Journal Publications
[50] Giada SR., Liberos A., Termenon-Rivas M., Barrios-Álvarez J., Serra D., Romero P., Calvo D., Lozano M., García-Fernández I., Sebastian R., Rodrigo M. Implementation of a Cellular Automaton for efficient simulations of atrial arrhythmias. Medical Image Analysis, :103484, 2025. doi:10.1016/j.media.2025.103484. IF: . (Q1/T1) [PDF]
[49] Romero P., Pedros A., Sebastian R., Lozano M., Garcia-Fernandez I. A robust shape model for blood vessels analysis. Applied Mathematics and Computation , 487:129078, 2025. doi:10.1016/j.amc.2024.129078. IF: . (Q1) [PDF]
[48] Romero P., Lozano M., Dux-Santoy L., Guala A., Teixido-Tura G., Sebastian R., Garcia-Fernandez I. Beyond the root: Geometric characterization for the diagnosis of syndromic heritable thoracic aortic diseases. Computers in Biology and Medicine , 182:109176, 2024. doi:10.1016/j.compbiomed.2024.109176. IF: . (Q1) [PDF]
[47] Camps J., Arantes-Berg L., Wang ZJ., Sebastian R., Luana-Riebel L., Doste R., Zhou X., Sachetto R., Coleman J., Lawson B., Grau V., Burrage K., Bueno-Orovio A., Weber Dos Santos R., Rodriguez B. Digital twinning of the human ventricular activation sequence to Clinical 12-lead ECGs and magnetic resonance imaging using realistic Purkinje networks for in silico clinical trials. Medical Image Analysis , 94:103108, 2024. doi:10.1016/j.media.2024.103108. IF: . (Q1) [PDF]
[46] Bocanegra-Perez A., Piella G., Sebastian R., Jimenez-Perez G., Falasconi G., Saglietto A., Soto-Iglesias D., Berruezo A., Penela D. Automatic and interpretable prediction of the site of origin in outflow tract ventricular arrhythmias: machine learning integrating electrocardiograms and clinical data. Frontiers in Cardiovascular Medicine , 11:1353096, 2023. doi:10.3389/fcvm.2024.1353096. IF: . (Q1) [PDF]
[45] Berg L.A., Rocha B.M., Sachetto R., Sebastian R., Rodriguez B., Bonfim de Queiroz R., Cherry E.M., Weber R. Enhanced Optimization-Based Method for the Generation of Patient-Specific Models of Purkinje Networks. Nature Scientific Reports , :, pp. -, 2023. doi:. IF: 4.9 (Q1) [PDF]
[44] Doste R., Lozano M., Gimenez-Perez G., Mont L., Berruezo, A., Penela D., Camara O., Sebastian R. Training machine learning models with synthetic data improves the prediction of ventricular origin in outflow tract ventricular arrhythmias. Frontiers in Physiology (Computational Physiology and Medicine) , 13:909372 , pp. 1-18, 2022. doi:10.3389/fphys.2022.. IF: 4.0 (Q2) [PDF]
[43] Albors C., Lluch E., Gomez J.F., Cedilnik N., Mountris K.A., Mansi T., Khamzin S., Dokuchaev A., Solovyova O., Pueyo E., Sermesant M., Sebastian R., Morales H., Camara O. Meshless electrophysiological modelling of cardiac resynchronization therapy - Benchmark analysis with finite-element methods in experimental data. Applied Sciences , 12, pp. 6438, 2022. doi:10.3390/app12136438. IF: 2.7 (Q2) [PDF]
[42] Serra D., Romero P., García-Fernández I., Lozano M., Liberos A., Rodrigo M., Bueno-Orovio A., Berruezo A., Sebastian R. An Automata-Based Cardiac Electrophysiology Simulator to Assess Arrhythmia Inducibility. Mathematics , Vol. 10(8) , pp.1293, 2022 doi:10.3390/math10081293. IF: 2.4 (D1/Q1) [PDF]
