RUBEN DARIO ARTERO ALLEPUZ
PDI-Catedratic/a d'Universitat
PDI-Catedratic/a d'Universitat
Àrea de coneixement: GENÈTICA
Departament: Genètica
Departament: Genètica
(9635) 43028
Biografia
El Dr. Artero és catedràtic de Genètica de la Universitat de València, on també es va doctorar en Bioquímica. Després de sis anys d'investigació postdoctoral sobre miogènesi al Memorial Sloan Kettering Cancer Center de Nova York, va tornar a Espanya l'any 2002 a través del Programa Ramón y Cajal i es va incorporar a la Universitat de València com a professor i investigador.
Actualment dirigeix el Laboratori de Genòmica Translacional Humana, centrat en l'estudi dels mecanismes moleculars i el desenvolupament de noves estratègies terapèutiques per a malalties neuromusculars minoritàries, com la distròfia miotònica i la LGMDD2, així com per a càncers neurològics i síndromes genètiques minoritàries. El seu grup combina l'ús de cèl·lules derivades de pacients, models murins i de Drosophila, juntament amb aproximacions multiómiques, per a investigar els mecanismes de la malaltia i avaluar noves estratègies terapèutiques. Les seues línies d'investigació inclouen, a més, el reposicionament de fàrmacs, les teràpies basades en oligonucleòtids i el desenvolupament de noves plataformes d'administració.
El Dr. Artero és autor de més de 93 publicacions científiques internacionals revisades per parells, ha dirigit 20 tesis doctorals i manté una àmplia xarxa de col·laboracions nacionals i internacionals. És inventor de diverses patents i cofundador de l'empresa biotecnològica ARTHEx Biotech.
Asignatures impartides i modalitats docents
Publicacions en revistes
- Peris-Moreno D; Sabater-Arcis M; Moreno N; Orduña L; López-Castel A; Bargiela A, Artero R. (2026) Oleic Acid Levels in HSALR Mouse Model of Myotonic Dystrophy Type 1. International Journal Of Molecular Sciences, 27(10), p. 4211 . ISSN: 1661-6596
- Giovanna Menduti; Raquel Perez-Gomez; Noémie Berenger-Currias; Cristina Ruatti; Jorge Espinosa-Espinosa; Camille Januel; Piotr Konieczny; Ruben Artero; Cecile Martinat; Marina Boido (2026) Haloperidol induces neuroprotection and enhances neuromuscular function in both murine and human models of spinal muscular atrophy. Experimental and Molecular Medicine, 58(4), pp. 1216 - 1229 . ISSN: 1226-3613
- Irene González-Martínez, Estefanía Cerro-Herreros, Marc Carrascosa-Sàez, Andrea García-Rey, Diego Piqueras Losilla, Anna Colom-Rodrigo, Nerea Moreno, Mouli Chakraborty, Aline Huguet-Lachon, Anchel González-Barriga, Neia Naldaiz-Gastesi, Martxel Dehesa, Ana Díaz-Maqueda, Nuria Barquero, Miguel A Varela, Adolfo López de Munain, Ramon Eritja, Geneviève Gourdon, Arturo López-Castel, Manuel Pérez-Alonso, Beatriz Llamusi, Rubén Artero (2026) Enhanced muscle uptake of chemically optimized miR-23b antisense oligonucleotides as lead compounds for Myotonic Dystrophy type 1. American Journal of Human Genetics, S0002-9297(26)0 . ISSN: 0002-9297
- Koon AC, Yeung KYW, Wu Y, Leong LI, Cheung JTP, Chen ZS, Peng SI, Armstrong NS, Frank CA, Magneron P, Gomes-Pereira M, Fung JMS, Bargiela A, Moreno N, Poyatos-Garcia J, Vilchez J, Huguet-Lachon A, Brewer CK, Zinter M, Beck ES, Artero R, Gourdon G, Budnik V, Thomson T, McCabe BD, Chan HYE. (2025) Pre- and postsynaptic upregulation of FasII synergistically underlies neuropathological and behavioral phenotypes in a Drosophila model of myotonic dystrophy. Nature Communications, 17(1), p. 1005 . ISSN: 2041-1723
- N Moreno, M Sabater-Arcis, J Espinosa-Espinosa, L Mulet-Rivero, E García-España, J González-García, D Seoane-Miraz, M J A Wood, M A Varela, J Ohana, T Sevilla, M Perez Alonso, A Bargiela, R Artero. (2025) miR-107 represses DMPK and is sequestered by CUG repeats triggering the MSI2/miR-7 pathogenesis axis in myotonic dystrophy. Molecular Therapy-Nucleic Acids, 36(3), pp. 102584-1 - 17 . ISSN: 2162-2531
- Marc Carrascosa-Sàez; Esfanía Cerro-Herreros; Anna Colom-Rodrigo; Irene González-Martínez; Rubén Artero (2025) Distrofia Miotónica Tipo 1: la importancia de incluir hembras en la investigación. Genética médica news. ISSN: 2386-5113
- Marc Carrascosa-Sàez; Anna Colom-Rodrigo; Irene González-Martínez; Raquel Pérez-Gómez; Andrea García-Rey; Diego Piqueras-Losilla; Ana Ballestar; Beatriz Llamusí; Estefanía Cerro-Herreros; Ruben Artero (2025) Use of HSA[LR] female mice as a model for the study of Myotonic Dystrophy type I. Lab Animal. ISSN: 0093-7355
- Judit Núñez-Manchón, Júlia Capó, Alicia Martínez-Piñeiro, Eduard Juanola, Jovan Pesovic, Laura Mosqueira-Martín, Klaudia González-Imaz, Pau Maestre-Mora, Renato Odria, Estefania Cerro-Herreros, Neia Naldaiz-Gastesi, Adolfo López de Munain, Rubén Artero, Dusanka Savic-Pavicevic, Ainara Vallejo-Illarramendi, Kamel Mamchaoui, Anne Bigot, Vincent Mouly, Mònica Suelves, Gisela Nogales-Gadea (2024) Erratum: Immortalized human myotonic dystrophy type 1 muscle cell lines to address patient heterogeneity. Iscience, 27(12), p. 111499 . ISSN: 2589-0042
