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University of Valencia

Genetics Department

I2SysBio



 

                                            

Virus evolution (Sanjuán lab)

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    1. Planas D., Bruel T., Staropoli I., Guivel-Benhassine F., Porrot F., Maes P., Grzelak L., Prot M., Mougari S., Planchais C.,  Puech J., Saliba M., Sahraoui R., Fémy F., Morel N., Dufloo J., Sanjuán R., Mouquet H., André E., Hocqueloux L., Simon-Loriere E., Veyer D., Prazuck T., Péré H., Schwartz O. (2023). Resistance of Omicron subvariants BA.2.75.2, BA.4.6, and BQ.1.1 to neutralizing antibodies. Nature Communications 14: 824.
    2. Beamud B., García-González N., Gómez-Ortega M., González-Candelas F., Domingo-Calap P., Sanjuán R. (2023). Genetic determinants of host tropism in Klebsiella phages. Cell Reports 42: 112048.
    3. Segredo-Otero E., Sanjuán R. (2023). Genetic complementation fosters evolvability in complex fitness landscapes. Scientific Reports 13: 662.
    4. Valero-Rello A., Sanjuán R.(2022). Enveloped viruses show increased propensity to cross-species transmission and zoonosis. PNAS  119: e2215600119.
    5.  Larrieux A., Sanjuán R. (2022). Cellular resistance to an oncolytic virus is driven by chronic activation of innate immunity. iScience 26: 105749.
    6. Segredo-Otero E., Sanjuán R. (2022). Cooperative virus-virus interactions: an evolutionary perspective. Biodesign Research, 9819272.
    7. Pazmiño-Ibarra V., Herrero S., Sanjuán R. (2022). Spatially segregated transmission of co-occluded baculoviruses limits virus–virus interactions mediated by cellular coinfection during primary infection. Viruses 14, 1697.
    8. Vázquez R., Díez-Martínez R., Domingo-Calap P., García P., Gutiérrez D., Muniesa M., Ruiz-Ruigómez M., Sanjuán R., Tomás M., Tormo-Mas M.A., García P. (2022). Essential topics for the regulatory consideration of phages as clinically valuable therapeutic agents: a perspective from Spain. Microorganisms 10: 717.
    9. Sanjuán R., Domingo-Calap P. (2021). Reliability of wastewater analysis for monitoring COVID-19 incidence revealed by a long-term follow-up study. Frontiers in Virology, fviro.2021.776998.
    10. Sanjuán R. (2021). The social life of viruses. Annual Review of Virology 8: 183-199.
    11. Cebriá-Mendoza M., Bracho M.A., Arbona C., Larrea L., Díaz W., Sanjuán R., Cuevas J.M. (2021). Exploring the diversity of the human blood virome. Viruses 13:2322.
    12. Al Zaher A., Domingo-Calap P., Sanjuán R. (2021). Experimental virus evolution in cancer cell monolayers, spheroids, and tissue explants. Virus Evolution 7:veab045.
    13. Sanjuán R., Illingworth C.J.R., Geoghegan J.L., Iranzo J., Zwart M.P., Ciota A.T., Moratorio G., Gago-Zachert S., Duffy S. and Vijaykrishna D. (2021). Christopher J. R. Five challenges in the field of viral diversity and evolution. Frontiers in Virology 1: 684949.
    14. Cebriá-Mendoza M., Cristina A., Larrea L., Díaza W., Arnau V., Peña C.,  Bou J.V., Sanjuán R., Cuevas J.M. (2021) Deep viral blood metagenomics reveals extensive anellovirus diversity in healthy humans. Scientific Reports 11: 6921.
    15. Sanjuán R., Domingo-Calap P. (2021). Genome instability in DNA viruses. Elsevier.
    16. Bou J.V., Sanjuán R. (2021). Experimental evolution reveals a genetic basis for membrane-associated virus release. Molecular Biology and Evolution 38: 358–367.
    17. Sanjuán R., Domingo-Calap P. (2021). Genetic Diversity and Evolution of Viral Populations. Encyclopedia of Virology, 4th Edition. Elsevier.
    18. Andreu-Moreno I., Bou J.V., Sanjuán R. (2020). Cooperative nature of viral replication. Science Advances 6:eabd4942.
    19. Siles Lucas M., González-Miguel J., Geller R., Sanjuán R., Pérez-Arévalo J., Martínez-Moreno A. (2020). Potential influence of helminth molecules on COVID-19 pathology. Trends in Parasitology 37:11-14.
