2023
Berg L.A., Rocha B.M., Sachetto R., Sebastian R., Rodriguez B., Bonfim de Queiroz R., Cherry E.M., Weber R. Enhanced Optimization-Based Method for the Generation of Patient-Specific Models of Purkinje Networks. Nature Scientific Reports , :, pp. -, 2023. doi:. IF: 4.9 (Q1) [PDF]
Duchateau N., Oscar Camara, Rafael Sebastian, Andrew King. Analysis of Non-imaging Data. Springer International Publishing, AI and Big Data in Cardiology: A Practical Guide. pp. 183-200, 2023. doi:https://doi.org/10.1007/978-3-031-05071-8_10. [PDF]
Serra D., Romero P., Garcia-Fernandez I., Lozano M. , Soto, D., Penela, D., Berruezo A., Camara O., Sebastian R. Personalized Fast Electrophysiology Simulations to Evaluate Arrhythmogenicity of Ventricular Slow Conduction Channels. Springer Cham International Publishing (LNCS 13593), pp. 1-9, 2023. doi:10.1007/978-3-031-23443-9_6. [PDF]
G. S. Romitti, A. Liberos, P. Romero, D. Serra, I. García, M. Lozano, R. Sebastian, M. Rodrigo. Cellular Automata for Fast Simulations of Arrhythmogenic Atrial Substrate. 12th International Conference on Functional Imaging and Modeling of the Heart (FIMH), Lyon, France, 19-22 June, 2023. [PDF]
Romitti G., Liberos A., Romero P., Serra D., García I., Lozano M., Sebastian R., Rodrigo M. Characterization of the Electrophysiological Characteristics of Chronic Atrial Fibrillation for Efficient Simulations. 45th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC), Sydney, Australia, 24-28 July, 2023. [PDF]
Serra D., Franco P., Romero P., Romitti, G., Garcia-Fernandez I, Lozano M., Liberos A., Penela D., Berruezo A., Camara O., Rodrigo M., Sebastian R. Assessment of Risk for Ventricular Tachycardia based on Extensive Electrophysiology Simulations. 45th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC), Sydney, Australia, 24-28 July, 2023. [PDF]
Romitti G.S., Liberos A., Termenón-Rivas M., Barrios-Alvarez J., Romero P., Serra D., García I., Lozano M., Sebastian R., Rodrigo M. Evaluation of Automata-based Simulations for Atrial Fibrillation in 2D/3D Geometries Reproducing Disease Progression. Computing in Cardiology Conference, Vol. 38, Atlanta, USA, 1-4 October, 2023. [PDF]
Barrios-Alvarez J., Termenón-Rivas M., Romitti G.S., Sebastian R., Liberos A., Rodrigo M. Role of Fiber Orientation and Ionic Heterogeneities to Simulate Chronic Atrial Arrhythmias. Computing in Cardiology Conference, Vol. 38, Atlanta, USA, 1-4 October, 2023. [PDF]
Bocanegra A., Penela D., Sebastian R., Jimenez-Perez G., Falasconi G., Saglietto A., Soto-Iglesias D., Berruezo A., Piella G., Camara O. Automatic Prediction of the Origin in Outflow Tract Ventricular Arrhythmias with Machine Learning Combining Clinical Data and Electrocardiogram Analysis. Computing in Cardiology Conference, Vol. 38, Atlanta, USA, 1-4 October, 2023. [PDF]
Liberos A., Garcia-Gimeno X., Romitti G., Garcia-Fernandez I. Lozano M., Sebastian R., Rodrigo M. Role of Heterogeneous Ionic Profiles in Atrial Fibrillation Propagation. A Population of Models Study. Computing in Cardiology Conference, Vol. 38, Atlanta, USA, 1-4 October, 2023. [PDF]
Termenón-Rivas M., Barrios-Alvarez J., Romitti G., Romero P., Serra D., Garcia-Fernandez I., Lozano M., Sebastian R., Liberos A., Rodrigo M., Substrate-Specific Simulations of Atrial Fibrillation Reproducing Electrophysiological Clinical Markers. Computing in Cardiology Conference, Vol. 38, Atlanta, USA, 1-4 October, 2023. [PDF]
2022
Doste R., Lozano M., Gimenez-Perez G., Mont L., Berruezo, A., Penela D., Camara O., Sebastian R. Training machine learning models with synthetic data improves the prediction of ventricular origin in outflow tract ventricular arrhythmias. Frontiers in Physiology (Computational Physiology and Medicine) , 13:909372 , pp. 1-18, 2022. doi:10.3389/fphys.2022. IF: 4.0 (Q2) [PDF]
Albors C., Lluch E., Gomez J.F., Cedilnik N., Mountris K.A., Mansi T., Khamzin S., Dokuchaev A., Solovyova O., Pueyo E., Sermesant M., Sebastian R., Morales H., Camara O. Meshless electrophysiological modelling of cardiac resynchronization therapy - Benchmark analysis with finite-element methods in experimental data. Applied Sciences , 12, pp. 6438, 2022. doi:10.3390/app12136438. IF: 2.7 (Q2) [PDF]
Serra D., Romero P., Garcia-Fernandez I., Lozano M., Liberos A., Rodrigo M., Bueno-Orovio A., Berruezo A., Sebastian R. An Automata-Based Cardiac Electrophysiology Simulator to Assess Arrhythmia Inducibility. Mathematics , Vol. 10(8) , pp.1293, 2022 . doi:10.3390/math10081293 . IF: 2.4 (D1/Q1) [PDF]
Romero P., Lozano M., Romitti G., Serra D., Garcia-Fernandez I., Liberos A., Rodrigo M., Sebastian R. Machine Learning Based Cell Model for fast approximation of cellular action potential to enable clinical translation. Computing in Cardiology Conference, Vol. 37, Tampere, Finland, 4-7 September, 2022. [PDF]