- Mikel García-Puga; Gorka Gerenu; Ariadna Bargiela; Jorge Espinosa-Espinosa; Laura Mosqueira-Martin; Maialen Sagartzazu-Aizpurua; Jesús M. Aizpurua; Ainara Vallejo-Illarramendi; Rubén Artero; Adolfo López de Munain; Ander Matheu (2024) A novel class of FKBP12 ligands rescues premature aging phenotypes associated with Myotonic Dystrophy type 1. Cells, 13(23), p. 1939 . ISSN: 2073-4409
- Maria Sabater-Arcis; Nerea Moreno; Teresa Sevilla; Manuel Perez Alonso; Ariadna Bargiela; Ruben Artero (2024) Msi2 enhances muscle dysfunction in a myotonic dystrophy type 1 mouse model. Biomedical Journal, 47(100667) . ISSN: 2319-4170
- Estefanía Cerro-Herreros; Judit Núñez-Manchón; Neia Naldaiz-Gastesi; Marc Carrascosa-Sàez; Andrea García-Rey; Diego Piqueras Losilla; Irene González-Martínez; Jorge Espinosa-Espinosa; Kevin Moreno; Javier Poyatos-García; Juan J Vilchez; Adolfo López de Munain; Mònica Suelves; Gisela Nogales-Gadea; Beatriz Llamusí; and Rubén Artero (2024) AntimiR treatment corrects myotonic dystrophy primary cell defects across several CTG repeat expansions with a dual mechanism of action. Science Advances, 10(41), pp. 1 - 17 . ISSN: 2375-2548
- Moreno N; Sabater-Arcis M; Sevilla T; Alonso MP; Ohana J; Bargiela A; Artero R. (2024) Therapeutic potential of oleic acid supplementation in myotonic dystrophy muscle cell models. Biological Research, 57(29), pp. 2 - 17 . ISSN: 0716-9760
- Sheeza Mughal; Maria Sabater-Arcis; Ruben Artero; Javier Ramón-Azcón; Juan M Fernández-Costa (2024) Taurine activates the AKT-mTOR axis to restore muscle mass and contractile strength in human 3D in vitro models of steroid myopathy. Disease Models & Mechanisms, 17(4) . ISSN: 1754-8403
- Irene González-Martínez; Estefanía Cerro-Herreros; Nerea Moreno; Andrea García-Rey; Jorge Espinosa-Espinosa; Marc Carrascosa-Sàez; Diego Piqueras-Losilla; Andrey Arzumanov; David Seoane-Miraz; Yahya Jad; Richard Raz; Matthew J Wood; Miguel A Varela; Beatriz Llamusí; Rubén Artero (2023) Peptide-conjugated antimiRs improve myotonic dystrophy type 1 phenotypes by promoting endogenous MBNL1 expression. Molecular Therapy-Nucleic Acids, 34, p. 102024 . ISSN: 2162-2531
- Mari Carmen Álvarez-Abril; Irma García-Alcover; Jordi Colonques-Bellmunt; Raquel Garijo; Manuel Pérez-Alonso; Rubén Artero; Arturo López-Castel (2023) Natural compound boldine lessens Myotonic Dystrophy type 1 phenotypes in DM1 Drosophila models, patient-derived cell lines, and HSA[LR] Mice. International Journal Of Molecular Sciences, 24(12), p. 9820 . ISSN: 1661-6596
- Sarah J Overby, Estefanía Cerro-Herreros, Jorge Espinosa-Espinosa, Irene González-Martínez, Nerea Moreno, Juan M Fernández-Costa, Jordina Balaguer-Trias, Javier Ramón-Azcón, Manuel Pérez-Alonso, Thorleif Møller, Beatriz Llamusí, Rubén Artero (2023) BlockmiR AONs as Site-Specific Therapeutic MBNL Modulation in Myotonic Dystrophy 2D and 3D Muscle Cells and HSALR Mice. Pharmaceutics, 15(4), p. 1118 . ISSN: 1999-4923
- Marta Pascual-Gilabert; Ruben Artero; Arturo López-Castel (2023) The myotonic dystrophy type 1 drug development pipeline: 2022 edition. Drug Discovery Today, 28(3), p. 103489 . ISSN: 1359-6446
- Poyatos-García J; Blázquez-Bernal Á; Selva-Giménez M; Bargiela A; Espinosa-Espinosa J; Vázquez-Manrique RP; Bigot A; Artero R; Vilchez JJ. (2023) CRISPR-Cas9 editing of a TNPO3 mutation in a muscle cell model of limb-girdle muscular dystrophy type D2. Molecular Therapy-Nucleic Acids, 31, pp. 324 - 338 . ISSN: 2162-2531
- Ariadna Bargiela; Amadeo Ten-Esteve; Luis Martí-Bonmatí; Teresa Sevilla; Manuel Perez Alonso; Ruben Artero (2023) Quantitative magnetic resonance imaging assessment of muscle composition in myotonic dystrophy mice. Scientific Reports, 13(1), p. 503 . ISSN: 2045-2322
- Januel C; Menduti G; Mamchaoui K; Martinat C; Artero R; Konieczny P; Boido M. (2022) Moxifloxacin rescues SMA phenotypes in patient-derived cells and animal model. Cellular and Molecular Life Sciences, 79(8), p. 441 . ISSN: 1420-682X
- Sarah J. Overby; Estefanía Cerro-Herreros; Irene González-Martínez; Miguel A. Varela; David Seoane-Miraz; Yahya Jad; Richard Raz; Thorleif Møller; Manuel Pérez-Alonso; Matthew J. Wood; Beatriz Llamusí; Rubén Artero (2022) Proof of concept of peptide-linked blockmiR-induced MBNL functional rescue in myotonic dystrophy type 1 mouse model. Molecular Therapy-Nucleic Acids, 27, pp. 1146 - 1155 . ISSN: 2162-2531
- Jorge Espinosa-Espinosa; Anchel González-Barriga; Arturo López-Castel; Rubén Artero (2022) Deciphering the Complex Molecular Pathogenesis of Myotonic Dystrophy Type 1 through Omics Studies. International Journal Of Molecular Sciences, 23(3), p. 1441 . ISSN: 1661-6596
- Ariadna Bargiela; Rubén Artero (2021) Modulación génica terapéutica con oligonucleótidos antisentido. Revista de la Sociedad Española de Bioquímica y Biología molecular(210), pp. 8 - 12 . ISSN: 1696-473X
