ALBA CORTES CARBONELL
PDI-Titular d'Universitat
PDI-Titular d'Universitat
Knowledge area: PARASITOLOGY
Department: Pharmacy, Pharmaceutical Technology and Parasitology
Department: Pharmacy, Pharmaceutical Technology and Parasitology
(9635) 44232
Academic training
- Licenciada en Farmacia. Facultat de Farmàcia, Universitat de València. 31/07/2009 (Diploma / Degree / Activities).
- Análisis de las interacciones parásito-hospedador en el modelo Echinostoma caproni-roedor, co. Facultat de Farmàcia, Universitat de València. 12/06/2015 (Ph.D.).
- Máster en Biología Molecular, Celular y Genética. Facultat de Ciències Biològiques, Universitat de València. 17/01/2011 (Official Master).
- Máster en Enfermedades Parasitarias Tropicales. Facultat de Farmàcia, Universitat de València. 31/07/2013 (Official Master).
Journal Publications
- Cortés A.; Sotillo J.; Muñoz-Antolí C.; Fried B.; Esteban J.G.; Toledo R. (2014) Intestinal IFN-γ production is associated with protection from clinical signs, but not with elimination of worms, in Echinostoma caproni infected-mice. Parasitology Research, 113, pp. 2037 - 2045 . ISSN: 0932-0113
- Muñoz-Antolí C.; Cortés A.; Sotillo J.; Fried B.; Esteban J.G.; Toledo R. (2014) Differential expression and glycosylation of proteins in the rat ileal epithelium in response to Echinostoma caproni infection. Journal Of Proteomics, 101, pp. 169 - 178 . ISSN: 1874-3919
- Muñoz-Antolí C.; Cortés A.; Torres D.; Esteban J.G.; Toledo R. (2015) Haematological changes in the laboratory rat Rattus norvegicus infected with Echinostoma caproni (Trematoda: Echinostomatidae). Journal of Helminthology, 89(5), pp. 636 - 640 . ISSN: 0022-149X
- Sotillo J.; Cortés A.; Muñoz-Antolí C.; Fried B.; Esteban J.G.; Toledo R. (2014) The effect of glycosylation of antigens on the antibody responses against Echinostoma caproni (Trematoda: Echinostomatidae). Parasitology, 141, pp. 1333 - 1340 . ISSN: 0031-1820
- Cortés A; Muñoz-Antoli C; Sotillo J; Fried B; Esteban JG; Toledo R (2015) Echinostoma caproni (Trematoda): differential in vivo mucin expression and glycosylation in high- and low-compatible hosts. Parasite Immunology, 37(1), pp. 32 - 42 . ISSN: 0141-9838
- Muñoz-Antolí, C; Cortés, A; Martín-Grau, C; Fried, B; Esteban, JG; Toledo, R. (2016) Partial resistance to homologous challenge infections of the digenean Echinostoma caproni in ICR mice. Journal of Helminthology, 90(4), pp. 428 - 433 . ISSN: 0022-149X
- Cortés A; Sotillo J; Muñoz-Antoli C; Martín-Grau C; Esteban JG; Toledo R (2016) Resistance against Echinostoma caproni (Trematoda) secondary infections is not dependent on the ileal protein production. Journal Of Proteomics, 140, pp. 37 - 47 . ISSN: 1874-3919
- Cortés A; Sotillo J; Muñoz-Antoli C; Trelis M; Esteban JG; Toledo R (2016) Definitive host influences the proteomic profile of excretory/secretory products of the trematode Echinostoma caproni. Parasites & Vectors, 9(1), p. 185 . ISSN: 1756-3305
- Cortés A.; Muñoz-Antoli C.; Sotillo J.; Fried B.; Esteban J.G.; Toledo R. (2015) Altered protein expression in the ileum of mice associated with the development of chronic infections with Echinostoma caproni (Trematoda). Plos Neglected Tropical Diseases, 9, p. e0004082 . ISSN: 1935-2735
- Muñoz-Antoli C; Cortés A; Santano R; Sotillo J; Esteban JG; Toledo R (2016) Interleukin-25 Induces Resistance Against Intestinal Trematodes. Scientific Reports, 23(6), p. 34142 . ISSN: 2045-2322
