Subjects taught and teaching methods
Academic training
- Graduado en Bioquímica y Ciencias Biomédicas. Universitat de Valéncia. (Diploma / Degree / Activities).
- Doctor en Fisiologia. Universidad de Valencia. (Ph.D.).
- Máster en Fisiología. Universitat de Valéncia. (Official Master).
Journal Publications
- Rius-Pérez S, Tormos AM, Pérez S, Taléns-Visconti R. (2018) Vascular pathology: Cause or effect in Alzheimer disease?. Neurologia, 33(2), pp. 112 - 120 . ISSN: 0213-4853
- Pérez S, Taléns-Visconti R, Rius-Pérez S, Finamor I, Sastre J. (2017) Redox signaling in the gastrointestinal tract. Free Radical Biology and Medicine, 104, pp. 75 - 103 . ISSN: 0891-5849
- Tormos AM, Rius-Pérez S, Jorques M, Rada P, Ramirez L, Valverde AM, Nebreda AR, Sastre J and Taléns-Visconti R. (2017) p38alpha regulates actin cytoskeleton and cytokinesis in hepatocytes during development and aging. Plos One, 12(2)(e0171738), pp. 1 - 22 . ISSN: 1932-6203
- Finamor I; Pérez S; Bressan CA; Brenner CE; Rius-Pérez S; Brittes PC; Cheiran G; Rocha MI; da Veiga M; Sastre J; Pavanato MA (2017) Chronic aspartame intake causes changes in the trans-sulphuration pathway, glutathione depletion and liver damage in mice. Redox Biology, 11, pp. 701 - 707 . ISSN: 2213-2317
- Pérez S, Rius-Pérez S, Tormos AM, Finamor I, Nebreda AR, Taléns-Visconti R, Sastre J. (2018) Age-dependent regulation of antioxidant genes by p38α MAPK in the liver. Redox Biology, 16, pp. 276 - 284 . ISSN: 2213-2317
- Rius-Pérez S, Tormos AM, Pérez S, Finamor I, Rada P, Valverde AM, Nebreda AR, Sastre J and Taléns-Visconti R. (2019) p38α deficiency restrains liver regeneration after partial hepatectomy triggering oxidative stress and liver injury. Scientific Reports, 9(1)(3775), pp. 1 - 11 . ISSN: 2045-2322
- Aliena-Valero A; Rius-Pérez S; Pérez S; Torregrosa G; Salom JB (2019) Optimised lyophilisation-based method for different biomolecule single-extractions from the same rat brain sample: Suitability for RNA and protein expression analyses after ischemic stroke. Journal of Neuroscience Methods, 327, p. 108402 . ISSN: 0165-0270
- Rius-Pérez S, Pérez S, Torres-Cuevas I, Martí-Andrés P, Taléns-Visconti R, Paradela A, Guerrero L, Franco L, López-Rodas G, Torres L, Corrales F, Sastre J. (2020) Blockade of the trans-sulfuration pathway in acute pancreatitis due to nitration of cystathionine β-synthase. Redox Biology, 28(101324), pp. 1 - 9 . ISSN: 2213-2317
- Salvador Pérez Garrido; Sergio Rius Pérez; Isabela Finamor; Pablo Martí Andrés; Ignacio Prieto; Raquel García; María Monsalve; Juan Sastre Belloch. (2019) Obesity causes PGC-1α deficiency in the pancreas leading to marked IL-6 upregulation via NF-κB in acute pancreatitis. Journal of Pathology, 247(1), pp. 48 - 59 . ISSN: 0022-3417
- Rius-Pérez S; Torres-Cuevas I; Millán I; Ortega ÁL; Pérez S. (2020) PGC-1α, Inflammation, and Oxidative Stress: An Integrative View in Metabolism. Oxidative Medicine And Cellular Longevity. ISSN: 1942-0900
- Sergio Rius-Pérez; Isabel Torres-Cuevas; María Monsalve; Francisco J. Miranda; Salvador Pérez (2020) Impairment of PGC-1 Alpha Up-Regulation Enhances Nitrosative Stress in the Liver during Acute Pancreatitis in Obese Mice. Antioxidants(9 (9)), p. 887 . ISSN: 2076-3921
- Alicia Aliena-Valero; Sergio Rius-Pérez; Júlia Baixauli-Martín; Germán Torregrosa; Ángel Chamorro; Salvador Pérez; Juan B Salom (2021) Uric acid neuroprotection associated to IL-6/STAT3 signaling pathway activation in rat ischemic stroke. Molecular Neurobiology, 58(1), pp. 408 - 423 . ISSN: 0893-7648
