Fitxa persona

JUAN NACHER ROSELLO
PDI-Catedratic/a d'Universitat

juan.nacher@uv.es
http://www.uv.es/nacher
http://nacher.blogs.uv.es

Knowledge area: CELLULAR BIOLOGY
Department: Cellular Biology, Functional Biology and Physical Anthropol.

(9635) 43241

Subjects taught and teaching methods

33067 - Neurobiology - Degree in Biology	Theory
33159 - Degree final project in biochemistry and biomedical sciences - Degree in Biochemistry and Biomedical Sciences	Work end of studies
33824 - Degree Final Project in Biologia - Degree in Biology	Work end of studies
36350 - Molecular Neurobiology and Neuropathology - Degree in Biochemistry and Biomedical Sciences	Theory
40142 - Cellular and molecular neurobiology - Master’s Degree in Basic and Applied Neurosciences	Theory
40145 - Experimental neurobiology - Master’s Degree in Basic and Applied Neurosciences	Theory
40148 - Master's final project - Master’s Degree in Basic and Applied Neurosciences	Work end of studies

Tutorials

Anual

Tuesday de 10:00 a 11:30. DESPATX 2.12.P4.018. EDIFICI B, 4º PIS, BIOLOGIQUES, PREVIA CONFIRMACIÓ CORREU ELECTRÒNIC

Anual

Thursday de 10:00 a 11:30. DESPATX 2.12.P4.018. EDIFICI B, 4º PIS, BIOLOGIQUES, PREVIA CONFIRMACIÓ CORREU ELECTRÒNIC

Observations

You participate in the electronic tutoring program of the Universitat de València

Journal Publications

Gilabert-Juan J, Varea E, Guirado R, Blasco-Ibáñez JM, Crespo C, Nácher J. (2012) Alterations in the expression of PSA-NCAM and synaptic proteins in the dorsolateral prefrontal cortex of psychiatric disorder patients. Neuroscience Letters. ISSN: 0304-3940
Martí-Mengual U, Varea E, Crespo C, Blasco-Ibáñez JM, Nacher J. (2013) Cells expressing markers of immature neurons in the amygdala of adult humans. European Journal of Neuroscience, 37(1), pp. 10 - 22 . ISSN: 0953-816X
van der Kooij MA; Fantin M; Kraev I; Korshunova I; Grosse J; Zanoletti O; Guirado R; Garcia-Mompó C; Nacher J; Stewart MG; Berezin V; Sandi C. (2014) Impaired hippocampal neuroligin-2 function by chronic stress or synthetic peptide treatment is linked to social deficits and increased aggression. Neuropsychopharmacology, 39(5), pp. 1148 - 1158 . ISSN: 0893-133X
Guirado R; Perez-Rando M; Sanchez-Matarredona D; Castillo-Gómez E; Liberia T; Rovira-Esteban L; Varea E; Crespo C; Blasco-Ibáñez JM; Nacher J. (2014) The Dendritic Spines of Interneurons Are Dynamic Structures Influenced by PSA-NCAM Expression. Cerebral Cortex, 24, pp. 3014 - 3024 . ISSN: 1047-3211
Nacher J; Bonfanti L. (2015) New neurons from old beliefs in the adult piriform cortex? A Commentary on: 'Occurrence of new neurons in the piriform cortex'. Frontiers In Neuroanatomy. ISSN: 1662-5129
Yasmina Curto; Clara Garcia-Mompo; Clara Bueno-Fernandez; Juan Nacher (2015) Chronic benzodiazepine treatment decreases spine density in cortical pyramidal neurons. Neuroscience Letters. ISSN: 0304-3940
Javier Gilabert-Juan; Clara Bueno-Fernandez; Esther Castillo-Gomez; Juan Nacher (2016) Reduced interneuronal dendritic arborization in CA1 but not in CA3 region of mice subjected to chronic mild stress. Brain And Behavior. ISSN: 2162-3279
Castillo-Gómez E; Perez-Rando M; Bellés M; Gilabert-Juan J; Llorens JV; Carceller H; Bueno-Fernández C; García-Mompó C; Ripoll-Martínez B; Curto Y; Sebastiá-Ortega N; Moltó MD; Sanjuan J; Nacher J (2017) Early Social isolation stress and perinatal nmda receptor antagonist treatment induce changes in the structure and neurochemistry of inhibitory neurons of the adult amygdala and prefrontal cortex. Eneuro, 4(2), pp. 1 - 23 . ISSN: 2373-2822
Perez-Rando M; Castillo-Gomez E; Bueno-Fernandez C; Nacher J. (2018) The TrkB agonist 7,8-dihydroxyflavone changes the structural dynamics of neocortical pyramidal neurons and improves object recognition in mice. Brain Structure & Function, 223(5), pp. 2393 - 2408 . ISSN: 1863-2653
Rotheneichner P; Belles M; Benedetti B: König R; Dannehl D; Kreutzer C; Zaunmair P; Engelhardt M; Aigner L; Nacher J; Couillard-Despres S. (2018) Cellular Plasticity in the Adult Murine Piriform Cortex: Continuous Maturation of Dormant Precursors Into Excitatory Neurons. Cerebral Cortex, 28(7), pp. 2610 - 2621 . ISSN: 1047-3211
Di Forti M; Quattrone D; Moltó MD; Nacher J; Olmeda MS; et al. (2019) The Contibution of cannabis use to variation in the incidence of psychotic disorder across Europe (EU-GEI): a multicentre case-control study. Lancet Psychiatry, 6(5), pp. 427 - 436 . ISSN: 2215-0374
Pesarico AP; Bueno-Fernandez C; Guirado R; Gómez-Climent MÁ; Curto Y; Carceller H; Nacher J. (2019) Chronic Stress Modulates Interneuronal Plasticity: Effects on PSA-NCAM and Perineuronal Nets in Cortical and Extracortical Regions. Frontiers In Cellular Neuroscience, 13(197) . ISSN: 1662-5102
Alcaide J; Guirado; Crespo C; Blasco-Ibáñez JM; Varea E; Sanjuan J; Nacher J. (2019) Alterations of perineuronal nets in the dorsolateral prefrontal cortex of neuropsychiatric patients. International Journal Of Bipolar Disorders, 7(1), p. 24 . ISSN: 2194-7511
Carceller H; Guirado R; Nacher J. (2020) Dark exposure affects plasticity-related molecules and interneurons throughout the visual system during adulthood. Journal of Comparative Neurology, 528(8), pp. 1349 - 1366 . ISSN: 0021-9967
Garcia-Mompo C; Curto Y; Carceller H; Gilabert-Juan J; Rodriguez-Flores E; Guirado R; Nacher J. (2020) Δ-9-Tetrahydrocannabinol treatment during adolescence and alterations in the inhibitory networks of the adult prefrontal cortex in mice subjected to perinatal NMDA receptor antagonist injection and to postweaning social isolation. Translational Psychiatry, 10(1), p. 177 . ISSN: 2158-3188
Carceller H; Guirado R; Ripolles-Campos E; Teruel-Marti V; Nacher J. (2020) Perineuronal nets regulate the inhibitory perisomatic input onto parvalbumin interneurons and γ activity in the prefrontal cortex. Journal of Neuroscience, 40(26), pp. 5008 - 5018 . ISSN: 0270-6474
Wakhloo D; Scharkowski F; Curto Y; Javed Butt U; Bansal V; Steixner-Kumar AA; Wüstefeld L; Rajput A; Arinrad S; Zillmann MR; Seelbach A; Hassouna I; Schneider K; Qadir Ibrahim A; Werner HB; Martens H; Miskowiak K; Wojcik SM; Bonn S; Nacher J; Nave KA; Ehrenreich H. (2020) Functional hypoxia drives neuroplasticity and neurogenesis via brain erythropoietin. Nature Communications, 11(1), p. 1313 . ISSN: 2041-1723
Coviello S; Gramuntell Y; Castillo-Gomez E; Nacher J (2020) Effects of Dopamine on the Immature Neurons of the Adult Rat Piriform Cortex. Frontiers In Neuroscience. ISSN: 1662-453X
Perez-Rando M; Guirado R; Tellez-Merlo G; Carceller H; Nacher J. (2021) Estradiol regulates PSA-NCAM expression and connectivity of O-LM interneurons in the hippocampus of adult female mice. Neuroendocrinology. ISSN: 0028-3835