Romitti G., Romero P., Liberos A., Serra D., Garcia-Fernandez I., Lozano M., Sebastian R., Rodrigo M. Effects of Long- and Short-term Memory on Action Potential Duration for Atrial Cellular Automata. Computing in Cardiology Conference, Vol. 37, Tampere, Finland, 4-7 September, 2022. [PDF]
Camps J., Sebastian R., Berg L., Wang Z.J., Zhou X., Trovato C., Riebel L., Coleman J., Sachetto R., Lawson B., Grau V., Burrage K., Bueno-Orovio A., Weber R., Rodriguez B. Inference of Purkinje structure and ventricular conduction properties from clinical 12-lead electrocardiograms. Computing in Cardiology Conference, Vol. 37, Tampere, Finland, 4-7 September, 2022. [PDF]
G. S. Romitti, A. Liberos, P. Romero, D. Serra, I. Garcia Fernandez, M. Lozano, R. Sebastian, M. Rodrigo Simulación de la actividad electrofisiologica auricular mediante automata celular. XL Congreso Anual de la Sociedad Española de Ingenieria Biomedica (CASEIB), Valladolid, Spain, 23-25 Noviembre, 2022. [PDF]
2021
Romero P., Lozano M., Martinez-Gil F., Serra D., Sebastian R., Lamata P., Garcia-Fernández I. Clinically-Driven Virtual Patient Cohorts Generation: an Application to Aorta. Frontiers in Physiology (Computational Physiology and Medicine) , Vol. 12(713118) , pp. 1-18, 2021. doi:10.3389/fphys.2021.713118. IF: 4.755 (Q1) [PDF]
Barber F., Langfield P., Lozano M., Garcia-Fernandez I., Duchateau J., Meleze H., Haissaguerre M., Vigmond E. Sebastian R. Estimation of personalized minimal Purkinje systems from human electro-anatomical maps. IEEE Transactions on Medical Imaging, Vol. 40(8), pp. 2182-2194, 2021. doi:10.1109/TMI.2021.3073499. IF: 11.037 (Q1/D1) [PDF]
Langfield P., Fenga Y., Beara L., Duchateau J., Sebastian R., Abella E., Dubois R., Labrousse L., Rogier J., Hocini M., Haissaguerre M., Vigmond E. A novel method to correct repolarization time estimation from unipolar electrograms distorted by standard filtering. Medical Image Analysis, Vol. 72, pp. 102075, 2021. doi:10.1016/j.media.2021.102075. IF: 13.828 (Q1/D1) [PDF]
Bragard J.R., Camara O., Echebarria B., Giorda L.G., Pueyo E, Saiz J, Sebastian R, Soudah E., Vazquez M. Cardiac computational modelling. REC Rev Esp Cardiol, Vol. 71(1), pp. 65-71, 2021. doi:10.1016/j.rec.2020.05.024 . IF: 6.975 (Q1) [PDF]
Serra D., Romero P., Lozano M., Garcia-Fernandez I., Liberos A., Rodrigo M., Berruezo A., Bueno-Orovio A., Sebastian R. Simplified Electrophysiology Modeling Framework to Assess Ventricular Arrhythmia Risk in Infarcted Patients. Springer Cham International Publishing (LNCS 12738), pp. 1-9, 2021. doi:10.1007/978-3-030-78710-3_51. [PDF]
Rodrigo M., Pagano B., Takur S., Liberos A., Sebastian R., Narayan S.M. Intra-Cardiac Signatures of Atrial Arrhythmias Identified By Machine Learning and Traditional Features Springer Cham International Publishing (LNCS 12738), pp. 1-9, 2021. doi: . [PDF]
Romero P., Serra D., Lozano M., Sebastian R., Garcia-Fernandez I. Assessment of geometric models for the approximation of aorta cross-sections. Springer Cham International Publishing (LNCS 12738), pp. 1-9, 2021. doi:10.1007/978-3-030-78710-3_9. [PDF]
Doste R., Lozano M., Gomez J.F., Alcaine A., Mont L., Berruezo A., Camara O., Sebastian R. Machine Learning Models Trained with Simulations Predict the Site of Origin of Outflow Tract Ventricular Arrhythmias from Multi-centric Databases. Computing in Cardiology Conference, Vol. 36, Brno, Czech Republic, 12-15 September, 2021. [PDF]
Barber F., Langfield P., Lozano M., Garcia-Fernandez I., Duchateau J., Meleze H., Haissaguerre M., Vigmond E. Sebastian R. Personalization of Ventricular Cardiac Conduction System Models to Reproduce Patient Electrocardiogram. Computing in Cardiology Conference, Vol. 36, Brno, Czech Republic, 12-15 September, 2021. [PDF]
Serra D., Romero P., Lozano M., Garcia-Fernandez I., Liberos A., Rodrigo M., Berruezo A., Bueno-Orovio A., Sebastian R. Arrhythmic3D: A Fast Automata-based Tool to Simulate and Assess Arrhythmia Risk in 3D Ventricular Models. Computing in Cardiology Conference, Vol. 36, Brno, Czech Republic, 12-15 September, 2021. [PDF]
Rodrigo M., Rogers A.J., Ganesan P., Alhusseini M.I., Liberos A., Sebastian R., Narayan S.M. Electrogram Signatures of Atrial Fibrillation identified by Deep Learning. Computing in Cardiology Conference, Vol. 36, Brno, Czech Republic, 12-15 September, 2021. [PDF]
Rodrigo M., Rogers A.J., Ganesan P., Alhusseini M.I., Liberos A., Sebastian R., Narayan S.M. Accuracy of Classic Features versus Deep Learning to Detect Atrial Fibrillation on Intracardiac Electrograms Computing in Cardiology Conference, Vol. 36, Brno, Czech Republic, 12-15 September, 2021. [PDF]
2020
Martinez-Gil F., Lozano M., Garcia-Fernandez I., Romero P., Serra D., Sebastian R. Using Inverse Reinforcement Learning with Real Trajectories to Get More Trustworthy Pedestrian Simulations. Mathematics, Vol.8(9), pp. 1479, 2020. doi:10.3390/math8091479. IF: 2.258(Q1/D1). [PDF]
