JUAN NACHER ROSELLO
PDI-Catedratic/a d'Universitat
PDI-Catedratic/a d'Universitat
Àrea de coneixement: BIOLOGIA CEL·LULAR
Departament: Biologia Cel·lular, Biologia Funcional i Antropologia Física
Departament: Biologia Cel·lular, Biologia Funcional i Antropologia Física
(9635) 43241
Asignatures impartides i modalitats docents
Tutories
| Anual |
| Dimarts de 10:00 a 11:30. DESPATX 2.12.P4.018, EDIF. B, FAC. BIOLÓGIQUES. 4ª PLANTA. PREVIA CONFIRMACIÓ CORREU ELECTRÒNIC |
| Anual |
| Dijous de 10:00 a 11:30. DESPATX 2.12.P4.018, EDIF. B, FAC. BIOLÓGIQUES. 4ª PLANTA. PREVIA CONFIRMACIÓ CORREU ELECTRÒNIC |
| Observacions |
| Participa en el programa de tutories electròniques de la Universitat de València |
Publicacions en revistes
- Martí-Mengual U, Varea E, Crespo C, Blasco-Ibáñez JM, Nacher J. (2013) Cells expressing markers of immature neurons in the amygdala of adult humans. European Journal of Neuroscience, 37(1), pp. 10 - 22 . ISSN: 0953-816X
- Nacher J; Guirado R; Castillo-Gómez E. (2013) Structural plasticity of interneurons in the adult brain: role of PSA-NCAM and implications for psychiatric disorders. Neurochemical Research. ISSN: 0364-3190
- Gilabert-Juan J; Castillo-Gomez E; Guirado R; Moltó MD; Nacher J (2013) Chronic stress alters inhibitory networks in the medial prefrontal cortex of adult mice. Brain Structure & Function, 218(6), pp. 1591 - 1605 . ISSN: 1863-2653
- McCall T; Weil ZM; Nacher J; Bloss EB; El Maarouf A; Rutishauser U; McEwen BS (2013) Depletion of polysialic acid from neural cell adhesion molecule (PSA-NCAM) increases CA3 dendritic arborization and increases vulnerability to excitotoxicity. Experimental Neurology, 241, pp. 5 - 12 . ISSN: 0014-4886
- Gilabert-Juan J; Belles M; Saez AR; Carceller H; Zamarbide-Fores S; Moltó MD; Nacher J. (2013) A 'double hit' murine model for schizophrenia shows alterations in the structure and neurochemistry of the medial prefrontal cortex and the hippocampus. Neurobiology of Disease, 59, pp. 126 - 140 . ISSN: 0969-9961
- Gilabert-Juan J; Nacher J; Sanjuán J; Moltó MD. (2013) Sex-specific association of the ST8SIAII gene with schizophrenia in a Spanish population. Psychiatry Research, 210(3), pp. 1293 - 1295 . ISSN: 0165-1781
- Crespo C; Liberia T; Blasco-Ibáñez JM; Nácher J; Varea E. (2013) The Circuits of the Olfactory Bulb. The Exception as a Rule. Anatomical Record-Advances In Integrative Anatomy And Evolutionary Biology, En prensa . ISSN: 1932-8486
- Ballestín R; Blasco-Ibáñez JM; Crespo C; Nacher J; López-Hidalgo R; Gilabert-Juan J; Moltó D; Varea E. (2014) Astrocytes of the murine model for Down Syndrome Ts65Dn display reduced intracellular ionic zinc. Neurochemistry International, 75, pp. 48 - 53 . ISSN: 0197-0186
- Guirado R; Perez-Rando M; Sanchez-Matarredona D; Castrén E; Nacher J. (2014) Chronic fluoxetine treatment alters the structure, connectivity and plasticity of cortical interneurons. International Journal of Neuropsychopharmacology, 30, pp. 1 - 12 . ISSN: 1461-1457
- Tzanoulinou S; García-Mompó C; Castillo-Gómez E; Veenit V; Nacher J; Sandi C. (2014) Long-term behavioral programming induced by peripuberty stress in rats is accompanied by GABAergic-related alterations in the Amygdala. Plos One, 9(4), p. e94666 . ISSN: 1932-6203
- van der Kooij MA; Fantin M; Kraev I; Korshunova I; Grosse J; Zanoletti O; Guirado R; Garcia-Mompó C; Nacher J; Stewart MG; Berezin V; Sandi C. (2014) Impaired hippocampal neuroligin-2 function by chronic stress or synthetic peptide treatment is linked to social deficits and increased aggression. Neuropsychopharmacology, 39(5), pp. 1148 - 1158 . ISSN: 0893-133X
- Guirado R; Perez-Rando M; Sanchez-Matarredona D; Castillo-Gómez E; Liberia T; Rovira-Esteban L; Varea E; Crespo C; Blasco-Ibáñez JM; Nacher J. (2014) The Dendritic Spines of Interneurons Are Dynamic Structures Influenced by PSA-NCAM Expression. Cerebral Cortex, 24, pp. 3014 - 3024 . ISSN: 1047-3211
