RAMIRO JOVER ATIENZA
PDI-Catedratic/a d'Universitat
PDI-Catedratic/a d'Universitat
Knowledge area: BIOCHEMISTRY AND MOLECULAR BIOLOGY
Department: Biochemistry and Molecular Biology
Department: Biochemistry and Molecular Biology
Departamento Bioquímica y Biología Molecular. Facultad de Medicina y Odontología.
Universitat de València.
Avda. Blasco Ibañez 15, E-46010 Valencia.
96 386 41 86
Unidad Mixta en Hepatología Experimental.
IIS Hospital La Fe.
Torre A, Planta 6ª, Lab. 6.07.
Avenida Fernando Abril Martorell, 106.
E-46026 Valencia.
51397
51397
Subjects taught and teaching methods
Tutorials
| 01/09/2024 - 31/08/2025 |
| MARTES de 09:00 a 12:00 DESPATX Entresuelo planta baja FACULTAT DE MEDICINA I ODONTOLOGIA |
| Observations |
| Participate in the e-tutoring programme of the Universitat de València |
Journal Publications
- van Ertvelde J; Verhoeven A; Maerten A; Cooreman A; Santos Rodrigues BD; Sanz-Serrano J; Mihajlovic M; Tripodi I; Teunis M; Jover R; Luechtefeld T; Vanhaecke T; Jiang J; Vinken M. (2023) Optimization of an adverse outcome pathway network on chemical-induced cholestasis using an artificial intelligence-assisted data collection and confidence level quantification approach. Journal of Biomedical Informatics, 145, p. 104465 . ISSN: 1532-0464
- Pérez-Rubio Á; Soluyanova P; Moro E; Quintás G; Rienda I; Periañez MD; Painel A; Vizuete J; Pérez-Rojas J; Castell JV; Trullenque-Juan R; Pareja E; Jover R. (2023) Gut microbiota and plasma bile acids associated with non-alcoholic fatty liver disease resolution in bariatric surgery patients. Nutrients, 15(14), p. 3187 . ISSN: 2072-6643
- Rodríguez-Agudo R; González-Recio I; Serrano-Maciá M; Bravo M; Petrov P; Blaya D; Herranz JM; Mercado-Gómez M; Rejano-Gordillo CM; Lachiondo-Ortega S; Gil-Pitarch C; Azkargorta M; Van Liempd SM; Martinez-Cruz LA; Simão AL; Elortza F; Martín C; Nevzorova YA; Cubero FJ; Delgado TC; Argemi J; Bataller R; Schoonjans K; Banales JM; Castro RE; Sancho-Bru P; Avila MA; Julve J; Jover R; Mabe J; Simon J; Goikoetxea-Usandizaga N; Martínez-Chantar ML. (2023) Anti-miR-873-5p improves alcohol-related liver disease by enhancing hepatic deacetylation via SIRT1. Jhep Reports, 6(1), p. 100918 . ISSN: 2589-5559
- Rienda I; Ten-Doménech I; Moro E; Moreno-Torres M; Pérez-Rojas J; Pareja E; Pérez-Rubio Á; Trullenque R; Jover R; Lendl B; Pérez-Guaita D; Kuligowski J; Castell JV; Quintás G. (2023) Enhancing the accuracy of mid-infrared spectroscopy liver steatosis quantification using digital image analysis as reference. Analyst, 148(13), pp. 3097 - 3106 . ISSN: 0003-2654
- Crespo-Masip M; Pérez-Gómez A; Guzmán C; Rayego S; Doladé N; García-Carrasco A; Jover R; Valdivielso JM (2022) PTEN Deletion in Adult Mice Induces Hypoinsulinemia With Concomitant Low Glucose Levels. Frontiers In Endocrinology, 13, pp. 1 - 13 . ISSN: 1664-2392
- Crespo-Masip M; Perez-Gomez A; Garcia-Carrasco A; Jover R; Guzmán C; Dolcet X; Ibarz M; Martínez C; Eritja À; Diaz-Tocados JM; Valdivielso JM (2022) Elimination of Vitamin D Signaling Causes Increased Mortality in a Model of Overactivation of the Insulin Receptor: Role of Lipid Metabolism. Nutrients, 14(7), pp. 1 - 16 . ISSN: 2072-6643
