ANDRZEJ CWETSCH
PI-Invest Disting Exper.Internacional
PI-Invest Disting Exper.Internacional
:
Departamento: Instituto Univ. de Biotecnología y Biomedicina (BIOTECMED)
Departamento: Instituto Univ. de Biotecnología y Biomedicina (BIOTECMED)
Asignaturas impartidas y modalidades docentes
Formación académica
- Bachelor Degree. Jagiellonian University. 30/06/2011 (Diplomatura / Licenciatura / Grado).
- X-linked PCDH19 Protein Regulates Cortical and Hippocampal Development and Seizure Susceptibility. Italian Institute of Technology - NBT Department /University of Genoa, Italy. 19/04/2017 (Doctorado).
- Effect of osteogenic factors on human MSC culture in 2D and 3D conditions. Jagiellonian University. 30/06/2013 (Máster Oficial).
Publicaciones en revistas
- Andrzej W Cwetsch; Ilias Ziogas; Roberto Narducci; Annalisa Savardi; Maria Bolla; Bruno Pinto; Laura E Perlini; Silvia Bassani; Maria Passafaro; Laura Cancedda (2022) A rat model of a focal mosaic expression of PCDH19 replicates human brain developmental abnormalities and behaviours. Brain Communications. ISSN: 2632-1297
- González-Martínez J, Cwetsch AW, Gilabert-Juan J, Gómez J, Garaulet G, Schneider P, de Cárcer G, Mulero F, Caleiras E, Megías D, Porlan E, Malumbres M. (2022) Genetic interaction between PLK1 and downstream MCPH proteins in the control of centrosome asymmetry and cell fate during neural progenitor division. Cell Death and Differentiation. ISSN: 1350-9047
- José González-Martínez; Andrzej W Cwetsch; Diego Martínez-Alonso; Luis R López-Sainz; Jorge Almagro; Anna Melati; Jesús Gómez; Manuel Pérez-Martínez; Diego Megías; Jasminka Boskovic; Javier Gilabert-Juan; Osvaldo Graña-Castro; Alessandra Pierani; Axel Behrens; Sagrario Ortega; Marcos Malumbres (2021) Deficient adaptation to centrosome duplication defects in neural progenitors causes microcephaly and subcortical heterotopias. Jci Insight. ISSN: 2379-3708
- Matthieu X Moreau; Yoann Saillour; Andrzej W Cwetsch; Alessandra Pierani; Frédéric Causeret (2021) Single-cell transcriptomics of the early developing mouse cerebral cortex disentangle the spatial and temporal components of neuronal fate acquisition. Development. ISSN: 0950-1991
- Francesco Trovato; Riccardo Parra; Enrico Pracucci; Silvia Landi; Olga Cozzolino; Gabriele Nardi; Federica Cruciani; Vinoshene Pillai; Laura Mosti; Andrzej W Cwetsch; Laura Cancedda; Laura Gritti; Carlo Sala; Chiara Verpelli; Andrea Maset; Claudia Lodovichi; Gian Michele Ratto (2020) Modelling genetic mosaicism of neurodevelopmental disorders in vivo by a Cre-amplifying fluorescent reporter. Nature Communications. ISSN: 2041-1723
- Joanna Szczurkowska; Seong-Il Lee; Alan Guo; Andrzej W Cwetsch; Tanvir Khan; Sneha Rao; Gerd Walz; Tobias B Huber; Laura Cancedda; Sophie Pautot; Maya Shelly (2020) A Localized Scaffold for cGMP Increase Is Required for Apical Dendrite Development. Cell Reports. ISSN: 2211-1247
- Yoko Arai; Andrzej W Cwetsch; Eva Coppola; Sara Cipriani; Hidenori Nishihara; Hiroaki Kanki; Yoann Saillour; Betty Freret-Hodara; Annie Dutriaux; Norihiro Okada; Hideyuki Okano; Colette Dehay; Jeannette Nardelli; Pierre Gressens; Tomomi Shimogori; Giuseppe D'Onofrio; Alessandra Pierani (2019) Evolutionary Gain of Dbx1 Expression Drives Subplate Identity in the Cerebral Cortex. Cell Reports. ISSN: 2211-1247