- Liberia T; Blasco-Ibáñez JM; Nácher J; Varea E; Lanciego JL; Crespo C. (2015) Synaptic connectivity of the cholinergic axons in the olfactory bulb of the cynomolgus monkey. Frontiers In Neuroanatomy. ISSN: 1662-5129
- Lopez-Campos G; Gilabert-Juan J; Sebastia-Ortega N; Gonzalez-Martinez R; Nacher J; Sanjuan J; Molto MD. (2015) Using gene expression and systems biology to interrogate auditory hallucinations in schizophrenic patients. Studies in health technology and informatics, 210, p. 950 . ISSN: 0926-9630
- Nacher J; Bonfanti L. (2015) New neurons from old beliefs in the adult piriform cortex? A Commentary on: 'Occurrence of new neurons in the piriform cortex'. Frontiers In Neuroanatomy. ISSN: 1662-5129
- Rubio A; Belles M; Belenguer G; Vidueira S; Fariñas I; Nacher J (2015) Characterization and isolation of immature neurons of the adult mouse piriform cortex. Developmental Neurobiology, 229(3), pp. 850 - 857 . ISSN: 1932-8451
- Gilabert-Juan J, Sáez AR, Lopez-Campos G, Sebastiá-Ortega N, González-Martínez R, Costa J, Haro JM, Callado LF, Meana JJ, Nacher J, Sanjuán J, Moltó MD. (2015) Semaphorin and plexin gene expression is altered in the prefrontal cortex of schizophrenia patients with and without auditory hallucinations. Psychiatry Research, 229(3), pp. 850 - 857 . ISSN: 0165-1781
- Castillo-Gomez E; Coviello S; Perez-Rando M; Curto Y; Carceller H; Salvador A; Nacher J. (2015) Streptozotocin diabetic mice display depressive-like behavior and alterations in the structure, neurotransmission and plasticity of medial prefrontal cortex interneurons. Brain Research Bulletin, 116, pp. 45 - 56 . ISSN: 0361-9230
- Hernández-González S; Ballestín R; López-Hidalgo R; Gilabert-Juan J; Blasco-Ibáñez JM; Crespo C; Nácher J; Varea E. (2015) Altered distribution of hippocampal interneurons in the murine Down Syndrome model Ts65Dn. Neurochemical Research, 40(1), pp. 151 - 164 . ISSN: 0364-3190
- Tzanoulinou S; García-Mompó C; Riccio O; Grosse J; Zanoletti O; Dedousis P; Nacher J; Sandi C (2016) Neuroligin-2 Expression in the Prefrontal Cortex is Involved in Attention Deficits Induced by Peripubertal Stress. Neuropsychopharmacology, 41(3), pp. 751 - 761 . ISSN: 0893-133X
- Castillo-Gómez E; Varea E; Blasco-Ibáñez JM; Crespo C; Nacher J. (2016) Effects of Chronic Dopamine D2R Agonist Treatment and Polysialic Acid Depletion on Dendritic Spine Density and Excitatory Neurotransmission in the mPFC of Adult Rats. Neural Plasticity, 2016, p. 1615363 . ISSN: 0792-8483
- López-Hidalgo R; Ballestín R; Vega J; Blasco-Ibáñez JM; Crespo C; Gilabert-Juan J; Nácher J; Varea E. (2016) Hypocellularity in the Murine Model for Down Syndrome Ts65Dn Is Not Affected by Adult Neurogenesis. Frontiers In Neuroscience. ISSN: 1662-453X
- Javier Gilabert-Juan; Clara Bueno-Fernandez; Esther Castillo-Gomez; Juan Nacher (2016) Reduced interneuronal dendritic arborization in CA1 but not in CA3 region of mice subjected to chronic mild stress. Brain And Behavior. ISSN: 2162-3279
- Castillo-Gómez E; Pérez-Rando M; Vidueira S; Nacher J (2016) Polysialic Acid Acute Depletion Induces Structural Plasticity in Interneurons and Impairs the Excitation/Inhibition Balance in Medial Prefrontal Cortex Organotypic Cultures. Frontiers In Cellular Neuroscience, 10, p. 170 . ISSN: 1662-5102
- König R; Benedetti B; Rotheneichner P; O' Sullivan A; Kreutzer C; Belles M; Nacher J; Weiger TM; Aigner L; Couillard-Després S (2016) Distribution and fate of DCX/PSA-NCAM expressing cells in the adult mammalian cortex: A local reservoir for adult cortical neuroplasticity?. Frontiers of Biology in China. ISSN: 1673-3509
- Carceller H; Rovira-Esteban L; Nacher J; Castren E; Guirado R. (2016) Neurochemical phenotype of Reelin immunoreactive cells in the piriform cortex layer II. Frontiers In Cellular Neuroscience, 10, pp. 1 - 11 . ISSN: 1662-5102