[41] Romero P., Lozano M., Martinez-Gil F., Serra D., Sebastian R., Lamata P., García-Fernández I. Clinically-Driven Virtual Patient Cohorts Generation: an Application to Aorta. Frontiers in Physiology (Computational Physiology and Medicine) ,Vol. 12(713118) , pp. 1-18, 2021. doi:10.3389/fphys.2021.713118. IF: 4.755 (Q1) [PDF]
[40] Barber F., Langfield P., Lozano M., Garcia-Fernandez I., Duchateau J., Meleze H., Haissaguerre M., Vigmond E. Sebastian R. Estimation of personalized minimal Purkinje systems from human electro-anatomical maps. IEEE Transactions on Medical Imaging, Vol. 40(8) , pp. 2182-2194, 2021. doi:10.1109/TMI.2021.3073499. IF: 11.037 (Q1/D1) [PDF]
[39] Langfield P., Fenga Y., Beara L., Duchateau J., Sebastian R., Abella E., Dubois R., Labrousse L., Rogier J., Hocini M., Haissaguerre M., Vigmond E. A novel method to correct repolarization time estimation from unipolar electrograms distorted by standard filtering. Medical Image Analysis, Vol. 22, pp. 102075, 2021. doi:10.1016/j.media.2021.102075. IF: 13.828 (Q1/D1) [PDF]
[38] Bragard J.R., Camara O., Echebarria B., Giorda L.G., Pueyo E, Saiz J, Sebastian R, Soudah E., Vazquez M. Cardiac computational modelling. REC Rev Esp Cardiol, Vol. 71(1) , pp. 65-71, 2021. doi:10.1016/j.rec.2020.05.024 . IF: 6.975 (Q1) [PDF]
[37] Martinez-Gil F., Lozano M., Garcia-Fernandez I., Romero P., Serra D., Sebastian R. Using Inverse Reinforcement Learning with Real Trajectories to Get More Trustworthy Pedestrian Simulations. Mathematics, Vol. 8(9) , pp. 1479, 2020. doi:10.3390/math8091479. IF:2.258(Q1/D1). [PDF]
[36] Doste R., Sebastian R., Gomez J.F., Soto-Iglesias D., Alcaine A., Monte L., Berruezo A., Penela D., Camara O. In-silico pace-mapping: prediction of left vs right outflow tract origin in idiopathic ventricular arrhythmias with multi-scale electrophysiological simulations. EP Europace, euaa102, 2020. doi:10.1093/europace/euaa102 . IF: 5.214 (Q2) [PDF]
[35] Gomez-Torresa F.A., R Sebastian R., Ruíz-Sauri A. Morphometry and comparative histology of sinus and atrioventricular nodes in humans and pigs and their relevance in the prevention of nodal arrhythmias. Research in Veterinary Science, Vol. 128, pp. 275-285, 2020. doi:10.1016/j.rvsc.2019.12.008. IF:2.534(Q1). [PDF]
[34] Lopez-Perez A., Sebastian R., Izquierdo M., Ruiz R., Bishop M., Ferrero J.M. Personalized cardiac computational models: from clinical data to simulation of infarct-related ventricular tachycardia. Frontiers in Physiology, Vol. 10:580, pp. 1-26 , 2019. doi:10.3389/fphys.2019.00580. IF: 3.367(Q1) [PDF]
[33] Garcia-Bustos V., Sebastian R., Izquierdo M., Rios-Navarro C., Bodi V., Chorro F.J., Ruiz-Sauri A. Changes in the spatial distribution of the Purkinje network after acute myocardial infarction in a swine model. PLoS ONE, Vol. E 14(2): e0212096, pp. 1-17 , 2019. doi:10.1371/journal.pone.0212096. IF: 2.740(Q2) [PDF]
[32] Carpio-Garay E., Gomez JF., Sebastian R., Lopez-Perez A., Castellanos E., Almendral J., Ferrero JM. Trenor B. Optimization of Lead Placement in the Right Ventricle During Cardiac Resynchronization Therapy. A Simulation Study. Frontiers in Physiology, Vol. 10:74, pp. 1-17 , 2019. doi:10.3389/fphys.2019.00074. IF: 3.367(Q1) [PDF]