- Rius-Pérez S; Pérez S; Martí-Andrés P; Monsalve M; Sastre J (2020) Nuclear Factor Kappa B Signaling Complexes in Acute Inflammation. Antioxidants & Redox Signaling, 33(3) . ISSN: 1523-0864
- González R., Rodríguez-Hernández M.A., Negrete M., Ranguelova K., Rossin A., Choya-Foces C., de la Cruz-Ojeda P., Miranda-Vizuete A., Martínez-Ruiz A., Rius-Pérez S., Sastre J. , Bárcena J.A., Hueber A.O. , Padilla C.A., Muntané J. (2020) Downregulation of thioredoxin-1-dependent CD95 S-nitrosation by Sorafenib Reduces Liver Cancer. Redox Biology, 34(101528) . ISSN: 2213-2317
- Fernández-Rodríguez S; Cano-Cebrián MJ; Rius-Pérez S; Pérez S; Guerri C; Granero L; Zornoza T; Polache A. (2022) Different brain oxidative and neuroinflammation status in rats during prolonged abstinence depending on their ethanol relapse-like drinking behavior: Effects of ethanol reintroduction. Drug and Alcohol Dependence, 232, p. 109284 . ISSN: 0376-8716
- Isabela Finamor; Caroline Bressan; Isabel Torres Cuevas; Sergio Rius Pérez; Marcelo Veiga; Maria Rocha; Maria Amalia Pavanato; Salvador Pérez Garrido. (2021) Long-Term Aspartame Administration Leads to Fibrosis, Inflammasome Activation, and Gluconeogenesis Impairment in the Liver of Mice. Biology-Basel. ISSN: 2079-7737
- Pérez S; Rius-Pérez S (2022) Macrophage Polarization and Reprogramming in Acute Inflammation: A Redox Perspective. Antioxidants. ISSN: 2076-3921
- Rius-Pérez S; Pérez S; Toledano MB; Sastre J (2022) p53 drives necroptosis via downregulation of sulfiredoxin and peroxiredoxin 3. Redox Biology, 56, pp. 102423-1 - 10 . ISSN: 2213-2317
- Rius-Pérez S; Pérez S; Toledano M; Sastre J (2023) Mitochondrial Reactive Oxygen Species and Lytic Programmed Cell Death in Acute Inflammation. Antioxidants & Redox Signaling. ISSN: 1523-0864
- Pablo Martí-Andrés; Isabela Finamor; Isabel Torres-Cuevas; Salvador Pérez; Sergio Rius-Pérez; Hildegard Colino-Lage; David Guerrero-Gómez; Esperanza Morato; Anabel Marina; Patrycja Michalska; Rafael León; Qing Cheng; Eszter Petra Jurányi; Klaudia Borbényi-Galambos; Iván Millán; Péter Nagy; Antonio Miranda-Vizuete; Edward E Schmidt; Antonio Martínez-Ruiz; Elias SJ Arnér and Juan Sastre (2024) TRP14 is the rate-limiting enzyme for intracellular cystine reduction and regulates proteome cysteinylation. Embo Journal. ISSN: 0261-4189
- Juan Sastre; Salvador Pérez; Luis Sabater; Sergio Rius-Pérez (2025) Redox signalling in the pancreas in health and disease. Physiological Reviews, 105(2), pp. 593 - 650 . ISSN: 0031-9333
- Iván Millan; Salvador Pérez; Sergio Rius-Pérez; Miguel Ángel Asensi; Máximo Vento; José Manuel García-Verdugo;Isabel Torres-Cuevas. (2024) Postnatal hypoxic preconditioning attenuates lung damage from hyperoxia in newborn mice. Pediatric Research. ISSN: 0031-3998
- Sergio Rius-Pérez (2023) p53 at the crossroad between mitochondrial reactive oxygen species and necroptosis. Free Radical Biology and Medicine. ISSN: 0891-5849
Stays abroad in Research Centers
- Paris. FRANCE, 2019. Subclonación de genes en S. cerevisiae. Estudio de glutationilación de proteínas mediante química click.. **Doctorand.
- Madrid. SPAIN, 2016. Aislamiento de hepatocitos de ratón. Cultivo primario de hepatocitos. Silenciamiento génico mediante siRNA.. **Doctorand.
- Barcelona. SPAIN, 2022. Estudios de dinámica mitocondrial y reprogramación metabólica.. **Post-doctoral.