- Guirado R; La Terra D; Bourguignon M; Carceller H; Umemori J; Sipilä P; Nacher J; Castrén E. (2016) Efects of PSA removal from NCAM on the critical period plasticity triggered by the antidepressant fluoxetine in the visual cortex. Frontiers In Cellular Neuroscience, 10(22), pp. 1 - 9 . ISSN: 1662-5102
- Esther Castillo-Gómez; Marta Pérez-Rando; María Bellés; Javier Gilabert-Juan, Jose Vicente Llorens; Héctor Carceller; Clara Bueno-Fernández; Clara García-Mompó; Beatriz Ripoll-Martínez; Yasmina Curto; Noelia Sebastiá-Ortega; María Dolores Moltó; Julio Sanjuan; Juan Nacher (2017) Early Social isolation stress and perinatal nmda receptor antagonist treatment induce changes in the structure and neurochemistry of inhibitory neurons of the adult amygdala and prefrontal cortex. Eneuro, 4(2), pp. 1 - 23 . ISSN: 2373-2822
- Perez-Rando M; Castillo-Gómez E; Guirado R; Blasco-Ibañez JM; Crespo C; Varea E; Nacher J (2017) NMDA Receptors Regulate the Structural Plasticity of Spines and Axonal Boutons in Hippocampal Interneurons. Frontiers In Cellular Neuroscience, 11(166) . ISSN: 1662-5102
- Perez-Rando M; Castillo-Gómez E; Bellés M; Carceller H; Nacher J (2017) The activation of NMDA receptors alters the structural dynamics of the spines of hippocampal interneurons. Neuroscience Letters, 658, pp. 79 - 84 . ISSN: 0304-3940
- Mulet M; Blasco-Ibañez JM; Crespo C; Nacher J; Varea E (2017) Early increased density of COX-2 immunoreactive neurons in Down Syndrome. Folia Neuropathologica, 55(2), pp. 1 - 7 . ISSN: 1641-4640
- Villarroya O; Ballestín R; López-Hidalgo R; Mulet M; Blasco-Ibánez JM; Crespo C; Nácher J; Gilabert-Juan J; Varea E (2018) Morphological alterations in the hippocampus of the Ts65Dn mouse model for Down Syndrome correlate with structural plasticity markers. Histology and Histopathology, 33(1), pp. 101 - 115 . ISSN: 0213-3911
- Nacher, J. (2018) Plasticity Molecule Reveals Interneuronal Alterations in Alzheimer's Disease. Neuroscience, 372, pp. 304 - 305 . ISSN: 0306-4522
- Perez-Rando M; Castillo-Gomez E; Bueno-Fernandez C; Nacher J. (2018) The TrkB agonist 7,8-dihydroxyflavone changes the structural dynamics of neocortical pyramidal neurons and improves object recognition in mice. Brain Structure & Function, 223(5), pp. 2393 - 2408 . ISSN: 1863-2653
- Guirado R; Carceller H; Castillo-Gómez E; Castrén E; Nacher J (2018) Automated analysis of images for molecular quantification in immunohistochemistry. Heliyon, 4(6), pp. 1 - 16 . ISSN: 2405-8440
- Carceller H; Perez-Rando M; Castren E; Nacher J; Guirado R. (2018) Effects of the antidepressant fluoxetine on the somatostatin interneurons in the basolateral amygdala. Neuroscience, 386(21 August 2018), pp. 205 - 213 . ISSN: 0306-4522
- Rotheneichner P; Belles M; Benedetti B: König R; Dannehl D; Kreutzer C; Zaunmair P; Engelhardt M; Aigner L; Nacher J; Couillard-Despres S. (2018) Cellular Plasticity in the Adult Murine Piriform Cortex: Continuous Maturation of Dormant Precursors Into Excitatory Neurons. Cerebral Cortex, 28(7), pp. 2610 - 2621 . ISSN: 1047-3211
- Crespo C; Liberia T; Blasco-Ibáñez JM; Nácher J; Varea E. (2019) Cranial Pair I: The Olfactory Nerve. The Anatomical Record, 302(3), pp. 405 - 427 . ISSN: 0003-276X
- Curto Y; Alcaide J; Röckle I; Hildebrandt H; Nacher J. (2019) Effects of the genetic depletion of polysialyltransferases on the structure and connectivity of interneurons in the adult prefrontal cortex. Frontiers In Neuroanatomy, 13(6) . ISSN: 1662-5129
- Bellés M; Carbonell J; Blasco-Ibáñez JM; Crespo C; Nácher J; Varea E (2019) Alterations in reelin and reelin receptors in Down syndrome. Neuroreport. ISSN: 0959-4965