- Cortés, A; Muñoz-Antolí, C; Martín-Grau, C; Esteban, JG; Grencis, RK; Toledo, R (2015) Differential alterations in the small intestine epithelial cell turnover during acute and chronic infection with Echinostoma caproni (Trematoda). Parasites & Vectors, 8(334) . ISSN: 1756-3305
- Cortés A; Muñoz-Antoli C; Esteban JG; Toledo R (2017) Th2 and Th1 Responses: Clear and Hidden Sides of Immunity Against Intestinal Helminths. Trends in Parasitology, 33(9), pp. 678 - 693 . ISSN: 1471-4922
- Cortés, A; Garcia-Ferrús, M; Sotillo, J; Esteban, JG; Toledo, R; Muñoz-Antoli C (2017) Effects of dietary intake of garlic on intestinal trematodes. Parasitology Research(116), pp. 2119 - 2129 . ISSN: 0932-0113
- Cortés A; Sotillo J; Muñoz-Antolí C; Molina-Durán J;Esteban JG; Toledo R. (2017) Antibody trapping: A novel mechanism of parasite immune evasion by the trematode Echinostoma caproni. Plos Neglected Tropical Diseases, 11(17), p. e0005773 . ISSN: 1935-2735
- Cortés A; Toledo R; Cantacessi C (2018) Classic Models for New Perspectives: Delving into Helminth-Microbiota-Immune System Interactions. Trends in Parasitology, 34(8), pp. 640 - 654 . ISSN: 1471-4922
- Cortés A; Muñoz-Antolí C; Álvarez-Izquierdo M; Sotillo J; Esteban JG; Toledo R (2018) Adaptation of the secretome of Echinostoma caproni may contribute to parasite survival in a Th1 milieu. Parasitology Research, 117, pp. 947 - 957 . ISSN: 0932-0113
- Cortés A; Mikes L; Muñoz-Antolí C; Álvarez-Izquierdo M; Esteban JG; Horák P; Toledo R. (2019) Secreted cathepsin L-like peptidases are involved in the degradation of trapped antibodies on the surface of Echinostoma caproni. Parasitology Research, 118(12), pp. 3377 - 3386 . ISSN: 0932-0113
- A Cortés; L Peachey; R Scotti; TP Jenkins; C Cantacessi (2019) Helminth-microbiota cross-talk - A journey through the vertebrate digestive system. Molecular and Biochemical Parasitology. ISSN: 0166-6851
- A Cortés; LE Peachey; TP Jenkins; R. Scotti; C Cantacessi (2019) Helminths and microbes within the vertebrate gut - not all studies are created equal. Parasitology. ISSN: 0031-1820
- IA. Yordanova; A Cortés; C Klotz; AA Kühl; MM Heimesaat; C Cantacessi; S Hartmann; S. Rausch (2019) RORγt+ Treg to Th17 ratios correlate with susceptibility to Giardia infection. Scientific Reports. ISSN: 2045-2322
- R Scotti; S Southern; C Boinett; TP Jenkins; A Cortés; C Cantacessi (2020) MICHELINdb: a web-based tool for mining of helminth-microbiota interaction datasets, and a meta-analysis of current research. Microbiome. ISSN: 2049-2618
- A Cortés; B Fried (2019) Form and function in the Digenea. Advances in Experimental Medicine and Biology. ISSN: 0065-2598
- Cortés, A; Wills, J; Su, X; Hewitt, RE; Robertson, J; Scotti, R; Price, DRG; Bartley, Y; McNeilly, TN; Krause, L; Powell, JP; Nisbet, AJ; Cantacessi C (2020) Infection with the sheep gastrointestinal nematode Teladorsagia circumcincta increases luminal pathobionts. Microbiome. ISSN: 2049-2618
- Cortés, A; Rooney, J; Bartley, DJ; Nisbet, AJ; Cantacessi, C (2020) Helminths, hosts, and their microbiota: new avenues for managing gastrointestinal helminthiases in ruminants. Expert Review Of Anti-Infective Therapy, 18(10), pp. 977 - 985 . ISSN: 1478-7210
- Formenti, F; Cortés, A; Brindley, PJ; Cantacessi, C; Rinaldi, G (2020) A bug's life: Delving into the challenges of helminth microbiome studies. Plos Neglected Tropical Diseases, 14(9), p. e0008446 . ISSN: 1935-2735