- Anna Rapisarda, Ariadna Bargiela, Beatriz Llamusi, Isabel Pont, Roger Estrada‑Tejedor, Enrique Garcia‑España, Ruben Artero and Manuel Perez‑Alonso (2021) Defined d-hexapeptides bind CUG repeats and rescue phenotypes of myotonic dystrophy myotubes in a Drosophila model of the disease. Scientific Reports, 11(19417), pp. 1 - 15 . ISSN: 2045-2322
- Águeda Blázquez-Bernal, Juan M Fernandez-Costa, Ariadna Bargiela, Ruben Artero (2021) Inhibition of autophagy rescues muscle atrophy in a LGMDD2 Drosophila model. Faseb Journal, 35(10), pp. 1 - 19 . ISSN: 0892-6638
- Maria Sabater-Arcis, Ariadna Bargiela, Nerea Moreno, Javier Poyatos-Garcia, Juan J. Vilchez, Ruben Artero (2021) Musashi-2 contributes to myotonic dystrophy muscle dysfunction by promoting excessive autophagy through miR-7 biogenesis repression. Molecular Therapy-Nucleic Acids, 25, pp. 652 - 667 . ISSN: 2162-2531
- Martínez-Chacón G, Paredes-Barquero M, Yakhine-Diop SMS, Uribe-Carretero E, Bargiela A, Sabater-Arcis M, Morales-García J, Alarcón-Gil J, Alegre-Cortés E, Canales-Cortés S, Rodríguez-Arribas M, Camello PJ, Pedro JMB, Perez-Castillo A, Artero R, Gonzalez-Polo RA, Fuentes JM, Niso-Santano M. (2021) Neuroprotective properties of queen bee acid by autophagy induction. Cell Biology and Toxicology. ISSN: 0742-2091
- Estefanía Cerro-Herreros; Irene González-Martínez; Nerea Moreno; Jorge Espinosa-Espinosa; Juan M Fernández-Costa; Anna Colom-Rodrigo; Sarah J Overby; David Seoane-Miraz; Javier Poyatos-García; Juan J Vilchez; Adolfo López de Munain; Miguel A Varela; Matthew J Wood; Manuel Pérez-Alonso; Beatriz Llamusí; Rubén Artero (2021) Preclinical characterization of antagomiR-218 as a potential treatment for myotonic dystrophy. Molecular Therapy-Nucleic Acids, 26, pp. 174 - 191 . ISSN: 2162-2531
- Estela Selma-Soriano, Carlos Casillas-Serra, Rubén Artero, Beatriz Llamusi, Juan Antonio Navarro, Josep Redón (2021) Rabphilin silencing causes dilated cardiomyopathy in a Drosophila model of nephrocyte damage. Scientific Reports, 11(Art. 15287) . ISSN: 2045-2322
- Ariadna Bargiela; Ruben Artero (2021) Practicing logical reasoning through Drosophila segmentation gene mutants. Biochemistry and Molecular Biology Education, 49(5) . ISSN: 1470-8175
- Xiomara Fernández-Garibay; María A Ortega; Estefanía Cerro-Herreros; Jordi Comelles; Elena Martínez; Rubén Artero; Juan M Fernandez-Costa; Javier Ramon (2021) Bioengineered in vitro 3D model of myotonic dystrophy type 1 human skeletal muscle. Biofabrication, 13(3) . ISSN: 1758-5082
- Lauren Ozimski; Maria Sabater Arcís; Ariadna Bargiela; Ruben Artero (2021) The Hallmarks of Myotonic Dystrophy type 1 Muscle Dysfunction. Biological Reviews of the Cambridge Philosophical Society, 96(2), pp. 716 - 730 . ISSN: 1464-7931
- Marta Pascual-Gilabert; Arturo López-Castel; Ruben Artero (2021) Myotonic dystrophy type 1 drug development: a pipeline toward the market. Drug Discovery Today, 26(7), pp. 1765 - 1772 . ISSN: 1359-6446
- Daniel J. Klionsky; (múltiples autores); Nadezda Apostolova (múltiples autores); Rubén Artero; (múltiples autores); Ariadna Bargiela; (múltiples autores); Ana Blas-García; (múltiples autores); María Sabater; (múltiples autores); Victor M. Victor (múltiples autores) (2021) Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition). Autophagy, 17(1), pp. 1 - 382 . ISSN: 1554-8627
- Estefanía Cerro-Herreros, Irene González-Martínez, Nerea Moreno-Cervera, Sarah Overby, Manuel Pérez-Alonso, Beatriz Llamusí, Rubén Artero (2020) Therapeutic Potential of AntagomiR-23b for Treating Myotonic Dystrophy. Molecular Therapy-Nucleic Acids, 21, pp. 837 - 849 . ISSN: 2162-2531
- Estela Selma-Soriano; Beatriz Llamusi; Juan Manuel Fernández-Costa; Lauren Louise Ozimski; Rubén Artero; Josep Redón (2020) Rabphilin involvement in filtration and molecular uptake in Drosophila nephrocytes suggests a similar role in human podocytes. Disease Models & Mechanisms, 13(9) . ISSN: 1754-8403
- Ramon-Duaso C; Rodríguez-Morató J; Selma-Soriano E; Fernández-Avilés C; Artero R; de la Torre R; Pozo ÓJ; Robledo P (2020) Protective effects of mirtazapine in mice lacking the Mbnl2 gene in forebrain glutamatergic neurons: Relevance for myotonic dystrophy 1. Neuropharmacology, 170(Article 108068) . ISSN: 0028-3908
- Sabater-Arcis M, Bargiela A, Furling D, Artero R. (2020) miR-7 Restores Phenotypes in Myotonic Dystrophy Muscle Cells by Repressing Hyperactivated Autophagy. Molecular Therapy-Nucleic Acids, 19, pp. 278 - 292 . ISSN: 2162-2531
- Piotr Konieczny; Rubén Artero (2020) Drosophila SMN2 minigene reporter model identifies moxifloxacin as a candidate therapy for SMA. Faseb Journal, 34 (2), pp. 3021 - 3036 . ISSN: 0892-6638