- Elena Martínez-Rodríguez; Ana Martín-Sánchez; Simona Coviello; Cristina Foiani; Emre Kul; Oliver Stork; Fernando Martínez-García; Juan Nacher; Enrique Lanuza; Mónica Santos; Carmen Agustín-Pavón (2019) Lack of MeCP2 leads to region-specific increase of doublecortin in the olfactory system. Brain Structure & Function, 224(4), pp. 1647 - 1658 . ISSN: 1863-2653
- Di Forti M; Quattrone D; Moltó MD; Nacher J; Olmeda MS; et al. (2019) The Contibution of cannabis use to variation in the incidence of psychotic disorder across Europe (EU-GEI): a multicentre case-control study. Lancet Psychiatry, 6(5), pp. 427 - 436 . ISSN: 2215-0374
- Pesarico AP; Bueno-Fernandez C; Guirado R; Gómez-Climent MÁ; Curto Y; Carceller H; Nacher J. (2019) Chronic Stress Modulates Interneuronal Plasticity: Effects on PSA-NCAM and Perineuronal Nets in Cortical and Extracortical Regions. Frontiers In Cellular Neuroscience, 13(197) . ISSN: 1662-5102
- Alcaide J; Guirado; Crespo C; Blasco-Ibáñez JM; Varea E; Sanjuan J; Nacher J. (2019) Alterations of perineuronal nets in the dorsolateral prefrontal cortex of neuropsychiatric patients. International Journal Of Bipolar Disorders, 7(1), p. 24 . ISSN: 2194-7511
- Mas S; Gassó P; Rodríguez N; Cabrera B; Mezquida G; Lobo A; González-Pinto A; Parellada M; Corripio I; Vieta E; Castro-Fornieles J; Bobes J; Usall J; Saiz-Ruiz J; Contreras F; Parellada E; Bernardo M; PEPs group. (2019) Personalized medicine begins with the phenotype: identifying antipsychotic response phenotypes in a first-episode psychosis cohort. Acta Psychiatrica Scandinavica. ISSN: 0001-690X
- Carceller H; Guirado R; Nacher J. (2020) Dark exposure affects plasticity-related molecules and interneurons throughout the visual system during adulthood. Journal of Comparative Neurology, 528(8), pp. 1349 - 1366 . ISSN: 0021-9967
- Rovira-Esteban L; Hájos N; Nagy GA; Crespo C; Nacher J; Varea E; Blasco-Ibáñez JM. (2020) Semilunar granule cells are the primary source of the perisomatic excitatory innervation onto parvalbumin-expressing interneurons in the dentate gyrus. Eneuro, ENEURO.0323-19. . ISSN: 2373-2822
- Garcia-Mompo C; Curto Y; Carceller H; Gilabert-Juan J; Rodriguez-Flores E; Guirado R; Nacher J. (2020) Δ-9-Tetrahydrocannabinol treatment during adolescence and alterations in the inhibitory networks of the adult prefrontal cortex in mice subjected to perinatal NMDA receptor antagonist injection and to postweaning social isolation. Translational Psychiatry, 10(1), p. 177 . ISSN: 2158-3188
- Carceller H; Guirado R; Ripolles-Campos E; Teruel-Marti V; Nacher J. (2020) Perineuronal nets regulate the inhibitory perisomatic input onto parvalbumin interneurons and γ activity in the prefrontal cortex. Journal of Neuroscience, 40(26), pp. 5008 - 5018 . ISSN: 0270-6474
- Wakhloo D; Scharkowski F; Curto Y; Javed Butt U; Bansal V; Steixner-Kumar AA; Wüstefeld L; Rajput A; Arinrad S; Zillmann MR; Seelbach A; Hassouna I; Schneider K; Qadir Ibrahim A; Werner HB; Martens H; Miskowiak K; Wojcik SM; Bonn S; Nacher J; Nave KA; Ehrenreich H. (2020) Functional hypoxia drives neuroplasticity and neurogenesis via brain erythropoietin. Nature Communications, 11(1), p. 1313 . ISSN: 2041-1723
- Coviello S; Gramuntell Y; Castillo-Gomez E; Nacher J (2020) Effects of Dopamine on the Immature Neurons of the Adult Rat Piriform Cortex. Frontiers In Neuroscience. ISSN: 1662-453X
- Guirado R; Perez-Rando M; Ferragud A; Gutierrez-Castellanos N; Umemori J; Carceller H; Nacher J; Castillo-Gómez E (2020) A critical period for prefrontal network configurations underlying psyquiatric disorders and addiction. Frontiers In Behavioral Neuroscience, 14(51) . ISSN: 1662-5153
- Carbonell J; Blasco-Ibáñez JM; Crespo C; Nácher J; Varea E (2020) Piriform cortex alterations in the Ts65Dn model for down syndrome. Brain Research. ISSN: 0006-8993
