SERGIO RIUS PEREZ
PDI-Ajudant Doctor/A
Biologia Cel.lular i Biologia Funcional, Facultat de Ciencies Biologiques
PDI-Ajudant Doctor/A
Biologia Cel.lular i Biologia Funcional, Facultat de Ciencies Biologiques
44887
Subjects taught and teaching methods
Academic training
- Graduado en Bioquímica y Ciencias Biomédicas. Universitat de Valéncia. (Diploma / Degree / Activities).
- Doctor en Fisiologia. Universidad de Valencia. (Ph.D.).
- Máster en Fisiología. Universitat de Valéncia. (Official Master).
Journal Publications
- Rius-Pérez S, Tormos AM, Pérez S, Taléns-Visconti R. (2018) Vascular pathology: Cause or effect in Alzheimer disease?. Neurologia, 33(2), pp. 112 - 120 . ISSN: 0213-4853
- Pérez S, Taléns-Visconti R, Rius-Pérez S, Finamor I, Sastre J. (2017) Redox signaling in the gastrointestinal tract. Free Radical Biology and Medicine, 104, pp. 75 - 103 . ISSN: 0891-5849
- Tormos AM, Rius-Pérez S, Jorques M, Rada P, Ramirez L, Valverde AM, Nebreda AR, Sastre J and Taléns-Visconti R. (2017) p38alpha regulates actin cytoskeleton and cytokinesis in hepatocytes during development and aging. Plos One, 12(2)(e0171738), pp. 1 - 22 . ISSN: 1932-6203
- Finamor I; Pérez S; Bressan CA; Brenner CE; Rius-Pérez S; Brittes PC; Cheiran G; Rocha MI; da Veiga M; Sastre J; Pavanato MA (2017) Chronic aspartame intake causes changes in the trans-sulphuration pathway, glutathione depletion and liver damage in mice. Redox Biology, 11, pp. 701 - 707 . ISSN: 2213-2317
- Pérez S, Rius-Pérez S, Tormos AM, Finamor I, Nebreda AR, Taléns-Visconti R, Sastre J. (2018) Age-dependent regulation of antioxidant genes by p38α MAPK in the liver. Redox Biology, 16, pp. 276 - 284 . ISSN: 2213-2317
- Rius-Pérez S, Tormos AM, Pérez S, Finamor I, Rada P, Valverde AM, Nebreda AR, Sastre J and Taléns-Visconti R. (2019) p38α deficiency restrains liver regeneration after partial hepatectomy triggering oxidative stress and liver injury. Scientific Reports, 9(1)(3775), pp. 1 - 11 . ISSN: 2045-2322
- Aliena-Valero A; Rius-Pérez S; Pérez S; Torregrosa G; Salom JB (2019) Optimised lyophilisation-based method for different biomolecule single-extractions from the same rat brain sample: Suitability for RNA and protein expression analyses after ischemic stroke. Journal of Neuroscience Methods, 327, p. 108402 . ISSN: 0165-0270
- Rius-Pérez S, Pérez S, Torres-Cuevas I, Martí-Andrés P, Taléns-Visconti R, Paradela A, Guerrero L, Franco L, López-Rodas G, Torres L, Corrales F, Sastre J. (2020) Blockade of the trans-sulfuration pathway in acute pancreatitis due to nitration of cystathionine β-synthase. Redox Biology, 28(101324), pp. 1 - 9 . ISSN: 2213-2317
- Salvador Pérez Garrido; Sergio Rius Pérez; Isabela Finamor; Pablo Martí Andrés; Ignacio Prieto; Raquel García; María Monsalve; Juan Sastre Belloch. (2019) Obesity causes PGC-1α deficiency in the pancreas leading to marked IL-6 upregulation via NF-κB in acute pancreatitis. Journal of Pathology, 247(1), pp. 48 - 59 . ISSN: 0022-3417
- Rius-Pérez S; Torres-Cuevas I; Millán I; Ortega ÁL; Pérez S. (2020) PGC-1α, Inflammation, and Oxidative Stress: An Integrative View in Metabolism. Oxidative Medicine And Cellular Longevity. ISSN: 1942-0900
- Sergio Rius-Pérez; Isabel Torres-Cuevas; María Monsalve; Francisco J. Miranda; Salvador Pérez (2020) Impairment of PGC-1 Alpha Up-Regulation Enhances Nitrosative Stress in the Liver during Acute Pancreatitis in Obese Mice. Antioxidants(9 (9)), p. 887 . ISSN: 2076-3921