- Bargiela A; Sabater-Arcis M; Espinosa-Espinosa J; Zulaica M; Lopez de Munain A; Artero R. (2019) Increased Muscleblind levels by chloroquine treatment improve myotonic dystrophy type 1 phenotypes in in vitro and in vivo models. Proceedings of the National Academy of Sciences of the United States of America, 116(50), pp. 25203 - 25213 . ISSN: 0027-8424
- Arturo Lopez Castel, Sarah Overby, Ruben Artero (2019) MicroRNA-Based Therapeutic Perspectives in Myotonic Dystrophy. International Journal Of Molecular Sciences, 20(22), p. 5600 . ISSN: 1661-6596
- A. Adam Artigues; E. Tormo; E. Cerro-Herreros; M. Sabater; I. Garrido-Cano; B. Pineda Merlo; B. Pattanayak; P. Cabello; R. Artero; P. Eroles (2018) Muscleblind-like 1 regulates epithelial to mesenchymal transition markers in triple-negative breast cancer. Annals of Oncology. ISSN: 0923-7534
- Sarah J.Overby; Estefanía Cerro‐Herreros; Beatriz Llamusi; Ruben Artero (2018) RNA-mediated therapies in myotonic dystrophy. Drug Discovery Today, 12(2013-2022) . ISSN: 1359-6446
- Chakraborty M; Llamusi B; Artero R. (2018) Modeling of Myotonic Dystrophy Cardiac Phenotypes in Drosophila. Frontiers In Neurology, 9(473) . ISSN: 1664-2295
- Nerea Moreno, Estefanía Cerro‐Herreros, María Sabater‐Arcis, Juan M. Fernández‐Costa, Manuel Pérez‐Alonso, Beatriz Llamusi , Rubén Artero (2018) El silenciamiento de microRNAs mejora fenotipos de la distrofia miotónica en modelos mamíferos de la enfermedad. Genética médica news, 5(106), pp. 31 - 33 . ISSN: 2386-5113
- Estefania Cerro-Herreros; María Sabater-Arcis;Juan M. Fernandez-Costa;Nerea Moreno; Manuel Perez-Alonso; Beatriz Llamusi; Ruben Artero (2018) miR-23b and miR-218 silencing increase Muscleblind-like expression and alleviate myotonic dystrophy phenotypes in mammalian models. Nature Communications, 9(2482) . ISSN: 2041-1723
- Amparo Garcia-Lopez; Francesca Tessaro; Hendrik R.A. Jonker; Anna Wacker; Christian Richter; Arnaud Comte; Nikolaos Berntenis; Roland Schmucki; Klas Hatje; Olivier Petermann; Gianpaolo Chiriano; Remo Perozzo; Daniel Sciarra; Piotr Konieczny; Ignacio Faustino; Guy Fournet; Modesto Orozco; Ruben Artero; Friedrich Metzger; Martin Ebeling; Peter Goekjian; Benoît Joseph; Harald Schwalbe; Leonardo Scapozza (2018) Targeting RNA structure in SMN2 reverses spinal muscular atrophy molecular phenotypes. Nature Communications, 9(2032) . ISSN: 2041-1723
- Chantal Sellier; Estefanía Cerro-Herreros; Markus Blatter; Fernande Freyermuth; Angeline Gaucherot; Frank Ruffenach; Partha Sarkar; Jack Puymirat; Bjarne Udd; John W. Day; Giovanni Meola; Guillaume Bassez; Harutoshi Fujimura; Masanori P. Takahashi; Benedikt Schoser; Denis Furling; Ruben Artero; Frédéric Allain; Beatriz Llamusi & Nicolas Charlet-Berguerand (2018) rbFOX1 competition with MBNL1 for binding to CCUG RNA repeats may contribute to the lesser toxicity of CCTG expansion in myotonic dystrophy type 2. Nature Communications, 9(2009) . ISSN: 2041-1723
- Chakraborty M; Sellier C; Ney M; Villa P; Charlet-Berguerand N; Artero R; Llamusi B (2018) Daunorubicin reduces MBNL1 titration by expanded CUG repeat RNA and rescues cardiac dysfunctions in a Drosophila model of myotonic dystrophy. Disease Models & Mechanisms, 11(4) . ISSN: 1754-8403
- Selma-Soriano E; Artero R; Llamusi B (2018) Optical Cross-Sectional Muscle Area Determination of Drosophila Melanogaster Adult Indirect Flight Muscles. Jove-Journal Of Visualized Experiments. ISSN: 1940-087X
- Eduardo Calpena; Víctor López del Amo; Mouli Chakraborty; Beatriz Llamusí; Rubén Artero; Carmen Espinós; Máximo I. Galindo (2018) The Drosophila junctophilin gene is functionally equivalent to its four mammalian counterparts and is a modifier of a Huntingtin poly-Q expansion and the Notch pathway. Disease Models & Mechanisms, 11(1), pp. 1 - 13 . ISSN: 1754-8403
- Konieczny P, Selma-Soriano E, Rapisarda AS, Fernandez-Costa JM, Perez-Alonso M, Artero R. (2017) Myotonic dystrophy: candidate small molecule therapeutics. Drug Discovery Today, 22(11), pp. 1740 - 1748 . ISSN: 1359-6446
- Estefanía Cerro‐Herreros, Mouli Chakraborty, Rubén Artero y Beatriz Llamusí (2017) Toxicidad mediada por repeticiones CUG vs CCUG en tejido muscular y cardiaco en modelos en Drosophila de distrofia miotónica. Genética médica news, 4(79), pp. 5 - 7 . ISSN: 2386-5113
- Àlex L. González; Piotr Konieczny; Beatriz Llamusi; José I. Borrell; Jordi Teixidó; Manuel Pérez-Alonso; Roger Estrada-Tejedor; Rubén Artero (2017) In silico discovery of substituted pyrido[2,3-d]pyrimidines and pentamidine-like compounds with biological activity in myotonic dystrophy models. Plos One, 12(6 ), p. e0178931 . ISSN: 1932-6203
- Estefania Cerro-Herreros, Mouli Chakraborty, Manuel Pérez-Alonso , Rubén Artero, and Beatriz Llamusí (2017) Expanded CCUG repeat RNA expression in Drosophila heart and muscle trigger Myotonic Dystrophy type 1-like phenotypes and activate autophagocytosis genes. Scientific Reports(Art. Id: 2829), p. 2843 . ISSN: 2045-2322