Doste R., Sebastian R., Gomez J.F., Soto-Iglesias D., Alcaine A., Monte L., Berruezo A., Penela D., Camara O. In-silico pace-mapping: prediction of left vs right outflow tract origin in idiopathic ventricular arrhythmias with multi-scale electrophysiological simulations. EP Europace, euaa102, 2020. doi:10.1093/europace/euaa102 . IF: 5.214 (Q2) [PDF]
Gomez-Torresa F.A., Sebastian R., Ruíz-Sauri A. Morphometry and comparative histology of sinus and atrioventricular nodes in humans and pigs and their relevance in the prevention of nodal arrhythmias. Research in Veterinary Science, Vol. 128, pp. 275-285, 2020. doi:10.1016/j.rvsc.2019.12.008. IF: 2.534 (Q1). [PDF]
Gomez-Garcia J.F., Trenor B., Sebastian R. Prediction of CRT activation sequence by personalization of biventricular models from electroanatomical maps. Springer Cham International Publishing (LNCS 12009), pp. 342-351, 2020. doi: 10.1007/978-3-030-39074-7_36. [PDF]
2019
Lopez-Perez A., Sebastian R., Izquierdo M., Ruiz R., Bishop M., Ferrero J.M. Personalized cardiac computational models: from clinical data to simulation of infarct-related ventricular tachycardia. Frontiers in Physiology, Vol. 10:580, pp. 1-26 , 2019. doi:10.3389/fphys.2019.00580. IF: 3.367(Q1) [PDF]
Garcia-Bustos V., Sebastian R., Izquierdo M., Rios-Navarro C., Bodi V., Chorro F.J., Ruiz-Sauri A. Changes in the spatial distribution of the Purkinje network after acute myocardial infarction in a swine model. PLoS ONE, Vol. E 14(2): e0212096, pp. 1-17 , 2019. doi:10.1371/journal.pone.0212096. IF: 2.740(Q2) [PDF]
Carpio-Garay E., Gomez JF., Sebastian R., Lopez-Perez A., Castellanos E., Almendral J., Ferrero JM. Trenor B. Optimization of Lead Placement in the Right Ventricle During Cardiac Resynchronization Therapy. A Simulation Study. Frontiers in Physiology, Vol. 10:74, pp. 1-17 , 2019. doi:10.3389/fphys.2019.00074. IF: 3.367(Q1) [PDF]
Doste R., Soto-Iglesias D., Bernardino G., Alcaine A., Sebastian R., Giffard-Roisin S., Sermesant M., Berruezo A., Sanchez-Quintana D., Camara O. A rule-based method to model myocardial fiber orientation in cardiac biventricular geometries with outflow tracts. International Journal for Numerical Methods in Biomedical Engineering, Vol. 35(4):e3185, pp. 1-17, 2019. doi: 10.1002/cnm.3185. IF: 2.097(Q2) [PDF]
Gil D., Aris R., Borras A., Ramirez E., Sebastian R., Vazquez M. Influence of Fiber Connectivity in Simulations of Cardiac BioMechanics. International Journal of Computer Assisted Radiology and Surgery, Vol. 14(1):, pp. 63 - 72, 2019. doi: 10.1007/s11548-018-1849-9. IF: 2.473(Q2) [PDF]
Barber F., Romero P., Langfield P., Lozano M., Garcia-Fernandez I., Duchateua J., Hocini M., Haissaguerre M., Vigmond E., Sebastian R. Estimation of a Compatible Cardiac Conduction System From Discrete Endocardial Time Samples. Proceedings Computational and Mathematical Biomedical Engineering, pp. 244-247. Sendai, Japan, 10-12 June, 2019. [PDF]
Romero P., Santos S., Sebastian R., Martinez-Gil F., Serra D., Calvillo P., Rodriguez A., Maldonado-Puig R., Marti-Bonmati L., Alberich-Bayarri A., Lozano M., Garcia-fernandez I. Reconstruction of the Aorta Geometry using Canal Surfaces. Proceedings Computational and Mathematical Biomedical Engineering, pp. 801-804. Sendai, Japan, 10-12 June, 2019. [PDF]
Doste R., Lozano M., Gomez J.F., Alcaine A., Mont L., Berruezo A., Camara O., Sebastian R. Predicting the Origin of Outflow Tract Ventricular Arrhythmias Using Machine Learning Techniques Trained with Patient-Specific Electrophysiological Simulations. Computing in Cardiology Conference, Vol. 34, Singapore, 8-11 September, 2019. [PDF]
Gómez-Torres F.A., Sebastian R., Ruíz-Sauri A. Histological and morphometric structure of the sinus and atrioventricular nodes in humans and pigs. XX Congreso de la Sociedad Española de Histología e Ingeniería Tisular, Vol. 46, Suppl. 1 Murcia, 4-6 September, 2019. [PDF]
Trovato C., Passini E., Tomek J., Sebastian R., Rodriguez B. Development and coupling of two novel human in silico ventricular and Purkinje models for investigation of pro-arrhythmia mechanisms across the Purkinje-Myocardial junction. Cardiac Physiome, Maastricht, 4-6 December, 2019. [PDF]
2018
Barber F., Lozano M., Garcia-Fernandez I., Sebastian R. Automatic Estimation of Purkinje-Myocardial Junction hot-spots from Noisy Endocardial Samples: A simulation study. International Journal for Numerical Methods in Biomedical Engineering, Vol. 34(7):e2988, pp. 1 - 17, 2018. doi:10.1002/mma.4280. IF: 2.082(Q2) [PDF]
Godoy E., Lozano M., Garcia-Fernandez I., Ferrer-Albero A., MacLeod R., Saiz J., Sebastian R. Atrial fibrosis hampers non-invasive localization of atrial ectopic foci from multi-electrode signals: A 3D simulation study. Frontiers in Physiology Vol. 9(404):, pp. 1 - 18, 2018. doi:10.3389/fphys.2018.00404. IF: 2.082(Q2) . [PDF].
