foto Mireia Coscolla Devis
MIREIA COSCOLLA DEVIS
PI Invest Cont Ramon y Cajal
:
Department: Institute for Biological Systems Integration (I2SYSBIO)
I2SYSBIO Parc Cientific - Universitat València C/Agustín Escardino, 9, 46980 Paterna (Valencia)
(9635) 43317
Biography

EDUCATION

  • 2009 PhD in Biology — University of Valencia — Cavanilles Institute for Biolodiversity and Evolutionary Biology
  • 2003 Biology degree — University of Valencia

CURRENT POSITION

  • Research scientist — University of Valencia from 2017

PREVIOUS POSITIONS

  •  
  • 2015-2017 Senior scientist — Swiss Tropical and Public Health Institute
  • 2010-2014 Postdoctorasl scientist — Swiss Tropical and Public Health Institute
  • 2010 Postdoctoral scientist —  Universitat Pompeu fabra, Barcelona.

TEACHING

  • 33053 - The tree of life
  • 33054 - Evolutionary processes and mechanisms

PUBLICACIONS

1: Ofori-Anyinam B, Dolganov G, Van T, Davis JL, Walter ND, Garcia BJ, Voskuil M,
Fissette K, Diels M, Driesen M, Meehan CJ, Yeboah-Manu D, Coscolla M, Gagneux S,
Antonio M, Schoolnik G, Gehre F, de Jong BC. Significant under expression of the
DosR regulon in M. tuberculosis complex lineage 6 in sputum. Tuberculosis
(Edinb). 2017 May;104:58-64. doi: 10.1016/j.tube.2017.03.001.

2: Blondiaux N, Moune M, Desroses M, Frita R, Flipo M, Mathys V, Soetaert K,
Kiass M, Delorme V, Djaout K, Trebosc V, Kemmer C, Wintjens R, Wohlkönig A,
Antoine R, Huot L, Hot D, Coscolla M, Feldmann J, Gagneux S, Locht C, Brodin P,
Gitzinger M, Déprez B, Willand N, Baulard AR. Reversion of antibiotic resistance
in Mycobacterium tuberculosis by spiroisoxazoline SMARt-420. Science. 2017 Mar
17;355(6330):1206-1211. doi: 10.1126/science.aag1006.

3: Copin R, Wang X, Louie E, Escuyer V, Coscolla M, Gagneux S, Palmer GH, Ernst
JD. Within Host Evolution Selects for a Dominant Genotype of Mycobacterium
tuberculosis while T Cells Increase Pathogen Genetic Diversity. PLoS Pathog. 2016
Dec 14;12(12):e1006111. doi: 10.1371/journal.ppat.1006111. eCollection 2016 Dec.

4: Stucki D, Brites D, Jeljeli L, Coscolla M, Liu Q, Trauner A, Fenner L,
Rutaihwa L, Borrell S, Luo T, Gao Q, Kato-Maeda M, Ballif M, Egger M, Macedo R,
Mardassi H, Moreno M, Tudo Vilanova G, Fyfe J, Globan M, Thomas J, Jamieson F,
Guthrie JL, Asante-Poku A, Yeboah-Manu D, Wampande E, Ssengooba W, Joloba M,
Henry Boom W, Basu I, Bower J, Saraiva M, Vaconcellos SEG, Suffys P, Koch A,
Wilkinson R, Gail-Bekker L, Malla B, Ley SD, Beck HP, de Jong BC, Toit K,
Sanchez-Padilla E, Bonnet M, Gil-Brusola A, Frank M, Penlap Beng VN, Eisenach K,
Alani I, Wangui Ndung'u P, Revathi G, Gehre F, Akter S, Ntoumi F,
Stewart-Isherwood L, Ntinginya NE, Rachow A, Hoelscher M, Cirillo DM, Skenders G,
Hoffner S, Bakonyte D, Stakenas P, Diel R, Crudu V, Moldovan O, Al-Hajoj S, Otero
L, Barletta F, Jane Carter E, Diero L, Supply P, Comas I, Niemann S, Gagneux S.
Mycobacterium tuberculosis lineage 4 comprises globally distributed and
geographically restricted sublineages. Nat Genet. 2016 Dec;48(12):1535-1543. doi:
10.1038/ng.3704.