- La Rosa C; Cavallo F; Pecora A; Chincarini M; Ala U; Faulkes CG; Nacher J; Cozzi B; Sherwood CC; Amrein I; Bonfanti L (2020) Phylogenetic variation in cortical layer II immature neuron reservoir of mammals. Elife. ISSN: 2050-084X
- Mulet M; Blasco-Ibáñez JM; Kirstein M; Crespo C; Nacher J; Varea E. (2020) Phenotypic characterization of MCP-1 expressing neurons in the rat cerebral cortex. Journal of Chemical Neuroanatomy, 106, p. 101785 . ISSN: 0891-0618
- Perez-Rando M; Guirado R; Tellez-Merlo G; Carceller H; Nacher J. (2021) Estradiol regulates PSA-NCAM expression and connectivity of O-LM interneurons in the hippocampus of adult female mice. Neuroendocrinology. ISSN: 0028-3835
- Vallejo, L; Zapater-Fajarí, M; Montoliu, T; Puig-Perez, S; Nacher, J; Hidalgo, V; Salvador, A (2021) No effects of acute psychosocial stress on working memory in older people with type 2 diabetes. Frontiers In Psychology, 11:596584 . ISSN: 1664-1078
- Etxeandia-Pradera JI; Martinez-Uribe D; Bellver-Pradas F; Gonzalez-Piqueras JC; Nacher J; Aguilar EJ. (2021) Training psychiatry residents in descriptive psychopathology: A systematic review. Psychopathology. ISSN: 0254-4962
- Pesarico AP; Chagas PM; Nacher J. (2021) Editorial: Animal models of stress - Current knowledge and potential directions. Frontiers In Behavioral Neuroscience, 15, p. 655214 . ISSN: 1662-5153
- Casquero-Veiga M; Bueno-Fernandez C; Romero-Miguel D; Lamanna-Rama N; Nacher J; Desco M; Soto-Montenegro ML. (2021) Exploratory study of the long-term footprint of deep brain stimulation on brain metabolism and neuroplasticity in an animal model of obesity. Scientific Reports, 11(1), p. 5580 . ISSN: 2045-2322
- Clara Bueno-Fernandez; Marta Perez-Rando; Julia Alcaide; Simona Coviello; Carmen Sandi; Esther Castillo-Gómez; Juan Nacher (2021) Long term effects of peripubertal stress on excitatory and inhibitory circuits in the prefrontal cortex of male and female mice. Neurobiology Of Stress(14) . ISSN: 2352-2895
- Coviello S; Benedetti B; Jakubecova D; Belles M; Klimczak P; Gramuntell Y; Couillard-Despres S; Nacher J. (2021) PSA depletion induces the differentiation of immature neurons in the piriform cortex of adult mice. International Journal Of Molecular Sciences. ISSN: 1661-6596
- Fernandez Garcia-Agudo L; Steixner-Kumar AA; Curto Y; Barnkothe N; Hassouna I; Jähne S; Butt UJ; Grewe K; Weber MS; Green K; Rizzoli S; Nacher J; Nave KA; Ehrenreich H. (2021) Brain erythropoietin fine-tunes a counterbalance between neurodifferentiation and microglia in the adult hippocampus. Cell Reports, 36(8), p. 109548 . ISSN: 2211-1247
- Perez-Caballero L; Carceller H; Nacher J; Teruel-Marti V; Pujades E; Casañ-Pastor N; Berrocoso E (2021) Modulation of wireless effects in implanted electrodes. Effects of implanting insulated electrodes on an animal test to screen antidepressant activity. Journal Of Clinical Medicine, 10(17), p. 4003 . ISSN: 2077-0383
- Klimczak P; Rizzo A; Castillo-Gómez E; Perez-Rando M; Gramuntell Y; Beltran M; Nacher J (2021) Parvalbumin interneurons and perineuronal nets in the hippocampus and retrosplenial cortex of adult male mice after early social isolation stress and perinatal NMDA receptor antagonist treatment. Frontiers In Synaptic Neuroscience, 13, p. 733989 . ISSN: 1663-3563
- Guirado R; La Terra D; Bourguignon M; Carceller H; Umemori J; Sipilä P; Nacher J; Castrén E. (2016) Effects of PSA Removal from NCAM on the Critical Period Plasticity Triggered by the Antidepressant Fluoxetine in the Visual Cortex. Frontiers In Cellular Neuroscience, 10, p. 22 . ISSN: 1662-5102
- Curto Y; Garcia-Mompo C; Bueno-Fernandez C; Nacher J. (2016) Chronic benzodiazepine treatment decreases spine density in cortical pyramidal neurons. Neuroscience Letters, 613, pp. 41 - 46 . ISSN: 0304-3940
- Rubio A; Belles M; Belenguer G; Vidueira S; Fariñas I; Nacher J (2016) Characterization and isolation of immature neurons of the adult mouse piriform cortex. Developmental Neurobiology, 76(7), pp. 748 - 763 . ISSN: 1932-8451
