Este miércoles día 10 abril , Mihai Spiridon Bodi doctorando del grupo de Regulación del Ciclo Celular, dará una charla con el título:

“Regulation and Function of the G1/S repressor Whi7 in stress”

Será a las 10:00h al SALÓN DE GRADOS DE FARMACIA

Resumen de la charla:  

Start is the main cell cycle checkpoint in Saccharomyces cerevisiae, where the cell irreversibly commits to enter in the cell cycle. At this point, yeast cells integrate internal and external signals with the Start control to decide whether to initiate or not a new round of cell division. Under normal conditions, Whi5 acts as the main transcriptional repressor of Start, while its functional paralog Whi7 plays a minor role. However, Whi7 protein levels increase during cell wall stress, suggesting a more relevant role for Whi7 under this condition. In this work we investigate the molecular bases that determine the strength of Whi7 and Whi5 as Start repressors during stress. We found that Whi7 is more unstable during cell wall stress, and that Whi7 degradation promotes cell cycle re‐entry under this condition. Furthermore, we show that Whi7 binding to Start promoters specifically increase during cell wall stress. In fact, Whi7 strength as G1/S repressor is influenced not only by its protein levels but also by other regulatory mechanisms that may confer to Whi7 specific function in stress. Surprisingly, we found that under osmotic stress the regulation and function of Whi7 is remarkably different than in cell wall stress. In summary, our findings highlight the complex regulation of Start under stress conditions and indicate that the interplay between Whi7 and Whi5 repressors is subject to multiple levels of control to ensure an appropriate response to environmental conditions.

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Después habrá café como siempre al bar de Farmacia    

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