Fitxa persona

M.MERCEDES COSTELL ROSSELLO
PDI-Catedratic/a d'Universitat

mercedes.costell@uv.es
http://www.uv.es/mcostell

Knowledge area: BIOCHEMISTRY AND MOLECULAR BIOLOGY
Department: Biochemistry and Molecular Biology

(9635) 43465

Subjects taught and teaching methods

33149 - Immunology and immunopathology - Degree in Biochemistry and Biomedical Sciences	Laboratory, Theory, Tutoring
33200 - Degree final project in biotechnology - Degree in Biotechnology	Work end of studies
43469 - New issues in the regulation of gene expression - Master's Degree in Research in Molecular and Cellular Biology and Genetics	Others, Theory

Tutorials

First semester

Tuesday de 10:00 a 13:00. 1143 FACULTAD BIOLOGÍA. EDIFICIO A

Observations

You participate in the electronic tutoring program of the Universitat de València

Journal Publications

Bettina Schulze; Takako Sasaki; Mercedes Costell; Karl Mann; Rupert Timpl. 1996 Structural and cell-adhesive properties of three recombinant fragments derived from perlecan domain III Matrix BiologyVolume 15. Number 5.
Mercedes Costell; Takako Sasaki; Karlheinz Mann; Yoshihiko Yamada; Rupert Timpl. 1996 Structural characterization of recombinant domain II of the basement membrane proteoglycan perlecan Febs LettersVolume 396. Number 2-3.
Mercedes Costell; Karlheinz Mann; Yoshihiko Yamada; Rupert Timpl. 1997 Characterization of recombinant perlecan domain I and its substitution by glycosaminoglycans and oligosaccharides European Journal of BiochemistryVolume 243. Number 1-2.
Takako Sasaki; Mercedes Costell; Karlheinz Mann; Rupert Timpl. 1998 Inhibition of glycosaminoglycan modification of perlecan domain I by site-directed mutagenesis changes protease sensitivity and laminin-1 binding activity Febs LettersVolume 435. Number 2-3.
Mercedes Costell; Erika Gustafsson; Attila Aszodi; Matthias Mörgelin; Wilhelm Bloch; Ernst Hunziker; Klaus Addicks; Rupert Timpl; Reinhard Fässler. 1999 Perlecan maintains the integrity of cartilage and some basement membranes Journal of Cell BiologyVolume 147.
Alfonso Fairen; José Morante-Oria; Elena Bellmunt; Amparo Giros; Mercedes Costell. 2000 Altered corticogenesis in perlecan deficient mice European Journal of NeuroscienceVolume 12.
Michael D. Henry; Cord Brakebusch; Jakob S. Satz; Mercedes Costell; Erika Gustafsson; Reinhard Fässler; Kevin P. Campbell. 2001 Distinc roles for dystroglycan, beta-1 integrin and perlecan in actin-dependent cell surface laminin organization Journal of Cell ScienceVolume 114.
Mercedes Costell; Rita Carmona; Erika Gustafsson; Mauricio González-Iriarte; Reinhard Fässler; Ramón Muñoz-Chápuli. 2002 Hyperplastic conotruncal endocardial cushions and transposition of great arteries in perlecan-null mice Circulation ResearchVolume 91.
Javier Sáez-Valero; Mercedes Costell; Magnus Sjögren; Niels Andreasen; Kaj Blennow; Juan M. Luque. 2003 Altered levels of cerebrospinal fluid reelin in frontotemporal dementia and Alzheimer disease Journal of Neuroscience ResearchVolume 72.
Manuel Gonzalez-Iriarte; Rita Carmona; José M. Perez-Pomares; Daniel Macias; Mercedes Costell; Ramón Muñoz-Chápuli. 2003 Development of the coronary arteries in a murine model of transposition of great arteries Journal of Molecular and Cellular CardiologyVolume 35.
Garl PJ, Wenzlau JM, Walker HA, Whitelock JM, Costell M, Weiser-Evans MCM. 2004 Perlecan-induced suppression of smooth muscle cell proliferation is mediated through increased activity of the tumor suppressor PTEN Circulation ResearchVolume 94.