- Gassó P; Rodríguez N; Martínez-Pinteño A; Mezquida G; Ribeiro M; González-Peñas J; Zorrilla I; Martínez-Sadurni L; Rodriguez-Jimenez R; Corripio I; Sarró S; Ibáñez A; Usall J; Lobo A; Moren C; Cuesta MJ; Parellada M; González-Pinto A; Berrocoso E; Bernardo M; Mas S; 2EPs Group. (2021) A longitudinal study of gene expression in first-episode schizophrenia; exploring relapse mechanisms by co-expression analysis in peripheral blood. Translational Psychiatry, 11(1), p. 539 . ISSN: 2158-3188
- Gramuntell Y; Klimczak P; Coviello S; Perez-Rando M; Nacher J. (2021) Effects of Aging on the Structure and Expression of NMDA Receptors of Somatostatin Expressing Neurons in the Mouse Hippocampus. Frontiers In Aging Neuroscience, 13, p. 782737 . ISSN: 1663-4365
- Pesarico AP; Carceller H; Guirado R; Coviello S; Nacher J (2022) Long term effects of 24-h-restraint stress on the connectivity and structure of interneurons in the basolateral amygdala. Progress in Neuro-Psychopharmacology & Biological Psychiatry, 115, p. 110512 . ISSN: 0278-5846
- Martínez-Pinteño A; Mezquida G; Bioque M; López-Ilundain JM; Andreu-Bernabeu Á; Zorrilla I; Mané A; Rodríguez-Jiménez R; Corripio I; Sarró S; Ibáñez Á; Usall J; Rivero O; Gassó P, Leza JC; Cuesta MJ; Parellada M; González-Pinto A; Berrocoso E; Mas S; Bernardo M; 2EPs Group. (2022) The role of BDNF and NGF plasma levels in first-episode schizophrenia: A longitudinal study. European Neuropsychopharmacology, 57, pp. 105 - 117 . ISSN: 0924-977X
- Pina-Camacho L; Martinez K; Diaz-Caneja CM; Mezquida G; Cuesta MJ; Moreno C; Amoretti S; González-Pinto A; Arango C; Vieta E; Castro-Fornieles J; Lobo A; Fraguas D; Bernardo M; Janssen J; Parellada M; PEPs Group. (2022) Cortical thinning over two years after first-episode psychosis depends on age of onset. Npj Schizophrenia, 8(1), p. 20 . ISSN: 2334-265X
- Coviello S; Gramuntell Y; Klimczak P; Varea E; Blasco-Ibañez JM; Crespo C; Gutierrez A; Nacher J. (2022) Phenotype and Distribution of Immature Neurons in the Human Cerebral Cortex Layer II. Frontiers In Neuroanatomy, 16, p. 851432 . ISSN: 1662-5129
- Perez-Rando M; Elvira UKA; García-Martí G; Gadea M; Aguilar EJ; Escarti MJ; Ahulló-Fuster MA; Grasa E; Corripio I; Sanjuan J; Nacher J (2022) Alterations in the volume of thalamic nuclei in patients with schizophrenia and persistent auditory hallucinations. Neuroimage-Clinical, 35, p. 103070 . ISSN: 2213-1582
- Al-Soufi L; Martorell L; Moltó MD; González-Peñas J; García-Portilla MP; Arrojo M; Rivero O; Gutiérrez-Zotes A; Nácher J; Muntané G; Paz E; Páramo M; Bobes J; Arango C; Sanjuan J; Vilella E, Costas J. (2022) A polygenic approach to the association between smoking and schizophrenia. Addiction Biology, 27(1) . ISSN: 1355-6215
- Mónica Alba Ahulló-Fuster; Tomás Ortiz; Enrique Varela-Donoso; Juan Nacher; M Luz Sánchez-Sánchez (2022) The Parietal Lobe in Alzheimer's Disease and Blindness. Journal Of Alzheimers Disease, 89(4), pp. 1193 - 1202 . ISSN: 1387-2877
- Perez-Rando M; Carceller H; Castillo-Gomez E; Bueno-Fernandez C; García-Mompó C; Gilabert-Juan J; Guirado R; Pesarico AP; Nacher J (2022) Impact of stress on inhibitory neuronal circuits, our tribute to Bruce McEwen. Neurobiology Of Stress, 13(19), p. 100460 . ISSN: 2352-2895
- Julio Sanjuán;Xochitl Helga Castro-Martínez; Gracián García-Martí; Javier González-Fernández;Roberto Sanz-Requena;Josep María Haro;J. Javier Meana; Luis Martí Bonmatí;Juan Nacher;Noelia Sebastiá-Ortega;Javier Gilabert-Juan;María Dolores Moltó. (2020) FOXP2 expression and gray matter density in the male brains of patients with schizophrenia. Brain Imaging And Behavior. ISSN: 1931-7557
