MARIA TERESA DONATO MARTIN
PDI-Prof. Permanent Laboral Ppl
PDI-Prof. Permanent Laboral Ppl
Knowledge area: BIOCHEMISTRY AND MOLECULAR BIOLOGY
Department: Biochemistry and Molecular Biology
Department: Biochemistry and Molecular Biology
(9638) 64134
Subjects taught and teaching methods
Tutorials
| First semester |
| Thursday de 11:30 a 14:30. DPTO. BIOQUÍMICA, FAC. MEDICINA I ODONTOLOGÍA |
| Observations |
| You participate in the electronic tutoring program of the Universitat de València |
Academic training
- Licenciada en Farmacia. Universitat de València. 1984 (Diploma / Degree / Activities).
- Licenciada en Ciencias Químicas. Universidad de Educación a Distancia UNED. 2001 (Diploma / Degree / Activities).
- Doctora en Farmacia. Universitat de València. 1989 (Ph.D.).
Journal Publications
- Carretero A, León Z, García-Cañaveras JC, Zaragoza A, Gómez-Lechón MJ, Donato MT, Lahoz A (2014) In vitro/in vivo screening of oxidative homeostasis and damage to DNA, protein, and lipids using UPLC/MS-MS. Analytical and Bioanalytical Chemistry, 406(22), pp. 5465 - 5476 . ISSN: 1618-2642
- Cortes M, Pareja E, García-Cañaveras JC, Donato MT, Montero S, Mir J, Castell JV, Lahoz A (2014) Metabolomics discloses donor liver biomarkers associated with early allograft dysfunction. Journal of Hepatology, 61(3), pp. 564 - 574 . ISSN: 0168-8278
- Gómez-Lechón MJ, Tolosa L, Conde I, Donato MT (2014) Competency of different cell models to predict human hepatotoxic drugs. Expert Opinion On Drug Metabolism & Toxicology, 10(11), pp. 1553 - 1568 . ISSN: 1742-5255
- García-Cañaveras JC, Donato MT, Lahoz A (2014) Ultra-performance liquid chromatography-mass spectrometry targeted profiling of bile acids: application to serum, liver tissue, and cultured cells of different species. Methods in Molecular Biology, 1198, pp. 233 - 247 . ISSN: 1064-3745
- Gómez-Lechón MJ, Tolosa L, Donato MT (2014) Cell-based models to predict human hepatotoxicity of drugs. Revista de Toxicología, 31(2), pp. 149 - 156 . ISSN: 0212-7113
- Benet M; Guzmán C; Pisonero-Vaquero S; García-Mediavilla MV; Sánchez-Campos S; Martínez-Chantar ML; Donato MT; Castell JV; Jover R (2015) Repression of the nuclear receptor small heterodimer partner by steatotic drugs and in advanced nonalcoholic fatty liver disease. Molecular Pharmacology, 87(4), pp. 582 - 594 . ISSN: 0026-895X
- Tolosa L, López S, Pareja E, Donato MT, Myara A, Nguyen TH, Castell JV, Gómez-Lechón MJ. (2015) Human neonatal hepatocyte transplantation induces long-term rescue of unconjugated hyperbilirubinemia in the Gunn rat. Liver Transplantation, 21(6), pp. 801 - 811 . ISSN: 1527-6465
- Tolosa L, Gómez-Lechón MJ, Donato MT (2015) High-content screening technology for studying drug-induced hepatotoxicity in cell models. Archives of Toxicology, 89(7), pp. 1007 - 1022 . ISSN: 0340-5761
- Benet M; Moya M; Donato MT; Lahoz A; Hervás D; Guzmán C; Gómez-Lechón MJ; Castell JV; Jover R (2014) A simple transcriptomic signature able to predict drug-induced hepatic steatosis. Archives of Toxicology, 88(4), pp. 967 - 982 . ISSN: 0340-5761
- Tolosa L, Carmona A, Castell JV, Gómez-Lechón MJ, Donato MT. (2015) High-content screening of drug-induced mitochondrial impairment in hepatic cells: effects of statins. Archives of Toxicology, 89(10), pp. 1847 - 1860 . ISSN: 0340-5761
- Donato MT, Tolosa L, Gómez-Lechón MJ (2015) Culture and functional characterization of human hepatoma HepG2 cells. Methods in Molecular Biology, 1250, pp. 77 - 93 . ISSN: 1064-3745
- Tolosa L, Donato MT, Gómez-Lechón MJ (2015) General cytotoxicity assessment by means of the MTT assay. Methods in Molecular Biology, 1250, pp. 333 - 348 . ISSN: 1064-3745
- García-Cañaveras JC; López S; Castell JV; Donato MT; Lahoz A (2016) Extending metabolome coverage for untargeted metabolite profiling of adherent cultured hepatic cells. Analytical and Bioanalytical Chemistry, 408(4), pp. 1217 - 1230 . ISSN: 1618-2642