    20. Randazzo W., Cuevas-Ferrando E., Sanjuán R., Domingo-Calap P., Sánchez G. (2020). Metropolitan wastewater analysis for COVID-19 epidemiological surveillance. Int. J. Hyg. Envir. Heal. 230: 113621.
    21. Domingo-Calap P., Mora-Quilis L., Sanjuán R. (2020). Social bacteriophages. Microorganisms 8: 533.
    22. Anschau V., Sanjuán R. (2020). Fibrinogen gamma chain promotes aggregation of vesicular stomatitis virus in saliva. Viruses 12: 282.
    23. Domingo-Calap P., Sanjuán R. (2020). Social interactions among bacteriophages. In: Biocommunication of phages. Springer. p. 103-119.
    24. Domingo-Calap P., Beamud B., Mora-Quilis L., González-Candelas F., Sanjuán R. (2020). Isolation and characterization of two Klebsiella pneumoniae phages encoding divergent depolymerases. International Journal of Molecular Sciences 21: 3160.
    25. Segredo-Otero E., Sanjuán R. (2020). The role of spatial structure in the evolution of viral innate immunity evasion: A diffusion-reaction cellular automaton model. PLoS Computational Biology 16: e1007656.
    26. Domingo-Calap P., Beamud B., Vienne J., González-Candelas F., Sanjuán R. (2020). Isolation of four lytic phages infecting Klebsiella pneumoniae K22 clinical isolates from Spain. International Journal of Molecular Sciences 21: 425.
    27. Andreu-Moreno I., Sanjuán R. (2020). Collective viral spread mediated by virion aggregates promotes the evolution of defective interfering particles. mBio 11: e02156-19.
    28. Risso-Ballester J., Sanjuán R. (2019). High fidelity deep sequencing reveals no effect of ATM, ATR, and DNA-PK cellular DNA damage response pathways on adenovirus mutation rate. Viruses 11: E938.
    29. Bou J.V., Geller R., Sanjuán R. (2019). Membrane-associated enteroviruses undergo intercellular transmission as pools of sibling viral genomes. Cell Reports 29: 714-723.
    30. Segredo-Otero E., Sanjuán R. (2019) The effect of genetic complementation on the fitness and diversity of viruses spreading as collective infectious units. Virus Research 267: 41-48.
    31.  Sanjuán R., Thoulouze M.I. (2019). Why viruses sometimes disperse in groups. Virus Evolution 5: vez014.
    32. Domingo-Calap P., Segredo-Otero E., Durán-Moreno M., Sanjuán R. (2019). Social evolution of innate immunity evasion in a virus. Nature Microbiology 4: 1006-1013.
    33. Cebriá-Mendoza M., Sanjuán R., Domingo-Calap P. (2019). Directed evolution of a mycobacteriophage. Antibiotics 8: E46.
    34. Leeks A., Sanjuán R., West S.A. (2019). The evolution of collective infectious units in viruses. Virus Research 265: 94-101.
    35. Sanjuán R. (2018). Collective properties of viral infectivity. Current Opinion in Virology 33: 1-6. [author pdf]
    36. Patiño-Galindo J.Á., Domínguez F., Cuevas M.T., Delgado E., Sánchez M., Pérez-Álvarez L., Thomson M.M., Sanjuán R., González-Candelas F., Cuevas J.M. (2018). Genome-scale analysis of evolutionary rate and selection in a fast-expanding Spanish cluster of HIV-1 subtype F1. Infection Genetics and Evolution 66: 43-47. [author pdf]
    37. Andreu-Moreno I., Sanjuán R. (2018). Collective infection of cells by viral aggregates promotes early viral proliferation and reveals a cellular-level Allee effect. Current Biology 28: 3212-3219. [author pdf]
    38. Leeks A., Segredo-Otero E.A., Sanjuán R., West S.A. (2018). Beneficial coinfection can promote within-host viral diversity. Virus Evolution 4: vey028.
    39. Benito J.M., Hillung J., Restrepo C., Cuevas J.M., León A., Ruiz-Mateos E., Palacios-Muñoz R., Górgolas M., Sanjuán R., Rallón N. (2018). Role of APOBEC3H in the viral control of HIV elite controller patients. Int. J. Med. Sci. 15:95-100.
    40. López-Carrasco A., Ballesteros C., Sentandreu V., Delgado S., Gago-Zachert S., Flores R., Sanjuán R. (2017). Different rates of spontaneous mutation of chloroplastic and nuclear viroids as determined by high-fidelity ultra-deep sequencing. PLoS Pathogens 13:e10065.