Martínez-Mateu L., Romero L., Ferrer A., Sebastian R., Rodríguez JF., Jalife J., Berenfeld O., Saiz J. Factors Affecting True and Phantom Detection of Rotors by Basket Catheters in the Atria: A computational Study. PLoS Comput Biol, Vol. 14(3):e1006017, pp. 1 - 26, 2018. doi:10.1371/journal.pcbi.1006017. IF: 4.428(Q1) . [PDF].
Barber F., Lozano M., Garcia-Fernandez. I., Sebastian R. Inverse Estimation of Terminal Connections in the Cardiac Conduction System. Mathematical Methods in Applied Sciences, Vol. 41(6):, pp. 2340 - 2349, 2018. doi: 10.1002/mma.4280. IF: 1.533(Q2) [PDF].
Gil D., Aris R., Borras A., Sebastian R., Vazquez M. Influence of Fiber Connectivity in Simulations of Cardiac BioMechanics. 32th Computer Assisted Radiology and Surgery (CARS) Conference. Berlin, 20-23 June, 2018.[PDF]
Godoy E., Ferrer-Albero A., Lozano M., Garcia-Fernandez I., MacLeod R., Saiz J., Sebastian R. Effect of fibrosis on BSPM of patients with focal atrial tachycardia. Virtual Physiological Human Conference (VPH2018). Zaragoza, 5-7 September, 2018. [PDF]
Godoy E., Lozano M., Garcia-Fernandez I., Sebastian R. Combining Biophysical Modeling and Machine Learning to predict location of atrial Ectopic Triggers. Computing in Cardiology Conference, Vol 45, Maastricht, 23-26 September, 2018.doi: 10.22489/CinC.2018.069 [PDF]
Romero, P. Santos, S., Barber, F. Lozano M., Garcia-Fernandez I., Sebastian R. From Personalization of Biophysical Simulations of the Heart to Population Based Machine Learning. Transcardio 2018. Barcelona, 18-19 December, 2018.[PDF]
2017
Galli V., Sebastian R., Moutel S., Ecard J., Perez F., Roux A. Uncoupling of dynamin polymerization and GTPase activity revealed by the conformation-specific nanobody Dynab. eLIFE, 6:e25197, 2017. doi: 10.7554/eLife.25197. IF: 7.616 [PDF].
Ferrer-Albero A., Godoy E.J., Lozano M., Martinez-Mateu L., Atienza F., Saiz J., Sebastian R. Non-invasive localization of atrial ectopic beats by using simulated body surface P-wave integral maps. PLoS ONE, Vol. 12(7):e0181263, pp. 1 - 23, 2017. doi:10.1371/journal.pone.0181263. IF: 2.766 [PDF]
Garcia-Bustos V., Sebastian R., Izquierdo M., Molina P., Chorro F.J., Ruiz-Sauri A. A quantitative structural and morphometric analysis of the Purkinje network and the Purkinje-myocardial junctions in pig hearts. Journal of Anatomy, Vol. 230(5):664 - 678, 2017. doi: 10.1111/joa.12594. IF: 2.479 [PDF]
Hoogendoorn C., Sebastian R., Rodriguez J.F., Lekadir K., Frangi A.F. An Atlas and Data-Driven Approach to Initializing Reaction-Diffusion Systems in Computer Cardiac Electrophysiology. International Journal for Numerical Methods in Biomedical Engineering, Vol. 33(8):e2846, 2017. doi: 10.1002/cnm.2846. IF: 2.338 [PDF]
Doste R., Soto-Iglesias D., Sebastian R., Sanchez-Quintana D., Sermesant M., Bernardino G., Berruezo A., O. Camara. A rule-based method to Model Myocardial Fiber Orientation for Simulating Ventricular Outflow Tract Arrhythmias. Springer Cham International Publishing (LNCS 10263), pp. 344-353, 2017. [PDF]
D. Soto-Iglesias, D. Penela, X. Planes, V. Zimmer, D. Andreu, J. Acosta, G. Piella, R. Sebastian, D. Sanchez-Quintana, A. Berruezo, O. Camara. Quasi-Conformal Technique For Integrating And Validating Myocardial Tissue Characterization In MRI With Ex-Vivo Human Histological Data. Springer International Publishing (LNCS 10124), pp. 172-181, 2017. [PDF]
F. Barber, M. Lozano, I. Garcia-Fernandez, R. Sebastian. Estimation of Location and Activation Time of Purkinje Myocardial Junctions from Sparse and Noisy Endocardial Electrical Samples. Computing in Cardiology, Vol. 44, pp. 1 - 4. Rennes, France, 2017.[PDF]
Godoy E., Lozano M., Ferrer A., Saiz J., Sebastian R. Optimal Surface ECG Electrode Set For Prediction of Atrial Ectopic Foci Region. 5th International Conference on Computational and Mathematical Biomedical Engineering - CMBE2017, 10–12 April 2017, USA. Vol 1. pp. 206-209, 2017. [PDF]
Ruiz-Sauri A., Garcia-Bustos V., Izquierdo M., Molina P., Chorro FJ., Rios C., Bodí V., Sebastian R. Histologic, Morphometric and Immunohistochemistry Study of the Conduction System of the Heart in Pigs. VII Internacional Congress of Histology and Tissue Engineering. P-HP 75. Santiago de Compostela, 5-8 September, 2017.[PDF]
Godoy E., Lozano M., Ferrer A., Garcia-Fernadez I., Saiz J., Sebastian R. A Machine Learning Pipeline for detection of Atrial Ectopic Focus Location in Patients with different Densities of Left Atrial Fibrosis. Atrial Signals Conference. Valencia, 5-8 October, 2017.[PDF]
Doste R., Soto-Iglesias D., Bernardino G., Sebastian R., Sermesant M., Berruezo A., Sanchez-Quintana D., Camara O. Non-invasive virtual prediction of site of origin in outflow tract ventricular arrhythmias with a patient-specific computational model. European Society of Cardiology Conference. Barcelona, 5-8 October, 2017. Proc. European Heart Journal, Vol. 38. issue. Suppl. 1, pag. 14. https://doi.org/10.1093/eurheartj/ehx501.87 [PDF]
2016
Romero D., Camara O., Sachse F., Sebastian R. Analysis of Microstructure of the Cardiac Conduction System Based on Three-dimensional Confocal Microscopy. PLoS ONE, Vol. 11(10):e0164093, pp. 1 - 19, 2016. IF: 2.806 [PDF]
F. Barber, M. Lozano, I. Garcia-Fernandez, R. Sebastian. Inverse estimation of terminal connections in the cardiac conduction system. Proceedings of the 16th International Conference on Computational and Mathematical Methods in Science and Engineering, (CMMSE), Cadiz, Spain. 2016.