- Rodríguez-Agudo R; Goikoetxea-Usandizaga N; Serrano-Maciá M; Fernández-Tussy P; Fernández-Ramos D; Lachiondo-Ortega S; González-Recio I; Gil-Pitarch C; Mercado-Gómez M; Morán L; Bizkarguenaga M; Lopitz-Otsoa F; Petrov P; Bravo M; Van Liempd SM; Falcon-Perez JM; Zabala-Letona A; Carracedo A; Castell JV; Jover R; Martínez-Cruz LA; Delgado TC; Cubero FJ; Lucena MI; Andrade RJ; Mabe J; Simón J; Martínez-Chantar (2022) Methionine cycle rewiring by targeting miR-873-5p modulates ammonia metabolism to protect the liver from acetaminophen. Antioxidants, 11(5), p. 897 . ISSN: 2076-3921
- Mercado-Gómez M; Prieto-Fernández E; Goikoetxea-Usandizaga N; Vila-Vecilla L; Azkargorta M; Bravo M; Serrano-Maciá M; Egia-Mendikute L; Rodríguez-Agudo R; Lachiondo-Ortega S; Lee SY; Eguileor Giné A; Gil-Pitarch C; González-Recio I; Simón J; Petrov P; Jover R; Martínez-Cruz LA; Ereño-Orbea J; Delgado TC; Elortza F; Jiménez-Barbero J; Nogueiras R; Prevot V; Palazon A; Martínez-Chantar ML (2022) The spike of SARS-CoV-2 promotes metabolic rewiring in hepatocytes. Communications Biology, 5(1), p. 827 . ISSN: 2399-3642
- Quintás G; Caiment F; Rienda I; Pérez-Rojas J; Pareja E; Castell JV; Jover R. (2022) Quantitative prediction of steatosis in patients with non-alcoholic fatty liver by means of hepatic microRNAs present in serum and correlating with hepatic fat. International Journal Of Molecular Sciences, 23(16), p. 9298 . ISSN: 1661-6596
- González-Recio I; Simón J; Goikoetxea-Usandizaga N; Serrano-Maciá M; Mercado-Gómez M; Rodríguez-Agudo R; Lachiondo-Ortega S; Gil-Pitarch C; Fernández-Rodríguez C; Castellana D; Latasa MU; Abecia L; Anguita J; Delgado TC; Iruzubieta P; Crespo J; Hardy S; Petrov PD; Jover R; Avila MA; Martín C; Schaeper U; Tremblay ML; Dear JW; Masson S; McCain MV; Reeves HL; Andrade RJ; Lucena MI; Buccella D; Martínez-Cruz LA; Martínez-Chantar ML. (2022) Restoring cellular magnesium balance through Cyclin M4 protects against acetaminophen-induced liver damage. Nature Communications, 13(1), p. 6816 . ISSN: 2041-1723
- Marta Moreno-Torres; Carla Guzmán; Petar D. Petrov; Ramiro Jover (2022) Valproate and Short-Chain Fatty Acids Activate Transcription of the Human Vitamin D Receptor Gene through a Proximal GC-Rich DNA Region Containing Two Putative Sp1 Binding Sites. Nutrients, 14(13), pp. 1 - 15 . ISSN: 2072-6643
- R. Jover, P. Soluyanova, E. Moro-Castaño, M. Moreno-Torres, A.V. Marco-Hernández, M. Tomas-Vila, J.V. Castell (2022) SOC-V-11 New serum miRNA biomarkers to predict liver steatosis by valproic acid in paediatric epileptic patients. Toxicology Letters, 368(2), p. 68 . ISSN: 0378-4274
- Vinken M; Benfenati E; Busquet F; Castell J; Clevert DA; de Kok TM; Dirven H; Fritsche E; Geris L; Gozalbes R; Hartung T; Jennen D; Jover R; Kandarova H; Kramer N; Krul C; Luechtefeld T; Masereeuw R; Roggen E; Schaller S; Vanhaecke T; Yang C; Piersma AH. (2021) Safer chemicals using less animals: kick-off of the European ONTOX project. Toxicology, 458, p. 152846 . ISSN: 0300-483X
- Juárez-Fernández M; Porras D; Petrov P; Román-Sagüillo S; García-Mediavilla MV; Soluyanova P; Martínez-Flórez S; González-Gallego J; Nistal E; Jover R; Sánchez-Campos S (2021) The Synbiotic combination of Akkermansia muciniphila and quercetin ameliorates early obesity and NAFLD through gut microbiota reshaping and bile acid metabolism modulation. Antioxidants, 10(12), p. 2001 . ISSN: 2076-3921