    41. Díaz-Muñoz S.L., Sanjuán R., West S. (2017). Sociovirology: conflict, cooperation, and communication among viruses. Cell Host Microbe 22: 437-441.
    42. Cuevas J.M., Durán-Moreno M., Sanjuán R. (2017). Multi-virion infectious units arise from free viral particles in an enveloped virus.  Nature Microbiology 2: 17078.
    43. Sanjuán R. (2017). Collective infectious units in  viruses. Trends in Microbiology 25:402-412

    44. Risso-Ballester J., Cuevas J.M., Sanjuán R. (2016). Genome-wide estimation of the spontaneous mutation rate of human adenovirus 5 by high-fidelity deep sequencing.  PLoS Pathog. 12:e1006013.
    45. Pereira-Gómez M., Bou J.V., Andreu I., Sanjuán R. (2016). Lamivudine/Adefovir treatment increases the rate of spontaneous mutation of hepatitis B virus in patients. PLoS One 11: e0163363.

    46. Sanjuán R., Domingo-Calap P. (2016). Mechanisms of viral mutation. Cell Mol Life Sci. 73:4433-4448.
    47. Geller R., Estada U., Peris J.B., Andreu I., Bou J.-V., Garijo R., Cuevas J.M., Sabariegos R., Mas A., Sanjuán R. (2016). Highly heterogeneous mutation rates in the hepatitis C virus genome. Nat. Microbiol. 1: 16045. Available at: http://rdcu.be/htU7.
    48. Cuevas J.M., Combe M., Torres-Puente M., Garijo R., Guix S., Buesa J., Rodríguez-Díaz J., Sanjuán R. (2016). Human norovirus hyper-mutation revealed by ultra-deep sequencing. Infect. Genet. Evol., 41: 233-239.
    49. Garijo R, Cuevas J.M., Briz A., Sanjuán R. (2016). Constrained evolvability of interferon suppression in an RNA virus. Sci. Reports 6: 24722.
    50. Sanjuán R., Pereira-Gómez, M., Risso, J. Genome instability in DNA viruses (2016) in: Genome Stability (Eds: I. Kovalchuk, O. Kovalchuk). Elsevier.
    51. Combe M., Garijo R., Geller R., Cuevas J.M., Sanjuán R. (2015). Single-cell analysis of RNA virus infection identifies multiple genetically diverse viral genomes within single infectious units. Cell Host Microbe 18: 424-432
    52. Geller R., Domingo-Calap P., Cuevas J.M., Rossolillo P., Negroni M., Sanjuán R. (2015). The external domains of the HIV-1 envelope are a mutational cold spot. Nat. Commun. 6: 8571.
    53. Cuevas J.M., Geller R., Garijo R., López-Aldeguer J., Sanjuán R. (2015). Extremely high mutation rate of HIV-1 in vivo. PLoS Biol. 13:e1002251.
    54. Sanjuán R. Viral mutation rates (2015) in: Virus Evolution: Current Research and Future Perspectives (Eds: S.C. Weaver, M. Denison, M. Roossinck, M. Vignuzzi). Caister Academic Press.
    55. Pereira-Gómez M., Sanjuán R. (2015). Effect of mismatch repair on the mutation rate of bacteriophage fX174. Virus Evol. 1: vev010.
    56. Hernández-Alonso P., Garijo R., Cuevas J.M., Sanjuán R. (2015). Experimental evolution of an RNA virus in cells with innate immunity defects. Virus Evol. 1: vev008.
    57. Sanjuán R., Grdzelishvili V.Z. (2015). Evolution of oncolytic viruses. Curr. Opin .Virol. 13: 1-5.
    58. Garijo R., Hernández-Alonso P., Rivas C., Diallo J.S., Sanjuán R. (2014). Experimental evolution of an oncolytic vesicular stomatitis virus with increased selectivity for p53-deficient cells. PLoS One 9:e102365.
    59. Flores R., Gago-Zachert S., Serra P., Sanjuán R., Elena SF. (2014). Viroids: survivors from the RNA world? Annu. Rev. Microbiol. 68: 395-414.
    60. Cabanillas L., Sanjuán R., Lázaro E. (2014). Changes in protein domains outside the catalytic site of the bacteriophage Qβ replicase reduce the mutagenic effect of 5-azacytidine. J. Virol. 88: 10480-10487.