- Estefania Cerro-Herreros; Juan M. Fernandez-Costa; María Sabater-Arcis; Beatriz Llamusi; Ruben Artero (2016) La desrepresión de la expresión de muscleblind mejora fenotipos característicos de distrofia miotónica en Drosophila. Genética médica news. ISSN: 2386-5113
- Estefania Cerro-Herreros; Juan M. Fernandez-Costa; Maria Sabater-Arcis; Beatriz Llamusi; Ruben Artero (2016) Derepressing muscleblind expression by miRNA sponges ameliorates myotonic dystrophy-like phenotypes in Drosophila. Scientific Reports, 6, p. 36230 . ISSN: 2045-2322
- Janani Iyer; Qingyu Wang; Thanh Le; Lucilla Pizzo; Sebastian Grönke; Surendra S. Ambegaokar; Yuzuru Imai; Ashutosh Srivastava; Claire Reynolds; Beatriz Llamusí Troisí; Graeme Mardon; Ruben Artero; George Jackson; Adrian Isaacs; Linda Partridge; Bingwei Lu; Justin Kumar; Santhosh Girirajan (2016) Quantitative assessment of eye phenotypes for functional genetic studies using Drosophila melanogaster. G3-Genes Genomes Genetics. ISSN: 2160-1836
- Juan M. Fernandez-Costa; Beatriz Llamusi; Ariadna Bargiela; Miren Zulaica; M. Carmen Álvarez-Abril; Manuel Perez-Alonso; Adolfo López de Munain; Arturo López-Castel; Ruben Artero (2016) Six serum miRNAs fail to validate as myotonic dystrophy type 1 biomarkers. Plos One, 11(2), p. e0150501 . ISSN: 1932-6203
- Estela Selma Soriano; Mouli Chakraborty; Rubén Artero Allepuz; Beatriz Llamusí Troisi (2016) La pentamidina rescata la contractilidad y la ritmicidad cardiaca en un modelo de distrofia miotónica en Drosophila. Genética médica news, Febrero 2016 . ISSN: 2386-5113
- Yasmine Ferchichi; Àngela Natividad; Rubén Artero; Arturo López-Castel (2026) The myotonic dystrophy type 1 drug development pipeline: 2026 Edition. Drug Discovery Today, 31(4), p. 104706 . ISSN: 1359-6446
Activitats anteriors
- Profesor Titular de Genética. Universidad de Valencia. 14/10/2009 - 14/11/2019.
- Prof. Contratado Doctor. Departamento de Genética. Universitat de València. 01/03/2006 - 13/10/2009.
- Inv. Ramón y Cajal (MEC). Departamento de Genética. Universitat de València. 01/02/2003 - 28/02/2006.
- Téc. Sup. Investigación. Departamento de Genética. Universitat de València. 23/05/2002 - 31/01/2003.
- Investigador postdoctoral. Mem. Sloan-Kettering Cancer Centre. New York. USA. 01/08/1996 - 16/03/2002.
- Profesor Asociado LRU. Departamento de Genética. Universitat de València. 01/01/1996 - 31/03/1996.
- Téc. Sup. Investigación. Departamento de Genética. Universitat de València. 01/10/1994 - 31/12/1995.
- Becario Predoctoral. Departamento de Genética. Universitat de València. 01/10/1990 - 30/09/1994.
Estades a Centres de Recerca
- Cambridge. ANGLATERRA, 1993. Clonación de genes regulados por el gen wingless de Drosophila melanogaster. Doctorand.
- New York. ESTATS UNITS D'AMÈRICA, 1996. Identification of novel genes involved in muscle differentiation. Post-doctoral.
- Valencia. ESPANYA, 2013. Desarrollo de métodos innovadores para descubrimiento de fármacos en enfermedades raras. Altres (especificar) - Estancias de personal investigador en empresas de la Comunidad Valenciana.
- Valencia. ESPANYA, 2014. Colaboración en la transferencia de resultados de investigación al sector productivo. Altres (especificar) - Estancias de personal investigador en empresas de la Comunidad Valenciana.
Participacions a Congressos
- Irene González-Martínez; Estefanía Cerro-Herreros; Marc Carrascosa-Sàez; Andrea García-Rey; Diego Piqueras Losilla; Anna Colom-Rodrigo; Nerea Moreno; Mouli Chakraborty; Aline Huguet-Lachon; Anchel González-Barriga; Neia Naldaiz-Gastesi; Martxel Dehesa; Nuria Barquero; Miguel A Varela; Adolfo López de Munain; Geneviève Gourdon; Arturo López-Castel; Beatriz Llamusi; Rubén Artero (2025). Enhanced muscle uptake of chemically optimized miR-23b antisense oligonucleotides as lead compounds for myotonic dystrophy. (Comunicació). XVIII Reunión anual CIBERER . Madrid . ESPANYA
- Irene González-Martínez; Estefanía Cerro-Herreros; Marc Carrascosa-Sàez; Andrea García-Rey; Diego Piqueras Losilla; Anna Colom-Rodrigo; Nerea Moreno; Mouli Chakraborty; Aline Huguet-Lachon; Anchel González-Barriga; Neia Naldaiz-Gastesi; Martxel Dehesa; Nuria Barquero; Miguel A Varela; Adolfo López de Munain; Geneviève Gourdon; Arturo López-Castel; Beatriz Llamusi; Rubén Artero (2025). Optimización de oligonucleótidos antisentido para mejorar su captación muscular en Distrofia Miotónica tipo 1. (Comunicació). Jornada predoctoral INCLIVA 2025 . ESPANYA
- Natalia Riedel; Dulce Peris-Moreno; Jorge Espinosa; Ariadna Bargiela Schönbrunn; Manuel Pérez Alonso; Rubén Artero (2025). Targeting Musashi-2 with antisense oligonucleotides: a therapeutic approach to mitigate muscle pathology in Myotonic Dystrophy type 1. (Comunicació). Synergistic Meeting on Oligonucleotide Therapeutics (SMOT4) . Valencia . ESPANYA
- Rubén Artero (2025). ENTRY-DM: Interdisciplinary doctoral training on oligonucleotide-based therapies for myotonic dystrophy. (Comunicació). Synergistic Meeting on Oligonucleotide Therapeutics (SMOT4) . Valencia . ESPANYA
