terms images

1.       Acantholysis:  Loss of cell–cell adhesión

2.       Acanthosis: Increase in thickness of the epidermis

a.       Regular (all rete pegs descend to the same level) or irregular (rete pegs descend to different levels in the papillary dermis)

3.       Anaplasia: Atypical nuclei (abnormal size, shape, staining) and pleomorphism (variation in nuclear characteristics)

4.       Apoptosis (Pronounced Apo tosis):  “Programmed cell death”,  “Dead red” keratinocytes with pyknotic nuclei, • Although the term is often applied to

5.       any necrotic or dyskeratotic keratinocyte, it is best reserved for physiologic programmed cell death or pathologic processes that produce death through a similar pathway

6.       Atrophy:  Decrease in thickness of epidermis

7.       Ballooning degeneration:  Destruction of epidermis by dissolution of cell attachments and intracellular edema

8.       Civatte/colloid bodies :  Pink, globular remnants of keratinocytes

9.       Cowdry A body:  Also known as the Lipshutz body,  Intranuclear pink inclusions of herpesvirus infection

10.   Crust:  Serum/fluid with inflammatory cells/debris in stratum corneum

11.   Epidermotropism:  Lymphocytes in epidermis with relative absence of spongiosis: term usually reserved for mycosis fungoides

12.   Exocytosis:  Lymphocytes in the epidermis with associated spongiosis: term usually used when discussing spongiotic dermatitis

13.   Granulomatous  Composed of granulomas (collections of histiocytes)

14.   Leukocytoclasia:  Fragmentation of neutrophils, also referred to as leukocytoclasis or karyorrhexis

15.   Lichenoid dermatitis:  Interface dermatitis with destruction of the basal layer and Civatte body formation

16.   Lichenoid infiltrate:  A band-like infiltrate, generally composed predominantly of lymphocytes, located at the dermoepidermal junction

17.   Munro microabscess:  Collection of neutrophils in the stratum corneum, as seen in psoriasis

18.   Orthokeratosis:  Increased thickness of the stratum corneum without retained nuclei

19.   Pagetoid cells  Large cells with abundant cytoplasm within the epidermis

20.   Papillomatosis:  Finger-like projections

21.   Parakeratosis:  Stratum corneum with retained nuclei

22.   Spongiform pustule of Kogoj:  Neutrophils in the stratum spinosum, associated with spongiosis at periphery (typical of psoriasis)

23.   Spongiosis:  Intercellular edema in epidermis with stretching of cell–cell junctions

24.   Vacuolar change:  Formation of clear spaces within the basal layer