    61. Pereira-Gómez M., Sanjuán R. (2014). Delayed lysis confers resistance to the nucleoside analogue 5-fluorouracil and alleviates mutation accumulation in the single-stranded DNA bacteriophage fX174. J. Virol. 88:5042-5049.
    62. Combe M., Sanjuán R. (2013). Variation in RNA virus mutation rates across host cells. PLoS Pathog. 10: e1003855.
    63. Bradwell K., Combe M., Domingo-Calap P., Sanjuán R. (2013). Correlation between mutation rate and genome size in riboviruses: mutation rate of bacteriophage Qβ. Genetics 195: 243-251.
    64. Sanjuán R., Nebot M.R., Peris J.B., Alcamí J. (2013). Immune activation promotes evolutionary conservation of T-cell epitopes in HIV-1. PLoS Biol. 11: e1001523.
    65. Pereira-Gómez M., Peris J.B., Sanjuán R. (2013). Seguint la pista del VIH: els estudis evolutius i la comprensió de la SIDA. Mètode 78: 61- 67.
    66. Furió V., Garijo R., Durán M., Moya A., Bell J.C., Sanjuán R. (2012). Relationship between within-host fitness and virulence in the vesicular stomatitis virus: correlation with partial decoupling. J. Virol. 86: 12228-36
    67. Vale P.F., Choisy M., Froissart R., Sanjuán R., Gandon S. (2012). The distribution of mutational fitness effects of phage fX174 on different hosts. Evolution 66: 3495-507.
    68. Domingo-Calap P., Pereira-Gómez M., Sanjuán R. (2012). Nucleoside analogue mutagenesis of a single-stranded DNA virus: evolution and resistance. J. Virol. 86: 9640-9646.
    69. Sanjuán R. (2012). From molecular genetics to phylodynamics: evolutionary relevance of mutation rates across viruses. PLoS Pathog. 8:e1002685.
    70. Manrubia S., Sanjuán R. (2012). Shape matters: effect of point mutations on RNA secondary structure. Advances in Complex Systems 13: 25.
    71. Sanjuán R., Lázaro E., Vignuzzi M. (2012). Biomedical implications of viral mutation and evolution. Future Virol. 7: 1-12.
    72. Cuevas J.M., Domingo-Calap P., Sanjuán R. (2012). The fitness effects of synonymous mutations in DNA and RNA viruses. Mol. Biol. Evol. 29: 17-20.
    73. Belshaw R., Sanjuán R., Pybus O.G. (2011). Viral mutation and substitution: units and levels. Curr. Opin. Virol. 1: 430-435.
    74. Cuevas J.M., Pereira-Gómez M., Sanjuán R. (2011). Mutation rate of bacteriophage ϕX174 modified through changes in GATC sequence context. Infect. Genet. Evol. 11:1820-1822.
    75.  Domingo-Calap P., Sanjuán R. (2011). Experimental evolution of RNA versus DNA viruses. Evolution 65: 2987-2994
    76. Sanjuán R., Domingo-Calap P. (2011). Experimental evolution in viruses. Encyclopedia of Life Sciences.  DOI: 10.1002/9780470015902.a0022857.
    77. Sanjuán R., Bordería A.V. (2011). Interplay between RNA structure and protein evolution in HIV-1. Mol. Biol. Evol. 28: 1333-1338.
    78. Sanjuán R., Nebot M.R., Chirico N., Mansky L.M., Belshaw R. (2010). Viral mutation rates. J. Virol. 84: 9733-9748 .
    79. Domingo-Calap P., Pereira-Gómez M., Sanjuán R. (2010). Selection for thermostability can lead to the emergence of mutational robustness in an RNA virus. J. Evol. Biol. 23: 2453-2460 .
    80. Sanjuán R., Bradwell K. (2010). Book review: The Evolution and Emergence of RNA viruses (Author: E.C. Holmes). Syst. Biol. 59: 610-612.
    81. Cuevas J.M., Sanjuán R., Moya A. Evolución experimental en virus (2010) in: Adaptación y Evolución (Eds: H. Dopazo, A. Navarro), p. 439-446. Obrapropia.
    82. González-Candelas F., Sanjuán R. The population genetics of human viral pathogens (2010) in: Microbial Population Genetics (Ed: Jianping Xu) p. 167-188.
    83. Sanjuán R. (2010). Mutational fitness effects in RNA and single-stranded DNA viruses: common patterns revealed by site-directed mutagenesis studies. Philos. Trans. Roy. Soc. Lond. B 365: 1975-1982 .
