Pilar Sepúlveda, Ph.D

Unit of Regenerative Cardiology

pilar.sepulveda@uv.es

PUBLICATIONS
1. Navarro, D., E. Monzonis, J.L. López-Ribot, P. Sepúlveda, M. Casanova, J.M. Nogueira, and J.P. Martínez. 1993. Diagnosis of systemic candidiasis by enzyme immunoassay detection of specific antibodies to mycelial phase cell wall and cytoplasmic candidal antigens. Eur. J. Clin. Microbiol. Infect. Dis. 12:839-846.
 2. López-Ribot, J.L., M. Casanova, C. Monteagudo, P. Sepúlveda, and J.P. Martínez. 1994. Evidence for the presence of a high-affinity laminin receptor-like molecule in the surface of Candida albicans  yeast cells. Infect. Immun. 62:742-746.
 3.  López-Ribot, J.L., D. Navarro, P. Sepúlveda, , J.M. Nogueira, M. Casanova, and J.P. Martínez. 1994. A comparative study on cell wall antigens and cell surface hydrophobicity in clinical isolates of Candida albicans. Mycopathologia. 127:1-13.
4.  Sepúlveda, P., A. Murgui, J.L. López-Ribot, M. Casanova, J.L. Timoneda, and J.P. Martínez.1995. Evidence for the presence of collagenous-like domains in Candida albicans cell surface proteins. Infect. Immun. 63:2173-2179.
5.  López-Ribot, J.L., D. Gozalbo, P. Sepúlveda, M. Casanova, and J.PMartínez. 1995.   Preliminary characterization of the material released to the culture medium by Candida albicans yeast and mycelial cells. Antonie van Leeuwenhoek J. of Microbiol. 68:195-201.
6 Sepúlveda, P., A. Cervera, J.L. López-Ribot, M. Casanova, W.L. Chaffin, J.P.      Martínez y D. Gozalbo. Cloning and characterization of a cDNA for Candida albicans polyubiquitin. 1996. R: J. Med. Vet. Mycol. 34: 315-322.           
7. Sepúlveda, P., López-Ribot, J.L., D. Gozalbo, W.L. Chaffin, and J.P. Martínez. Ubiquitination of Receptor-like Molecules on the Surface of Candida albicans. 1996.R: Infect. Immun. 64:4406-4408.          
8. López-Ribot, J.L., C. Monteagudo, P. Sepúlveda, M. Casanova, J. P. Martínez, and W. L. Chaffin. Expression of the fibrinogen binding mannoprotein and the laminin receptor of Candida albicans in vitro and in infected tissues. 1996.R: FEMS Microbiol. Lett.142:117-122.
9.  López-Ribot, J.L, P. Sepúlveda, A. Cervera, P. Roig, D. Gozalbo and J.P. Martinez. TITULO:  Cloning of a cDNA fragment encoding part of the protein moiety of the 58-kDa fibrinogen-binding mannoprotein of Candida albicans. 1997. R: FEMS Microbiol. Lett. 157:273-278.
10. Sepúlveda, P., J. L. López-Ribot, A. Murgui, E. Cantón, D. Navarro, y J. P. Martínez. Candida albicans fibrinogen binding mannoprotein: expression in clinical strains and immunogenicity in patients with systemic candidiasis. 1998.R: Int. Microbiol. 1:209-216.
11. Hontebeyrie, M,  P. Sepúlveda and C. Aznar.Trypanosoma cruzi: agent de la maladie de Chagas ou Trypanosomose américaine. 1999. R: Ann. Institut Pasteur. 10:51-65.                     
12. Sepúlveda, P., P. Liegeard, G. Wallukat, and M. Hontebeyrie. Modulation of cardiocyte functional activity by antibodies against Trypanosoma cruzi ribosomal P2 protein C-terminus. 2000. R: Infect. Immun. 68:5114-5119.        
13. Sepúlveda, P., M. Hontebeyrie, P. Liegeard, A. Mascilli and K. Norris. DNA-based immunization with Trypanosoma cruzi complement receptor protein elicits complement lytic antibodies and confers protection against Trypanosoma cruzi infection. 2000. R: Infect. Immun. 68: 4986-4991.     