[31] Doste R., Soto-Iglesias D., Bernardino G., Alcaine A., Sebastian R., Giffard-Roisin S., Sermesant M., Berruezo A., Sanchez-Quintana D., Camara O. A rule-based method to model myocardial fiber orientation in cardiac biventricular geometries with outflow tracts. International Journal for Numerical Methods in Biomedical Engineering, Vol. 35(4):e3185, pp. 1-17, 2019. doi: 10.1002/cnm.3185. IF: 2.097(Q2) [PDF]
[30] Gil D., Aris R., Borras A., Ramirez, E., Sebastian R., Vazquez M. Influence of Fiber Connectivity in Simulations of Cardiac BioMechanics. International Journal of Computer Assisted Radiology and Surgery, Vol. 14(1):, pp. 63 - 72, 2019. doi: 10.1007/s11548-018-1849-9. IF: 2.473(Q2) [PDF]
[29] Barber F., Lozano M., Garcia-Fernandez. I., Sebastian R. Automatic Estimation of Purkinje-Myocardial Junction hot-spots from Noisy Endocardial Samples: A simulation study. International Journal for Numerical Methods in Biomedical Engineering, Vol. 34(7):e2988, pp. 1 - 17, 2018. doi:10.1002/mma.4280. IF: 2.082(Q2) [PDF]
[28] Godoy E., Lozano M., García-Fernández I., Ferrer-Albero A., MacLeod R., Saiz J., Sebastian R. Atrial fibrosis hampers non-invasive localization of atrial ectopic foci from multi-electrode signals: A 3D simulation study. Frontiers in Physiology Vol. 9(404):, pp. 1 - 18, 2018. doi:10.3389/fphys.2018.00404. IF: 3.201(Q2) . [PDF].
[27] Martínez-Mateu L., Romero L., Ferrer A., Sebastian R., Rodríguez JF., Jalife J., Berenfeld O., Saiz J., Factors Affecting True and Phantom Detection of Rotors by Basket Catheters in the Atria: A computational Study. PLoS Comput Biol, Vol. 14(3):e1006017, pp. 1 - 26, 2018. doi:10.1371/journal.pcbi.1006017 . IF: 4.428(Q1) . [PDF].
[26] Barber F., Lozano M., Garcia-Fernandez. I., Sebastian R. Inverse Estimation of Terminal Connections in the Cardiac Conduction System. Mathematical Methods in Applied Sciences, Vol. 41(6):, pp. 2340 - 2349, 2018. doi:10.1002/mma.4280. IF: 1.553(Q2) [PDF]
[25] Galli V., Sebastian R., Moutel S., Ecard J., Perez F., Roux A. Uncoupling of dynamin polymerization and GTPase activity revealed by the conformation-specific nanobody Dynab. eLIFE, 6:e25197, 2017. doi: 10.7554/eLife.25197. IF: 7.616(Q1) [PDF].
[24] Ferrer-Albero A., Godoy E.J., Lozano M., Martinez-Mateu L., Atienza F., Saiz J., Sebastian R. Non-invasive localization of atrial ectopic beats by using simulated body surface P-wave integral maps. PLoS ONE, Vol. 12(7):e0181263, pp. 1 - 23, 2017. doi:10.1371/journal.pone.0181263. IF: 2.766(Q1) [PDF]
[23] Garcia-Bustos V., Sebastian R., Izquierdo M., Molina P., Chorro F.J., Ruiz-Sauri A. A quantitative structural and morphometric analysis of the Purkinje network and the Purkinje-myocardial junctions in pig hearts. Journal of Anatomy, Vol. 230(5):664 - 678, 2017. doi: 10.1111/joa.12594. IF: 2.479(Q1) [PDF]
[22] Hoogendoorn C., Sebastian R., Rodriguez J.F., Lekadir K., Frangi A.F. An Atlas and Data-Driven Approach to Initializing Reaction-Diffusion Systems in Computer Cardiac Electrophysiology. International Journal for Numerical Methods in Biomedical Engineering, Vol. 33(8):e2846, 2017. doi: 10.1002/cnm.2846. IF: 2.338(Q1) [PDF]