- Ariadna Bargiela; Natalia Riedel; Dulce Peris; Ruben Artero (2025). Non-clinical development of therapeutic molecules targeting MSI2 in Myotonic Dystrophy. (Comunicació). Neurodegenerative & Neuromuscular Diseases (NND-2025) . Barcelona . ESPANYA
- Alberto García-Martin, Dulce Peris-Moreno, Ariadna Bargiela, Rubén Artero (2025). Antisense oligonucleotides therapy effectively reduces MSI2 in skeletal muscle of HSALR mice. (Comunicació). 23th International Istanbul Scientific Research Congress on Life, Engineering, Architecture, and Mathematical Sciences . TURQUIA
- Paola Yánez, Natalia Galindo, María Sabater, Ariadna Bargiela, Rubén Artero (2025). ASO therapy modulates disease pathways and enhances myotube fusion in Limb-Girdle Muscular Dystrophy D2. (Comunicació). 7th International Palestra Scientific Research Congress ISBN: 978-9952-8605-4-2 DOI: https://doi.org/10.30546/19023.978-9952-8605-4-2.2025.056 . Skopje . MACEDÒNIA DEL NORD
- Paola Yánez, Natalia Galindo, María Sabater, Ariadna Bargiela, Rubén Artero (2025). Transcriptomic Profiling and Subcellular Localization Analysis Reveal MSI2-Associated Alterations in Limb-Girdle Muscular Dystrophy D2. (Comunicació). 2nd International Health Sciences Congress in the 21st Century ISBN: 978-9952-8605-5-9 DOI: https://doi.org/10.30546/19023.978-9952-8605-5-9.2025.0347 . Kuşadası . TURQUIA
- Paola Dalgo Aguilar, Ariadna Bargiela, Rubén Artero (2025). Modulation of TNPO3 expression in Limb-Girdle Muscular Dystrophy type D2 (LGMDD2) cells. (Comunicació). 23th International Istanbul Scientific Research Congress on Life, Engineering, Architecture, and Mathematical Sciences . TURQUIA
- Anna Colom-Rodrigo; Mireia Gromaz-Iborra; Estefanía Cerro-Herreros; Rubén Artero (2025). Development and validation of a bichromatic reporter system in human myoblasts to optimize the delivery of therapeutic ASOs. (Comunicació). 2nd International Health Sciences Congress . Kuşadası . TURQUIA
- Irene González-Martínez; Piotr Koniezcny; Rubén Artero (2025). Improving SMA treatments with the use of haloperidol. (Comunicació). Mobile World Capital Barcelona - 4YFN . ESPANYA
- Irene González-Martínez; Piotr Koniezcny; Rubén Artero (2025). Improving SMA treatments with the use of haloperidol. (Comunicació). Science for Industry (S4i) . ESPANYA
- Alicia Novella; Javier Poyatos-García; Ariadna Bargiela; Rubén Artero. (2025). Antisense Oligonucleotide-Mediated Silencing of mutTNPO3 as a Therapeutic Strategy for LGMDD2. (Poster). I Jornada predoctoral INCLIVA . ESPANYA
- L.M. Bedoya Del Olmo, M. Beltrán Vicente, P. Jiménez Santana, M. Bermejo Herrero, A. Cascajero Díaz, N. González Fernández, I. Díaz-Marín, J. Poyatos-García, A. Novella, A. Bargiela, R. Artero, F. Díez-Fuertes, J. García-Pérez, J. Alcamí Pertejo (2025). Discovery of novel drugs acting in HIV-1 replication through screening of an FDA/EMA-approved chemical library. (Poster). XVI Congreso Nacional GeSIDA . Granada . ESPANYA
- Paola Yánez, Natalia Galindo, María Sabater, Ariadna Bargiela, Rubén Artero (2025). La supresión de Musashi2 con el gapmer GT44 rescata parcialmente el fenotipo de LGMDD2. (Poster). I Jornada Predoctoral de INCLIVA . Valencia . ESPANYA
- Anna Colom-Rodrigo; Mireia Gromaz-Iborra; Dulce Peris-Moreno; Estefanía Cerro-Herreros; Rubén Artero (2025). Desarrollo y validación de un sistema reportero bicromático en mioblastos humanos para optimizar la entrega de ASOs terapéuticos. (Poster). I Jornada Predoctoral de INCLIVA . València . ESPANYA
- Alicia Novella; Javier Poyatos-García; Ariadna Bargiela; Rubén Artero. (2025). Antisense Oligonucleotide-Mediated Silencing of mutTNPO3 as a Therapeutic Strategy for LGMDD2. (Poster). OTS Annual Meeting, Oligonucleotide Therapeutics Society. 2025 . HONGRIA
- Diego Piqueras-Losilla; Judith Walker; Andrea García-Rey; Argimiro Mayoral-Olmos; Ana Díaz-Maqueda; Nuria Barquero; Rubén Artero; Beatriz Llamusí; Estefanía Cerro-Herreros. (2025). Fatty Acid Mediated Oligonucleotide Uptake System (FAMOUS) enables antimiR-23b mediated functional and molecular rescue of cognitive dysfunction in DMSXL mice. (Poster). 2025 Myotonic Dystrophy Foundation (MDF) Conference . Indianapolis . ESTATS UNITS D'AMÈRICA
- Andrea García-Rey; Diego Piqueras-Losilla; Argimiro Mayoral-Olmos; Ana Díaz-Maqueda; Nuria Barquero; Rubén Artero; Beatriz Llamusí; Estefanía Cerro-Herreros. (2025). New insights into DM1 mechanism of pathogenesis: DMPK, MBNL and miR-23b balance as the master key of DM1 pathology. (Poster). 2025 Myotonic Dystrophy Foundation (MDF) Conference . Indianapolis . ESTATS UNITS D'AMÈRICA
- Estefanía Cerro-Herreros; Andrea García-Rey; Mouli Chakraborty; Nuria Barquero; Isabel Campillo; Irene González-Martínez; Argimiro Mayoral-Olmos; Diego Piqueras-Losilla; Isabella Castano; Melanie Nufer; Rubén Artero; Beatriz Llamusi. (2025). Fatty Acid Mediated Uptake System (FAMOUS) enables improved oligo delivery to muscle and brain. (Poster). 2025 Myotonic Dystrophy Foundation (MDF) Conference . Indianapolis . ESTATS UNITS D'AMÈRICA