A. Ferrer, R. Sebastian, E.J. Godoy, J. Saiz. Analysis of in-silico Body Surface Maps show important differences depending on the connections between Coronary sinus and Left atria. Computing in Cardiology, Vol. 43, pp. 745-748. Vancouver, Canada, 2016.[PDF]
F. Barber, M. Lozano, I. Garcia-Fernandez, R. Sebastian. Automatic location of sources of electrical activation from electrophysiology maps. Computing in Cardiology, Vol. 43, pp. 445-448. Vancouver, Canada, 2016.[PDF]
2015
Ferrer A., Sebastian R., Sanchez-Quintana D., Rodriguez J.F., Godoy E.J., Martinez, L., Saiz J. Detailed anatomical and electrophysiological models of human atria and torso for the simulation of atrial activation. PLOS One, Vol. 10(11):e0141573, pp. 1 - 29, 2015. IF: 3.06 [PDF]
Calvo D., Atienza F., Saiz J.,Martinez L., Avila P., Rubin J., Herreros B., Arenal A., Garcia-Fernandez J., Ferrer A., Sebastian R., Martínez-Camblor P., Jalife J., Berenfeld O. Ventricular Tachycardia and Early Fibrillation in Brugada Syndrome and Ischemic Cardiomyopathy Patients Show Predictable Frequency-Phase Properties on the Precordial ECG Consistent with the Respective Arrhythmogenic Substrate. Circulation: Arrhythmia and Electrophysiology . Vol. 8(5), pp. 1133-1143, 2015. IF: 5.42 [PDF]
Lopez-Perez A., Sebastian R., Ferrero JM. Three-dimensional cardiac computational modelling: methods, features and applications. Review Biomedical Engineering Online. Vol. 14(35), pp. 1 - 31, 2015. IF: 1.75 [PDF]
Cardenes R., Sebastian R., Soto-Iglesias D., Berruezo A., Camara O. Estimation of Purkinje Trees from Electro-Anatomical Mapping of the Left Ventricle Using Minimal Cost Geodesics Medical Image Analysis. Vol. 4(1), pp. 52 - 62, 2015. IF: 4.565 [PDF]
M. Guardiola, A. Pashaei, R. Sebastian, A. López, J. Acosta, D. Andreu, A. Berruezo, O. Camara. Computational electrophysiology for prediction of the outflow tract origin in idiopathic ventricular tachycardia. Cardiac Physiome, Auckland, New Zealand, 2015.
K. Cardona, J.F. Gomez, O. Camara, B. Trenor, R. Sebastian. In-silico Analysis of Influence of Fibroblasts in the Generation of Late-Potentials in Conducting Channels. Cardiac Physiome, Auckland, New Zealand, 2015.
2014
R. Cardenes, R. Sebastian, D. Soto-Iglesias, D. Andreu, J. Fernández-Armenta, B. Bijnens, A. Berruezo, O. Camara Estimation of Electrical Pathways Finding Minimal Cost Paths from Electro-Anatomical Mapping of the Left Ventricle. Springer-verlag Berlin Heidelberg (LNCS 8330), pp. 220-227, 2014. [PDF]
A. Lopez-Perez, R. Sebastian, J.M. Ferrero, D. Andreu, A. Berruezo. Methods for image-based three-dimensional reconstruction of infarct-derived scars to locate conducting channels as radiofrequency ablation targets. European Society of Cardiology Congress (ESC), Barcelona, Spain, 2014.
A. Pashaei, R. Sebastian, A. Lopez-Perez, D. Soto-Iglesias, J. M. Ferrero, D. Andreu, J. Acosta, J. Fernández-Armenta, A. Berruezo, O. Camara. Determining the origin of the ectopic beat in idiopathic ventricular arrhythmias with a computational model. European Society of Cardiology Congress (ESC), Barcelona, Spain, 2014.
R. Cardenes, R. Sebastian, A. Berruezo, O. Camara. Inverse estimation of ventricular Purkinje tree pathways from sequences of depolarization. Computing in Cardiology, Boston, USA. IEEE Pulbications Vol. 41, pp. 677-680 2014.