- Alicia Aliena-Valero; Sergio Rius-Pérez; Júlia Baixauli-Martín; Germán Torregrosa; Ángel Chamorro; Salvador Pérez; Juan B Salom (2021) Uric acid neuroprotection associated to IL-6/STAT3 signaling pathway activation in rat ischemic stroke. Molecular Neurobiology, 58(1), pp. 408 - 423 . ISSN: 0893-7648
- Rius-Pérez S; Pérez S; Martí-Andrés P; Monsalve M; Sastre J (2020) Nuclear Factor Kappa B Signaling Complexes in Acute Inflammation. Antioxidants & Redox Signaling, 33(3) . ISSN: 1523-0864
- González R., Rodríguez-Hernández M.A., Negrete M., Ranguelova K., Rossin A., Choya-Foces C., de la Cruz-Ojeda P., Miranda-Vizuete A., Martínez-Ruiz A., Rius-Pérez S., Sastre J. , Bárcena J.A., Hueber A.O. , Padilla C.A., Muntané J. (2020) Downregulation of thioredoxin-1-dependent CD95 S-nitrosation by Sorafenib Reduces Liver Cancer. Redox Biology, 34(101528) . ISSN: 2213-2317
- Fernández-Rodríguez S; Cano-Cebrián MJ; Rius-Pérez S; Pérez S; Guerri C; Granero L; Zornoza T; Polache A. (2022) Different brain oxidative and neuroinflammation status in rats during prolonged abstinence depending on their ethanol relapse-like drinking behavior: Effects of ethanol reintroduction. Drug and Alcohol Dependence, 232, p. 109284 . ISSN: 0376-8716
- Isabela Finamor; Caroline Bressan; Isabel Torres Cuevas; Sergio Rius Pérez; Marcelo Veiga; Maria Rocha; Maria Amalia Pavanato; Salvador Pérez Garrido. (2021) Long-Term Aspartame Administration Leads to Fibrosis, Inflammasome Activation, and Gluconeogenesis Impairment in the Liver of Mice. Biology-Basel. ISSN: 2079-7737
- Pérez S; Rius-Pérez S (2022) Macrophage Polarization and Reprogramming in Acute Inflammation: A Redox Perspective. Antioxidants. ISSN: 2076-3921
- Rius-Pérez S; Pérez S; Toledano MB; Sastre J (2022) p53 drives necroptosis via downregulation of sulfiredoxin and peroxiredoxin 3. Redox Biology, 56, pp. 102423-1 - 10 . ISSN: 2213-2317
- Rius-Pérez S; Pérez S; Toledano M; Sastre J (2023) Mitochondrial Reactive Oxygen Species and Lytic Programmed Cell Death in Acute Inflammation. Antioxidants & Redox Signaling. ISSN: 1523-0864
- Pablo Martí-Andrés; Isabela Finamor; Isabel Torres-Cuevas; Salvador Pérez; Sergio Rius-Pérez; Hildegard Colino-Lage; David Guerrero-Gómez; Esperanza Morato; Anabel Marina; Patrycja Michalska; Rafael León; Qing Cheng; Eszter Petra Jurányi; Klaudia Borbényi-Galambos; Iván Millán; Péter Nagy; Antonio Miranda-Vizuete; Edward E Schmidt; Antonio Martínez-Ruiz; Elias SJ Arnér and Juan Sastre (2024) TRP14 is the rate-limiting enzyme for intracellular cystine reduction and regulates proteome cysteinylation. Embo Journal. ISSN: 0261-4189
- Iván Millan; Salvador Pérez; Sergio Rius-Pérez; Miguel Ángel Asensi; Máximo Vento; José Manuel García-Verdugo;Isabel Torres-Cuevas. (2024) Postnatal hypoxic preconditioning attenuates lung damage from hyperoxia in newborn mice. Pediatric Research. ISSN: 0031-3998
- Sergio Rius-Pérez (2023) p53 at the crossroad between mitochondrial reactive oxygen species and necroptosis. Free Radical Biology and Medicine. ISSN: 0891-5849
- Juan Sastre; Salvador Pérez; Luis Sabater; Sergio Rius-Pérez (2025) Redox signalling in the pancreas in health and disease. Physiological Reviews, 105(2), pp. 593 - 650 . ISSN: 0031-9333
- Juan Sastre; Salvador Pérez; Luis Sabater; Sergio Rius-Pérez (2025) Redox signalling in the pancreas in health and disease. Physiological Reviews, 105(2), pp. 593 - 650 . ISSN: 0031-9333
Stays abroad in Research Centers
- Paris. FRANCE, 2019. Subclonación de genes en S. cerevisiae. Estudio de glutationilación de proteínas mediante química click.. **Doctorand.
