Peptide and Protein Chemistry Laboratory

Enrique Pérez Payá

Full Research Professor of the Consejo Superior de Investigaciones Científicas (Spanish Research Council – CSIC) and Group Leader at the Centro de Investigación Príncipe Felipe (CIPF).

Pérez-Payá was Assistant and Associate Professor (1993 – 2002) of Biochemistry and Molecular Biology at the University of Valencia. Prof. Pérez-Payá has a long standing experience in teaching and supervision of students and post-docs from different countries. The research group has been continuously funded (since 1995) by grants from various national agencies and pharmaceutical companies, and has participated in EU-funded projects (partner BIO4-CT-97 2086). Prof. Pérez-Payá has served as chairman of scientific workshops and meetings, including the VIth European Symposium of the Protein Society (more than 600 attendees).

• Apoptosis in medicine.
• Medicinal chemistry.
• Protein–protein interactions as a field of study and the use of diversity-oriented chemical libraries as source of modulators.
• Special focus in the development of new inhibitors of unwanted cell death and in the molecular mechanism of apoptosis.

Mar Orzáez, PhD. Research associate.
Mónica Sancho, PhD. Postdoctoral.
Ainhoa Genovés, PhD. Postdoctoral. JAE-Doc CSIC
Tatiana Guevara. Graduate student. JAE-Pre CSIC
Andrés Herrera. Graduate student. Beca Santiago Grisolía
Guillermo García-Laínez. Graduate student. JAE-Pre CSIC
Christian De Ford. Graduate student. Beca Santiago Grisolía
Vicente Andreu. Graduate student. Prometeo 2010 005
Inmaculada Micó. Lab technician.
Ana Giménez. Lab technician.
Alicia García. Lab technician.
Eliana Sirvent. Lab technician.
Rosa García. Lab technician.

Chemical tools that modify cellular fate: Molecular mechanism of action of apoptosis modulators. Spanish Ministry of Science and Innovation (MICINN). SAF2010 15512.

Chemical Biology of protein-protein interactions. MICINN. BIO2007 60066

New protein-protein-based therapeutic tools in angiogenesis and apoptosis. Excelence award Generalitat Valenciana PROMETEO. 2010-2013.

Spanish Ion Channel Inniciative. MICINN. CSD2008-00005

Discovery of anti-myotonic dystrohphy drugs using a Drosophila model. Muscular dystrophy assoc. Research Dep.01/2006 - 1/2009

Chemical modulation of protein-protein interactions of relevance in apoptosis and autoimmunity. Spanish Ministry of Science (MEC). BIO2004 998.

Research Award Fundació La Marató de TV3. 2/2004 – 2/2007.

Aznar E., Mondragón L., Ros-Lis, J.V, Sancenón, F., Marcos, M.D., Martínez-Máñez, R.*, Soto, J., Pérez-Payá, E., Amorós, P. Temperature-controlled release via paraffin-capped mesoporous silica nanoparticles
Angewandte Chemie Int Ed (in press)

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Ferraro E., Pesaresi, M.G., De Zio, D., Cencioni, M.T., Gortat, A., Cozzolino, M., Oettinghaus, B., Salvatore, A.M., Pérez-Payá E., Cecconi, F. Apaf-1 plays a pro-survival role by regulating centrosomes morphology and function
J Cell Sci (in press)

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García-López, A., Llamusi, B., Orzáez, M., Pérez-Payá E. and Artero R.
In vivo discovery of a peptide that prevents CUG RNA hairpin formation and reverses RNA toxicity in Myotonic Dystrophy models.
Proc. Natl. Acad. Sci. USA (in press).

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Coll, C., Mondragón, L., Martínez-Máñez, R., Sancenón, F., Marcos, M.D., Soto, J., Amorós, P., Pérez-Payá E.
Click chemistry anchoring of peptide sequences for the design of enzyme-mediated controlled release systems based on silica mesoporous supports
Angewandte Chemie Int Ed 50(9), 2138-40 (2011)

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Sancho M., Herrera, A.E., Gortat, A., Carbajo, R.J., Pineda-Lucena, A., Orzáez, M., Pérez-Payá E.
Minocycline inhibits cell death and decreases mutant Huntingtin aggregation by targeting Apaf-1
Human Mol Gen 20(18) 3545-53 (2011)

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Orzáez, M., Gortat, A., Sancho M., Carbajo, R.J., Pineda-Lucena, A., Palacios-Rodríguez, Y., Pérez-Payá, E.
Characterization of Dequalinium as a XIAP antagonist that targets the BIR2 domain
Apoptosis 10(5), 460-7 (2011)

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Pérez-Payá, E., Orzáez, M., Mondragón, L., Wolan, D., Wells, J.A., Messeguer, A., Vicent, M.J.
Molecules that modulate Apaf-1 activity
Medicinal Research Reviews (in press) Jan 22 Epub ahead of print (2010)

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Vicent, M.J., Cascales, L., Carbajo, R.J., Cortés, N., Messeguer, A. Pérez-Payá, E.
Nanoconjugates as intracorporeal neutralizers of bacterial endotoxins
J Control Release 142(2), 277-85 (2010)

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García-Saez, A., Ries, J., Orzáez, M., Pérez-Payá, E., Schwille, P.
Lipid membranes promote tBid interaction with Bcl-xL.
Nature Structural and Molecular Biology 16(11), 1178-85 (2009)

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Orzáez, M., Mondragón, L., García-Jareño, A., Mosulén, S., Pineda-Lucena, A., Pérez-Payá, E.
Deciphering the antitumoral activity of quinacrine: binding to and inhibition of Bcl-xL.
Bioorg. Med Chem Lett 19(6) 1592-5 (2009)

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Centro de Investigación Príncipe Felipe
Peptide and Protein Chemistry Laboratory
Av. Autopista del Saler, 16
46012 Valencia

Phone. +34-963289680.

E-mail: eperez@cipf.es

Website: http://www.cipf.es/RESEARCH/group.aspx?id=30