Universitat de ValènciaResearch Institute of Personnel Psychology, Organizational Development and Quality of Working Life Logo del portal

Acronym

Molecular-mechanisms-2021-2025

Reference code

CIPROM/2021/82

Description

DESCRIPTION

Hyperammonemia is considered to contribute primarily to neurological impairments in SSc. Animal models of chronic SSc (e.g., rats with 'portal-caval' shunts) or of 'pure' hyperammonemia also show impaired cognitive function. The studies summarized here demonstrate that impairment of some types of cognitive function in chronic SSc is due to impaired function of the glutamate-nitric oxide-GMPC pathway in the brain.

 

DEVELOP THE PROJECT

Laboratory of Cognitive Social Neuroscience (LabNSC)

Web: https://www.uv.es/labnsc

Email: labnsc@uv.es / labnscuv@uv.es

 

Keywords

Hepatic encephalopathy, Hyperammonemia, Cognitive function GMPN Receptors, MDA, Nitrogen oxide, Neuroinflammation

Principal investigators:
  • Salvador Fernandez-montejo, Otilia Alicia
  • PDI-Catedratic/a d'Universitat
View details
alicia.salvador@uv.es
Non-UV principal researchers

Vicente Felipo.

Non-UV participating researchers

Pilar Monfort, Omar Cauli, Carmina Montoliu, Regina Rodrigo, Marta Llansola, Blanca Piedrafita, Nisrin el Mlili, Jordi Boix, Ana Agustí,

Start date
2021 January
End date
2027 January
Funding agencies:

  • Generalitat Valenciana.

Partners:

  • Laboratory of Neurobiology, Centro de Investigacion Principe Felipe, Valencia.
  • Fundación Hospital Clínico Universitario, Valencia.