- García-Cañaveras JC; Jiménez N; Gómez-Lechón MJ; Castell JV; Donato MT; Lahoz A (2015) LC-MS untargeted metabolomic analysis of drug-induced hepatotoxicity in HepG2 cells. Electrophoresis, 36(18), pp. 2294 - 2302 . ISSN: 0173-0835
- Tolosa L; Gómez-Lechón MJ; Jiménez N; Hervás D; Jover R; Donato MT; (2016) Advantageous use of HepaRG cells for the screening and mechanistic study of drug-induced steatosis. Toxicology and Applied Pharmacology, 302, pp. 1 - 9 . ISSN: 0041-008X
- García-Cañaveras JC; Castell JV; Donato MT; Lahoz A (2016) A metabolomics cell-based approach for anticipating and investigating drug-induced liver injury. Scientific Reports, 6, p. 27239 . ISSN: 2045-2322
- Tolosa L; Gómez-Lechón MJ; López S; Guzmán C; Castell JV; Donato MT; Jover R (2016) Human upcyte hepatocytes: Characterization of the hepatic phenotype and evaluation for acute and long-term hepatotoxicity routine testing. Toxicological Sciences, 152(1), pp. 214 - 229 . ISSN: 1096-6080
- Gómez-Lechón MJ; Tolosa L; Donato MT (2016) Metabolic activation and drug-induced liver injury: in vitro approaches for the safety risk assessment of new drugs. Journal of Applied Toxicology, 36(6), pp. 752 - 768 . ISSN: 0260-437X
- Donato MT, López-Riera M, Castell JV, Gómez-Lechón MJ, Jover R. (2016) Both cholestatic and steatotic drugs trigger extensive alterations in the mRNA level of biliary transporters in rat hepatocytes: Application to develop new predictive biomarkers for early drug development. Toxicology Letters, 263, pp. 58 - 67 . ISSN: 0378-4274
- Gómez-Lechón MJ; Tolosa L; Donato MT (2017) Upgrading HepG2 cells with adenoviral vectors that encode drug-metabolizing enzymes: Application for Drug hepatotoxicity testing. Expert Opinion On Drug Metabolism & Toxicology, 13(2), pp. 137 - 148 . ISSN: 1742-5255
- Donato MT; Gómez-Lechón MJ; Tolosa L (2017) Using high-content screening technology for studying drug-induced hepatotoxicity in preclinical studies. Expert Opinion On Drug Discovery, 12(2), pp. 201 - 211 . ISSN: 1746-0441
- Donato MT (2017) Hepatotoxicidad idiosincrásica por fármacos: promesas y limitaciones de las estrategias in vitro. Anales de la Real Academia Nacional de Farmacia, 83(2), pp. 268 - 283 . ISSN: 1697-4271
- García-Cañaveras JC, Peris-Díaz MD, Alcoriza-Balaguer MI, Cerdán-Calero M, Donato MT, Lahoz A (2017) A lipidomic cell-based assay for studying drug-induced phospholipidosis and steatosis. Electrophoresis, 38(18), pp. 2331 - 2340 . ISSN: 0173-0835
- Tolosa L, Gómez-Lechón MJ, Donato MT (2017) A Multi-Parametric Fluorescent Assay for the Screening and Mechanistic Study of Drug-Induced Steatosis in Liver Cells in Culture. Current Protocols in Toxicology, 72, pp. 14.15.1 - 14.15.11 . ISSN: 1934-9254
- Pérez CL; Donato MT; Hernández I; Paz Lopes MT; Marrero E; Herrera JA; Gómez-Lechón MJ; Rodeiro I (2017) In vitro modulation of the cytochrome P450 and ABCB1/P-glycoprotein activities of the aqueous extract of Allophylus cominia (L) Sw. leaves. Drug Metabolism and Personalized Therapy, 32(4), pp. 201 - 220 . ISSN: 2363-8907
- Pelechá M, Gómez-Lechón MJ, Tolosa L, Donato MT (2017) Hepatocitos Humanos Upcytes como modelo experimental in vitro para el estudio del daño hepático inducido por fármacos a largo plazo. Revista de Toxicología, 34(2), pp. 109 - 117 . ISSN: 0212-7113
- Rodeiro I, Hernández I, Herrera JA, Riera M, Donato MT, Tolosa L, González K, Ansoar Y, Gómez-Lechón MJ, Vanden Berghe W, Lopes M (2018) Assessment of the cytotoxic potential of an aqueous-ethanolic extract from Thalassia testudinum angiosperm marine grown in the Caribbean Sea. Journal of Pharmacy and Pharmacology, 70(11), pp. 1553 - 1560 . ISSN: 0022-3573