Amparo Girós, Javier Morante, Cristina Gil-Sanz, Alfonso Fairén, Mercedes Costell. 2007 Perlecan controls neurogenesis in the developing telencephalon Bmc Developmental BiologyVolume 7. Number 1.
Philipp Sasse; Daniela Malan; Michaela Fleischmann; Wilhelm Roell; Erika Gustafsson; Toktam Bostani; Yun Fan; Thomas Kolbe; Martin Breitbach; Klaus Addicks; Armin Welz; Gottfried Brem; Jurgen Hescheler; Attila Aszodi; Mercedes Costell; Wilhelm Bloch; Bernd K. Fleischmann. 2008 Perlecan is critical for heart stability Cardiovascular researchVolume 80. Number 3.
Michael Leiss; Karsten Beckmann; Amparo Girós; Mercedes Costell; Reinhard Fässler. 2008 The role of integrin binding sites in fibronectin matrix assembly in vivo Current Opinion in Cell BiologyVolume 20. Number 5.
Ralf T. Böttcher; Sebastian Wiesner; Attila Braun; Reiner Wimmer; Alejandro Berna; Nadav Elad; Ohad Medalia; Alexander Pfeifer A; Attila Aszodi; Mercedes Costell; Reinhard Fässler. 2009 Profilin 1 is required for abscission during late cytokinesis of chondrocytes Embo JournalVolume 28. Number 8.
Ralf T. Böttcher; Mercedes Costell. 2011 Vital functions of profilin1 for late cytokinesis in differentiated mammalian cells Cell NewsVolume 1.
Amparo Girós; Katja Grgur; Achim Gossler; Mercedes Costell. 2011 α5β1 Integrin-mediated adhesion to fibronectin is required for axis elongation and somitogenesis in mice Plos OneVolume 6. Number 7.
Denise Stenzel; Andrea Lundkvist; Dominique Sauvaget; Marta Busse; Mariona Graupera; Arjan ven der Flier; Errol Wijelath; Jacqueline Murray; Michael Sobel; Mercedes Costell; Seiichiro Takahashi; Reinhard Fässler; Yu Yamaguchi; David Gutmann; Richard Hynes; Holger Gerhardt. 2011 Integrin-dependent and independent functions of astrocytic fibronectin in retinal angiogenesis DevelopmentVolume 138.
Jan Kullmann; A. Neumeyer; Ines Wickertsheim; Ralf T. Böttcher; Mercedes Costell; J. W. Deitmer; W. Witke; Eckhard Friauf; Marco B. Rust. 2012 Purkinje cell loss and motor coordination defects in profilin1 mutant mice NeuroscienceVolume 223.
Daisuke Miyajima; Tadayoshi Hayata; Takafumi Suzuki; Hiroaki Hemmi; Tetsuya Nakamoto; Takuya Notomi; Teruo Amagasa; Ralf T. Böttcher ; Mercedes Costell; Reinhard Fässler ; Yoichi Ezura; Masaki Noda. 2012 Profilin1 Regulates Sternum Development and Endochondral Bone Formation Journal of Biological ChemistryVolume 287. Number 40.
Gustafsson E; Almonte-Becerril M; Bloch W; Costell M. 2013 Perlecan Maintains microvessel integrity in vivo and modulates their formation in vitro Plos OneVolume 8. Number 1.
Junke Zheng; Zhigang Lu; Fatih Kocabas; Ralph T Böttcher; Mercedes Costell; Xunlei Kang; Xiaoye Liu; Ralph J. DeBerardinis; Qianming Wang; Guoqiang Chen; Hesham Sadek; Cheng Cheng Zhang. 2014 Profilin 1 is essential for retention and metabolism of mouse hematopoietic stem cells in bone marrow BloodVolume 123. Number 7.
Laura Montani; Tina Buerki-Thurnherr; Joana Paes de Faria; Jorge A. Pereira; Nuno G. Dias; Rui Fernandes; Ana F. Gonçalves; Attila Braun; Yves Benninger; Ralph T. Böttcher; Mercedes Costell; Klaus-Armin Nave; Robin J. M. Franklin; Dies Meijer; Ueli Suter; João B. Relvas. 2014 Profilin 1 is required for peripheral nervous system myelination DevelopmentVolume 141.
Maylin Almonte-Becerril; Maria M. Costell; Juan B. Kouri. 2014 Changes in the Integrins Expression are related with the Osteoarthritis Severity in an Experimental Animal Model in Rats Journal of Orthopaedic ResearchVolume 32. Number 9.