- Rui O Costa; Helena Martins; Luís F Martins; Andrzej W Cwetsch; Miranda Mele; Joana R Pedro; Diogo Tomé; Noo Li Jeon; Laura Cancedda; Samie R Jaffrey; Ramiro D Almeida (2019) Synaptogenesis Stimulates a Proteasome-Mediated Ribosome Reduction in Axons. Cell Reports. ISSN: 2211-1247
- Shovan Naskar; Roberto Narducci; Edoardo Balzani; Andrzej W Cwetsch; Valter Tucci; Laura Cancedda (2019) The development of synaptic transmission is time-locked to early social behaviors in rats. Nature Communications. ISSN: 2041-1723
- Andrzej W Cwetsch; Bruno Pinto; Annalisa Savardi; Laura Cancedda (2018) In vivo methods for acute modulation of gene expression in the central nervous system. Progress in Neurobiology. ISSN: 0301-0082
- Silvia Bassani; Andrzej W Cwetsch; Laura Gerosa; Giulia M Serratto; Alessandra Folci; Ignacio F Hall; Michele Mazzanti; Laura Cancedda; Maria Passafaro (2018) The female epilepsy protein PCDH19 is a new GABAAR-binding partner that regulates GABAergic transmission as well as migration and morphological maturation of hippocampal neurons. Human Molecular Genetics. ISSN: 0964-6906
- Caterina Montani; Mariana Ramos-Brossier; Luisa Ponzoni; Laura Gritti; Andrzej W Cwetsch; Daniela Braida; Yoann Saillour; Benedetta Terragni; Massimo Mantegazza; Mariaelvina Sala; Chiara Verpelli; Pierre Billuart; Carlo Sala (2017) The X-Linked Intellectual Disability Protein IL1RAPL1 Regulates Dendrite Complexity. Journal of Neuroscience. ISSN: 0270-6474
- Joanna Szczurkowska*; Andrzej W Cwetsch*; Marco dal Maschio; Diego Ghezzi; Gian Michele Ratto; Laura Cancedda *co-authors (2016) Targeted in vivo genetic manipulation of the mouse or rat brain by in utero electroporation with a triple-electrode probe. Nature Protocols. ISSN: 1754-2189
- Daniela De Zio; Francesca Molinari; Salvatore Rizza; Lucia Gatta; Maria Teresa Ciotti; Anna Maria Salvatore; Søs Grønbæk Mathiassen; Andrzej W Cwetsch; Giuseppe Filomeni; Giuseppe Rosano; Elisabetta Ferraro (2015) Apaf1-deficient cortical neurons exhibit defects in axonal outgrowth. Cellular and Molecular Life Sciences. ISSN: 1420-682X
- Joanna Szczurkowska; Marco dal Maschio; Andrzej W Cwetsch; Diego Ghezzi; Guillaume Bony; Alessandro Alabastri; Remo Proietti Zaccaria; Enzo di Fabrizio; Gian Michele Ratto; Laura Cancedda (2013) Increased performance in genetic manipulation by modeling the dielectric properties of the rodent brain. Annual International Conference of the IEEE Engineering in Medicine and Biology Society. ISSN: 2375-7477
- Joanna Szczurkowska; Andrzej W. Cwetsch; Marco dal Maschio; Diego Ghezzi; Gian Michele Ratto; Laura Cancedda (2013) High-performance and reliable site-directe in vivo genetic manipulation of mouse and rat brain by in utero electroporation with a triple-electrode probe. Protocol Exchange. ISSN: 2043-0116
Otras Actividades
- LA EVALUACIÓN DE LA ACTIVIDAD INVESTIGADORA DEL PERSONAL INVESTIGADOR CONTRATADO Sexenios. ().
- Grado de Biotecnología Practicas Biología Celular. ().
- Máster en Neurociencia "Plasticidad del Cerebro Inmaduro Lesionado", de 3 créditos ECTS: -"Bases moleculares y celulares de la epilepsia en la edad pediátrica". -"Tratamientos para la epilepsia, historia, mecanismos de acción y nuevos desafíos". ().
Actividades anteriores
- Post-Doctoral Researcher. Imagine - Institut des maladies génétiques; Institut de Psychiatrie et Neurosciences de Paris. 01/09/2017 - 31/10/2021.
- Post-Doctoral Researcher. Institute Jacques Monod - University De Paris, France. 01/02/2017 - 31/08/2017.