- Paola Yánez, Natalia Galindo, María Sabater, Ariadna Bargiela, Rubén Artero (2025). Musashi2 Suppression with GT44 Gapmer Partially Rescues LGMDD2 Phenotype. (Poster). 21th Annual Meeting of the Oligonucleotide Therapeutics Society . Budapest . HONGRIA
- Poyatos García, Javier; Vílchez , Roger; Azorín , Inmaculada; Novella , Alicia; Muelas , Nuria; Sevilla , Teresa; Martí , Pilar; Artero , Ruben; Vílchez , Juan J (2025). Estudio patológico y transcriptómico en la distrofia muscular de cinturas LGMDD2. (Ponència). LXXVII Reunión Anual de la Sociedad Española de Neurología . ESPANYA
- Javier Poyatos-García; Roger Vilchez; Nuria Muelas; Teresa Sevilla; Alicia Novella; Inmaculada Azorín; Pilar Martí; Ariadna Bargiela; Ruben Artero; Juan J Vílchez. (2025). LGMDD2 muscular dystrophy pathological and transcriptomic study. (Ponència). 30th Anual Congress of the World Muscle Society (WMS) . ÀUSTRIA
- Rubén Artero (2025). From Flies to Drugs: Beating the Odds. (Ponència invitada). European Drosophila Research Conference 2025 (EDRC2025) . Alicante . ESPANYA
- Ariadna Bargiela; Rubén Artero (2024). Promoting meaningful learning through the acquisition of competencies by using an electronic laboratory notebook. (Comunicació). 6th International 'ARTEMİS' Congress on Health and Sports Sciences . Izmir . TURQUIA
- Maria Sabater-Arcís; Nerea Moreno; Ariadna Bargiela; David Seoane-Miraz; Mathew Wood; Miguel Varela; Jorge Espinosa-Espinosa; Ruben Artero; Manuel Pérez-Alonso (2024). Mutant DMPK transcripts interacts with miR-107 triggering the MSI2>mir-7>autophagy axis in myotonic dystrophy. (Comunicació). IDMC-14 . Nijmegen . PAÏSOS BAIXOS
- Alicia Novella; Javier Poyatos; Ariadna Bargiela; Rubén Artero (2024). Gapmer technology as a therapeutic approach for LGMDD2. (Comunicació). 10th International ARTEMIS Scientific Research Congress ISBN: 978-9952-8541-1-4 . Bucarest . ROMANIA
- Natalia Riedel; Dulce Peris; Rubén Artero; Manuel Pérez Alonso; Ariadna Bargiela Schönbrunn (2024). Development of gapmers targeting MSI2: a novel therapeutic target for muscle atrophy in Myotonic Dystrophy type 1. (Comunicació). 10th International ARTEMIS Scientific Research Congress ISBN: 978-9952-8541-1-4 . Bucarest . ROMANIA
- Paola Yánez; Natalia Galindo; María Sabater; Ariadna Bargiela; Rubén Artero (2024). Exploring the dynamics of MSI2 expression in LGMDD2: influence of cell differentiation and seeding. (Comunicació). 10th International ARTEMIS Scientific Research Congress ISBN: 978-9952-8541-1-4 . Bucarest . ROMANIA
- Paola Dalgo Aguilar; Rubén Artero; Ariadna Bargiela (2024). In vitro evaluation of TNPO3 gene expression levels in Limb-Girdle Muscular Dystrophy D2 (LGMDD2) cells. (Comunicació). 10th International ARTEMIS Scientific Research Congress ISBN: 978-9952-8541-1-4 . Bucarest . ROMANIA
- Natalia Galindo; Paola Yánez; María Sabater; Ariadna Bargiela; Ruben Artero (2024). MSI2 as an example of cell differentiation and seeding effects on cell-cycle-regulated genes. (Comunicació). 9th International ACHARAKA Congress on Medicine, Nursing, Midwifery, and Health Sciences . Izmir . TURQUIA
- Paola Yánez; Natalia Galindo; María Sabater; Ariadna Bargiela; Rubén Artero (2024). MSI2 expression in LGMDD2: effects of differentiation and cell seeding density. (Comunicació). 9th International Azerbaijan Congress on Life, Engineering, Mathematical, and Applied Sciences ISBN 978-9952-8541-4-5 . AZERBAITJAN
- Javier Poyatos-García; Alicia Novella; Marta casado; Carme Cucarella; Juan J Vilchez; Ariadna Bargiela; Rubén Artero (2024). Caracterización y retos de un modelo murino de LGMDD2. (Poster). XVII Reunión Anual del CIBERER 2024 . El Escorial . ESPANYA
- I González-Martínez; E Cerro-Herreros; N Moreno-Cervera; Marieke Willemse; Sarah Overby; Walther J.A.A. van den Broek; Derick G. Wansink; B Llamusí; R Artero (2024). Novel antagomiRs that upregulate MBNL1 as candidate therapies for Myotonic dystrophy. (Poster). IDMC-14 . PAÏSOS BAIXOS
- G. Menduti; C. Januel; C. Ruatti; N. Berenger-Currias; P. Konieczny; R. Artero; C. Martinat; M. Boido (2024). Exploiting the drug repositioning strategy for the treatment of Spinal Muscular Atrophy: in vitro and in vivo results of a new effective SMN-dependent molecule. (Poster). 4th Scientific International Congress on Spinal Muscular Atrophy . Ghent . BÈLGICA
- Ariadna Bargiela, Natalia Riedel, Jorge Espinosa Espinosa, Dulce Peris Moreno, Manuel Pérez Alonso, Rubén Artero (2024). Preclinical development of therapeutic molecules targeting MSI2 in Myotonic Dystrophy. (Poster). International Myotonic Dystrophy Consortium Meeting 14 (IDMC14) . Nijmegen . PAÏSOS BAIXOS