Participations in Conferences
- Pérez, Salvador; Tormos, Ana M.; Rius-Pérez, Sergio; Talens-Visconti, Raquel; Sastre, Juan. (2015). Gamma glutamyl cysteine attenuates the inflammatory response in acute pancreatitis via protein phosphatases. (Poster). Oxygen Club of Califormia World Congress (OCC) 'Oxidants and antioxidants in biology' Book of abstracts 2015, page 131, P53 . Valencia . SPAIN
- Ana M Tormos, Sergio Rius-Pérez, Salvador Pérez, Raquel Taléns-Visconti and Juan Sastre (2015). Gamma glutamyl cysteine prevents inflammation during acute pancreatitis. (Poster). 5th Congress of UV Pharmacy Students - 3th International Edition Book of abstracts . Valencia . SPAIN
- Salvador Perez, Ana M. Tormos, Sergio Rius, Raquel Talens-Visconti, Juan Sastre (2015). γ-Glutamyl cysteine modulates the inflammatory response via protein phosphatases Stuttgart 2015 Stuttgart, Germany. (Poster). SFRR-Europe/SNFS Meeting, Redox Biology Meets Nutrition September 2-‐4, University of Hohenheim Free Radical Biology and Medicine 86 (2015) S22 . Stuttgart . GERMANY
- P. Martí-Andrés, S. Pérez, S. Rius, R. Taléns-Visconti, J. Sastre. (2016). TNF-alpha upregulation is abrogated by γ-glutamylcysteine in acute pancreatitis. (Communication). 6th Congress of UV Pharmacy Students - 4th International Edition Book of Abstracts 2016; pag 91, O10. ISSN: 2254-2280 . Valencia . SPAIN
- Rius-Pérez S, Tormos A.M., Finamor I., Taléns-Visconti R., Sastre J. (2016). Role of p38 alpha in the regulation of liver regeneration after partial hepatectomy. (Communication). 6th Congress of UV Pharmacy Students - 4th International Edition Book of Abstracts 2016; pag 92, O11. ISSN: 2254-2280 . Valencia . SPAIN
- Salvador Pérez, Isabela Finamor, Sergio Rius-Pérez, Pablo Martí-Andrés, Raquel Taléns, Juan Sastre (2016). Gamma Glutamyl cysteine suppresses TNF-alpha up-regulation via protein phosphatases in acute pancreatitis. (Poster). SFRR- Europe 2016 Meeting Free Radical Biology and Medicine 96, Supplement 1, July 2016, S62; P-71 http://dx.doi.org/10.1016/j.freeradbiomed.2016.04.134 . Budapest . HUNGARY
- Pablo Martí-Andrés, Salador Pérez, Isabela Finamor, Sergio Rius-Pérez, Raquel Taléns, Juan Sastre (2016). γ-Glutamylcysteine exhibits anti-inflammatory effects via down-regulation of TNF-α and the JNK pathway in acute pancreatitis. (Communication). 76th FIP World Congress of Pharmacy and Pharmaceutical Sciences . Buenos Aires . ARGENTINA
- Sergio Rius-Pérez, Salvador Pérez, Ana-Martínez Tormos, Raquel Taléns-Visconti, Juan Sastre. (2016). Regulation of the antioxidant defense in the liver by p38α and NF-κB. (Communication). XI Reunión del Grupo Español de Investigación en Radicales Libres (GEIRLI) Libro de comunicaciones 2016, CO9, pg 44 . Granada . SPAIN
- Pablo Martí-Andrés; Salvador Pérez; Sergio Rius; Raquel Taléns; Juan Sastre (2016). TNF-alpha upregulation is abrogated by gamma-glutamyl cysteine in acute pancreatitis. (Communication). 6th Congress of Pharmacy Students - 4th international Edition . Valencia . SPAIN
- Sergio Rius-Pérez; Salvador Pérez; Isabela Finamor; Ana M. Tormos; Pablo Martí-Andrés; Raquel Taléns-Visconti; Juan Sastre (2017). NF-κB regulates liver antioxidant gene expression via p38α with aging. (Communication). 7th Congress of UV Pharmacy Students - 5th International Edition Book of Abstracts 2017; pag 46. ISSN: 2254-2280 . Valencia . SPAIN
- Salvador Pérez, Sergio Rius-Pérez, Isabela Finamor, Ana Martínez, Pablo Martí-Andrés, Ángel Nebreda, Raquel Taléns, Juan Sastre (2017). p38α and NF-κB regulate antioxidant defense in the liver through an age-dependent mechanism. (Poster). Anual Meeting of the SFRR-Europe Free Radical Biology and Medicine 108, Supplement 1, July 2017, S47; P-088 https://doi.org/10.1016/j.freeradbiomed.2017.04.173 . Berlin . GERMANY