14. Sepúlveda, P., Mahler, E., O. Jeannequin, P. Liegeard, P. Gounon, G. Wallukat, M. J. Levin, J. Hoebeke and M. Hontebeyrie. A monoclonal antibody recognizing an immunodominant epitope on the ribosomal P2beta protein of Trypanosoma cruzi interacts with the human beta1-adrenergic receptor. 2001. R: Eur. J. Immunol. 31: 2210-2216
15. Sepúlveda P., Garcia F,  P. Liegeard, J. Gregoire, E. Hermann, F.Lemonnier, P. Langlade-Demoyen, M. Hontebeyrie e Y. C. Lone. Identification of HLA-A*0201-restricted cytotoxic T-cell epitopes of Trypanosoma cruzi TcP2b protein in HLA-transgenic mice and patients. 2003. R: Microbes Infect.5:351-359.
16. A. Encabo, E. P. Solves, Mateu, P. Sepúlveda, F. Carbonell-Uberos and M.D. Miñana. Selective generation of different dendritic cell precursors from CD34+ by IL-6 and IL-3. Stem Cells, 2004. 22:725-740.              
17. V. Mirabet, M.D. Miñana, P. Solves, S. Bonanad, A. Encabo, P. Sepúlveda, F. Carbonell-Uberos, M. A. Soler y R.J. Roig. El banco de tejidos como fuente de células madre mesenquimales.Rev. Esp de transplant. 2005. 14: 22-31.
18. A. Encabo, V. Mirabet, P. Sepúlveda, F. Carbonell y MD. Miñana. Optimización de las condiciones de cultivo de las células mesenquimales de médula ósea humana para su uso en traumatología. Patología del aparato locomotor. 2005. 3:132-143.
19. P. Sepulveda, A. Encabo, F. Carbonell, and M.D. Miñana. Bcl-2 is mainly regulated by JAK/STAK3 pathway in human CD34+ hematopoietic cells. Cell death and differenciation. Cell Death Differ. 2007 Feb;14(2):378-80.

20.  P.Sepúlveda, J. Martinez-León y J.M. García Verdugo. Neoangiogenesis with endotelial precursors for the treatment of ischemia. R:Transplantation Proceedings. 2007. Sep;39(7):2089-94.

21. L. Mondragón, M. Orzáez, G. Sanclimens, A. Moure,  A. Armiñán, P. Sepúlveda, A. Messeguer, M. J. Vicent, and E. Pérez-Payá. Modulation of Cellular Apoptosis with Apaf-1 Inhibitors. 2008. J Med Chem. 51:521-529.

22.  C. Gandia, A. Armiñan, J. M. García-Verdugo, E. Lledó, A. Ruiz, M.D. Miñana, J. Sanchez-Torrijos, R. Payá, V. Mirabet, F. Carbonell-Uberos, M. LLop, J. A. Montero and P. Sepúlveda. Human dental pulp stem cells improve left ventricular function, induce angiogenesis and reduce infarct size in rats with acute myocardial infarction. Stem Cells. 2008. 26:638-645.
23. A. Armiñan, C. Gandia, M.C. Bartual, J. M. García-Verdugo, E. Lledó, V. Mirabet, M. LLop, J. Barea, J. A. Montero and P. Sepúlveda. Cardiac differentiation is driven by NKX2.5 and GATA4 nuclear translocation in tissue specific mesenchymal stem cells. Stem Cells and Development. 2009.18(6):907-18.

24. A. Armiñán , C. Gandia , J. M. García-Verdugo , E. Lledó , C. Trigueros , A. Ruiz-Saurí , M D. Miñana , P. Solves , R. Paya , J. A Montero, y P. Sepúlveda. Mesenchymal stem cells provide better results than hematopoietic precursors for the treatment of myocardial infarction. Journal of the American college of Cardiology,in press)

26. S. Prado-Lopez, A. Conesa, A. Armiñán, M. Martínez-Losa, M. C. Escobedo1, C. Gandia, S. Tarazona, D. Melguizo, D. Montaner, S. Sanz-González, P. Sepúlveda, S. Götz, J. E. O’Connor, R. Moreno, J. Dopazo2, D. J. Burks y M. Stojkovic. Hypoxia promotes efficient differentiation of human embryonic stem cells to functional endothelium. Stem Cells (In press)

27- Ana Armiñán, Carolina Gandía, José Manuel García-Verdugo, Elisa Lledó, José Luis Mullor, José Anastasio Montero, y Pilar Sepúlveda.Cardiac transcription factors driven lineage-specification of adult stem cells.
REVISTA: Journal of Cardiovascular Translational Research (In Press)