- Andreu-Bernabeu Á; Díaz-Caneja CM; Costas J; De Hoyos L; Stella C; Gurriarán X; Alloza C; Fañanás L; Bobes J; González-Pinto A; Crespo-Facorro B; Martorell L; Vilella E; Muntané G; Nacher J; Molto MD; Aguilar EJ; Parellada M; Arango C; González-Peñas J. (2022) Polygenic contribution to the relationship of loneliness and social isolation with schizophrenia. Nature Communications, 13(1), p. 51 . ISSN: 2041-1723
- Browne CA; Conant K; Lasek AW; Nacher J (2022) Editorial: Perineuronal Nets as Therapeutic Targets for the Treatment of Neuropsychiatric Disorders. Frontiers In Synaptic Neuroscience, 14, p. 889800 . ISSN: 1663-3563
- Rodríguez N; Gassó P; Martínez-Pinteño A; Segura ÀG; Mezquida G; Moreno-Izco L; González-Peñas J; Zorrilla I; Martin M; Rodriguez-Jimenez R; Corripio I; Sarró S; Ibáñez A; Butjosa A; Contreras F; Bioque M; Cuesta MJ; Parellada M; González-Pinto A; Berrocoso E; Bernardo M; Mas S; 2EPS group (2022) Gene co-expression architecture in peripheral blood in a cohort of remitted first-episode schizophrenia patients. Npj Schizophrenia, 8(1), p. 45 . ISSN: 2334-265X
- Serra-Navarro M, Amoretti S, Verdolini N, Forte MF, Sánchez-Torres AM, Vieta E, Clougher D, Lobo A, González-Pinto A, Panadero R, Roldán A, Carvalho AF, de la Serna E, Toll A, Ramos-Quiroga JA, Torrent C, Cuesta MJ, Bernardo M; PEPs Group. (2022) Influence of clinical and neurocognitive factors in psychosocial functioning after a first episode non-affective psychosis: Differences between males and females. Frontiers In Psychiatry, 13(982583) . ISSN: 1664-0640
- Carceller H; Gramuntell Y; Klimczak P; Nacher J (2022) Perineuronal Nets: Subtle Structures with Large Implications. Neuroscientist, 23, p. 107385842211063 . ISSN: 1073-8584
- Bravo L; Mariscal P; Llorca-Torralba M; López-Cepero JM; Nacher J; Berrocoso E (2022) Altered expression of vesicular glutamate transporter-2 and cleaved caspase-3 in the locus coeruleus of nerve-injured rats. Frontiers In Molecular Neuroscience, 15, p. 918321 . ISSN: 1662-5099
- González-Vivas C; Valdés-Florido MJ; García-Martí G; Soldevila-Matías P; Martí-Bonmatí L; Nacher J; Sanjuan J. (2022) How voices change the brain. Two fMRI follow-up case reports. Schizophrenia Research, 248, pp. 329 - 330 . ISSN: 0920-9964
- Valli I, Segura AG, Verdolini N, Garcia-Rizo C, Berge D, Baeza I, Cuesta MJ, Gonzalez-Pinto A, Lobo A, Martinez-Aran A, Mezquida G, Pina-Camacho L, Bejarano AR, Mas S, McGuire P, Bernardo M, Vieta E; PEPs group; Amoretti S, Aina AP, Balanzá-Martínez V, Borras R, Butjosa A, Castro-Fornirles J, De-la-Cámara C, De la Serna E, Etxeandia-Pradera JI, Forte MF, García-Portilla P, González JM, González-Blanco L, Gonzalez-Ortega I, Ibañez A, Madero S, Martínez-Sadurni L, Nacher J, Panadero R, Edith PC, Fatjó-Vilas M, Rodriguez-Jimenez R, Ruiz P, Sanchez-Pastor L, Rafael SE, Sánchez-Torres AM, Judith SG, Trabsa A, Urbiola E, Usall J, Arantzazu ZR, Zorrilla I. (2023) Obstetric complications and genetic risk for schizophrenia: differential role of antenatal and perinatal events in first episode psychosis. Acta Psychiatrica Scandinavica. ISSN: 0001-690X
- Saiz-Masvidal C; Contreras F; Soriano-Mas C; Mezquida G; Díaz-Caneja CM; Vieta E; Amoretti S; Lobo A; González-Pinto A; Janssen J; Sagué-Vilavella M; Castro-Fornieles J; Bergé D; Bioque M; Lois NG; Parellada M; Bernardo M; PEPs Group. (2023) Structural covariance predictors of clinical improvement at 2-year follow-up in first-episode psychosis. Progress in Neuro-Psychopharmacology & Biological Psychiatry, 120(110645) . ISSN: 0278-5846
- Olivas-Cano I; Rodriguez-Andreu JM; Blasco-Ibañez JM; Crespo C; Nácher J; Varea E (2023) Fluoxetine increased adult neurogenesis is mediated by 5-HT3 receptor. Neuroscience Letters, 795, p. 137027 . ISSN: 0304-3940
- Casquero-Veiga M; Lamanna-Rama N; Romero-Miguel D; Rojas-Marquez H; Alcaide J; Beltran M; Nacher J; Desco M; Soto-Montenegro ML (2023) The Poly I:C maternal immune stimulation model shows unique patterns of brain metabolism, morphometry, and plasticity in female rats. Frontiers In Behavioral Neuroscience, 16, p. 1022622 . ISSN: 1662-5153