[21] Romero D., Camara O., Sachse F., Sebastian R. Analysis of Microstructure of the Cardiac Conduction System Based on Three-dimensional Confocal Microscopy. PLoS ONE. Vol. 11(10):e0164093, pp. 1 - 19, 2016. IF: 2.806(Q1) [PDF]
[20] Ferrer A., Sebastian R., Sanchez-Quintana D., Rodriguez J.F., Godoy E.J., Martinez, L., Saiz J. Detailed anatomical and electrophysiological models of human atria and torso for the simulation of atrial activation. PLOS One. Vol. 10(11):e0141573, pp. 1 - 29, 2015. IF: 3.06(Q1) [PDF]
[19] Calvo D., Atienza F., Saiz J.,Martinez L., Avila P., Rubin J., Herreros B., Arenal A., García-Fernández J., Ferrer A., Sebastian R., Martínez-Camblor P., Jalife J., Berenfeld O. Ventricular Tachycardia and Early Fibrillation in Brugada Syndrome and Ischemic Cardiomyopathy Patients Show Predictable Frequency-Phase Properties on the Precordial ECG Consistent with the Respective Arrhythmogenic Substrate. Circulation: Arrhythmia and Electrophysiology . Vol. 8(5), pp. 1133-1143, 2015. IF: 4.43(Q1) [PDF]
[18] Lopez-Perez A., Sebastian R., Ferrero JM. Three-dimensional cardiac computational modelling: methods, features and applications. Review Biomedical Engineering Online. Vol. 14(35), pp. 1 - 31, 2015. IF: 1.75 [PDF]
[17] Cardenes R., Sebastian R., Soto-Iglesias D., Berruezo A., Camara O. Estimation of Purkinje Trees from Electro-Anatomical Mapping of the Left Ventricle Using Minimal Cost Geodesics Medical Image Analysis. Vol. 4(1), pp. 52 - 62, 2015. IF: 4.565(Q1) [PDF]
[16] Tobon-Gomez C., Duchateau N., Sebastian R., Marchesseau S., Donal E., De Craene M., Pashaei A., Relan J., Steghofer M., Lamata P., Camara O., Delingette H., Duckett S., Garreau M., Hernandez A., Rhode K.S., Sermesant M., Ayache N., Leclercq C., Razavi R., Smith N., Frangi A.F. Understanding the mechanisms amenable to CRT response: from pre-operative multimodal image data to patient-specific computational models. Medical and Biological Engineering and Computing. Vol. 51, pp. 1235-1250, 2013 . IF: 1.878(Q2) [PDF]
[15] Sebastian R., Zimmerman V., Romero D., Sanchez-Quintana D., Frangi A.F. Characterization and Modeling of the Peripheral Cardiac Conduction System. IEEE Transactions on Medical Imaging. Vol. 32(1), pp. 45 - 55, 2013. IF: 3.643(Q1) [PDF]
[14] Sebastian R., Zimmerman V., Romero D., Frangi A.F. Construction of a Computational Anatomical Model of the Peripheral Cardiac Conduction System. IEEE Transactions on Biomedical Engineering. Vol. 58(12), pp. 3479-82, 2011. IF: 2.278 [PDF]
[13] Dux-Santoy L., Sebastian R., Felix-Rodriguez J., Ferrero J.M., Saiz J. Interaction of specialized cardiac conduction system with antiarrhythmic drugs: a simulation study. IEEE Transactions on Biomedical Engineering. Vol. 58(12), pp. 3475-78, 2011. IF: 2.278 [PDF]
[12] Pashaei A., Romero D., Sebastian R., Camara O., Frangi, AF. Fast Multiscale Modeling of Cardiac Electrophysiology Including Purkinje System. IEEE Transactions on Biomedical Engineering. Vol. 58(10), pp. 2956-2960 2011. IF: 2.278 [PDF]