Klinberg F; Chow ML; Koehler A; Boo S; Buscemi L; Quinn TM; Costell M; Alman BA; Genot E; Hinz B. 2014 Prestress in the extracellular matrix sensitizes latent TGF-b1 for activation Journal of Cell BiologyVolume 207. Number 2.
Jan Kullmann; Ines Wickertsheim; Lara Minnerup; Mercedes Costell; Eckhard Friauf; Marco Rust. 2015 Profilin1 activity in cerebelar granule neurons is required for radial migration in vivo Cell Adhesion and MigrationVolume 9. Number 3.
María Benito-Jardón; Sarah Klapproth; Irene Gimeno-LLuch; Tobias Petzold; Mitasha Bharadwaj; Daniel J. Müller; Gabriele Zuchtriegel; Christoph Andreas Reichel; Mercedes Costell. 2017 The Fibronectin synergy site re-enforces cell adhesion and mediates a crosstalk between integrin classes ElifeNumber 6.
Vladimíra Moulisova ; Cristina Gonzalez-García; Marco Cantini; Aleixandre Rodrigo-Navarro; Jessica Weaver; Mercedes Costell; Roser Sabater i Serra; Matthew J. Dalby; Andr es J. García; Manuel Salmer on-S anchez. 2017 Engineered microenvironments for synergistic VEGF e Integrin signalling during vascularization BiomaterialsVolume 126.
Wanting Lin; Yayoi Izu; Arayal Smriti; Makiri Kawasaki; Chantida Pawaputanon; Ralph Bottcher; Mercedes Costell; Keiji Moriyama; Masaki Noda; Yoichi Ezura. 2017 Profilin1 is expressed in osteocytes and regulates cell shape and migration Journal of Cellular PhysiologyVolume 9999.
Nico Strohmeyer; Mitasha Bharadwaj; Mercedes Costell; Reinhard Fässler; Daniel J. Müller. 2017 Fibronectin-bound α5β1 integrins sense load and signal to reinforce adhesion in less than a second Nature MaterialsVolume 16.
Almonte-Becerril M; Gimeno-LLuch I; Villarroya O; Benito-Jardón M; Kouri J B; Costell M. 2018 Genetic abrogation of the fibronectin-α5β1 integrin interaction in articular cartilage aggravates osteoarthritis in mice Plos OneVolume 13. Number 6.
Sun Z; Costell M; Fässler R. 2019 Integrin activation by talin, kindlin and mechanical forces Nature Cell BiologyVolume 21.
Rico P; Rodrigo-Navarro A; de la Peña M; Moulisová V; Costell M; Salmerón-Sánchez M. 2018 Simultaneous boron ion-channel/growth factor receptor activation for enhanced vascularization Advanced BiosystemsVolume 1800220.
Shirakawa J; Kajikawa S; Böttcher R; Costell M; Izu Y; Hayata T; Noda M; Ezura Y. 2019 Profilin 1 negatively regulates osteoclast migration in postnatal skeletal growth, remodeling, and homeostasis in mice JBMR PlusVolume 3. Number 6.
Pinto-Costa R; Sousa SC; Leite SC; Nogueira-Rodrigues J; Ferreira da Silva T; Machado D; Marques J; Costa AC; Liz MA; Bartolini F; Brites P; Costell M; Faessler R; Sousa M. 2020 Profilin1 delivery tunes cytoskeleton dynamics towards CNS axon regeneration Journal of Clinical InvestigationVolume 130. Number 4.
Altstätter J; Hess MW; Costell M; Montanez E. 2020 a-parvin is required for epidermal morphogenesis, hair follicle development and basal keratinocyte polarity Plos OneVolume 15. Number 3.
Mpoyi EN; Cantini M; Yan Sin Y; Fleming L; Zhou DW; Costell M; Lu Y; Kadler K; García AJ; Agtmael TV; Salmeron-Sanchez M. 2020 Material-driven fibronectin assembly rescues matrix defects due to mutations in collagen IV in fibroblasts BiomaterialsVolume 252.
Benito Jardón, Maria; Nico Strohmeyer; Sheila Ortega-Sanchís; Mitasha Bharadwaj; Markus Moser; Daniel J. Müller; Reinhard Fässler; Mercedes Costell. 2020 αv-Class integrin binding to fibronectin is solely mediated by RGD and unaffected by an RGE mutation Journal of Cell BiologyVolume 219. Number 12.

Projects