- Petrov PD; Soluyanova P; Sánchez-Campos S; Castell JV; Jover R (2021) Molecular mechanisms of hepatotoxic cholestasis by clavulanic acid: Role of NRF2 and FXR pathways. Food and Chemical Toxicology, 158, p. 112664 . ISSN: 0278-6915
- Pérez-Guaita D; Moreno-Torres M; Jover R; Pareja E; Lendl B; Kuligowski J; Quintás G; Castell JV (2020) Toward rapid screening of liver grafts at the operating room using mid-infrared spectroscopy. Analytical Chemistry, 92(21), pp. 14542 - 14549 . ISSN: 0003-2700
- Martínez-Sena T; Soluyanova P; Guzmán C; Valdivielso JM; Castell JV; Jover R (2020) The Vitamin D Receptor Regulates Glycerolipid and Phospholipid Metabolism in Human Hepatocytes. Biomolecules, 10(3), p. 493 . ISSN: 2218-273X
- Petrov PD; Fernández-Murga ML; Conde I; Martínez-Sena T; Guzmán C; Castell JV; Jover R (2020) Epistane, an anabolic steroid used for recreational purposes, causes cholestasis with elevated levels of cholic acid conjugates, by upregulating bile acid synthesis (CYP8B1) and cross-talking with nuclear receptors in human hepatocytes. Archives of Toxicology, 94(2), pp. 589 - 607 . ISSN: 0340-5761
- López-Riera M; Conde I; Castell JV; Jover R (2020) A novel microRNA signature for cholestatic drugs in human hepatocytes and its translation into novel circulating biomarkers for drug-induced liver injury patients. Toxicological Sciences, 173(2), pp. 229 - 243 . ISSN: 1096-6080
- Petrov PD; García-Mediavilla MV; Guzmán C; Porras D; Nistal E; Martínez-Flórez S; Castell JV; González-Gallego J; Sánchez-Campos S; Jover R (2019) A network involving gut microbiota, circulating bile acids, and hepatic metabolism genes that protects against non-alcoholic fatty liver disease. Molecular Nutrition & Food Research, 63(20), p. e1900487 . ISSN: 1613-4125
- Porras D; Nistal E; Martínez-Flórez S; Olcoz JL; Jover R; Jorquera F; González-Gallego J; García-Mediavilla MV; Sánchez-Campos S (2019) Functional Interactions between Gut Microbiota Transplantation, Quercetin, and High-Fat Diet Determine Non-Alcoholic Fatty Liver Disease Development in Germ-Free Mice. Molecular Nutrition & Food Research, 63(8), p. e1800930 . ISSN: 1613-4125
- García-Monzón C; Petrov PD; Rey E; Marañón P; Pozo-Maroto ED; Guzmán C; Rodríguez de Cía J; Casado-Collado AJ; Vargas-Castrillón J; Saez A; Miquilena-Colina ME; Lo Iacono O; Castell JV; González-Rodríguez Á; Jover R (2018) Angiopoietin-like protein 8 is a novel vitamin D receptor target gene involved in non-alcoholic fatty liver pathogenesis. American Journal of Pathology, 188(12), pp. 2800 - 2810 . ISSN: 0002-9440
- López-Riera M; Conde I; Quintas G; Pedrola L; Zaragoza Á; Perez-Rojas J; Salcedo M; Benlloch S; Castell JV; Jover R (2018) Non-invasive prediction of NAFLD severity: a comprehensive, independent validation of previously postulated serum microRNA biomarkers. Scientific Reports, 8(1), p. 10606 . ISSN: 2045-2322
- Fernández-Murga ML; Petrov PD; Conde I; Castell JV; Goméz-Lechón MJ; Jover R (2018) Advances in drug-induced cholestasis: Clinical perspectives, potential mechanisms and in vitro systems. Food and Chemical Toxicology, 120, pp. 196 - 212 . ISSN: 0278-6915
- Petrov PD; Fernández-Murga ML; López-Riera M; Goméz-Lechón MJ; Castell JV; Jover R (2018) Predicting drug-induced cholestasis: preclinical models. Expert Opinion On Drug Metabolism & Toxicology, 14(7), pp. 721 - 738 . ISSN: 1742-5255