5: Stucki D, Ballif M, Egger M, Furrer H, Altpeter E, Battegay M, Droz S,
Bruderer T, Coscolla M, Borrell S, Zürcher K, Janssens JP, Calmy A, Mazza Stalder
J, Jaton K, Rieder HL, Pfyffer GE, Siegrist HH, Hoffmann M, Fehr J, Dolina M,
Frei R, Schrenzel J, Böttger EC, Gagneux S, Fenner L. Standard Genotyping
Overestimates Transmission of Mycobacterium tuberculosis among Immigrants in a
Low-Incidence Country. J Clin Microbiol. 2016 Jul;54(7):1862-70. doi:
10.1128/JCM.00126-16.

6: Coscolla M, Copin R, Sutherland J, Gehre F, de Jong B, Owolabi O, Mbayo G,
Giardina F, Ernst JD, Gagneux S. M. tuberculosis T Cell Epitope Analysis Reveals
Paucity of Antigenic Variation and Identifies Rare Variable TB Antigens. Cell
Host Microbe. 2015 Nov 11;18(5):538-48.

7: Bloemberg GV, Keller PM, Stucki D, Trauner A, Borrell S, Latshang T, Coscolla
M, Rothe T, Hömke R, Ritter C, Feldmann J, Schulthess B, Gagneux S, Böttger EC.
Acquired Resistance to Bedaquiline and Delamanid in Therapy for Tuberculosis. N
Engl J Med. 2015 Nov 12;373(20):1986-8. doi: 10.1056/NEJMc1505196. Erratum in: N
Engl J Med. 2015 Dec 17;373(25):e29. Stuckia, David [corrected to Stucki, David].

8: Sánchez-Busó L, Coscollà M, Palero F, Camaró ML, Gimeno A, Moreno P, Escribano
I, López Perezagua MM, Colomina J, Vanaclocha H, González-Candelas F.
Geographical and Temporal Structures of Legionella pneumophila Sequence Types in
Comunitat Valenciana (Spain), 1998 to 2013. Appl Environ Microbiol. 2015
Oct;81(20):7106-13. doi: 10.1128/AEM.02196-15. Epub 2015 Jul 31.

9: Young DC, Layre E, Pan SJ, Tapley A, Adamson J, Seshadri C, Wu Z, Buter J,
Minnaard AJ, Coscolla M, Gagneux S, Copin R, Ernst JD, Bishai WR, Snider BB,
Moody DB. In vivo biosynthesis of terpene nucleosides provides unique chemical
markers of Mycobacterium tuberculosis infection. Chem Biol. 2015 Apr
23;22(4):516-526. doi: 10.1016/j.chembiol.2015.03.015.

10: Rock JM, Lang UF, Chase MR, Ford CB, Gerrick ER, Gawande R, Coscolla M,
Gagneux S, Fortune SM, Lamers MH. DNA replication fidelity in Mycobacterium
tuberculosis is mediated by an ancestral prokaryotic proofreader. Nat Genet. 2015
Jun;47(6):677-81. doi: 10.1038/ng.3269. Epub 2015 Apr 20.

11: Coscolla M, Barry PM, Oeltmann JE, Koshinsky H, Shaw T, Cilnis M, Posey J,
Rose J, Weber T, Fofanov VY, Gagneux S, Kato-Maeda M, Metcalfe JZ. Genomic
epidemiology of multidrug-resistant Mycobacterium tuberculosis during
transcontinental spread. J Infect Dis. 2015 Jul 15;212(2):302-10. doi:
10.1093/infdis/jiv025. Epub 2015 Jan 18.

12: Coscolla M, Gagneux S. Consequences of genomic diversity in Mycobacterium
tuberculosis. Semin Immunol. 2014 Dec;26(6):431-44. doi:
10.1016/j.smim.2014.09.012. Epub 2014 Oct 22. Review.

13: Stucki D, Ballif M, Bodmer T, Coscolla M, Maurer AM, Droz S, Butz C, Borrell
S, Längle C, Feldmann J, Furrer H, Mordasini C, Helbling P, Rieder HL, Egger M,
Gagneux S, Fenner L. Tracking a tuberculosis outbreak over 21 years:
strain-specific single-nucleotide polymorphism typing combined with targeted
whole-genome sequencing. J Infect Dis. 2015 Apr 15;211(8):1306-16. doi:
10.1093/infdis/jiu601. Epub 2014 Oct 30.