- Sideli L; Aas M; Quattrone D; La Barbera D; La Cascia C; Ferraro L; Alameda L; Velthorst E; Trotta G; Tripoli G; Schimmenti A; Fontana A; Gayer-Anderson C; Stilo S; Seminerio F; Sartorio C; Marrazzo G; Lasalvia A; Tosato S; Tarricone I; Berardi D; D'Andrea G; EU-GEI WP2 Group; Arango C; Arrojo M; Bernardo M; Bobes J; Sanjuán J; Santos JL; Menezes PR; Del-Ben CM; Jongsma HE; Jones PB; Kirkbride JB; Llorca PM; Tortelli A; Pignon B; de Haan L; Selten JP; Van Os J; Rutten BP; Bentall R; Di Forti M; Murray RM; Morgan C; Fisher HL (2023) The relationship between genetic liability, childhood maltreatment, and IQ: findings from the EU-GEI multicentric case-control study. Social Psychiatry and Psychiatric Epidemiology. ISSN: 0933-7954
Textos del currículum
- Resum de la trajectòria científica. El objetivo principal de mi investigación es el estudio de la plasticidad estructural neuronal en el sistema nervioso central adulto, que incluye remodelación sináptica y de neuritas y neurogénesis adulta. Estamos particularmente interesados en cómo esta plasticidad estructural está involucrada en la etiología de diferentes trastornos psiquiátricos y su tratamiento. Nuestros focos principales son los circuitos inhibidores corticales y la forma polisializada de la molécula de adhesión celular neural (PSA-NCAM) como modulador de su plasticidad. Nuestro grupo descubrió que la expresión de PSA-NCAM en la corteza prefrontal medial está regulada por serotonina (a través de receptores 5HT3) y dopamina (a través de receptores D2), dos monoaminas profundamente implicadas en la etiología y el tratamiento de la esquizofrenia y la depresión y cambios en la expresión de moléculas relacionadas con la neurotransmisión inhibidora También describimos la distribución de las células que expresan PSA-NCAM en la amígdala, la corteza prefrontal medial y otras regiones corticales durante la vida adulta y el envejecimiento y encontramos que la mayoría de estas células eran interneuronas maduras polisializadas exclusivamente por la polisialiltransferasa St8SiaIV. Recientemente descubrimos que la expresión de PSA-NCAM es un regulador crítico de la estructura y conectividad de las interneuronas corticales, especialmente en la inhibición perisomática de las células piramidales.
- RESUMEN DEL CV. Catedrático en la Unidad de Neurobiología del ERI BIOTECMED de la Universitat de València (http://www.nacherlab.com), co-IP del G23 de CIBERSAM, investigador asociado a INCLIVA. Doctor en Neurobiología por la Universitat de València, realizó estancia postdoctoral en el laboratorio de Neuroendocrinología de la Universidad Rockefeller en Nueva York (EE.UU). Líneas de investigación sobre la plasticidad del sistema nervioso adulto y su implicación en la etiología y el tratamiento de las enfermedades psiquiátricas. 141 artículos en revistas internacionales, h index: 43. Vicepresidente y secretario de la Sociedad Española de Neurociencia (SENC) (13-17). 2005-2010 Director of the Graduate Program in Basic and Applied Neurosciences, University of València. 2012-2014. Director of the Master in Basic and Applied Neurosciences, University of València. Investigador principal de 6 proyectos I+D de plan nacional y diversos proyectos de comunidad autónoma y fundaciones privadas nacionales e internacionales. IP de nodo nacional de proyecto ERA-NET Neuron. Organizador de eventos de divulgación científica: Pint of science, Brainshake, Neuromascletá, semana del cerebro, @neuronacher en twitter, autor del libro 'La regeneración neuronal' (RBA/National Geographic). Fundador y director científico de la start up biotecnológica Neuropharmatest S.L..
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