- Cortés, A; Clare, S; Costain, A; Almeida, A; McCarthy, C; Harcourt, K; Brandt, C; Tolley, C; Rooney, J; Berriman, M; Lawley, T; MacDonald, AS; Rinaldi, G; Cantacessi, C (2020) Baseline gut microbiota composition is associated with Schistosoma mansoni infection burden in rodent models. Frontiers in Immunology, 11, p. 593838 . ISSN: 1664-3224
- Ronney, J; Cortés, A; Scotti, R; Price, DRG; Bartley, Y; Fairlie-Clarke, K; McNeilly, TN; Nisbet, AJ; Cantacessi, C (2021) Vaccination against the brown stomach worm, Teladorsagia circumcincta, followed by parasite challenge, induces inconsistent modifications in gut microbiota composition of lambs. Parasites & Vectors, 14, p. 189 . ISSN: 1756-3305
- Jenkins, TP; Pritchard, DI; Tanasescu, R; Telford, G; Papaiakovou, M; Scotti, R; Cortés, A; Constantinescu, CS; Cantacessi, C (2021) Experimental infection with the hookworm, Necator americanus, is associated with stable gut microbial diversity in human volunteers with relapsing multiple sclerosis. Bmc Biology, 19, p. 74 . ISSN: 1741-7007
- Cortés, A; Sotillo, J; Rinaldi, G; Cantacessi, C (2021) Gut-microbiota-derived extracellular vesicles: Overlooked mediators in host-helminth interactions?. Trends in Parasitology, 37(8), pp. 690 - 693 . ISSN: 1471-4922
- Ronney, J; Northcote, HM; Williams, TL; Cortés, A; Cantacessi, C; Morphew RM (2022) Parasitic helminths and the host microbiome - a missing 'extracellular vesicle-sized' link?. Trends in Parasitology. ISSN: 1471-4922
- Cortés, A; Martin, J; Rosa, BA; Stark, KA; Clare, S; McCarthy, C; Harcourt, K; Brandt, C; Tolley, C; Lawley, TD; Mitreva, M; Berriman, M; Rinaldi, G; Cantacessi, C (2022) The gut microbial metabolic capacity of microbiome-humanized vs. wild type rodents reveals a likely dual role of intestinal bacteria in hepato-intestinal schistosomiasis. Plos Neglected Tropical Diseases. ISSN: 1935-2735
- Rooney, J; Cantacessi, C; Sotillo, J; Cortés A (2022) Gastrointestinal worms and bacteria: From association to intervention. Parasite Immunology. ISSN: 0141-9838
- Stark, KA; Rinaldi, G; Cortés, A; Costain, A; MacDonald, AS; Cantacessi, C (2023) The role of the host gut microbiome in the pathophysiology of schistosomiasis. Parasite Immunology. ISSN: 0141-9838
- Formenti F., Cortés A., Deiana M., Salter S., Parkhill J., Berriman M., Rinaldi G., Cantacessi, C. (2023) The human blood fluke, Schistosoma mansoni, harbours bacteria throughout the parasite's life cycle. Journal of Infectious Diseases. ISSN: 0022-1899
- Stark, K. A.; Rinaldi, G.; Costain, A.; Clare, S.; Tolley, C.; Almeida, A.; McCarthy, C.; Harcourt, K.; Brandt, C.; Lawley, T. D.; Berriman, M; MacDonald, A. S.; Forde‑Thomas, J. E.; Hulme, B. J.; Hoffmann, K. F.; Cantacessi, C.; Cortés, A. (2024) Gut microbiota and immune profiling of microbiota‑humanised versus wildtype mouse models of hepatointestinal schistosomiasis. Animal Microbiome. ISSN: 2524-4671
- Rinaldi, G.; Paz Meseguer, C.; Cantacessi, C.; Cortés, A (2024) Form and function in the Digenea, with an emphasis on host-parasite and parasite-bacteria interactions. Advances in Experimental Medicine and Biology. ISSN: 0065-2598
Other publications
- Toledo R; Cortés A; Álvarez-Izquierdo M; Muñoz-Antoli M; Esteban JG (2019). New insights into the treatment of foodborne trematode infections Neglected Tropical Diseases: Drug Discovery and Development . (pp. 289 - 323) .