    84. Peris J.B., Davis P., Cuevas J.M., Nebot M.R., Sanjuán R. (2010). Distribution of fitness effects caused by single-nucleotide substitutions in bacteriophage f1. Genetics 185: 603-609.
    85. Domingo-Calap P., Cuevas J.M., Sanjuán R. (2009). The fitness effects of random mutations in single-stranded DNA and RNA bacteriophages. PLoS Genet. 5: e1000742 .
    86. Cuevas J.M., Duffy S., Sanjuán R. (2009). Point muation rate of bacteriophage fX174. Genetics 183: 747-749 .
    87. Cuevas J.M., Moya A., Sanjuán R. (2009). A genetic background with low mutational robustness is associated with increased adaptability to a novel host in an RNA virus. J. Evol. Biol. 22: 2041-2048 .
    88. Domingo-Calap P., Sentandreu V., Bracho A., González-Candelas F., Moya A., Sanjuán R. (2009). Unequal distribution of RT-PCR artifacts along the E1-E2 region of hepatitis C virus. J. Virol. Methods 161: 136-140.
    89. Cuevas J.M., Domingo-Calap P., Pereira-Gómez M., Sanjuán R. (2009). Experimental evolution and population genetics of RNA viruses.  The Open Evolution Journal 3: 9-16.
    90. Cuevas J.M., González-Candelas F., Moya A., Sanjuán R. (2009), Effect of ribavirin on the mutation rate and spectrum of hepatitis C virus in vivo. J. Virol. 83: 5760-5764.
    91. Cuevas J.M., Sanjuán R. (2009). Evolución experimental: evolución en tiempo real. Apuntes de Ciencia y Tecnología 30: 30-34.
    92. Sanjuán R., Agudelo-Romero P., Elena S.F. (2009). Upper-limit mutation rate estimation for a plant virus. Biol. Lett. 5: 394-396.
    93. Gago S., Elena S.F., Flores R., Sanjuán R. (2009). Extremely high mutation rate of a hammerhead viroid. Science 323: 1308.
    94. Elena S.F., Sanjuán R. (2008) The effect of genetic robustness on evolvability in digital organisms. BMC Evol. Biol. 8: 284.
    95. Clune J., Misevic D., Ofria C., Lenski R., Elena S.F., Sanjuán R. (2008). Selection fails to optimize mutation rates in rugged fitness landscapes. PLoS Comput. Biol. 4: e1000187 .
    96. Carrillo F.Y., Sanjuán R., Moya A., Cuevas J.M. (2008). Enhanced adaptation of vesicular stomatitis virus in cells infected with vaccinia virus. Infect. Genet. Evol. 8: 614-620.
    97. Sanjuán R., Nebot M.R. (2008) A network model for the correlation between epistasis and genomic complexity. PLoS ONE 3: e2663.
    98. Bull J.J., Sanjuán R., and Wilke C.O. Lethal mutagenesis (2008) in: Origin and Evolution of Viruses (Eds: E. Domingo, C. Parrish, J. Holland), p. 207-218.
    99. Sanjuán R. Quasispecies and experimental evolution of RNA viruses (2008) in: Enciclopedia of Virology (Eds: B.W.J. Mahy, M.H.V. Van Regenmortel), p. 359-365.
    100. Elena S.F., Agudelo-Romero P., Carrasco P., Codoñer F.M., Martín S., Torres C., and Sanjuán R. (2008). Experimental evolution of plant RNA viruses. Heredity 100: 478-483.
    101. Serrani J.C., Sanjuán R., Fos M., García-Martínez J.L. (2007). Gibberellin regulation of fruit-set and growth in tomato. Plant Physiol. 145: 246-257 .
    102. Elena S.F. and Sanjuán R. (2007). Virus evolution: insights from an experimental approach. Annu. Rev. Ecol. Evol. Syst. 38: 27-52 .
    103. Sanjuán R. and Daròs J.A. (2007). Site-directed mutagenesis of viroid dimeric cDNA. J. Virol. Methods 145: 71-75.
    104. Sanjuán R., Cuevas J.M., Furió V., Holmes E.C., and Moya A. (2007). Selection for robustness in mutagenized RNA viruses. PLOS Genet. 15: e93.
    105. Bordería A.V., Codoñer F.M., and Sanjuán R. (2007) Selection promotes organ compartmentalization in HIV-1: evidence form gag and pol genes. Evolution 61: 272-279.
    106. Bull J.J., Sanjuán R., and Wilke C.O. (2007) Theory of lethal mutagenesis for viruses. J. Virol. 81: 2930-2939 .
    107. Furió V., Moya A., and Sanjuán R. (2007). The cost of replication fidelity in human immunodeficiency virus type 1. Proc. Biol. Sci. 274: 225-230.
