The major aim of our group was to determine the intercellular mechanisms of toxicity of amyloid beta, its interaction with mitochondrial metabolism, and its consequences in cell signalling. One major idea in this group is that Alzheimer’s and tau toxicities are related and that free radicals play a major signalling role in this process. Interventions aimed at controlling or delaying Alzheimer’s may be involved in interfering with the pathological cell signalling unleashed by amyloid beta. An important aim of our group is to find biomarkers of Alzheimer’s to help clinicians detect the onset of this disease as early as possible: we are using a proteomic approach to identify blood plasma biomarkers of very early Alzheimer’s disease.