14: Steiner A, Stucki D, Coscolla M, Borrell S, Gagneux S. KvarQ: targeted and
direct variant calling from fastq reads of bacterial genomes. BMC Genomics. 2014
Oct 9;15:881. doi: 10.1186/1471-2164-15-881.

15: Portevin D, Sukumar S, Coscolla M, Shui G, Li B, Guan XL, Bendt AK, Young D,
Gagneux S, Wenk MR. Lipidomics and genomics of Mycobacterium tuberculosis reveal
lineage-specific trends in mycolic acid biosynthesis. Microbiologyopen. 2014
Dec;3(6):823-35. doi: 10.1002/mbo3.193.

16: Copin R, Coscollá M, Efstathiadis E, Gagneux S, Ernst JD. Impact of in vitro
evolution on antigenic diversity of Mycobacterium bovis bacillus Calmette-Guerin
(BCG). Vaccine. 2014 Oct 14;32(45):5998-6004. doi: 10.1016/j.vaccine.2014.07.113.

17: Bos KI, Harkins KM, Herbig A, Coscolla M, Weber N, Comas I, Forrest SA,
Bryant JM, Harris SR, Schuenemann VJ, Campbell TJ, Majander K, Wilbur AK, Guichon
RA, Wolfe Steadman DL, Cook DC, Niemann S, Behr MA, Zumarraga M, Bastida R, Huson
D, Nieselt K, Young D, Parkhill J, Buikstra JE, Gagneux S, Stone AC, Krause J.
Pre-Columbian mycobacterial genomes reveal seals as a source of New World human
tuberculosis. Nature. 2014 Oct 23;514(7523):494-7. doi: 10.1038/nature13591.

18: Copin R, Coscollá M, Seiffert SN, Bothamley G, Sutherland J, Mbayo G, Gagneux
S, Ernst JD. Sequence diversity in the pe_pgrs genes of Mycobacterium
tuberculosis is independent of human T cell recognition. MBio. 2014 Jan
14;5(1):e00960-13. doi: 10.1128/mBio.00960-13. PubMed PMID: 24425732; PubMed
Central PMCID: PMC3903279.

19: Coscollá M, Fernández C, Colomina J, Sánchez-Busó L, González-Candelas F.
Mixed infection by Legionella pneumophila in outbreak patients. Int J Med
Microbiol. 2014 May;304(3-4):307-13. doi: 10.1016/j.ijmm.2013.11.002.

20: Rose G, Cortes T, Comas I, Coscolla M, Gagneux S, Young DB. Mapping of
genotype-phenotype diversity among clinical isolates of mycobacterium
tuberculosis by sequence-based transcriptional profiling. Genome Biol Evol.
2013;5(10):1849-62. doi: 10.1093/gbe/evt138.

21: Garcia-Garcerà M, Garcia-Etxebarria K, Coscollà M, Latorre A, Calafell F. A
new method for extracting skin microbes allows metagenomic analysis of whole-deep
skin. PLoS One. 2013 Sep 20;8(9):e74914. doi: 10.1371/journal.pone.0074914.
eCollection 2013.

22: Comas I, Coscolla M, Luo T, Borrell S, Holt KE, Kato-Maeda M, Parkhill J,
Malla B, Berg S, Thwaites G, Yeboah-Manu D, Bothamley G, Mei J, Wei L, Bentley S,
Harris SR, Niemann S, Diel R, Aseffa A, Gao Q, Young D, Gagneux S. Out-of-Africa
migration and Neolithic coexpansion of Mycobacterium tuberculosis with modern
humans. Nat Genet. 2013 Oct;45(10):1176-82. doi: 10.1038/ng.2744.

23: Coscolla M, Lewin A, Metzger S, Maetz-Rennsing K, Calvignac-Spencer S,
Nitsche A, Dabrowski PW, Radonic A, Niemann S, Parkhill J, Couacy-Hymann E,
Feldman J, Comas I, Boesch C, Gagneux S, Leendertz FH. Novel Mycobacterium
tuberculosis complex isolate from a wild chimpanzee. Emerg Infect Dis. 2013
Jun;19(6):969-76. doi: 10.3201/eid1906.121012.

24: Sánchez-Busó L, Coscollá M, Pinto-Carbó M, Catalán V, González-Candelas F.
Genetic Characterization of Legionella pneumophila Isolated from a Common
Watershed in Comunidad Valenciana, Spain. PLoS One. 2013 Apr 25;8(4):e61564. doi:
10.1371/journal.pone.0061564. Print 2013.