- Donato MT, Tolosa L (2019) Stem-cell derived hepatocyte-like cells for the assessment of drug-induced liver injury. Differentiation, 10622, pp. 15 - 22 . ISSN: 0301-4681
- Tolosa L, Jiménez N, Pelechá M, Castell JV, Gómez-Lechón MJ, Donato MT (2019) Long-term and mechanistic evaluation of drug-induced liver injury in Upcyte human hepatocytes. Archives of Toxicology, 93(2), pp. 519 - 532 . ISSN: 0340-5761
- Tolosa L; Jiménez N; Pérez G; Castell JV; Gómez-Lechón MJ; Donato MT (2018) Customised in vitro model to detect human metabolism-dependent idiosyncratic drug-induced liver injury. Archives of Toxicology, 92(1), pp. 383 - 399 . ISSN: 0340-5761
- Donato MT, Bolonio M, Cabezas E, Pelechá M, Pareja E, Domènech A, Castell JV, Gómez-Lechón MJ, Tolosa L (2020) Improved in vivo efficacy of clinical-grade cryopreserved human hepatocytes in mice with acute liver failure. Cytotherapy, 22(2), pp. 114 - 121 . ISSN: 1465-3249
- Donato MT, Tolosa L (2021) Application of high-content screening for the study of hepatotoxicity: Focus on food toxicology. Food and Chemical Toxicology, 147, p. 111872 . ISSN: 0278-6915
- Donato MT, Tolosa L (2021) High-Content Screening for the Detection of Drug-Induced Oxidative Stress in Liver Cells. Antioxidants, 10(1), p. 106 . ISSN: 2076-3921
- Pelechá M; Villanueva-Badenas E; Timor-Lopez E; Donato MT; Tolosa L (2021) Cell models and omics techniques for the study of non-alcoholic fatty liver disease: focusing on stem cell-derived cell models. Antioxidants, 11(1), p. 86 . ISSN: 2076-3921
- Donato MT; Jiménez N; Pelechá M; Tolosa L (2022) Oxidative-stress and long-term hepatotoxicity: comparative study in Upcyte human hepatocytes and hepaRG cells. Archives of Toxicology, 96(4), pp. 1021 - 1037 . ISSN: 0340-5761
- Donato MT; Gallego-Ferrer G; Tolosa L (2022) In Vitro Models for Studying Chronic Drug-Induced Liver Injury. International Journal Of Molecular Sciences, 23(19), p. 11428 . ISSN: 1661-6596
- Villanueva-Bádenas E, Donato MT; Tolosa L (2023) Mechanistic understanding of idiosyncratic drug-induced hepatotoxicity using co-cultures of hepatocytes and macrophages. Antioxidants. ISSN: 2076-3921
- Rodriguez-Fernandez J; Garcia-Legler E; Villanueva-Badenas E: Donato MT; Gomez-Ribelles JL; Salmeron-Sanchez M; Gallego-Ferrer G; Tolosa L. (2023) Primary human hepatocytes-laden scaffolds for the treatment of acute liver failure. Biomaterials Advances. ISSN: 2772-9516
Other publications
- Gómez-Lechón MJ, Tolosa L, Donato MT (2015). Safety risk assessment of hepatotoxicity in early phase of drug development Hepatotoxicity: Symptoms, management and Health implications . (pp. 123 - 159) .
- Donato M.T., Pelechá M., Tolosa L. (2021). Induced pluripotent stem cells in liver disease Advances in Stem Cell Biology. Recent Advances in iPSCs for Therapy, Volume 3 . (pp. 225 - 250) .
Projects
- Innovaliv-Innovative strategies to generate human hepatocytes for treatment of metabolic liver diseases: tools for personalized cell therapy (). 2011 - 2014. VII Programa Marco de la Comisión Europea. . PI: José Vicente Castell.
- Aproximaciones metabonómicas para el estudio de la hepatotoxicidad idiosincrásica con base metabólica y la identificación del agente causal (). 2013 - 2016. Instituto de Salud Carlos III, Fondo de Investigación Sanitaria (FIS).. . PI: M. Teresa Donato.
- Nuevos biomateriales para la mejor de los modelos basados en cultivos celulares hepáticos (). 2014. Colaboración Universidad Politécnica de Valencia -Hospital Universitario y Politécnico. Instituto de investigación sanitaria La Fe. PI: Patricia Rico y Ramiro Jover.
- Hepatotoxicidad idiosincrásica por fármacos: Estrategias in vitro para un diagnóstico retrospectivo, atribución de la causalidad y evaluación del potencial de riesgo clínico en pacientes susceptibles (). 2017 - 2019. Instituto de Salud Carlos III, Fondo de Investigación Sanitaria (FIS).. . PI: M. Teresa Donato.