- Madrid. SPAIN, 2016. Aislamiento de hepatocitos de ratón. Cultivo primario de hepatocitos. Silenciamiento génico mediante siRNA.. **Doctorand.
- Barcelona. SPAIN, 2022. Estudios de dinámica mitocondrial y reprogramación metabólica.. **Post-doctoral.
Participations in Conferences
- P. Martí-Andrés, S. Pérez, S. Rius, R. Taléns-Visconti, J. Sastre. (2016). TNF-alpha upregulation is abrogated by γ-glutamylcysteine in acute pancreatitis. (Communication). 6th Congress of UV Pharmacy Students - 4th International Edition Book of Abstracts 2016; pag 91, O10. ISSN: 2254-2280 . Valencia . SPAIN
- Rius-Pérez S, Tormos A.M., Finamor I., Taléns-Visconti R., Sastre J. (2016). Role of p38 alpha in the regulation of liver regeneration after partial hepatectomy. (Communication). 6th Congress of UV Pharmacy Students - 4th International Edition Book of Abstracts 2016; pag 92, O11. ISSN: 2254-2280 . Valencia . SPAIN
- Salvador Pérez, Isabela Finamor, Sergio Rius-Pérez, Pablo Martí-Andrés, Raquel Taléns, Juan Sastre (2016). Gamma Glutamyl cysteine suppresses TNF-alpha up-regulation via protein phosphatases in acute pancreatitis. (Poster). SFRR- Europe 2016 Meeting Free Radical Biology and Medicine 96, Supplement 1, July 2016, S62; P-71 http://dx.doi.org/10.1016/j.freeradbiomed.2016.04.134 . Budapest . HUNGARY
- Pablo Martí-Andrés, Salador Pérez, Isabela Finamor, Sergio Rius-Pérez, Raquel Taléns, Juan Sastre (2016). γ-Glutamylcysteine exhibits anti-inflammatory effects via down-regulation of TNF-α and the JNK pathway in acute pancreatitis. (Communication). 76th FIP World Congress of Pharmacy and Pharmaceutical Sciences . Buenos Aires . ARGENTINA
- Sergio Rius-Pérez, Salvador Pérez, Ana-Martínez Tormos, Raquel Taléns-Visconti, Juan Sastre. (2016). Regulation of the antioxidant defense in the liver by p38α and NF-κB. (Communication). XI Reunión del Grupo Español de Investigación en Radicales Libres (GEIRLI) Libro de comunicaciones 2016, CO9, pg 44 . Granada . SPAIN
- Pablo Martí-Andrés; Salvador Pérez; Sergio Rius; Raquel Taléns; Juan Sastre (2016). TNF-alpha upregulation is abrogated by gamma-glutamyl cysteine in acute pancreatitis. (Communication). 6th Congress of Pharmacy Students - 4th international Edition . Valencia . SPAIN
- Sergio Rius-Pérez; Salvador Pérez; Isabela Finamor; Ana M. Tormos; Pablo Martí-Andrés; Raquel Taléns-Visconti; Juan Sastre (2017). NF-κB regulates liver antioxidant gene expression via p38α with aging. (Communication). 7th Congress of UV Pharmacy Students - 5th International Edition Book of Abstracts 2017; pag 46. ISSN: 2254-2280 . Valencia . SPAIN
- Salvador Pérez, Sergio Rius-Pérez, Isabela Finamor, Ana Martínez, Pablo Martí-Andrés, Ángel Nebreda, Raquel Taléns, Juan Sastre (2017). p38α and NF-κB regulate antioxidant defense in the liver through an age-dependent mechanism. (Poster). Anual Meeting of the SFRR-Europe Free Radical Biology and Medicine 108, Supplement 1, July 2017, S47; P-088 https://doi.org/10.1016/j.freeradbiomed.2017.04.173 . Berlin . GERMANY
- Isabela Finamor, Salvador Pérez, Pablo Martí-Andrés, Anabel Gil, Mari Luz Moreno, Sergio Rius-Pérez, Rafael León, Gethin Mcbean, Antonio Martínez-Ruíz, Juan Sastre (2017). Acute pancreatitis and cystinosis as experimental models of disulfide stress characterized by protein cysteinylation. (Communication). Anual Meeting of the SFRR-Europe . GERMANY