- Post-Doctoral Researcher. Istituto Italiano di Tecnologia - IIT. 01/01/2017 - 31/01/2017.
- PhD student. Istituto Italiano di Tecnologia - IIT / UUniversity of Genoa. 01/01/2014 - 31/12/2017.
- PreDoc Internship. Istituto Italiano di Tecnologia - IIT. 01/08/2013 - 31/12/2013.
- Scientific Master in Cellular Biology. Jagiellonian University. 01/09/2011 - 30/06/2013.
- Bachelor Degree. Jagiellonian University. 01/09/2007 - 30/06/2011.
Otros Méritos o aclaraciones
- Teaching and supervising the surgery and electroporation techniques of the researchers and students: Seong-ll Lee, Stony Brook University, New York, USA Rui O. Costa, Universidade de Coimbra, Portugal Antonio de Iure, University of Padova, Italy Archana Iyer, Tata Institute of fundamental research, India Marta Kopanska, Rzeszow University, Poland. (Méritos relacionados con la calidad y difusión de resultados de la actividad Investigadora).
- AWARDS / PREMIOS Type of award: Project selected for Seal of Excellence in Horizon 2020's Marie Skłodowska-Curie actions call; Awarded by: European Commission Title: Role of Protocadherin 19 mosaic expression in Cajal-Retzius cells in the development of Early Infantile Epileptic Encephalopathy-9, 2021 Type of award: EMBO short stay; Funded by EMBO, Place: Spanish National Cancer Research Center - CNIO, Madrid, Spain; Title: Role of transcription factor Dbx1 in regulation of the cell cycle machinery, 2019 Type of award: Travel Grant; Funded by: Place: 1st IN PhD Student & Postdoc Meeting, Alicante, Spain; Title: 'Building Neuroscience: The future of a multidisciplinary field', 2016 Type of award: Travel Grant; Funded by: IBRO Congress in Rio de Janeiro, Brasil Title: 9th IBRO World Congress on Neuroscience, 2015 Type of award: Course Grant; Funded by: Okinawa Institute of Science and Technology Graduate University, Japan; Title: Developmental Neurobiology Course, 2014. (Méritos relacionados con la actividad investigadora).
- INSTITUTIONAL FUNCTIONS / FUNCIONES INSTITUCIONALES Review Editor in Frontiers in Cellular Neuroscience Guest Associate Editor in Cellular Neuropathology of Frontiers in Cellular Neuroscience Ad hoc reviewer for international scientific journals: Frontiers in Neuroscience, IEEE Engineering in Medicine and Biology Society Project reviewer for Maria Sklodowska Cure Actions (MSCA) 'COFUND' by the SFI 'FutureNeuro' and 'INSIGHT' Certificado R3: CR32023-041695 European Innovation Council Expert (EX2022D698703) for EIC Accelerator Grant. (Méritos relacionados con la actividad profesional).
- MEMBERSHIPS / MEMBRESÍAS Communication manager of Young Researchers of Imagine Institute 2018-2021 Member of the Scientific committee of the 5th edition of YR2I congress, Paris, France 2019 Member of Society for Neuroscience (SfN) 2016-2017, 2022-2023 Member of Federation of European Neuroscience Societies (FENS) 2022, 2024 Member of Spanish Society of Neuroscience (SENC) 2021, 2022, 2023, 2024. (Méritos relacionados con la actividad profesional).
- INTERNATIONAL COURSES / CURSOS INTERNACIONALES Specific training to design and perform surgical procedures on rodents, Institute Pasteur, France, 2020 Animal Experimentation Design Course, Institute Pasteur, Paris, France, 2019 Reproducibility in animal research, Journee Scientific Sorbonne Univ. and RPPA, France, 2019 Neuroscience review, Ecole des Neurosciences de Paris ile de France Workshop, Paris, France, 2017 International Fragile X and other Early-Onset Cognitive Disorders Workshop, Strasbourg, France 2015 Developmental Neurobiology Course, Okinawa Institute of Science and Technology, Japan, 2014 Neuroscience and Brain Technologies Workshop, IIT Genova, Italy, 2014. (Méritos relacionados con la actividad investigadora).