- Isabela Finamor, Salvador Pérez, Pablo Martí-Andrés, Anabel Gil, Mari Luz Moreno, Sergio Rius-Pérez, Rafael León, Gethin Mcbean, Antonio Martínez-Ruíz, Juan Sastre (2017). Acute pancreatitis and cystinosis as experimental models of disulfide stress characterized by protein cysteinylation. (Communication). Anual Meeting of the SFRR-Europe . GERMANY
- P. Martí-Andrés, Salvador Pérez, I. Finamor, S. Rius-Pérez, J. Sastre (2017). Gamma-glutamylcysteine prevents the activation of the JNK pathway whilst recovering protein phosphatase levels in acute pancreatitis. (Poster). Gordon Research Conference on 'Oxidative stress and disease' . Lucca . ITALY
- Sergio Rius-Pérez; Salvador Pérez; Isabela Finamor; Ana-Martínez Tormos; Pablo Martí-Andrés; Ángel R. Nebreda; Raquel Taléns-Visconti; Juan Sastre (2017). p38alpha regulates liver antioxidant gene expression via NF-kappaB through an age-dependent mechanism. (Poster). Gordon Research Conference on 'Oxidative stress and disease' Book of abstracts . Lucca (Barga) . ITALY
- P. Martí-Andrés, S. Pérez, I. Finamor, S. Rius-Pérez, J. Pereda, A. Campos, R. Domingues, L. Sabater, J. Sastre (2017). Ascitic fluid triggers the release of extracellular nucleosomes in acute pancreatitis. Role of obesity. (Communication). VII Congreso de Estudiantes de Farmacia de la UV. 5ª Edición Internacional . Valencia . SPAIN
- Martí-Andrés P, Finamor I, Espinosa B, Pérez S, Rius-Pérez S, Taléns-Visconti R, León R, Martínez-Ruiz A, Arnér E, Sastre, J (2018). Thioredoxin-related protein of 14 kDa may directly reduce protein cysteinylation motifs. (Communication). Anual Meeting of the SFRR-Europe Free Radical Biology and Medicine 120, Supplement 1, 2018, Page S34; OP-15. http://dx.doi.org/10.1016/j.freeradbiomed.2018.04.116 . Lisboa . PORTUGAL
- Rius-Pérez S, Pérez S, Martí-Andrés P, Finamor I, Taléns-Visconti R, Cuadrado A, Toledano MB, Sastre J. (2018). Time-course of thiol oxidation of protein phosphatases during cerulein-induced acute pancreatitis. (Poster). Anual Meeting of the SFRR-Europe Free Radical Biology and Medicine 120, Supplement 1, 2018, Page S143; P-324. https://doi.org/10.1016/j.freeradbiomed.2018.04.471 . Lisboa . PORTUGAL
- Isabela Finamor, Salvador Pérez, Caroline Azzolin Bressan, Sergio Rius-Pérez, Pablo Martí-Andrés, Juan Sastre, Maria Amália Pavanato (2018). Chronic aspartame intake causes deficient glutathione synthesis and induces cxcl1 up-regulation in mice liver. (Poster). Anual Meeting of the SFRR-Europe . Lisboa . PORTUGAL
- Sergio Rius (2018). Redox signaling in acute pancreatitis. (Communication). Redox biology as a major drive to the understanding of pathophysiology: Contributions from the CONSOLREDOX network . Salamanca . SPAIN
- Alicia Aliena-Valero, Sergio Rius-Pérez, Salvador Pérez, Germán Torregrosa, Juan B. Salom (2019). Optimised lyophilisation-based method for different biomolecule single-extractions from the same rat brain sample: suitability for RNA and protein expression analyses after ischemic stroke. (Communication). III Congreso Anual INVICTUS+ ISCIII . Santiago de Compostela . SPAIN
- Isabel Torres Cuevas; Sergio Rius Perez; Salvador Perez Garrido; Ivan Millan; Elena Cubells; Jose Manuel Garcia Verdugo; Maximo Vento. (2019). Perinatal hypoxic preconditioning in a mice model preserves lung surfactant and reduces oxidative stress after an intense and prolongated hyperoxic insult. (Communication). Pediatric Academic Societies Annual Meeting . UNITED STATES