- P. Martí-Andrés, Salvador Pérez, I. Finamor, S. Rius-Pérez, J. Sastre (2017). Gamma-glutamylcysteine prevents the activation of the JNK pathway whilst recovering protein phosphatase levels in acute pancreatitis. (Poster). Gordon Research Conference on 'Oxidative stress and disease' . Lucca . ITALY
- Sergio Rius-Pérez; Salvador Pérez; Isabela Finamor; Ana-Martínez Tormos; Pablo Martí-Andrés; Ángel R. Nebreda; Raquel Taléns-Visconti; Juan Sastre (2017). p38alpha regulates liver antioxidant gene expression via NF-kappaB through an age-dependent mechanism. (Poster). Gordon Research Conference on 'Oxidative stress and disease' Book of abstracts . Lucca (Barga) . ITALY
- P. Martí-Andrés, S. Pérez, I. Finamor, S. Rius-Pérez, J. Pereda, A. Campos, R. Domingues, L. Sabater, J. Sastre (2017). Ascitic fluid triggers the release of extracellular nucleosomes in acute pancreatitis. Role of obesity. (Communication). VII Congreso de Estudiantes de Farmacia de la UV. 5ª Edición Internacional . Valencia . SPAIN
- Martí-Andrés P, Finamor I, Espinosa B, Pérez S, Rius-Pérez S, Taléns-Visconti R, León R, Martínez-Ruiz A, Arnér E, Sastre, J (2018). Thioredoxin-related protein of 14 kDa may directly reduce protein cysteinylation motifs. (Communication). Anual Meeting of the SFRR-Europe Free Radical Biology and Medicine 120, Supplement 1, 2018, Page S34; OP-15. http://dx.doi.org/10.1016/j.freeradbiomed.2018.04.116 . Lisboa . PORTUGAL
- Rius-Pérez S, Pérez S, Martí-Andrés P, Finamor I, Taléns-Visconti R, Cuadrado A, Toledano MB, Sastre J. (2018). Time-course of thiol oxidation of protein phosphatases during cerulein-induced acute pancreatitis. (Poster). Anual Meeting of the SFRR-Europe Free Radical Biology and Medicine 120, Supplement 1, 2018, Page S143; P-324. https://doi.org/10.1016/j.freeradbiomed.2018.04.471 . Lisboa . PORTUGAL
- Isabela Finamor, Salvador Pérez, Caroline Azzolin Bressan, Sergio Rius-Pérez, Pablo Martí-Andrés, Juan Sastre, Maria Amália Pavanato (2018). Chronic aspartame intake causes deficient glutathione synthesis and induces cxcl1 up-regulation in mice liver. (Poster). Anual Meeting of the SFRR-Europe . Lisboa . PORTUGAL
- Sergio Rius (2018). Redox signaling in acute pancreatitis. (Communication). Redox biology as a major drive to the understanding of pathophysiology: Contributions from the CONSOLREDOX network . Salamanca . SPAIN
- Alicia Aliena-Valero, Sergio Rius-Pérez, Salvador Pérez, Germán Torregrosa, Juan B. Salom (2019). Optimised lyophilisation-based method for different biomolecule single-extractions from the same rat brain sample: suitability for RNA and protein expression analyses after ischemic stroke. (Communication). III Congreso Anual INVICTUS+ ISCIII . Santiago de Compostela . SPAIN
- Isabel Torres Cuevas; Sergio Rius Perez; Salvador Perez Garrido; Ivan Millan; Elena Cubells; Jose Manuel Garcia Verdugo; Maximo Vento. (2019). Perinatal hypoxic preconditioning in a mice model preserves lung surfactant and reduces oxidative stress after an intense and prolongated hyperoxic insult. (Communication). Pediatric Academic Societies Annual Meeting . UNITED STATES
- Rius-Pérez S, Pérez S, Torres-Cuevas I, Martí-Andrés P, Taléns-Visconti R, Paradela A, Guerrero L, Franco L, López-Rodas G, Torres L Corrales F, Sastre J. (2021). Nitration of cystathionine β-synthase in acute pancreatitis. (Communication). SFRR-International Free Radical Biology and Medicine 165, Supplement 1, 2021, Page 36; NC36. https://doi.org/10.1016/j.freeradbiomed.2020.12.354 . virtual meeting . **Sense Especificar