- PATENTS Name of the patent: 'Three-Electrode electroporation device' (Patent Number TO2011A000411) Investors: Laura Cancedda and Gian Michele Ratto Participation in vivo validation: Andrzej W Cwetsch, Joanna Szczurkowska, Marco dal Maschio. (Méritos relacionados con la actividad investigadora).
- Agencia Estatal de Investigación. Certificado R3 CR32023-041695. (Méritos relacionados con la actividad investigadora).
Conferencias
- Bases moleculares y celulares de la epilepsia en la edad pediátrica. Molecular and cellular bases of epilepsy in children. (Master in Neuroscience), 28/02/2022. Universidad Autónoma de Madrid. ESPAÑA.
- Tratamientos para la epilepsia, historia, mecanismos de acción y nuevos desafíos. Treatments for epilepsy, history, mechanisms of action and new challenges. (Master in Neuroscience), 01/03/2022. Universidad Autónoma de Madrid. ESPAÑA.
- Protocadherins -at the crossroad of adhesion and cell fate in the early brain development. (Programa de Doctorado UAM Cajal y del Máster en Neurociencia de la UAM), 05/11/2021. Universidad Autónoma de Madrid. ESPAÑA.
- Advantages of in vivo genetic manipulations of the rodent brain by innovative side-directed in utero electroporation with a triple-electrode probe. (Neuronus 2015 IBRO&IRUN Neuroscience Forum), 18/04/2015. Jagiellonian University. POLONIA.
Participaciones en Congresos
- J Szczurkowska; AW Cwetsch; I Fernandez; L Perlini; F Succoli; P Cossette; F Benfenati; A Barberis; L Cancedda (2013). Role of GABA A-receptor mutations in idiopathic generalized epilepsy: a developmental study. (Poster). XVII Scientific Convention, Telethon Foundation, Riva del Garda . ITALIA
- AW Cwetsch; J Filipowska; M Dubiel; G Tylko; AM Osyczka (2013). Osteogenesis of adult human MSC in 2D vs. 3D cultures with InsertTM-PS scaffolds. (Poster). III Summer Symposium on Nanomaterials and their application to Biology and Medicine . POLONIA
- AW Cwetsch; J Szczurkowska; M dal Maschio; D Ghezzi; GM Ratto; L Cancedda (2014). High-performance and reliable site-directed in vivo genetic manipulation of rodent brain by in utero electroporation with a triple-electrode probe. (Poster). Neuronus 2014 IMBRO&IRUN Neuroscience Forum . POLONIA
- AW Cwetsch; J Szczurkowska; M dal Maschio; D Ghezzi; GM Ratto; L Cancedda (2014). High-performance and reliable site-directed in vivo genetic manipulation of rodent brain by in utero electroporation with a triple-electrode probe. (Poster). Developmental Neurobiology Course, Okinawa Institute of Science and Technology . JAPÓN
- AW Cwetsch; A Alabastri; M dal Maschio; R Proietti Zaccaria; L Cancedda (2014). Multielectrode array for in utero electroporation: Towards transfection of the new brain regions. (Poster). Brain- Neuroscience and Brain Technologies Workshop . ITALIA
- AW Cwetsch; J Szczurkowska; S Naskar; G Deidda; M Allegra; L Perlini; F Succol; P Cossette; F Benfenati; A Barberis; M Caleo; L Cancedda; (2015). Role of GABAA−Receptor Mutations in Idiopathic Generalized Epilepsy: A Developmental Study. (Poster). XVIII Scientific Convention, Telethon Foundation . ITALIA
- AW Cwetsch; J Szczurkowska; M dal Maschio; D Ghezzi; GM Ratto; L Cancedda (2015). High-performance and reliable site-directed in vivo genetic manipulation of the mouse and rat brain by in utero electroporation with a triple-electrode probe. (Ponencia). The 9th IBRO World Congress of Neuroscience . BRASIL
- AW Cwetsch; L Perlini; S Bassani; M Passafaro; L Cancedda (2015). Protocadherin 19 downregulation affects hippocampal development and causes increased seizure susceptibility in rats. (Poster). 17th International Fragile X and other Early-Onset Cognitive Disorders Workshop . FRANCIA
- AW Cwetsch; L Perlini; S Bassani; M Passafaro; L Cancedda; (2016). Protocadherin 19 Downregulation Affects Neuronal Development, Causes Increased Seizure Susceptibility and Impaired Ultrasonic Vocalization in Rats. (Poster). ISDN 2016: 21st Biennial Meeting of the International Society for Developmental Neuroscience . FRANCIA