- López-Riera M; Conde I; Tolosa L; Zaragoza A; Castell JV; Gómez-Lechón MJ; Jover R (2017) New microRNA biomarkers for drug-induced steatosis and their potential to predict the contribution of drugs to non-alcoholic fatty liver disease. Frontiers In Pharmacology, 8(3), pp. 1 - 12 . ISSN: 1663-9812
- Porras D; Nistal E; Martínez-Flórez S; Pisonero-Vaquero S; Olcoz JL; Jover R; González-Gallego J; García-Mediavilla MV; Sánchez-Campos S (2017) Protective effect of quercetin on high-fat diet-induced non-alcoholic fatty liver disease in mice is mediated by modulating intestinal microbiota imbalance and related gut-liver axis activation. Free Radical Biology and Medicine, 102, pp. 188 - 202 . ISSN: 0891-5849
- Colleypriest BJ; Burke ZD; Griffiths LP; Chen Y; Yu WY; Jover R; Bock M; Biddlestone L; Quinlan JM; Ward SG; Mark Farrant J; Slack JM; Tosh D (2017) Hnf4α is a key gene that can generate columnar metaplasia in oesophageal epithelium. Differentiation, 93, pp. 39 - 49 . ISSN: 0301-4681
- Ramiro Jover (2017) Esteatosis y colestasis inducida por medicamentos: mecanismos y biomarcadores. Anales de la Real Academia Nacional de Farmacia, 83(2), pp. 284 - 293 . ISSN: 1697-4271
- Bozic M; Guzmán C; Benet M; Sánchez-Campos S; García-Monzón C; Gari E; Gatius S; Valdivielso JM; Jover R (2016) Hepatocyte vitamin D receptor regulates lipid metabolism and mediates experimental diet-induced steatosis. Journal of Hepatology, 65(4), pp. 748 - 757 . ISSN: 0168-8278
- Donato MT, López-Riera M, Castell JV, Gómez-Lechón MJ, Jover R. (2016) Both cholestatic and steatotic drugs trigger extensive alterations in the mRNA level of biliary transporters in rat hepatocytes: Application to develop new predictive biomarkers for early drug development. Toxicology Letters, 263, pp. 58 - 67 . ISSN: 0378-4274
- Tolosa L; Gómez-Lechón MJ; López S; Guzmán C; Castell JV; Donato MT; Jover R (2016) Human upcyte hepatocytes: Characterization of the hepatic phenotype and evaluation for acute and long-term hepatotoxicity routine testing. Toxicological Sciences, 152(1), pp. 214 - 229 . ISSN: 1096-6080
- Tolosa L; Gómez-Lechón MJ; Jiménez N; Hervás D; Jover R; Donato MT; (2016) Advantageous use of HepaRG cells for the screening and mechanistic study of drug-induced steatosis. Toxicology and Applied Pharmacology, 302, pp. 1 - 9 . ISSN: 0041-008X
- Benet M, Jover R, Bort R. (2015) Transfection of Primary Hepatocytes with Liver-Enriched Transcription Factors Using Adenoviral Vectors. Methods in Molecular Biology, 1250, pp. 213 - 221 . ISSN: 1064-3745
- Sangan CB; Jover R; Heimberg H; Tosh D (2015) In vitro reprogramming of pancreatic alpha cells towards a beta cell phenotype following ectopic HNF4α expression. Molecular and Cellular Endocrinology, 399, pp. 50 - 59 . ISSN: 0303-7207
- Benet M; Guzmán C; Pisonero-Vaquero S; García-Mediavilla MV; Sánchez-Campos S; Martínez-Chantar ML; Donato MT; Castell JV; Jover R (2015) Repression of the nuclear receptor small heterodimer partner by steatotic drugs and in advanced nonalcoholic fatty liver disease. Molecular Pharmacology, 87(4), pp. 582 - 594 . ISSN: 0026-895X