Currricul@'s texts

Resum de la trajectòria científica. El objetivo principal de mi investigación es el estudio de la plasticidad estructural neuronal en el sistema nervioso central adulto, que incluye remodelación sináptica y de neuritas y neurogénesis adulta. Estamos particularmente interesados en cómo esta plasticidad estructural está involucrada en la etiología de diferentes trastornos psiquiátricos y su tratamiento. Nuestros focos principales son los circuitos inhibidores corticales y la forma polisializada de la molécula de adhesión celular neural (PSA-NCAM) como modulador de su plasticidad. Nuestro grupo descubrió que la expresión de PSA-NCAM en la corteza prefrontal medial está regulada por serotonina (a través de receptores 5HT3) y dopamina (a través de receptores D2), dos monoaminas profundamente implicadas en la etiología y el tratamiento de la esquizofrenia y la depresión y cambios en la expresión de moléculas relacionadas con la neurotransmisión inhibidora También describimos la distribución de las células que expresan PSA-NCAM en la amígdala, la corteza prefrontal medial y otras regiones corticales durante la vida adulta y el envejecimiento y encontramos que la mayoría de estas células eran interneuronas maduras polisializadas exclusivamente por la polisialiltransferasa St8SiaIV. Recientemente descubrimos que la expresión de PSA-NCAM es un regulador crítico de la estructura y conectividad de las interneuronas corticales, especialmente en la inhibición perisomática de las células piramidales.
CV SUMMARY. Full Professor of Cell Biology in the Neurobiology Unit of the Institute of Botechnology and Biomedicine of the Universitat de València (www.uv.es/biotecmed/neuro), co-IP G23 CIBERSAM, INCLIVA researcher. PhD in Neurobiology Universitat de València, postdoctoral work at the Laboratory of Neuroendocrinology of the Rockefeller University (New York). Research lines on the plasticity of the adult central nervous system and its involvement in the etiology and treatment of psychiatric disorders. 130 papers in international JCR journals, h index: 42. Vicepresident and secretary Sociedad Española de Neurociencia (SENC) (2013-17). 2005-10 Director of the Graduate Program in Basic and Applied Neurosciences, University of València. 2012-14. Director of the Master in Basic and Applied Neurosciences, University of València. PI 5 R+D projects from Spanish government and several projects from local government and private foundations. Local PI partner ERA-NET Neuron project. 11 thesis directed, most of the students working now in research/academia. Organizer of different events for the public dissemination of neuroscience: Pint of science, Brainshake, Neuromascletá, brain awareness week, @neuronacher on twitter, author 'Neuroregeneración' book (RBA/National Geographic).