- AW Cwetsch; R Parra; F Trovato; S Landi; L Mosti; GM Ratto; L Cancedda (2016). MeCP2 Downregulation Affects Axonal Versus Dendritic Specification in Hippocampal Neurons in Vitro. (Poster). Telethon Tri-Retreat Meeting in Rome . ITALIA
- AW Cwetsch; L Perlini; S Bassani; M Passafaro; L Cancedda (2016). Protocadherin 19 Downregulation Affects Hippocampal Development and Causes Increased Seizure Susceptibility in Rats. (Poster). The 10th FENS (Federation of European Neuroscience Societies) Forum of Neuroscience . DINAMARCA
- AW Cwetsch; L Perlini; S Bassani; M Passafaro; L Cancedda (2016). Protocadherin 19 Downregulation Affects Hippocampal Development and Causes Increased Seizure Susceptibility in Rats. (Poster). Society for Neuroscience 2016 San Diego . ESTADOS UNIDOS DE AMÉRICA
- AW Cwetsch; L Perlini; S Bassani; M Passafaro; L Cancedda (2017). Protocadherin 19 Downregulation Affects Hippocampal Development and Causes Increased Seizure Susceptibility in Rats. (Poster). European College of Neuropsychopharmacology Congress 2017 . FRANCIA
- AW Cwetsch; J Gilabert-Juan; S Ferreira; M X Moreau; F Causeret; Y Saillour; E Delberghe; J González Martínez; S Nedelec; U Borello; S Thomas; A Pierani (2022). Crosstalk between Protocadherin 8 and transcription factor Dbx1 regulate the formation of developing cerebral cortex. (Poster). Federation of European Neuroscience Societies 2022 Meeting . FRANCIA
- AW Cwetsch; J Gilabert-Juan; S Ferreira; M X Moreau; F Causeret; Y Saillour; E Delberghe; J González Martínez; S Nedelec; U Borello; S Thomas; A Pierani (2022). Crosstalk between Protocadherin 8 and transcription factor Dbx1 regulate the formation of developing cerebral cortex. (Poster). Neuroscience 2022 - Society for Neuroscience San Diego . ESTADOS UNIDOS DE AMÉRICA
- AW Cwetsch, J Gilabert-Juan, S Ferreira, M X Moreau, F Causeret, Y Saillour, E Delberghe, J González Martínez, S Nedelec, U Borello, S Thomas, A Pierani (2023). Crosstalk between Protocadherin 8 and transcription factor Dbx1 regulate the formation of developing cerebral cortex. (Comunicación). IBRO 2023 meeting, Granada, Spain, 2023 . ESPAÑA
- Andrzej W Cwetsch (2023). . (Comunicación). Sociedad Española de Neurociencia SENC day 2023 . ESPAÑA
- AW Cwetsch, J Gilabert-Juan, S Ferreira, M X Moreau, F Causeret, Y Saillour, E Delberghe, J González Martínez, S Nedelec, U Borello, S Thomas, A Pierani (2024). Crosstalk between Protocadherin 8 and transcription factor Dbx1 regulate the formation of developing cerebral cortex. (Comunicación). FENS 2024 Federation of European Neuroscience Societies . AUSTRIA
- Presidente: Dr. Javier Gilabert Juan. Universidad Autónoma de Madrid Secreatrio: Dr. Miguel Ángel García Cabezas. Universidad Autónoma de Madrid Dr. David Vega Avelaira. Universidad Autónoma de Madrid Dra. Lucía Prensa. Universidad Autónoma de Madrid Dr. Jorge García Piqueras. Universidad Autónoma de Madrid Dra. Rocio Gómez Lencero. Universidad Autónoma de Madrid Dr. Andrzej Cwetsch. Universidad de Valencia Dra. Josefa Zaldivar Diez de Bonilla. Universidad Carlos III Dr. Javier Blesa. Universidad Camilo José Cela Dr. José Luis Ferrán. Universidad de Murcia Dr. Alberto Muñoz Céspedes. Universidad Complutense de Madrid Dra. Mercé Masana. Universidad de Barcelona Dra. Esther Castillo Gómez. Universidad Jaime I Castellón (2025). . (Participación comité organizador). I Congreso Nacional de Innovación Docente en Anatomía, Histología y Biología Celular . ESPAÑA
- Andrzej W Cwetsch (2024). ADHD and Autism: New Insights on Their Relationship and Background. (Ponencia invitada). CIVIS Course: Neurobiology of Mental Disorders 2024 . ESPAÑA
Proyectos
- Phenotype characterization of PCDH19 mutations underlying 'Epilepsy with Mental Retardation limited to Females' (EFMR) syndrome using in vitro and in vivo models (). 2013. Cariplo Bank. . IP: Laura Cancedda.