- Pisonero-Vaquero S; Martínez-Ferreras Á; García-Mediavilla MV; Martínez-Flórez S; Fernández A; Benet M; Olcoz JL; Jover R; González-Gallego J; Sánchez-Campos S (2015) Quercetin ameliorates dysregulation of lipid metabolism genes via the PI3K/AKT pathway in a diet-induced mouse model of nonalcoholic fatty liver disease. Molecular Nutrition & Food Research, 59(5), pp. 879 - 893 . ISSN: 1613-4125
- Moscardó A; Vallés J; Latorre A; Jover R; Santos MT (2015) The histone deacetylase sirtuin 2 is a new player in the regulation of platelet function. Journal Of Thrombosis And Haemostasis, 13(7), pp. 1335 - 1344 . ISSN: 1538-7933
- Pisonero-Vaquero S; García-Mediavilla MV; Jorquera F; Majano PL; Benet M; Jover R; González-Gallego J; Sánchez-Campos S (2014) Modulation of PI3K-LXRα-dependent lipogenesis mediated by oxidative/nitrosative stress contributes to inhibition of HCV replication by quercetin. Laboratory Investigation, 94(3), pp. 262 - 274 . ISSN: 0023-6837
- Benet M; Moya M; Donato MT; Lahoz A; Hervás D; Guzmán C; Gómez-Lechón MJ; Castell JV; Jover R (2014) A simple transcriptomic signature able to predict drug-induced hepatic steatosis. Archives of Toxicology, 88(4), pp. 967 - 982 . ISSN: 0340-5761
- M. Moreno Torres; E. Lopez Pascual; A. S. Rapisarda; G. López; T. Bozada Jr; J. Jiang; J. van Ertvelde; I.-L. Steffensen; B. Lindeman; T. Luechtefeld; H. Dirven; M. Vinken; R. Jover (2023) OS02 | Short Orals Session 2 OS02-01 Novel clinical phenotypes and chemical classifications in drug-induced cholestasis: analysis of a database of 390 patients developed by collaborative literature review and machine learning support. Toxicology Letters, 384S1, pp. S63 - S64 . ISSN: 0378-4274
- T. Martinez-Sena; E. Moro; M. Moreno-Torres; G. Quintas; J. Hengstler; R. Jover; J. V. Castell Ripoll (2023) P16-55. Using Metabolomics to Uncover Ontogeny of Drug-Induced Hepatotoxicity and Underlying AOP Mechanisms. Toxicology Letters, 384S1, pp. S207 - S207 . ISSN: 0378-4274
Projects
- ONTOX: Ontology-driven and artificial intelligence-based repeated dose toxicity testing of chemicals for next generation risk assessment (Biomedical sciences and health. BIOMED.). 2021 - 2026. Comisión Europea, Programa H2020. . PI: Ramiro Jover y José Vicente Castell.
- Factores de susceptibilidad y biomarcadores no invasivos para la esteatosis hepática inducida por valproato en pacientes pediátricos con epilepsia (Programa Nacional de Salud). 2021 - 2023. Fondo de Investigación Sanitaria (FIS), Instituto de Salud Carlos III. Instituto de Salud Carlos III, Fondo de Investigación Sanitaria (FIS).. PI: Ramiro Jover Atienza.
- Nuevos mecanismos y biomarcadores diagnósticos en la colestasis iatrogénica (Programa Nacional de Salud). 2018 - 2020. Fondo de Investigación Sanitaria (FIS), Instituto de Salud Carlos III. Instituto de Salud Carlos III, Fondo de Investigación Sanitaria (FIS).. PI: Ramiro Jover Atienza.
- Esteatosis hepática por medicamentos: nuevos mecanismos y biomarcadores aplicables al desarrollo farmacéutico y a una terapia más racional en pacientes con síndrome metabólico (Programa Nacional de Salud). 2014 - 2016. Fondo de Investigación Sanitaria (FIS), Instituto de Salud Carlos III. Instituto de Salud Carlos III, Fondo de Investigación Sanitaria (FIS).. PI: Ramiro Jover Atienza.
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