    108. Carrillo F.Y., Sanjuán R., Moya A., and Cuevas F.M. (2007). The effect of co- and superinfection on the adaptive dynamics of vesicular stomatitis virus. Infect. Genet. Evol. 7: 69-73.
    109. Czarna A., Sanjuán R., González-Candelas F., and Wróbel B. (2006). Topology testing of phylogenies using least squares methods. BMC Evol. Biol., 6: 105.
    110. Sanjuán R. and Elena S.F. (2006). Epistasis correlates to genomic complexity. Proc. Natl. Acad. Sci. USA 103: 14402-14405.
    111. Sanjuán R., Forment J., and Elena S.F. (2006). In silico predicted robustness of viroids RNA secondary structures. II. Interaction between mutation pairs. Mol. Biol. Evol. 23: 2123-2130.
    112.  Sanjuán R., Forment J., and Elena S.F. (2006). In silico predicted robustness of viroids RNA secondary structures. I. The effect of single mutations. Mol. Biol. Evol. 23: 1427-1436.
    113. Sanjuán R. (2006) Quantifying antagonistic epistasis in a multifunctional RNA secondary structure of the Rous sarcoma virus. J. Gen. Virol., 87: 1595-1602 .
    114. Elena SF., Carrasco P., Daròs J.A., and Sanjuán R. (2006). Mechanisms of genetic robustness in RNA viruses. EMBO R. 7: 168-173.
    115. Furió V., Moya A., and Sanjuán R. (2005). The cost of replication fidelity in an RNA virus. Proc. Natl. Acad. Sci. USA 102: 10233-10237.
    116. Elena S.F. and Sanjuán R. (2005). On the adaptive value of high mutation rates in RNA viruses: separating causes from consequences. J. Virol., 79, 11555-11558.
    117. Sanjuán R., Cuevas J.M., Moya A., and Elena S.F. (2005). Epistasis and the adaptability of an RNA virus. Genetics 170: 1001-1008.
    118. Elena S.F. and Sanjuán R. (2005). RNA viruses as complex adaptive systems. Biosystems 81: 31-41.
    119. Sanjuán R. and Wróbel B. (2005). Weighted least-squares likelihood ratio test for branch testing in phylogenies reconstructed from distance methods. Syst. Biol., 54: 218-229.
    120. Cuevas J.M., Sanjuán R., Moya A., and Elena S.F. (2005). Mode of selection and experimental evolution of antiviral drugs resistance in vesicular stomatitis virus. Infect. Genet. Evol. 5: 55-65.
    121. Cuevas J.M., Moya A., and Sanjuán R. (2005). Following the very initial growth of biological RNA viral clones. J Gen. Virol. 86: 435-443.
    122. Sanjuán R., Moya A., and Elena S.F. (2004). The contribution of epistasis to the architecture of fitness in an RNA virus. Proc. Natl. Acad. Sci. USA 101: 15376-15379 .
    123. Sanjuán R., Moya A., and Elena S.F. (2004). The distribution of fitness effects caused by single-nucleotide substitutions in an RNA virus. Proc. Natl. Acad. Sci. USA 101: 8396-8401.
    124. Sanjuán R., Codoner F.M., Moya A., and Elena S.F. (2004). Natural selection and the organ-specific differentiation of HIV-1 V3 hypervariable region. Evolution 58: 1185-1194.
    125. Elena S.F. and Sanjuán R. (2003). Evolution: Climb every mountain? Science 302: 2074-2075.
    126. Elena S.F., Codoñer F.M., Cuevas J.M., and Sanjuán R. (2003). Adaptive dynamics during experimental evolution of RNA viruses. Biology International 44: 75-78.
    127. Elena S.F., Codoñer F.M., and Sanjuán R. (2003). Intraclonal variation in RNA viruses: generation, maintenance and consequences. Biol. J. Linn. Soc. 79: 17-26.
    128. Elena S.F., Sanjuán R., Borderia A.V., and Turner P.E. (2002). Differential effects of horizontal and vertical transmission in the fitness of an RNA virus: A reanalysis. Infect. Genet. Evol. 1: 307-309.
    129. Sanjuán R. and Marín I. (2001). Tracing the origin of the compensasome: evolutionary history of DEAH helicase and MYST acetyltransferase gene families. Mol. Biol Evol. 18: 330-343. 

     
     






Universitat de València, 2020