- Epilepsy with Mental Retardation limited to Females' (EFMR) syndrome using in vitro and in vivo models (). 2014 - 2015. Cariplo Bank. . IP: Laura Cancedda.
- Unravelling the Rett syndrome: effects of MeCP2 mutations on synaptic function (). 2014 - 2016. Telethon Foundation. . IP: Laura Cancedda.
- Mosaic Rett Syndrome Investigation (). 2017. Telethon Foundation. . IP: Laura Cancedda.
- Le rôle développemental des Protocadherines delta dans les cellules de Cajal-Retzius et la construction de circuits corticaux fonctionnels et dysfonctionnels (). 2017 - 2018. Fondation FYSSEN. . IP: Andrzej Cwetsch.
- Developmental role of delta Protocadherins in Dbx1 regulated CRs (). 2019 - 2021. Fondation pour la Recherche Médicale en France. . IP: Andrzej Cwetsch.
- Ayudas Juan De La Cierva-Incorporación - Convocatoria 2020 * declined / rechazado (). 2021. Agencia Estatal de Investigación. . IP: Andrzej Cwetsch.
- PlanSubvenciones Para La Contratación De Doctores Y Doctoras Con Experiencia Internacional 2021 Role of Protocadherin 19 mosaic expression in Cajal-Retzius cells in the development of early infantile epileptic encephalopathy-9 (). 2021 - 2025. Proyectos de Investigación I+D Competitivos. Generalidad Valencia. Consellería de cultura, Educación y Ciencia. . IP: Andrzej Cwetsch.
Textos del currículum
- . Andrzej W Cwetsch se graduó en Biología Celular en la Universidad Jagellónica de Cracovia, Polonia, en 2013, con una tesis sobre la regulación de las células madre en la regeneración ósea. Obtuvo el título de Doctor en Neurociencia y Tecnologías Cerebrales en el Instituto Italiano de Tecnología (Génova) en 2017, bajo la supervisión de la Dra. Laura Cancedda. En Génova, investigó el papel de las moléculas de adhesión celular, en particular la Protocadherina 19, en patologías del neurodesarrollo como la epilepsia y el autismo. En 2017, se mudó a París para trabajar en el Instituto Imagine y el Instituto de Psiquiatría y Neurociencia en el grupo de investigación de la Dra. Alessandra Pierani. Allí, centró sus estudios en los primeros pasos de la formación del cerebro y el papel de las moléculas de adhesión celular en la segregación de los progenitores neurales y su diferenciación..
- . Google Scholar Citations 283 h-index 9 i10-index 8.
- . Andrzej W Cwetsch se graduó en Biología Celular en la Universidad Jagellónica de Cracovia, Polonia, en 2013, con una tesis sobre la regulación de las células madre en la regeneración ósea. Obtuvo el título de Doctor en Neurociencia y Tecnologías Cerebrales en el Instituto Italiano de Tecnología (Génova) en 2017, bajo la supervisión de la Dra. Laura Cancedda. En Génova, investigó el papel de las moléculas de adhesión celular, en particular la Protocadherina 19, en patologías del neurodesarrollo como la epilepsia y el autismo. En 2017, se mudó a París para trabajar en el Instituto Imagine y el Instituto de Psiquiatría y Neurociencia en el grupo de investigación de la Dra. Alessandra Pierani. Allí, centró sus estudios en los primeros pasos de la formación del cerebro y el papel de las moléculas de adhesión celular en la segregación de los progenitores neurales y su diferenciación..
- . Google Scholar Citations 283 h-index 9 i10-index 8.
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