[11] Bradley C., Bowery A., Britten R., Budelmann V., Camara O., Christie R., Cookson A., Frangi A., Gamage T.B., Heidlauf T., Krittian S., Ladd D., Little D., Mithraratne K., Nash M., Nickerson D., Nielsen P., Nordbo Y., Omholt S., Pashaei A., Paterson D., Rajagopal V., Reeve A., Röhrle O., Safaei S., Sebastian R., Steghöfer M., Wu T., Yu T., Zhang H., Hunter P. OpenCMISS: A multi-physics and multi-scale computational infrastructure for the VPH/Physiome project. Progress in Biophysics and Molecular Biology. Vol. 107(1), pp. 32-47, 2011. IF: 3.964 [PDF]
[10] Camara O., Sermesant M., Lamata P., Wang L., Pop M., Relan J., De Craene M., Delingette H., Liu H., Niederer S., Pashaei A., Plank G., Romero D., Sebastian R., Wong K.C.L., Zhang H., Ayache N., Frangi A.F., Shif P., Smith N., Wright G.A. Inter-Model Consistency and Complementarity: Learning from ex-vivo Imaging and Electrophysiological Data towards an Integrated Understanding of Cardiac Physiology. Progress in Biophysics and Molecular Biology. Vol. 107(1), pp. 122-133, 2011. IF: 3.964 [PDF]
[9] Letinic K, Sebastian R, Barthel, A., Toomre D. Deciphering Sub-Cellular Processes in Live Imaging Data Sets via Dynamic Probabilistic Networks. Bioinformatics. Vol. 26(16), pp. 2029-2036, 2010. IF: 4.877 [PDF]
[8] Romero D., Sebastian, R., Bijnens, B., Zimmerman, V., Boyle, PM., Vigmond, EJ., Frangi, AF. Effects of the Purkinje system and cardiac geometry on biventricular pacing: a model study. Annals of Biomedical Engineering. Vol 39(4), pp.1388-1398, 2010. IF: 2.374 [PDF]
[7] Letinic K, Sebastian R, Toomre D, Rakic P. Exocyst is involved in polarized cell migration and cerebral cortical development. Proc Natl Acad Sci U S A. Vol. 106(27), pp. 11342-11347. 2009. IF: 9.432 . [PDF]
[6] Diaz, E., Sebastian, R. Ayala, G. Díaz, M.E,.Zoncu, R., Toomre, D., Gasman, S. Measuring spatial temporal interaction in bivariate temporal random sets with applications to cell biology. IEEE Trans Pattern Anal Mach Intell. Vol. 30(9), pp. 1659-1671 . 2008. IF:5.960. [PDF]
[5] Zoncu, R. Perera, R.M., Sebastian, R., Chen, H. Ayala, G., Toomre, D., De Camilli, P. Acute depletion of phosphotidylinositol 4,5 biphosphate results in loss of endocytic clathrin coated pits. Proc Natl Acad Sci U S A. , Vol. 104(10), pp. 3793-3798. 2007. IF: 9.598. [PDF]
[4] Díaz, M.E., Ayala, G., Sebastian, R., Martinez-costa, L. Granulometric Analysis of Corneal Endothelium specular images by using a germ-grain model. Comput Biol Med. Vol. 37(3), pp. 364-375, 2007. IF: 1.170. [PDF]
[3] Sebastian, R., Díaz, E., Ayala, G., M.E. Diaz, Zoncu, R., Toomre, D. Studying Endocytosis in Space and Time by means of Temporal Boolean Models. Pattern Recognition. 39(11):2175-2185, 2006. IF: 1.822. [PDF]
[2] Ayala, G., Sebastian, R., Díaz, M.E., Diaz, E., Zoncu, R., Toomre, D. Analysis of Spatially and Temporally Overlapping Events with Application to Image Sequences. IEEE Trans Pattern Anal Mach Intell. Vol. 28(10), pp. 1707-1712, 2006. IF: 4.306. [PDF]
[1] Sebastian, R., Díaz, M.E., Ayala, G., Letinic, K., Moncho-Bogani, J, Toomre, D. Spatio-temporal Analysis of Constitutive Exocytosis in Epithelial Cells. IEEE/ACM Trans Comput Biol Bioinform. Vol. 3(1), pp. 17-32. 2006. IF: 2.283. [PDF]
