRIDAS FÚNGICAS. (Master Thesis). .
Ángela Tierno Martín, (2025). ESTUDIO ESTRUCTURAL Y FUNCIONAL DE LA COMUNICACIÓN ENTRE RECEPTORES Y FACTORES TRANSCRIPCIONALES DE SALMONELLA. (Final Degree work). .
Francisco Paredes Martínez, (2026). Desgranando las bases moleculares de los sistemas phosphorelay en hongos. (Doctoral Thesis). .