2013
Tobon-Gomez C., Duchateau N., Sebastian R., Marchesseau S., Donal E., De Craene M., Pashaei A., Relan J., Steghofer M., Lamata P., Camara O., Delingette H., Duckett S., Garreau M., Hernandez A., Rhode K.S., Sermesant M., Ayache N., Leclercq C., Razavi R., Smith N., Frangi A.F. Understanding the mechanisms amenable to CRT response: from pre-operative multimodal image data to patient-specific computational models. Medical and Biological Engineering and Computing. Vol. 51, pp. 1235-1250, 2013 . IF: 1.878 [PDF]
Sebastian R., Zimmerman V., Romero D., Sanchez-Quintana D., Frangi A.F. Characterization and Modeling of the Peripheral Cardiac Conduction System. IEEE Transactions on Medical Imaging. Vol. 32(1), pp. 45 - 55, 2013. IF: 3.643 [PDF]
A. Ferrer, R. Sebastian, J.F. Rodriguez, C. Tobon, M. Guillem, EJ. Godoy, J. Saiz. Computational Simulation and Analysis of 3D Body Surface Potential Patterns Generated by Common Atrial Arrhythmias. Computing in Cardiology, Zaragoza, Spain. IEEE Publications Vol. 40 pp. 919-922. 2013.
L. Dux-Santoy, R. Sebastian, J.F. Rodriguez, JM Ferrero. Modeling the Different Sections of the Cardiac Conduction System to Obtain Realistic Electrocardiograms. 35th Conference of IEEE Engineering in Medicine and Biology (EMBC), Osaka, Japan. June 2013.
A. Pashaei, H. Fernandez, R. Sebastian, A.F. Frangi. A computer framework for visualization of cardiac acceleration based on medical images . SPIE Medical Imaging, Florida, USA. February 2013.
2012
A. Ferrer, R. Sebastian, J.F. Rodriguez, C. Tobon, J. Saiz. Modeling of Human Torso for the Study and Characterization of Atrial Arrhythmias. Cardiac Physiome, San Diego, USA. December 2012.
L Dux-Santoy, JF Rodríguez, R. Sebastian, J. Saiz, JM Ferrero,. Biophysical modelling of Bundle Branch Reentry initiation and maintenance. Computing in Cardiology, IEEE Publications, Vol. 39, pp. 222-224, Krakovia, 2012.
2011
Sebastian R., Zimmerman V., Romero D., Frangi A.F.. Construction of a Computational Anatomical Model of the Peripheral Cardiac Conduction System. IEEE Transactions on Biomedical Engineering. Vol. 58(12), pp. 3479-82, 2011. IF: 2.278 [PDF]
Dux-Santoy L., Sebastian R., Felix-Rodriguez J., Ferrero J.M., Saiz J. Interaction of specialized cardiac conduction system with antiarrhythmic drugs: a simulation study. IEEE Transactions on Biomedical Engineering. Vol. 58(12), pp. 3475-78, 2011. IF: 2.278 [PDF]
Pashaei A., Romero D., Sebastian R., Camara O., Frangi, AF. Fast Multiscale Modeling of Cardiac Electrophysiology Including Purkinje System. IEEE Transactions on Biomedical Engineering. Vol. 58(10), pp. 2956-2960 2011. IF: 2.278 [PDF]
Bradley C., Bowery A., Britten R., Budelmann V., Camara O., Christie R., Cookson A., Frangi A., Gamage T.B., Heidlauf T., Krittian S., Ladd D., Little D., Mithraratne K., Nash M., Nickerson D., Nielsen P., Nordbo Y., Omholt S., Pashaei A., Paterson D., Rajagopal V., Reeve A., Röhrle O., Safaei S., Sebastian R., Steghöfer M., Wu T., Yu T., Zhang H., Hunter P. OpenCMISS: A multi-physics and multi-scale computational infrastructure for the VPH/Physiome project. Progress in Biophysics and Molecular Biology. Vol. 107(1), pp. 32-47, 2011. IF: 3.964 [PDF]
Camara O., Sermesant M., Lamata P., Wang L., Pop M., Relan J., De Craene M., Delingette H., Liu H., Niederer S., Pashaei A., Plank G., Romero D., Sebastian R., Wong K.C.L., Zhang H., Ayache N., Frangi A.F., Shif P., Smith N., Wright G.A. Inter-Model Consistency and Complementarity: Learning from ex-vivo Imaging and Electrophysiological Data towards an Integrated Understanding of Cardiac Physiology. Progress in Biophysics and Molecular Biology. Vol. 107(1), pp. 122-133, 2011. IF: 3.964 [PDF]
A. Pashaei, C. Hoogendoorn, D. Romero, R. Sebastian, O. Camara and A.F. Frangi. Effect of scar development on fast electrophysiologial models of the human heart: In-silico study on atlas-based virtual populations. Springer-verlag Berlin Heidelberg (LNCS 6666), pp. 427-436, 2011. [PDF]
C. Hoogendoorn, A. Pashaei, R. Sebastian, F. Sukno, O. Camara and A.F. Frangi.Sensitivity analysis of mesh warping and subsampling strategies for generating large scale electrophysiological simulation data. Springer-verlag Berlin Heidelberg (LNCS 6666), pp. 418-426, 2011. [PDF]
D. Romero, F. B. Sachse, R. Sebastian and A.F. Frangi. Towards high resolution computational models of the cardiac conduction system: a pipeline for characterization of Purkinje-ventricular-junctions., Springer-verlag Berlin Heidelberg (LNCS 6666), pp. 28-35, 2011. [PDF]
2010
Letinic K, Sebastian R, Barthel, A., Toomre D. Deciphering Sub-Cellular Processes in Live Imaging Data Sets via Dynamic Probabilistic Networks. Bioinformatics. Vol. 26(16), pp. 2029-2036, 2010. IF: 4.877 [PDF]
Romero D., Sebastian, R., Bijnens, B., Zimmerman, V., Boyle, PM., Vigmond, EJ., Frangi, AF. Effects of the Purkinje system and cardiac geometry on biventricular pacing: a model study. Annals of Biomedical Engineering. Vol 39(4), pp.1388-1398, 2010. IF: 2.374 [PDF]
MD Craene, F Sukno, C Tobon-Gomez, C Butakoff, RM. Figueras i Ventura, C Hoogendoorn, G Piella, N Duchateau, E Muñoz-Moreno, R Sebastian. Atlas Construction and Image Analysis Using Statistical Cardiac Models. STACOM/CESC Springer-verlag Berlin Heidelberg (LNCS 6364), pp.1-13, 2010. [PDF]
O Camara, A Pashaei, R Sebastian, AF. Frangi. Personalization of Fast Conduction Purkinje System in Eikonal-Based Electrophysiological Models with Optical Mapping Data. STACOM/CESC Springer-verlag Berlin Heidelberg (LNCS 6364), pp.281-290, 2010. [PDF]
C Hoogendoorn, A Pashaei, R Sebastian, F Sukno, O Camara, AF. Frangi. Influence of Geometric Variations on LV Activation Times: A Study on an Atlas-Based Virtual Population. STACOM/CESC Springer-verlag Berlin Heidelberg (LNCS 6364), pp.242-251, 2010. [PDF]
R Sebastian, E Heidenreich, L Dux-Santoy, JF. Rodriguez, JM Ferrero, J Saiz. Modeling Drug Effects on Personalized 3D Models of the Heart: A Simulation Study. STACOM/CESC Springer-Verlag (LNCS 6364), pp.222-231, 2010. [PDF]
L Dux-Santoy, R. Sebastian, E. Heidenreich, JF Rodríguez, JM Ferrero, J. Saiz. Estudio de simulación del efecto del dofetilide en un modelo 3D del corazón humano. CASEIB, Madrid, Spain November, 2010.