- Formenti, F; Rinaldi, G; Cantacessi, C; Cortés, A (2021). Helminth Microbiota Profiling Using Bacterial 16S rRNA Gene Amplicon Sequencing: From Sampling to Sequence Data Mining Parasite Genomics. Methods and Protocols. . (pp. 263 - 298) .
Previous Tasks
- Técnico superior de investigación. Programa PROMETEO/2009/081. Dep. Biologia Cel·lular i Parasitologia, Facultat de Farmàcia, Universitat de València. 01/07/2010 - 15/09/2011.
- Investigador en formación. Contrato Predoctoral Atracció de Talent de la Universitat de València. Dep. Biologia Cel·lular i Parasitologia, Facultat de Farmàcia, Universitat de València. 16/09/2011 - 30/06/2014.
- Tècnic Mitjà d'Investigació. Dep. Farmàciai Tecnologia Farmacèutica i Parasitologia. Facultat de Farmàcia. Universitat deValència. 01/11/2014 - 31/05/2016.
- Investigador Doctor Sènior. Dep. Farmàciai Tecnologia Farmacèutica i Parasitologia. Facultat de Farmàcia. Universitat deValència. 01/06/2016 - 23/12/2017.
- Investigador Postdoctoral. Dep. of Veterinary Medicine. University of Cambridge. 01/01/2018 - 31/08/2019.
- Profesora Ayudante Doctora (Parasitología). Dep. Farmàcia Tecnologia Farmacèutica i Parasitologia. Facultat de Farmàcia. Universitat de València. 01/09/2019 - 16/11/2023.
Stays abroad in Research Centers
- Praga. CZECH REPUBLIC, 2014. Caracteritzación preliminar de catepsinas de la fase adulta de Echinostoma caproni. **Doctorand.
- Manchester. UNITED KINGDOM, 2022. Study of Schistosoma mansoni-gut and lung microbiome interactions in mice, and their role in the amelioration of allergic airway inflammation. **Altres (especificar) - Co-IP proyecto International Exchanges 2020: IES\R1\201339 (Royal Society).
Projects
- Study of Schistosoma mansoni-gut and lung microbiome interactions in mice, and their role in the amelioration of allergic airway inflammation (). 2020 - 2022. Royal Society (UK). . PI: Andrew MacDonald; Alba Cortés Carbonell.
- Análisis de factores determinantes del desarrollo de resistencia o cronicidad en infecciones por helmintos intestinales (GVPROMETEOII-2014-083) (). 2014 - 2017. CONSELLERIA D'EDUCACIO, INVESTIGACIO, CULTURA I ESPORT - GVA. . PI: J. Guillermo Esteban Sanchís.
- EXTRACELLULAR VESICLES: INTERCONNECTING KINGDOMS FOR AN INTEGRATED CONTROL OF FASCIOLIASIS (Programa Prometeo (GV)). 2024 - 2028. Generalitat Valenciana, Programa I+D. . PI: Antonio Marcilla Díaz/María Dolores Bernal Membrilla.
- CARACTERIZACIÓN BIOQUÍMICA Y FUNCIONAL DE VESÍCULAS EXTRACELULARES DERIVADAS DE PLANTAS COMESTIBLES: UTILIDAD POTENCIAL EN LA MEJORA DE LA SALUD HUMANA (Proyectos de Investigación del Plan Nacional de I+D+I). 2024 - 2028. Ministerio de Ciencia, Innovación y Universidades, Agencia Estatal de Investigación. . PI: Antonio Marcilla Díaz.
- Nanopartículas biomiméticas y vesículas extracelulares para tratamiento tópico de enfermedades inflamatorias de la piel y cicatrización de heridas: retos y soluciones (BioNPs&EVs@SKIN) (). 2024 - 2028. MINISTERIO DE CIENCIA, INNOVACIÓN Y UNIVERSIDADES. . PI: Ana Melero Zaera.
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