- Estrategias innovadoras en el estudio de la hepatotoxicidad idiosincrásica inducida por medicamentos (Programa Prometeo (GV)). 2019 - 2022. Conselleria de Educación, investigación, Cultura y Deporte. Generalitat Valenciana.. . PI: M. Teresa Donato Martín.
- Modelos innovadores de células hepáticas humanas en 3D para la predicción mecanística del daño hepático inducido por fármacos (). 2020 - 2023. Ministerio de Ciencia e Innovación y a la Agencia Estatal de Investigación. . PI: M. Teresa Donato Martín.
- Nuevos modelos multicelulares 3D para el estudio de los mecanismos de la enfermedad del hígado graso no alcohólico (). 2023 - 2026. Ministerio de Ciencia e Innovación y a la Agencia Estatal de Investigación. . PI: M. Teresa Donato Martín.
Thesis, minor thesis and research reports
- Pérez de la Fuente, Rubén, (2014). Desarrollo de adenovirus recombinantes para la expresión transitoria de UGT2B7 en cultivos celulares. (Working Master or third cycle over 12 credits). Valencia..
- Cañes Esteve, Laia, (2015). Generación de células hepáticas con capacidad biotransformadora: Aplicación al estudio in vitro de fenotipos de riesgo frente a la hepatotoxicidad por fármacos. (Working Master or third cycle over 12 credits). València..
- García Cañaveras, Juan Carlos, (2015). Metabolomics as a tool for the study of drug-induced hepatotoxicity. (Doctoral Thesis with International Mention). Valencia..
- Parra Gómez, Laura, (2015). Bases bioquímicas y moleculares de la colestasis inducida por fármacos: Exploración del cultivo de hepatocitos en sándwich de colágeno como modelo in vitro para su estudio. (Final Degree work). Valencia..
- Lillo Navarro, Noemí, (2016). Nuevas aproximaciones in vitro para el estudio de la hepatotoxicidad idiosincrásica inducida por fármacos. (Working Master or third cycle over 12 credits). València..
- El Fadalí García, Sara, (2016). Fosfolipidosis y esteatosis inducida por fármacos: Predicción mediante un ensayo in vitro fluorescente. (Working Master or third cycle over 12 credits). València..
- Pelechá Salvador, María, (2017). Hepatocitos humanos® como modelo experimental in vitro para el estudio del daño hepático inducido por fármacos a largo plazo. (Working Master or third cycle over 12 credits). València..
- Escrivà Fernández, Josep, (2017). Avaluació de l'eficàcia de cèl.lules pluripotents diferenciades per a terapia cel.lular hepática. (Working Master or third cycle over 12 credits). València..
- Alcoriza Balaguer, María Isabel, (2017). LipidMS a R package for lipid annotation of LC-MS/MS DIA data. (Working Master or third cycle over 12 credits). València..
- Centelles Lodeiro, Javier, (2017). Estudio mecanístico de la hepatotoxicidad de tiopurinas en modelos celulares. (Working Master or third cycle over 12 credits). València..
- Carretero Martínez, Aitor, (2017). Aproximaciones metabolómicas para el estudio de la enfermedad del hígado graso no alcohólico. Búsqueda de marcadores para su diagnóstico. (Doctoral Thesis). Valencia..
- Moya González, Marina, (2018). Modelos hepáticos para el estudio de la hepatotoxicidad por fármacos: Inducción del estrés oxidativo. (Working Master or third cycle over 12 credits). València..
- Madrid García, Cristina, (2019). Modelos celulares hepáticos para el estudio del daño oxidativo inducido por fármacos. (Working Master or third cycle over 12 credits). València..
- Duaso Inostrosa, Juan Gabriel, (2019). Estudio comparativo de modelos celulares hepáticos para el estudio in vitro de la hepatotoxicidad crónica inducida por fármacos. (Working Master or third cycle over 12 credits). València..
- López Peña, Marta, (2019). Células stem diferenciadas en hepatología: Uso en estudios de toxicidad inducida por fármacos y en terapia celular hepática. (Working Master or third cycle over 12 credits). València..
- Gutiérrez Borrajo, Marta, (2020). Estudio multiparamétrico del daño Inducido por fármacos en hepatocitos derivados de iPSC. (Working Master or third cycle over 12 credits). València..
- Sánchez González, Estela, (2021). Cultivo de células hepáticas en hidrogeles inyectables biomiméticos como modelo in vitro. (Working Master or third cycle over 12 credits). Valencia..
- Pelechá Salvador, María, (2023). Modelos in vitro personalizados basados en células pluripotentes para el estudio de la toxicidad hepática inducida por fármacos de carácter idiosincrásico. (Doctoral Thesis). València..
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