- Rius-Pérez S, Pérez S, Torres-Cuevas I, Martí-Andrés P, Taléns-Visconti R, Paradela A, Guerrero L, Franco L, López-Rodas G, Torres L Corrales F, Sastre J. (2021). Nitration of cystathionine β-synthase in acute pancreatitis. (Communication). SFRR-International Free Radical Biology and Medicine 165, Supplement 1, 2021, Page 36; NC36. https://doi.org/10.1016/j.freeradbiomed.2020.12.354 . virtual meeting . **Sense Especificar
- Fernández-Rodríguez S, Zornoza T, Pérez S, Rius-Pérez S, Guerri C, Cano-Cebrián MJ, Polache A (2021). Discovery and characterization of ADE and non-ADE rats under longterm alcohol exposure protocol. Biochemical differences in rat brain during alcohol abstinence. (Paper). 18th European Society for Biomedical Research on Alcoholism Conference Abstract book . Timisoara . ROMANIA
- Rius-Pérez S, Torres-Cuevas I, Pérez S, Martí-Andrés P, Taléns R, Paradela A, Guerrero L, Franco L, López-Rodas G, Torres L, Corrales F, Sastre J. (2021). S-Adenosyl methionine administration enhances nitrosative stress in acute pancreatitis leading to blockade of the trans-sulfuration pathway and accumulation of homocysteine. (Poster). Anual Meeting of the SFRR-Europe Free Radical Biology and Medicine 177, Supplement 1, 2021, Page S128; PP137. https://doi.org/10.1016/j.freeradbiomed.2021.08.212 . Belgrade . SERBIA
- Sergio Rius Pérez; Salvador Pérez Garrido; Pablo Martí Andrés; Isabela Finamor; Ignacio Prieto; Raquel García; María Monsalve; Juan Sastre Belloch. (2021). Blockade of IL-6 abrogates pancreatic and lung damage caused by acute pancreatitis in PGC-1α knock-out mice. (Paper). Anual Meeting of the SFRR-Europe . SERBIA
- Pablo Martí Andrés; Salvador Pérez Garrido; Isabela Finamor; Isabel Torres Cuevas; Sergio Rius Pérez; Antonio Martínez Ruiz; Edward Schmidt; Elias Arner; Juan Sastre Belloch. (2021). TRP14 deficiency markedly reduces the inflammatory response in acute pancreatitis through Nrf2 activation. (Paper). Anual Meeting of the SFRR-Europe . SERBIA
- Sergio Rius Pérez; Salvador Pérez Garrido; Pablo Martí Andrés; Isabela Finamor; Ignacio Prieto; Raquel García; María Monsalve; Juan Sastre Belloch. (2021). Obesidad causa PGC-1α deficiency en exocrine pancreas leading to IL-6 upregulación vía NF-κB in acute pancreatitis. (Paper). 20th Biennial Meeting of Society for Free Radical Research International . ENGLAND
- Claudia Esposito Zapero; Sandra Fernandez Rodriguez; Salvador Pérez Garrido; Sergio Rius Pérez; Ana Polache; Teodoro Zornoza; María José Cano Cebrián. (2021). Anti-relapse effect of N-acetilcysteine in ADE model: Role of hippocampus redox imbalance. (Poster). International Narcotics Research Conference 2021 . UNITED STATES
- Pablo Martí Andrés; Isabela; Salvador Pérez; Sergio Rius Pérez; Isabel Torres-Cuevas; Hildegard Colino; David Guerrero-Gómez; Esperanza Morato; Anabel Marina; Patrycja Michalska; Rafael Leon; Qing Cheng; Antonio Miranda-Vizuete; Edward E. Schmidt; Antonio Martínez-Ruiz; Elias S J Arnér; Juan Sastre (2023). TRP14 is the cellular cystine reductase and also reduces cysteinylated proteins. (Poster). REDOX BIOLOGY CONGRESS 202306-09 JUNE 2023, VIENNA, AUSTRIA . AUSTRIA
- Pablo Martí-Andrés; Isabela Finamor; Isabel Torres-Cuevas; Salvador Pérez; Sergio Rius-Pérez; Hildegard Colino-Lage; David Guerrero-Gómez; Esperanza Morato; Anabel Marina; Patrycja Michalska; Rafael León; Qing Cheng; Eszter Petra Juranyi; Klaudia Borbenyi-Galambos; Ivan Millán; Peter Nagy; Antonio Martínez-Ruiz; Edward Schmidt; Elias S.J. Arnér; Juan Sastre (2024). . (Communication). Annual Meating SFRR-E 2024 . TURKEY
- Sergio Rius-Pérez; Juan Sastre (2024). p53 causes necroptosis in acute pancreatitis through down-regulation of sulfiredoxin and peroxiredoxin 3. (Invited paper). XV ApoRed Meeting . SPAIN
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