D Romero, V Zimmerman, R Sebastian and AF Frangi. Flexible Modeling for Anatomically-Based Cardiac Conduction System. IEEE Annual International Conference on Engineering in Medicine and Biology Conference (EMBS), Buenos Aires, Argentina 2010.
A Pashaei, D Romero, R Sebastian, O Camara, AF. Frangi. Comparison of phenomenological and biophysical cardiac models coupled with heterogenous structures for prediction of electrical activation sequence. Computing in Cardiology, Belfast. IEEE Publications, Vol. 37, pp. 871-874, 2010.
2009
Letinic K, Sebastian R, Toomre D, Rakic P. Exocyst is involved in polarized cell migration and cerebral cortical development. Proc Natl Acad Sci U S A. Vol. 106(27), pp. 11342-11347. 2009. IF: 9.432 . [PDF]
R. Sebastian, V. Zimmerman, F. Sukno, B.H. Bijnens, A.F. Frangi. Cardiac Modelling for Pathophysiology Research and Clinical Applications. The Need for an Automated Pipeline. World Congress on Medical Physics and Biomedical Engineering. IFMBE Proceedings, 25(4):2207-2210, Springer-verlag Berlin Heidelberg. ISBN: 978-3-642-03881-5. Germany, 2009. [PDF]
D. Romero, R. Sebastian, B. H. Bijnens, V. Zimmerman,P. M. Boyle, E. J.Vigmond, A.F. Frangi, The Purkinje System and Cardiac Geometry: Assessing their Influence on the Paced Heart. Lecture Notes in Computer Science. Springer-verlag Berlin Heidelberg (LNCS 5528), Nice, France, 2009.
I. Larrabide, P. Omedas, Y. Martelli, X. Planes, M. Nieber, J.A. Moya, C. Butakof, R. Sebastian, O. Camara, M. DeCraene, B.H. Bijnens, A.F. Frangi. GIMIAS: An open source framework for efficient development of research tools and clinical prototypes. Lecture Notes in Computer Science. Springer-verlag Berlin Heidelberg (LNCS 5528). Nice, France, 2009.
O. Camara, S.Oeltze, M. DeCraene, R. Sebastian, E. Silva, D. Tamborero, L. Mont, M. Sitges, B.H. Bijnens, A. F. Frangi. Cardiac motion estimation from intracardiac electrical mapping data: identifying a septal flash in heart failure. Lecture Notes in Computer Science. Springer-verlag Bberlin Heidelberg (LNCS 5528), pp.21-29. Nice, France, 2009.
O. Camara, B. H. Bijnens, E. Silva, D. Andreu, S. Oeltze, D. Romero, M. De Craene, D. Tamborero, R. Sebastian, L. Mont, M. Sitges A. F. Frangi. Dyssynchrony indices from an electrophysiological contact mapping system predict response to CRT. MICCAI, London, UK 2009. [PDF]
A Pashaei, R Sebastian, V Zimmerman, BB Bijnens, AF Frangi. A Mesh-less Approach for Fast Estimation of Electrical Activation Time in Ventricular Wall. Computers in cardiology, Utah, USA, 2009. [PDF]
V. Zimmerman, R Sebastian, BH Bijnens, AF Frangi. Modeling the Purkinje conduction system with a non deterministic rule based iterative method. Computers in cardiology, Utah, USA, 2009.
R. Sebastian. The Role of the myocardial Fiber Orientation in Homogenizing Transmural electrical Activation. European Society of Cardiology Congress (ESC), Barcelona, Spain, 2009.
O. Camara, B. H. Bijnens, E. Silva, D. Andreu, S. Oeltze, D. Romero, M. De Craene, D. Tamborero, R. Sebastian, L. Mont, M. Sitges, AF. Frangi. Detecting abnormal septal motion by combining spatial and electrical information from endocardial mapping. European Society of Cardiology Congress (ESC), Barcelona, Spain, 2009.
2008
Diaz, E., Sebastian, R. Ayala, G. Díaz, M.E,.Zoncu, R., Toomre, D., Gasman, S. Measuring spatial temporal interaction in bivariate temporal random sets with applications to cell biology. IEEE Trans Pattern Anal Mach Intell. Vol. 30(9), pp. 1659-1671 . 2008. IF:5.960. [PDF]
D.Romero, R.Sebastian, G. Plank, E.J. Vigmond , A.F. Frangi. Modeling the influence of the VV delay for CRT on the electrical activation patterns in absence of conduction through the AV node. SPIE Medical Imaging. Progress in biomedical optics and imaging. ISBN: 9780819470409 California, USA, February 2008.