- Rubén Artero; Arturo López-Castel; Raquel Pérez-Gómez; Monica Suelves; Gisela Nogales; Andrea López-Martínez: Virginia Arechavala-Gomeza; Juan M Fernández-Costa; Javier Ramón; Inmaculada Azorín; Nuria Muelas; Carme Fàbrega; Ramón Eritja; Sonia Alonso-Martín; Adolfo López de Munain (2024). RED-DM, the Spanish National Network on Myotonic Dystrophy. (Poster). The 14th International Myotonic Dystrophy Consortium Meeting (IDMC-14) . PAÏSOS BAIXOS
- Raquel Perez-Gomez; Irene González-Martínez; Giovanna Menduti; Noemie Berenguer-Currias; Cécile Martinat; Marina Boido; Rubén Artero (2024). Characterization of GT5-Induced Transcriptome Changes in Skeletal Muscles and Spinal Cord of an SMA Mouse Model. (Poster). Motor neuron diseases: understanding the pathogenetic mechanisms to develop therapies - III edition . Turin . ITÀLIA
- Paola Dalgo Aguilar; Rubén Artero; Ariadna Bargiela (2024). Modulation of TNPO3 expression in limb-girdle muscular dystrophy D2 (LGMDD2) cells. (Poster). 20th Annual Oligonucleotide Therapeutics Society Meeting . Montreal . CANADÀ
- Xiomara Fernández-Garibay, Maria Sabater-Arcís, Judit Núñez-Manchón, Ainoa Tejedera- Villafranca, Rubén Artero, Mònica Suelves, Gisela Nogales-Gadea, Javier Ramón-Azcón, Juan M. Fernández-Costa (2024). Advancing Preclinical Research of Myotonic Dystrophy Type 1 with 3D Functional Human Skeletal Muscle Tissues. (Poster). The 29th Annual Congress of the World Muscle Society (Prague, Czechia) http://dx.doi.org/10.1016/j.nmd.2024.07.548 . Praga . REPÚBLICA TXECA
- Rubén Artero (2024). Investigación traslacional en miopatías y síndromes neurológicos raros. (Ponència). XVII Reunión Anual CIBERER 2024 . El Escorial . ESPANYA
- María Sabater Arcis; Dulce Peris Moreno; Ariadna Bargiela; Rubén Artero (2024). Boron-containing compounds partially rescue Myotonic Dystrophy type 1 (DM1) molecular signature and phenotype. (Ponència). 6th International 'ARTEMIS' Congress on Health and Sports Sciences DOI:10.13140/RG.2.2.33024.40965 . Izmir . TURQUIA
- Paola Dalgo AGUILAR; Rubén ARTERO; Ariadna BARGIELA (2023). Intervention in TNPO3 gene expression in Limb-Girdle Muscular Dystrophy D2 (LGMDD2). (Comunicació). The 8TH INTERNATIONAL 'BAŞKENT' CONGRESS ON MEDICINE, NURSING, AND HEALTH SCIENCES . Ankara . TURQUIA
- Andrea García-Rey; Estefanía Cerro-Herreros; Mouli Chakraborty; Nuria Baquero; Isabel Campillo; Irene González-Martínez; Diego Piqueras-Losilla; Isabella Castano; Melanie Nufer; Rubén Artero; Beatriz Llamusí (2023). Lipophilic conjugation ameliorates antimiR PK/PD properties. (Comunicació). 19th Annual Meeting of the Oligonucleotide Therapeutics Society . Barcelona . ESPANYA
- Alicia Novella ESTELLÉS; Águeda Blázquez BERNAL; Carme CUCARELLA; Marta CASADO; Ariadna BARGIELA; Rubén ARTERO (2023). Pilot characterization of a LGMDD2 mouse model. (Comunicació). The 8TH INTERNATIONAL 'BAŞKENT' CONGRESS ON MEDICINE, NURSING, AND HEALTH SCIENCES . Ankara . TURQUIA
- Natalia Riedel; Ariadna Bargiela Schönbrunn; Rubén Artero; Manuel Pérez Alonso (2023). "Development of gapmers against MSI2, a new therapeutic target against muscle atrophy in myotonic dystrophy type 1". (Poster). Final Meeting COST DARTER Bilbao 2023 . ESPANYA
- Maria Sabater-Arcís; Nerea Moreno; Ariadna Bargiela; Rubén Artero (2023). Musashi-2 overexpression enhances atrophy phenotypes in vivo by miR-7 repression. (Poster). DARTER COST Action CA17103 Final Meeting - Bilbao . Bilbao . ESPANYA
- Diego Piqueras-Losilla; Isabel Campillo; Laura Perea-Galera; Sandra López-Domènech; Beatriz Ballester Llobell; Milagros Rocha-Barajas; Maria Jose Roig-Revert; Ester Fernandez-López; Cristina Peris-Martinez; Clara Barbera-Fuset; Aline Huguet-Lachon; Geneviève Gourdon; Rubén Artero; Beatriz Llamusí; Estefanía Cerro-Herreros (2023). Advancing in vivo modeling and delivery systems for triplet repeat expansion-mediated corneal endothelial dystrophy: Implications in AntimiR therapy. (Poster). 19th Annual Meeting of the Oligonucleotide Therapeutics Society . Barcelona . ESPANYA
- Isabella Castano; Argimiro Mayoral; Isabel Campillo; Diego Piqueras-Losilla; Nuria Barquero; Andrea García-Rey; Melanie Nufer; Lara Milián; Manuel Mata; María Sancho-Tello; Mauro Llop; Rubén Artero; Beatriz Llamusí; Estefanía Cerro-Herreros (2023). Effect of K2210 on a knee osteoarthritis rat model. (Poster). 19th Annual Meeting of the Oligonucleotide Therapeutics Society . Barcelona . ESPANYA
- Beatriz Llamusí; Diego Piqueras Losilla; Isabel Campillo; Andrea Garcia Rey; Melanie Nufer; Nuria Barquero; Aline Huguet; Geneviève Gourdon; Ruben Artero; Estefanía Cerro Herreros (2023). Systemic treatment with a lipophilic conjugated antimiR 23b rescues functional and molecular phenotypes of DM1 cognitive dysfunction in DMSXL mice. (Poster). 19th Annual Meeting of the Oligonucleotide Therapeutics Society . Barcelona . ESPANYA
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