- Fernández-Rodríguez S, Zornoza T, Pérez S, Rius-Pérez S, Guerri C, Cano-Cebrián MJ, Polache A (2021). Discovery and characterization of ADE and non-ADE rats under longterm alcohol exposure protocol. Biochemical differences in rat brain during alcohol abstinence. (Paper). 18th European Society for Biomedical Research on Alcoholism Conference Abstract book . Timisoara . ROMANIA
- Rius-Pérez S, Torres-Cuevas I, Pérez S, Martí-Andrés P, Taléns R, Paradela A, Guerrero L, Franco L, López-Rodas G, Torres L, Corrales F, Sastre J. (2021). S-Adenosyl methionine administration enhances nitrosative stress in acute pancreatitis leading to blockade of the trans-sulfuration pathway and accumulation of homocysteine. (Poster). Anual Meeting of the SFRR-Europe Free Radical Biology and Medicine 177, Supplement 1, 2021, Page S128; PP137. https://doi.org/10.1016/j.freeradbiomed.2021.08.212 . Belgrade . SERBIA
- Sergio Rius Pérez; Salvador Pérez Garrido; Pablo Martí Andrés; Isabela Finamor; Ignacio Prieto; Raquel García; María Monsalve; Juan Sastre Belloch. (2021). Blockade of IL-6 abrogates pancreatic and lung damage caused by acute pancreatitis in PGC-1α knock-out mice. (Paper). Anual Meeting of the SFRR-Europe . SERBIA
- Pablo Martí Andrés; Salvador Pérez Garrido; Isabela Finamor; Isabel Torres Cuevas; Sergio Rius Pérez; Antonio Martínez Ruiz; Edward Schmidt; Elias Arner; Juan Sastre Belloch. (2021). TRP14 deficiency markedly reduces the inflammatory response in acute pancreatitis through Nrf2 activation. (Paper). Anual Meeting of the SFRR-Europe . SERBIA
- Sergio Rius Pérez; Salvador Pérez Garrido; Pablo Martí Andrés; Isabela Finamor; Ignacio Prieto; Raquel García; María Monsalve; Juan Sastre Belloch. (2021). Obesidad causa PGC-1α deficiency en exocrine pancreas leading to IL-6 upregulación vía NF-κB in acute pancreatitis. (Paper). 20th Biennial Meeting of Society for Free Radical Research International . ENGLAND
- Claudia Esposito Zapero; Sandra Fernandez Rodriguez; Salvador Pérez Garrido; Sergio Rius Pérez; Ana Polache; Teodoro Zornoza; María José Cano Cebrián. (2021). Anti-relapse effect of N-acetilcysteine in ADE model: Role of hippocampus redox imbalance. (Poster). International Narcotics Research Conference 2021 . UNITED STATES
- Pablo Martí Andrés; Isabela; Salvador Pérez; Sergio Rius Pérez; Isabel Torres-Cuevas; Hildegard Colino; David Guerrero-Gómez; Esperanza Morato; Anabel Marina; Patrycja Michalska; Rafael Leon; Qing Cheng; Antonio Miranda-Vizuete; Edward E. Schmidt; Antonio Martínez-Ruiz; Elias S J Arnér; Juan Sastre (2023). TRP14 is the cellular cystine reductase and also reduces cysteinylated proteins. (Poster). REDOX BIOLOGY CONGRESS 202306-09 JUNE 2023, VIENNA, AUSTRIA . AUSTRIA
- Pablo Martí-Andrés; Isabela Finamor; Isabel Torres-Cuevas; Salvador Pérez; Sergio Rius-Pérez; Hildegard Colino-Lage; David Guerrero-Gómez; Esperanza Morato; Anabel Marina; Patrycja Michalska; Rafael León; Qing Cheng; Eszter Petra Juranyi; Klaudia Borbenyi-Galambos; Ivan Millán; Peter Nagy; Antonio Martínez-Ruiz; Edward Schmidt; Elias S.J. Arnér; Juan Sastre (2024). . (Communication). Annual Meating SFRR-E 2024 . TURKEY
- Sergio Rius-Pérez; Juan Sastre (2024). p53 causes necroptosis in acute pancreatitis through down-regulation of sulfiredoxin and peroxiredoxin 3. (Invited paper). XV ApoRed Meeting . SPAIN
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