R.Sebastian, S.Ordas, E.J. Vigmond, G. Plank, B. Rodriguez, A.F. Frangi. Assessing Influence of Conductivity in Heart Modelling with the aim of Studying Cardiovascular Diseases. SPIE Medical Imaging. Progress in biomedical optics and imaging. ISBN: 9780819470409, California, USA, February 2008.
R. Sebastian, D. Romero, V. Zimmerman, E. Vigmond, B.H. Bijnens, A.F. Frangi. Detailed cardiac electromechanical modeling and simulation. From medical images to simulation. Euroecho, 12th Annual Meeting of the European Society of Cardiology. Lyon, France, December, 2008.
Bijnens B. , Sebastian R., Romero D., and Frangi A.F, Anatomo-functional model suitable for Cardiac Resynchronization therapy. 4th European Congress for Medical and Biomedical Engineering, Antwerp, November 23-27, 2008.
B. Bijnens, C. Parsai, R. Sebastian, L. Anderson, A. Frangi, G.R. Sutherland. An integrated, model based, approach for the quantification of cardiac function based on cardiac imaging and knowledge of cardiac physiology and applied to cardiac resynchronisation therapy. Workshop on Multi-scale Modelling of the Heart. MSMH. Auckland, New Zealand, March 2008.
R. Sebastian, S.Ordas, G.Plank, B. Rodriguez, E. J.Vigmond, A.F. Frangi. Sensitivity study in a 3D human ventricular FEM cardiac model for electrical simulation. Workshop on Multi-scale Modelling of the Heart. MSMH. Auckland, New Zealand, March 2008.
2007
Zoncu, R. Perera, R.M., Sebastian, R., Chen, H. Ayala, G., Toomre, D., De Camilli, P. Acute depletion of phosphotidylinositol 4,5 biphosphate results in loss of endocytic clathrin coated pits. Proc Natl Acad Sci U S A. , Vol. 104(10), pp. 3793-3798. 2007. IF: 9.598. [PDF]
Díaz, M.E., Ayala, G., Sebastian, R., Martinez-costa, L. Granulometric Analysis of Corneal Endothelium specular images by using a germ-grain model. Comput Biol Med. Vol. 37(3), pp. 364-375, 2007. IF: 1.170. [PDF]
S. Ordas, E, Oubel , R. Sebastian, Frangi, AF. Computational Atlas of the Heart. I5th International Symposium on Image and Signal Processing and Analysis. Istambul, Turkey. 2007
R T. Leon, R. Sebastian, G. Ayala, E. Diaz and R. Zoncu. Fuzzy temporal random sets with an application to cell biology. IEEE International Conference on Fuzzy Systems, FUZZ-IEEE. ISBN: 1-4244-1210-2. Londres.(UK), July, 2007.
R. Sebastian, G. Ayala, M.E. Diaz, R. Zoncu, D. Toomre. Estimating the duration of endocytic events. IEEE International Symposium on Biomedical Imaging: From Nano to Macro (ISBI). Washington D.C. April, 12, 2007. [PDF]
2006
Sebastian, R. Image Sequence Analysis Based on Spatial Temporal Stochastic Models with Application to Cell Biology. PhD thesis. Universitat de Valencia, December 2006. Advisors: Diaz, M.E. and Ayala, G. [PDF]
Sebastian, R., Díaz, E., Ayala, G., M.E. Diaz, Zoncu, R., Toomre, D. Studying Endocytosis in Space and Time by means of Temporal Boolean Models. Pattern Recognition. 39(11):2175-2185, 2006. IF: 1.822. [PDF]
Ayala, G., Sebastian, R., Díaz, M.E., Diaz, E., Zoncu, R., Toomre, D. Analysis of Spatially and Temporally Overlapping Events with Application to Image Sequences. IEEE Trans Pattern Anal Mach Intell. Vol. 28(10), pp. 1707-1712, 2006. IF: 4.306. [PDF]
Sebastian, R., Díaz, M.E., Ayala, G., Letinic, K., Moncho-Bogani, J, Toomre, D. Spatio-temporal Analysis of Constitutive Exocytosis in Epithelial Cells. IEEE/ACM Trans Comput Biol Bioinform. Vol. 3(1), pp. 17-32. 2006. IF: 2.283. [PDF]
R. Zoncu, R. Perera, A. Raimondi, R. Sebastian, E. Diaz, D. K. Toomre, P. de Camilli. Functional Characterization of Stable Clathrin Patches at the Cell Surface. Proceedings of 46th Annual meeting of the American Society for Cell Biology (ASBC). San Diego, USA, 9 December, 2006.
R. Sebastian, M.E. Diaz, G. Ayala, R. Zoncu, D. Toomre. Analysis of spatial dependencies of endocytic proteins by using temporal random closed sets. Conf Proc IEEE Eng Med Biol Soc (EMBS), Vol. 1, pp. 4175-4178. New York, USA, 2006.
2005
K. Letinic, R. Sebastian, G. Ayala, R. Perera, M.E. Díaz, D. Toomre. Anaylsis of Spatial-Temporal Coordination of Exocytosis in Migrating Astrocytes. The 58th Annual Meeting of the Japan Society for Cell Biology (JSCB). Saitama (Japan), 15-17 June, 2005.
R. Zoncu, R. Sebastian, R. Perera, M.E. Díaz, P. de Camilli, D. Toomre. Rapid dynamics of dynamin and its interactors at endocytic hotspots. The 58th Annual Meeting of the Japan Society for Cell Biology (JSCB). Saitama (Japan), 15-17 June, 2005.
2004
Zoncu, R. Sebastian, R., Díaz, M.E., de Camilli, P., Toomre, D. Spatial and temporal relationships between ligand-receptor complex formation and clathrin-mediated receptor internalization. 44th Annual meeting of the American Society for Biology. Procedings of 44th Annual meeting of the American Society for Cell Biology (ASBC). Washington, DC (USA), 2004.