25: Ballif M, Harino P, Ley S, Coscolla M, Niemann S, Carter R, Coulter C,
Borrell S, Siba P, Phuanukoonnon S, Gagneux S, Beck HP. Drug
resistance-conferring mutations in Mycobacterium tuberculosis from Madang, Papua
New Guinea. BMC Microbiol. 2012 Sep 4;12:191. doi: 10.1186/1471-2180-12-191.

26: Stucki D, Malla B, Hostettler S, Huna T, Feldmann J, Yeboah-Manu D, Borrell
S, Fenner L, Comas I, Coscollà M, Gagneux S. Two new rapid SNP-typing methods for
classifying Mycobacterium tuberculosis complex into the main phylogenetic
lineages. PLoS One. 2012;7(7):e41253. doi: 10.1371/journal.pone.0041253.

27: Kato-Maeda M, Shanley CA, Ackart D, Jarlsberg LG, Shang S, Obregon-Henao A,
Harton M, Basaraba RJ, Henao-Tamayo M, Barrozo JC, Rose J, Kawamura LM, Coscolla
M, Fofanov VY, Koshinsky H, Gagneux S, Hopewell PC, Ordway DJ, Orme IM. Beijing
sublineages of Mycobacterium tuberculosis differ in pathogenicity in the guinea
pig. Clin Vaccine Immunol. 2012 Aug;19(8):1227-37. doi: 10.1128/CVI.00250-12.

28: Garcia-Garcerà M, Coscollà M, Garcia-Etxebarria K, Martín-Caballero J,
González-Candelas F, Latorre A, Calafell F. Staphylococcus prevails in the skin
microbiota of long-term immunodeficient mice. Environ Microbiol. 2012
Aug;14(8):2087-98. doi: 10.1111/j.1462-2920.2012.02756.x.

29: Coscolla M, Gagneux S. Does M. tuberculosis genomic diversity explain disease
diversity? Drug Discov Today Dis Mech. 2010 Spring;7(1):e43-e59.

30: Coscollá M, Comas I, González-Candelas F. Quantifying nonvertical inheritance
in the evolution of Legionella pneumophila. Mol Biol Evol. 2011
Feb;28(2):985-1001. doi: 10.1093/molbev/msq278.

31: Coscollá M, Fenollar J, Escribano I, González-Candelas F. Legionellosis
outbreak associated with asphalt paving machine, Spain, 2009. Emerg Infect Dis.
2010 Sep;16(9):1381-7. doi: 10.3201/eid1609.100248.

32: Coscollá M, González-Candelas F. Direct sequencing of Legionella pneumophila
from respiratory samples for sequence-based typing analysis. J Clin Microbiol.
2009 Sep;47(9):2901-5. doi: 10.1128/JCM.00268-09.

33: Coscollá M, González-Candelas F. Comparison of clinical and environmental
samples of Legionella pneumophila at the nucleotide sequence level. Infect Genet
Evol. 2009 Sep;9(5):882-8. doi: 10.1016/j.meegid.2009.05.013.

34: Coscollá M, González-Candelas F. Population structure and recombination in
environmental isolates of Legionella pneumophila.

35: Coscollá M, Gosalbes MJ, Catalán V, González-Candelas F. Genetic variability
in environmental isolates of Legionella pneumophila from Comunidad Valenciana
(Spain). Environ Microbiol. 2006 Jun;8(6):1056-63.

36: López-Labrador FX, Bracho MA, Berenguer M, Coscollà M, Rayón JM, Prieto M,
Carrasco D, Gómez MD, Moya A, González-Candelas F. Genetic similarity of
hepatitis C virus and fibrosis progression in chronic and recurrent infection
after liver transplantation. J Viral Hepat. 2006 Feb;13(2):104-15.

Subjects taught and teaching methods
33047 - GeneticsTheory, Tutoring
33142 - BioinformaticsComputer Classroom, Theory, Tutoring
34191 - BiologyLaboratory
42587 - Developmental bioinformaticsLaboratory, Theory
42596 - Master's final projectWork end of studies
43471 - Master's final projectWork end of studies
Tutorials
Observations
You don't participate in the electronic tutoring program of the Universitat de València