CARLOS ROMA MATEO
PDI-Titular d'Universitat
Knowledge area: PHYSIOLOGY
Department: Physiology
Despacho departamento de Fisiología (planta 0)
(9639) 83170
Biography
Carlos Romá Mateo (Valencia, 1980) is a Biochemist and holds a Ph. D. in molecular biology and genetics. The theme of his doctoral thesis (2004 - 2009, Prince Felipe Research Center and Faculty of Life Sciences, University of Manchester) was the study of protein families involved in cell signaling in the context of cancer, after which he studied the disease of Lafora, a rare type of epilepsy of fatal consequences (2009 - 2013, Institute of Biomedicine of Valencia - CSIC). From there, his research career has been deepening in the field of rare diseases, from the perspective of oxidative stress and epigenetic alterations. Recently, he has initiated a line of research focused on the molecular alterations resulting from cytotoxicity mediated by circulating histones in the context of sepsis. His teaching career began in 2015 at the European University of Valencia, to finally join the Faculty of Medicine and Dentistry of the Universitat de València as professor and researcher since 2017. In recent years he has been doing many scientific outreach activities, writing in his own blog and in other web pages, performing talks and monologues, as well as participating in all kinds of science dissemination events. He is a writer in Principia, collaborator in Mapping Ignorance, and co-creator and scriptwriter of the bio-science fiction comic The OOBIK proteotype, together with the illustrator Gerardo Sanz, as well as the author of three books about epigenetics, and evolution.
Journal Publications (last 10 years)
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Gloria Olaso-González; Carlos Romá Mateo; Marta Piqueras Franco
(2021)
"Alimental, querido Watson" - escape room virtual para la asignatura de Alimentación y Dietética. In-Red 2020 - VI Congreso Nacional de Innovación Educativa y Docencia en Red. ISSN: 2603-5863
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Gloria Olaso González; Carlos Romá Mateo; Marta Piqueras
(2020)
DEBATMITAL 2.0: 2ª Edición de los debates sobre mitos en Alimentación. In-Red 2020 - VI Congreso Nacional de Innovación Educativa y Docencia en Red. ISSN: 2603-5863
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Gloria Olaso González; Carlos Romá Mateo; Juan Gambini; Ángela G. Correas; Consuelo Borras; Marta Piqueras; Mari Carmen Gómez Cabrera
(2020)
Uso de la infografía en la optativa "Alimentación y Dietética" del grado de Medicina. In-Red 2020 - VI Congreso Nacional de Innovación Educativa y Docencia en Red. ISSN: 2603-5863
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C. Romá-Mateo; C.J. Calvo; G. Olaso-González; A. Alberola; A. M. Pons; P. Antón-Enguídanos; M. Avinent-Pérez; L. Blasco-García; D.J. Medina- Corrales; B. Perez-Gómez; M. Serrano-Carsi
(2020)
Physiology comics: potential of graphic narrative resources for the teaching-learning process in health sciences. ICERI proceedings. ISSN: 2340-1095
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García-Giménez, José Luis ;Pérez-Machado, Gisselle ;Beltrán-García, Jesús ;García-López, Eva María ;Berenguer, Ester ;Romá-Mateo, Carlos ;Mena-Mollá, Salvador
(2018)
Biomarcadores epigenéticos: hacia su implantación en la rutina clínica. Genética médica news. ISSN: 2386-5113
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Ibáñez Cabellos, Jose Santiago; Aguado, Carmen; Pérez Cremades, Daniel; García-Giménez, Jose Luis; Bueno Betí, Carlos; García-López, Eva, M.; Romá-Mateo, Carlos; Novella, Susana; arlos; Pallardó, Federico V.;
(2018)
Extracellular histones activate autophagy and apoptosis via mTOR signaling in human endothelial cells. Biochimica et Biophysica Acta-Molecular Basis of Disease, 1864, pp. 3234 - 3246
. ISSN: 0925-4439 -
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García-Giménez JL, Romá-Mateo C, Carbonell N, Palacios L, Peiró-Chova L, García-López E, García-Simón M, Lahuerta R, Giménez-Garzó C, Berenguer-Pascual E, Mora M.I, Valero M.L, Alpízar A, Corrales F.J, Blanquer J, Pallardó FV
(2017)
A new mass spectrometry-based method for the quantification of histones in plasma from septic shock patients. Scientific Reports, 7
. ISSN: 2045-2322 -
José L García-Giménez; Nieves Carbonell; Carlos Romá-Mateo;Eva García-López; Lorena Palacios; Lorena Peiró-Chova; Ester Berenguer; Carla Giménez-Garzó; Federico V Pallardó; José Blanquer
(2016)
Epigenetics as the Driving Force in Long-Term Immunosuppression. Journal of clinical epigenetics, 2(2), pp. 1 - 17
. ISSN: 2472-1158
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Romá-Mateo C1; Aguado C; García-Giménez JL;Ibáñez-Cabellos JS; Seco-Cervera M, Pallardó FV; Knecht E; Sanz P.
(2014)
Increased Oxidative Stress and Impaired Antioxidant Response in Lafora Disease. Molecular Neurobiology. ISSN: 0893-7648
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García-Giménez JL; Seco-Cervera M; Aguado C; Romá-Mateo C; Dasí F; Priego S; Markovic J; Knecht E; Sanz P; Pallardó FV.
(2013)
Lafora disease fibroblasts exemplify the molecular interdependence between thioredoxin 1 and the proteasome in mammalian cells. Free Radical Biology and Medicine, 65, pp. 347 - 359
. ISSN: 0891-5849
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Sánchez-Martin P; Madushi R; Travis M;Husodo S;Gentry M; Sanz P; Romá-Mateo C
(2013)
Dimerization of the glucan phosphatase laforin requires the participation of cysteine 329. Plos One. ISSN: 1932-6203
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García-Giménez JL; Velázquez Ledesma AM; Esmoris I; Romá-Mateo C; Sanz P; Viña J; Pallardó FV
(2012)
Histone carbonylation occurs in proliferating cells. Free Radical Biology and Medicine, 52, pp. 1453 - 1464
. ISSN: 0891-5849
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Romá-Mateo C; Solaz-Fuster M;gimeno-Alcañiz JV;Dukhande VV;Donderis J;Worby CA; Marina A; Criado O;Koller A;Rodríguez de Cordoba S; Gentry MS; Sanz P
(2011)
Laforin, a dual-specificity phosphatase involved in Lafora disease, is phosphorylated at Ser25 by AMP-activated proteim kinase. Biochemical Journal, 439, pp. 265 - 275
. ISSN: 0264-6021
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Projects
CITOTOXICIDAD MEDIADA POR MACROMOLECULAS NUCLEARES: MECANISMOS MOLECULARES Y POTENCIAL PARA EL DESARROLLO DE BIOMARCADORES DE SEPSIS Y CHOQUE SEPTICO. 2021 - 2024. Ministerio de Ciencia e Innovación. . PI: Carlos Romá-Mateo.
CUANTIFICACIÓN DE MACROMOLÉCULAS CIRCULANTES DE ORIGEN NUCLEAR PARA EL DIAGNÓSTICO PRECOZ DE AMILOIDOSIS CARDIACA TIPO ATTRwt. 2021. Universitat de Valéncia (UV) y INCLIVA. . PI: Carlos Romá-Mateo, Enrique Santas Olmeda.
BÚSQUEDA DE BIOMARCADORES Y NUEVAS TERAPIAS PARA LA ENFERMEDAD DE LAFORA. 2021. CIBERER. . PI: Marina Sánchez.